التفاصيل البيبلوغرافية
| العنوان: |
MTA1, a transcriptional activator of breast cancer amplified sequence 3. |
| المؤلفون: |
Gururaj, Anupama E., Singh, Rajesh R., Rayala, Suresh K., Holm, Caroline, den Hollander, Petra, Hao Zhang, Balasenthil, Seetharaman, Talukder, Amjad H., Landberg, Goran, Kumar, Rakesh |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 4/25/2006, Vol. 103 Issue 17, p6670-6675, 6p, 1 Color Photograph, 1 Chart, 5 Graphs |
| مصطلحات موضوعية: |
BREAST cancer, CANCER, ESTROGEN, GENE expression, POLYMERASE chain reaction, TUMORS |
| مستخلص: |
Here we define a function of metastasis-associated protein 1 (MTA1), a presumed corepressor of estrogen receptor α(ERα), as a transcriptional activator of Breast Cancer Amplified Sequence 3 (BCAS3), a gene amplified and overexpressed in breast cancers. We identified BCAS3 as a MTA1 chromatin target in a functional genomic screen. MTA1 stimulation of BCAS3 transcription required ERα and involved a functional ERE half-site in BCAS3. Furthermore, we discovered that MTA1 is acetylated on lysine 626, and that this acetylation is necessary for a productive transcriptional recruitment of RNA polymerase II complex to the BCAS3 enhancer sequence. BCAS3 expression was elevated in mammary tumors from MTA1 transgenic mice and 60% of the human breast tumors, and correlated with the coexpression of MTA1 as well as with tumor grade and proliferation of primary breast tumor samples. These findings reveal a previously unrecognized function of MTA1 in stimulating BCAS3 expression and suggest an important role for MTA1-BCAS3 pathway in promoting cancerous phenotypes in breast tumor cells. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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