التفاصيل البيبلوغرافية
| العنوان: |
Biomarkers for site-specific response to neoadjuvant chemotherapy in epithelial ovarian cancer: relating MRI changes to tumour cell load and necrosis. |
| المؤلفون: |
Winfield, Jessica M., Wakefield, Jennifer C., Brenton, James D., AbdulJabbar, Khalid, Savio, Antonella, Freeman, Susan, Pace, Erika, Lutchman-Singh, Kerryn, Vroobel, Katherine M., Yuan, Yinyin, Banerjee, Susana, Porta, Nuria, Ahmed Raza, Shan E., deSouza, Nandita M. |
| المصدر: |
British Journal of Cancer; Mar2021, Vol. 124 Issue 6, p1130-1137, 8p |
| مصطلحات موضوعية: |
THERAPEUTIC use of antineoplastic agents, RESEARCH, CLINICAL trials, CARCINOGENESIS, ANTHROPOMETRY, RESEARCH methodology, MAGNETIC resonance imaging, PROGNOSIS, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RESEARCH funding, COMBINED modality therapy, NECROSIS, LONGITUDINAL method, METABOLISM |
| مستخلص: |
Background: Diffusion-weighted magnetic resonance imaging (DW-MRI) potentially interrogates site-specific response to neoadjuvant chemotherapy (NAC) in epithelial ovarian cancer (EOC).Methods: Participants with newly diagnosed EOC due for platinum-based chemotherapy and interval debulking surgery were recruited prospectively in a multicentre study (n = 47 participants). Apparent diffusion coefficient (ADC) and solid tumour volume (up to 10 lesions per participant) were obtained from DW-MRI before and after NAC (including double-baseline for repeatability assessment in n = 19). Anatomically matched lesions were analysed after surgical excision (65 lesions obtained from 25 participants). A trained algorithm determined tumour cell fraction, percentage tumour and percentage necrosis on histology. Whole-lesion post-NAC ADC and pre/post-NAC ADC changes were compared with histological metrics (residual tumour/necrosis) for each tumour site (ovarian, omental, peritoneal, lymph node).Results: Tumour volume reduced at all sites after NAC. ADC increased between pre- and post-NAC measurements. Post-NAC ADC correlated negatively with tumour cell fraction. Pre/post-NAC changes in ADC correlated positively with percentage necrosis. Significant correlations were driven by peritoneal lesions.Conclusions: Following NAC in EOC, the ADC (measured using DW-MRI) increases differentially at disease sites despite similar tumour shrinkage, making its utility site-specific. After NAC, ADC correlates negatively with tumour cell fraction; change in ADC correlates positively with percentage necrosis.Clinical Trial Registration: ClinicalTrials.gov NCT01505829. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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