التفاصيل البيبلوغرافية
| العنوان: |
Clinical predictors of non‐response to lithium treatment in the Pharmacogenomics of Bipolar Disorder (PGBD) study. |
| المؤلفون: |
Lin, Yian, Maihofer, Adam X., Stapp, Emma, Ritchey, Megan, Alliey‐Rodriguez, Ney, Anand, Amit, Balaraman, Yokesh, Berrettini, Wade H., Bertram, Holli, Bhattacharjee, Abesh, Calkin, Cynthia V., Conroy, Carla, Coryell, William, D'Arcangelo, Nicole, DeModena, Anna, Biernacka, Joanna M., Fisher, Carrie, Frazier, Nicole, Frye, Mark, Gao, Keming |
| المصدر: |
Bipolar Disorders; Dec2021, Vol. 23 Issue 8, p821-831, 11p, 1 Diagram, 3 Charts, 1 Graph |
| مصطلحات موضوعية: |
THERAPEUTIC use of lithium, BIPOLAR disorder, PROPORTIONAL hazards models, PHARMACOGENOMICS, LIFE change events, DISEASE remission |
| مستخلص: |
Background: Lithium is regarded as a first‐line treatment for bipolar disorder (BD), but partial response and non‐response commonly occurs. There exists a need to identify lithium non‐responders prior to initiating treatment. The Pharmacogenomics of Bipolar Disorder (PGBD) Study was designed to identify predictors of lithium response. Methods: The PGBD Study was an eleven site prospective trial of lithium treatment in bipolar I disorder. Subjects were stabilized on lithium monotherapy over 4 months and gradually discontinued from all other psychotropic medications. After ensuring a sustained clinical remission (defined by a score of ≤3 on the CGI for 4 weeks) had been achieved, subjects were followed for up to 2 years to monitor clinical response. Cox proportional hazard models were used to examine the relationship between clinical measures and time until failure to remit or relapse. Results: A total of 345 individuals were enrolled into the study and included in the analysis. Of these, 101 subjects failed to remit or relapsed, 88 achieved remission and continued to study completion, and 156 were terminated from the study for other reasons. Significant clinical predictors of treatment failure (p < 0.05) included baseline anxiety symptoms, functional impairments, negative life events and lifetime clinical features such as a history of migraine, suicidal ideation/attempts, and mixed episodes, as well as a chronic course of illness. Conclusions: In this PGBD Study of lithium response, several clinical features were found to be associated with failure to respond to lithium. Future validation is needed to confirm these clinical predictors of treatment failure and their use clinically to distinguish who will do well on lithium before starting pharmacotherapy. [ABSTRACT FROM AUTHOR] |
|
Copyright of Bipolar Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
