التفاصيل البيبلوغرافية
| العنوان: |
The Heart failure and Optimal Outcomes from Pharmacy Study (HOOPS): rationale, design, and baseline characteristics. |
| المؤلفون: |
Lowrie, Richard, Mair, Frances S., Greenlaw, Nicola, Forsyth, Paul, McConnachie, Alex, Richardson, Janice, Khan, Nina, Morrison, Deborah, Messow, Claudia-Martina, Rae, Brian, McMurray, John J.V. |
| المصدر: |
European Journal of Heart Failure; Aug2011, Vol. 13 Issue 8, p917-924, 8p, 1 Diagram, 4 Charts |
| مصطلحات موضوعية: |
HEART failure treatment, PRIMARY care, HEALTH outcome assessment, PHARMACY, RANDOMIZED controlled trials, ACE inhibitors, ANGIOTENSIN-receptor blockers, CLINICAL trials |
| مستخلص: |
Aims The effect on mortality and morbidity of pharmacist-led intervention to optimize pharmacological therapy in patients with systolic heart failure (HF) has not been tested in a large-scale, long-term, clinical trial. Methods We describe the rationale and design of a UK, primary care-based, prospective cluster-randomized controlled trial of a pharmacist-led intervention in HF and report baseline characteristics of the patients randomized. Eighty-seven practices (1092 patients) were assigned to the intervention arm and 87 practices (1077 patients) to usual care. The average age of patients at baseline was 71 years, 70% were male, 86% were treated with an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker and 62% with a beta-blocker. Data for the primary outcome of death from any cause or hospitalization for HF will be available up to 31 December 2010, giving a mean follow-up of 5 years. More than 750 patients would have experienced the primary outcome during this period. The first secondary outcome is death from any cause or hospitalization for a cardiovascular reason. Deaths and hospitalizations are being identified using the Scottish National Health Service electronic patient record-linkage system (hence the delay between the end of follow-up and database lock). Conclusion This trial is powered to provide a robust evaluation of the effect of pharmacist-led treatment optimization in patients with systolic HF in primary care. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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