المصدر: A Multi-center, Randomized, Double-blind, Active-controlled, Phase Ⅲ Study to Evaluate Efficacy and Safety of Narlumosbart (JMT103) in Patients With Giant Cell Tumor of Bone

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05813665Test

المصدر: Zoledronic Acid-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Bone Tumor After Intralesional Curettage: a Prospective, Multicenter, Single Blinded, Randomized Control Trial.

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05595603Test

المصدر: A Real-world Study on Patients of Surgically Unsalvageable or Severe Post-surgery Morbidity Associated Giant Cell Tumor of Bone

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05402865Test

المصدر: An Open-label, Multi-center, Phase 4 Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the Bone

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04586660Test

Other URLs: http://www.amgentrials.comTest

المصدر: A Phase Ib/II, Multicenter, Single-Arm, Open-Label Study to Evaluate the Efficacy and Safety of JMT103 in Surgically Unsalvageable or Refractory Giant Cell Tumor of Bone

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04255576Test

المصدر: Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987 Jan;69(1):106-14.
Al-Ibraheemi A, Inwards CY, Zreik RT, Wenger DE, Jenkins SM, Carter JM, Boland JM, Rose PS, Jin L, Oliveira AM, Fritchie KJ. Histologic Spectrum of Giant Cell Tumor (GCT) of Bone in Patients 18 Years of Age and Below: A Study of 63 Patients. Am J Surg Pathol. 2016 Dec;40(12):1702-1712. doi: 10.1097/PAS.0000000000000715.
Dahlin DC, Cupps RE, Johnson EW Jr. Giant-cell tumor: a study of 195 cases. Cancer. 1970 May;25(5):1061-70. doi: 10.1002/1097-0142(197005)25:53.0.co;2-e. No abstract available.
Giant Cell Tumor of the Bone in Patients Under 15 Years Old: a Single Institution Case-series

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04002817Test

المؤلفون: Iovance Biotherapeutics, Inc., National Cancer Institute (NCI)

المصدر: Clinical Study to Assess Efficacy and Safety of LN-145/LN-145-S1 (Autologous Centrally Manufactured Tumor Infiltrating Lymphocytes) Across Multiple Tumor Types

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03449108Test

Other URLs: http://www.mdanderson.orgTest

المساهمون: GUO WEI, Chief of Musculoskeltal Tumor Center

المصدر: RutkowskP, FerrarS, Grer RJ, Stalley PD, Dkstra SP, PnkowskA, Vaz G, Wunder JS, Seeger LL, Feng A, Roberts ZJ, Bach BA. Surgal downstagg an open-label phase trl of denosumab patnts wh gnt cell tumor of bone. Ann Surg Oncol. 2015 Sep;22(9):2860-8. do 10.1245/s10434-015-4634-9. Epub 2015 Jun 2.
Mak , Evanw N, Popov S, Tozer R, Ghert M. A Translatnal Study of the Neoplast Cells of Gnt Cell Tumor of Bone Followg Neoadjuvant Denosumab. J Bone Jot Surg Am. 2014 Aug 6;96(15):e127. do 10.2106/JBJS.M.01332.
Ueda T, Morka H, Nha Y, Kakunaga S, Tsucha H, Matsumoto Y, AsamY, oue T, Yoneda T. Objecte tumor response to denosumab patnts wh gnt cell tumor of bone: a multenter phase trl. Ann Oncol. 2015 Oct;26(10):2149-54. do 10.1093/annonc/mdv307. Epub 2015 Jul 23.
Branstetter DG, Nelson SD, Manel JC, Blay JY, Chawla S, Thomas DM, Jun S, Jacobs Denosumab duces tumor reductn and bone formatn patnts wh gnt-cell tumor of bone. Cl Cancer Res. 2012 Aug 15;18(16):4415-24. do 10.1158/1078-0432.CCR-12-0578. Epub 2012 Jun 18.
Wojc J, Rosenberg AE, Bredella MA, Choy E, Hornek FJ, Nlsen GP, Deshpande V. Denosumab-treated Gnt Cell Tumor of Bone Exhs Morpholog Overlap Wh Malnant Gnt Cell Tumor of Bone. Am J Surg Pathol. 2016 Jan;40(1):72-80. do 10.1097/PAS.0000000000000506.
Chawla S, Henshaw R, Seeger L, Choy E, Blay JY, FerrarS, Kroep J, Grer R, Rehardt P, RutkowskP, Schuetze S, Skubz K, Staddon A, Thomas D, Qn Y, Jacobs Safety and effacy of denosumab for adults and skeletally mature adolescents wh gnt cell tumour of bone: ter analys of an open-label, parallel-group, phase 2 study. Lancet Oncol. 2013 Aug;14(9):901-8. do 10.1016/S1470-2045(13)70277-8. Epub 2013 Jul 16.
Safety and Efficacy of Post-operative Denosumab Strategy for Giant Cell Tumor of Bone Treatment in China：Correlation Between Recurrence and Drug Withdrawl

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03358212Test

المصدر: Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03301857Test

Other URLs: http://www.amgentrials.comTest

المؤلفون: Orthopedic Research and Education Foundation, Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute), University of Iowa, Johns Hopkins University, McGill University Health Centre/Research Institute of the McGill University Health Centre, The Cleveland Clinic, Wake Forest University, University of Kansas, Indiana University, University of Oklahoma, Beth Israel Deaconess Medical Center, Boston Children's Hospital, American Academy of Orthopaedic Surgeons, Massachusetts General Hospital, All India Institute of Medical Science

المساهمون: David Greenberg, MD;; Associate Professor, Associate Professor Orthopaedic Surgery Saint Louis University

المصدر: Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone: A Prospective Randomized Controlled Trial

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03295981Test