| مستخلص: |
This study examined the effect of pre‐germinated brown rice extract (PGBRE), containing no dietary fibers, but γ‐oryzanol, γ‐aminobutyric acid (GABA), flavonoids, and anthocyanidin, on high‐fat‐diet (HFD)‐induced metabolic syndrome. C57BL/6 mice were divided into five groups: regular diet, HFD, HFD with oral PGBRE 30, 300, or 600 mg/kg per day for 18 weeks. In the HFD group, higher body and liver weight gain, hyperglycemia, HbA1c, and insulin; higher TG, TC, LDL‐C, non‐HDL, atherosclerosis index, lower HDL, adiponectin in blood; higher TG in the liver; higher TG, bile acid in feces; and lower protein levels of AMP‐activated protein kinase, insulin receptor, insulin receptor substrate‐1, insulin receptor substrate‐2, peroxisome proliferator‐activated receptor‐γ, phosphatidylinositol‐3‐kinase, Akt/PKB, glucose transporter‐1, glucose transporter‐4, glucokinase in the skeletal muscle; lower glucagon‐like peptide 1 (GLP‐1) in the intestine; higher sterol regulatory element‐binding protein‐1 (SREBP‐1), stearoyl‐CoA desaturase 1 (SCD‐1), fatty acid synthase (FAS), 3‐hydroxy‐3‐methylglutaryl‐CoA reductase, proprotein convertase subtilisin/kexin type 9 (PCSK9), and lower PPAR‐α, low‐density lipoprotein receptor, cholesterol‐7α‐hydroxylase in the liver; higher SREBP‐1, SCD‐1, FAS, and lower PPAR‐α, adiponectin in the adipose tissue were found. In HFD + PGBRE groups, the above biochemical parameters were improved. Practical applications: According to the results, we suggested that dietary fibers played a minor role in this study. Extract of PGBR, excluding dietary fiber, showed beneficial activity to ameliorate metabolic syndrome. γ‐oryzanol, GABA, flavonoids, and anthocyanidin in PGBRE can inhibit HFD‐induced metabolic syndrome and we demonstrated clearly its action mechanisms. This is the first report to examine the relation between PGBRE, GLP‐1, and PCSK9. Taken together, PGBRE can potentially be used to develop a good supplement to control metabolic syndrome. Extract of PGBR, excluding dietary fiber, showed beneficial activity to ameliorate metabolic syndrome. γ‐Oryzanol, GABA, flavonoids and anthocyanidin in PGBRE can inhibit HFD‐induced metabolic syndrome and we demonstrated clearly its action mechanisms. This is the first report to examine the relation between PGBRE, GLP‐1 and PCSK9. Taken together, PGBRE can potentially be used to develop a good supplement to control metabolic syndrome. [ABSTRACT FROM AUTHOR] |
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