التفاصيل البيبلوغرافية
| العنوان: |
Elevated serum levels of soluble Tac peptide in adult T-cell leukemia: correlation with clinical status during chemotherapy. |
| المؤلفون: |
Marcon, Luisa, Rubin, Laurence a., Kurman, Carole C., Fritz, Mary Elizabeth, Longo, Dan L., Uchiyama, Takashi, Edwards, Brenda K., Nelson, David L., Marcon, L, Rubin, L A, Kurman, C C, Fritz, M E, Longo, D L, Uchiyama, T, Edwards, B K, Nelson, D L |
| المصدر: |
Annals of Internal Medicine; 8/15/88, Vol. 109 Issue 4, p274-279, 6p, 3 Graphs |
| مصطلحات موضوعية: |
SEROTHERAPY, PEPTIDES, ADULT T-cell leukemia, LEUKEMIA treatment, THERAPEUTICS, CELL receptors, CHRONIC diseases, ENZYME-linked immunosorbent assay, LACTATE dehydrogenase, LEUKEMIA, PROGNOSIS, RETROVIRUS diseases, PREDICTIVE tests, ACUTE diseases, LEUKOCYTE count |
| مستخلص: |
Adult T-cell leukemia associated with human T-cell leukemia virus type I (HTLV-I) is characterized by a clonal expansion of a CD4-positive subset of T lymphocytes that constitutively express high numbers of interleukin-2 receptors and that frequently infiltrate the skin; osteolytic bone lesions, and hypercalcemia. Using an enzyme-linked immunosorbent assay (ELISA) test, we measured the level of soluble Tac peptide, one chain of the human interleukin-2 receptor, in the serum of 50 patients with adult T-cell leukemia (38 Japanese and 12 American patients), 8 patients with other hematologic malignancies, 8 asymptomatic HTLV-I-antibody-positive carriers, and 17 normal controls. The serum level of soluble Tac peptide (geometric mean U/mL, 95% CI) was elevated at presentation in all patients with adult T-cell leukemia (16,461; 819 to 330,896) when compared with normal controls (238; 112 to 502), patients with other hematologic malignancies (1302; 475 to 3569), and healthy HTLV-I antibody-positive carriers (490; 115 to 2086). The highest levels were seen in patients (n = 33) with acute (32,154; 2587 to 399,598) compared with chronic (5464; 661 to 45,156) disease (n = 14). Serum levels of Tac peptide also tended to be more elevated in patients with adult T-cell leukemia with hypercalcemia (32,072; 2461 to 417,908) compared with normocalcemic patients (13,885; 496 to 388,436). Serial measurements of soluble Tac peptide levels in serum were done in four patients with adult T-cell leukemia during chemotherapy and the levels reflected disease activity. These observations suggest that the measurement of soluble Tac peptide levels in patients with adult T-cell leukemia is useful as a noninvasive measure of tumor burden and will help in the diagnosis of the disease and management of these patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
