التفاصيل البيبلوغرافية
| العنوان: |
Effect of aminophylline on coronary reactive and functional hyperaemic response in conscious dogs. |
| المؤلفون: |
RADFORD, MARTHA J, McHALE, PHILIP A, SADICK, NORMAN, SCHWARTZ, GREGORY G, GREENFIELD, JOSEPH C |
| المصدر: |
Cardiovascular Research; Jun1984, Vol. 18 Issue 6, p377-383, 7p |
| مستخلص: |
This study was undertaken to determine whether adenosine release from myocardial cells plays a role in coronary reactive and functional vasomotion. Reactive hyperaemic blood flow responses to 10 s complete occlusions and 400 ms diastolic occlusions of the left circumflex coronary artery and to the vasomotor respones to the increased cardiac demand following ventricular extra-activation were examined in a chronic, heart-blocked dog preparation during a control period and following intravenous bolus administration of aminophylline (5 mg·kg−1). Aminophylline administration resulted in a 19% decrease in the blood flow debt repayment ratio of 10 s reactive hyperaemic responses compared with the control period. However, administration of aminophylline had no effect on the coronary vascular response to 400 ms diastolic occlusions or to ventricular extra-activations. These observations indicate that adenosine may play a role in the coronary vascular response to prolonged interventions but that other factors, as yet unidentified, may be implicated in the beat-to-beat regulation of coronary vascular resistance. [ABSTRACT FROM PUBLISHER] |
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| قاعدة البيانات: |
Complementary Index |
