المساهمون: Jun-Lin Yi, MD, Radiotherapy director

المصدر: Optimization of Cervical Nodal Clinical Tumor Volume for Early and Medium Stage Nasopharyngeal Carcinoma: a Multicenter Non-inferior Randomized Controlled Phase III Clinical Trial

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05145660Test

المساهمون: Jun-Lin Yi, MD, Vice director of Dept. Radiotherapy

المصدر: Bah H, Aub F, Stagg J, Gologan O, Bally O, Bsada E, Nguyen-Tan FP, Soulres D, Guert L, Fn E, Chrtopoulos A, Lambert L, Tehfe M, Ayad T, Charpentr D, Jamal R, Wong P. Phase trl of Durvalumab plus Tremelumab and stereotact body radtherapy for metastat head and neck carcoma. BMC Cancer. 2019 Jan 14;19(1):68. do 10.1186/s12885-019-5266-4.
Burtness B, Harrgton KJ, Gre R, Soulres D, Tahara M, de Castro G Jr, PsyrrA, Baste N, Neupane P, Bratland A, Fuereder T, Hughes BGM, Mes R, Ngamphaoon N, Rordorf T, Wan hak WZ, Hong RL, Gonzalez Mendoza R, Roy A, Zhang Y, Gumuscu B, Cheng JD, J F, Rch D; KEYNOTE-048 vestators. Pembrolumab alone or wh chemotherapy versus cetuxab wh chemotherapy for recurrent or metastat squamous cell carcoma of the head and neck (KEYNOTE-048): a randomed, open-label, phase 3 study. Lancet. 2019 Nov 23;394(10212):1915-1928. do 10.1016/S0140-6736(19)32591-7. Epub 2019 Nov 1. Erratum : Lancet. 2020 Jan 25;395(10220):272. Lancet. 2020 Feb 22;395(10224):564. Lancet. 2021 Jun 12;397(10291):2252.
McBre S, Sherman E, TsaCJ, BaxS, Aghalar J, Eng J, ZhW McFarland D, Mhel LS, Young R, Lefkowz R, Splsger D, Zhang Z, Flynn J, Dunn L, Ho A, Rz N, Pfter D, Lee N. Randomed Phase Trl of Nolumab Wh Stereotact Body Radtherapy Versus Nolumab Alone Metastat Head and Neck Squamous Cell Carcoma. J Cl Oncol. 2021 Jan 1;39(1):30-37. do 10.1200/JCO.20.00290. Epub 2020 Aug 21.
Phase II Clinical Study of Sintilimab Combined With Platinum-based Chemotherapy and SBRT in the First-line Treatment of Limited Metastatic Head and Neck Squamous Cell Carcinoma

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05136768Test

المساهمون: Jun-Lin Yi, MD, Professor

المصدر: A Randomized, Open Study of Camrelizumab vs Placebo as a Maintenance Therapy After Chemoradiation in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04861467Test

المساهمون: Jun-Lin Yi, MD, professor

المصدر: Xu C, Sun R, Tang LL, Chen L, LWF, Mao YP, Zhou GQ, Guo R, L AH, Sun Y, Ma J, Hu WH. Role of sequentl chemoradtherapy stage and low-rk stage nasopharyngeal carcoma the era of tensy-modulated radtherapy: A propensy score-matched analys. Oral Oncol. 2018 Mar;78:37-45. do 10.1016/j.oraloncology.2018.01.008. Epub 2018 Feb 20.
L YC, Wang WY, Twu CW, Jng RS, Lng KL, L PJ, L JW, L JC. Comparon Long-term Outcome of Defe Radtherapy plus Dferent Chemotherapy Schedules Patnts wh Advanced Nasopharyngeal Carcoma. ScRep. 2018 Jan 11;8(1):470. do 10.1038/s41598-017-18713-z.
Yao JJ, Yu XL, Zhang F, Zhang WJ, Zhou GQ, Tang LL, Mao YP, Chen L, Ma J, Sun Y. Radtherapy wh neoadjuvant chemotherapy versus concurrent chemoradtherapy for ascendg-type nasopharyngeal carcoma: a retrospecte comparon of toxy and prognos. Ch J Cancer. 2017 Mar 6;36(1):26. do 10.1186/s40880-017-0195-6.
Xu C, Zhang LH, Chen YP, L X, Zhou GQ, L AH, Sun Y, Ma J. Chemoradtherapy Versus Radtherapy Alone Stage Nasopharyngeal Carcoma: A System Revw and Meta-analys of 2138 Patnts. J Cancer. 2017 Jan 15;8(2):287-297. do 10.7150/jca.17317. eCollectn 2017.
A Randomized Multicenter Phase II/III Study of Optimized Treatment Strategies for Stage II and III Nasopharyngeal Carcinoma

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03908372Test

المساهمون: Jun-Lin Yi, MD, Chief physician

المصدر: Cao C, Hu Q, Chen X. tensy-modulated radtherapy for elderly patnts wh nasopharyngeal carcoma. Head Neck. 2018 Mar;40(3):590-595. do 10.1002/hed.25016. Epub 2017 Nov 20.
L H, Chen QY, Guo L, Tang LQ, Mo HY, Zhong ZL, Huang PY, Luo DH, Sun R, Guo X, Cao KJ, Hong MH, MaHQ. Feasy and effacy of chemoradtherapy for elderly patnts wh locoregnally advanced nasopharyngeal carcoma: results from a matched cohort analys. Radt Oncol. 2013 Mar 22;8:70. do 10.1186/1748-717X-8-70.
Zhang Y, Yi JL, Huang XD, Xu GZ, Xiao JP, Li SY, Luo JW, Zhang SP, Wang K, Qu Y, Gao L. Inherently poor survival of elderly patients with nasopharyngeal carcinoma. Head Neck. 2015 Jun;37(6):771-6. doi: 10.1002/hed.23497. Epub 2015 Feb 11.
Jin YN, Zhang WJ, Cai XY, Li MS, Lawrence WR, Wang SY, Mai DM, Du YY, Luo DH, Mo HY. The Characteristics and Survival Outcomes in Patients Aged 70 Years and Older with Nasopharyngeal Carcinoma in the Intensity-Modulated Radiotherapy Era. Cancer Res Treat. 2019 Jan;51(1):34-42. doi: 10.4143/crt.2017.551. Epub 2018 Feb 6.
Phase II Trial of Nimotuzumab Combined With Volumetric Modulated Arc Therapy in Elderly Patients With Nasopharyngeal Carcinoma

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03915132Test

المساهمون: Jun-Lin Yi, MD, Vice director of department of radiation oncology

المصدر: A Prospective, Open-label, Single-arm Study for Efficacy and Safety of Three-drug Antiemetic Regimen to Prevent the Emesis During Radiotherapy With Concurrent Chemoradiotherapy in Locally Advanced HNSCC

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03572829Test

المساهمون: Jun-Lin Yi, MD, Professor

المصدر: Blanchard P, Baujat B, Holostenco V, Bourredjem A, Baey C, Bourh J, Pnon JP; MACH-CH Collaborate group. Meta-analys of chemotherapy head and neck cancer (MACH-NC): a comprehense analys by tumour se. Radther Oncol. 2011 Jul;100(1):33-40. do 10.1016/j.radonc.2011.05.036. Epub 2011 Jun 16.
Blanchard P, Bourh J, Lacas B, Posner MR, Vermorken JB, Cruz Hernandez JJ, Bourredjem A, Cala G, Paccagnella A, Ht R, Pnon JP; Meta-Analys of Chemotherapy Head and Neck Cancer, ductn Project, Collaborate Group. Taxane-cplat-fluorourac as ductn chemotherapy locally advanced head and neck cancers: an dual patnt data meta-analys of the meta-analys of chemotherapy head and neck cancer group. J Cl Oncol. 2013 Aug 10;31(23):2854-60. do 10.1200/JCO.2012.47.7802. Epub 2013 Jul 8.
Potreau Y, Garaud P, Chapet S, Se C, Tucha C, Tortochaux J, Fare S, Guerr S, AlfonsM, Cala G. Randomed trl of ductn chemotherapy wh cplat and 5-fluorourac wh or whout docetaxel for larynx preservatn. J Natl Cancer st. 2009 Apr 1;101(7):498-506. do 10.1093/jncdjp007. Epub 2009 Mar 24.
New Strategy of Improving Treatment Outcome and Larynx-preservation Rate in Locally Advanced Hypopharyngeal Carcinoma

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03558035Test

المساهمون: Jun-Lin Yi, MD, Professor

المصدر: Kam MK, Leung SF, Zee B, Chau RM, Suen JJ, Mo F, LaM, Ho R, Cheung KY, Yu BK, Ch SK, ChoPH, Teo PM, Kwan WH, Chan AT. Prospecte randomed study of tensy-modulated radtherapy on salary gland functn early-stage nasopharyngeal carcoma patnts. J Cl Oncol. 2007 Nov 1;25(31):4873-9. do 10.1200/JCO.2007.11.5501.
Chua DT, Sham JS, Kwong DL, Au GK. Treatment outcome after radtherapy alone for patnts wh Stage nasopharyngeal carcoma. Cancer. 2003 Jul 1;98(1):74-80. do 10.1002/cncr.11485.
Chua DT, Ma J, Sham JS, Mai HQ, Choy DT, Hong MH, Lu TX, Au GK, Min HQ. Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trials. Int J Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1300-6. doi: 10.1016/j.ijrobp.2006.02.016. Epub 2006 Jun 5.
Cheng SH, Tsai SY, Yen KL, Jian JJ, Chu NM, Chan KY, Tan TD, Cheng JC, Hsieh CY, Huang AT. Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. J Clin Oncol. 2000 May;18(10):2040-5. doi: 10.1200/JCO.2000.18.10.2040.
A Randomized Multicenter Phase II Study of Intensity-modulated Radiotherapy Combined With Chemotherapy Versus Intensity-modulated Radiotherapy Alone for Stage II Nasopharyngeal Carcinoma

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT01187238Test

المساهمون: Jun-Lin Yi, MD, Vice chairman， Department of Radiation Oncology, Cancer hospital

المصدر: Multicenter Phase III Study of Intensity-modulated Radiotherapy Alone Compared to Intensity-modulated Radiotherapy Combined Chemotherapy for Lower Risk Locally Advanced Nasopharyngeal Carcinoma

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT01817023Test