التفاصيل البيبلوغرافية
| العنوان: |
Ameliorative Effect of Rhoifolin in Cisplatin-Induced Nephrotoxicity via Regulating Nuclear Factor-κB Pathway. |
| المؤلفون: |
Yanfang Song1 ShufangYandhj@163.com, Shufang Yan2, Hong Zhang1, Rui Liu1, Xin An1, Qifeng Zhang1 |
| المصدر: |
Current Topics in Nutraceutical Research. Aug2020, Vol. 18 Issue 3, p266-272. 7p. |
| مصطلحات موضوعية: |
INFLAMMATION prevention, ANIMAL experimentation, ANTIOXIDANTS, BIOLOGICAL models, CELLULAR signal transduction, FLAVONOIDS, GLUTATHIONE, INTERLEUKINS, NEPHROTOXICOLOGY, PHOSPHORYLATION, RATS, SUPEROXIDE dismutase, TUMOR necrosis factors, DNA-binding proteins, MALONDIALDEHYDE, PLANT extracts, OXIDATIVE stress, TREATMENT effectiveness |
| مستخلص: |
Dose-dependent nephrotoxicity limits the therapeutic use of cisplatin in tumor chemotherapy. Natural compounds show a protective effect against cisplatin-induced nephrotoxicity. Rhoifolin is a flavone glycoside that demonstrates antioxidant and antiproliferative effects. The influence and mechanism of rhoifolin on cisplatin-induced nephrotoxicity were investigated in this study. First, a rat model of cisplatin-induced nephrotoxicity was established. Intraperitoneal administration of cisplatin induced renal damage in rats as demonstrated by a decrease in body weight, increase in blood urea, nitrogen and creatinine, and destruction of histological integrity. However, treatment with rhoifolin attenuated cisplatin-induced nephrotoxicity. Second, cisplatin induced oxidative stress and inflammatory response in rats as demonstrated by a decrease in superoxide dismutase, glutathione, glutathione S-transferase and catalase, and an increase in malondialdehyde, tumor necrosis factor-α, and interleukin-6. Also, the administration of rhoifolin led to alleviation of cisplatin-induced oxidative stress and inflammatory response. Finally, cisplatin activated the nuclear factor-kappa B signaling pathway via degradation and phosphorylation of IκBα (inhibitor of kappa B). Administration of rhoifolin inhibited nuclear translocation of NF-κB via downregulation of phospho-IκBα and phospho-p65, as well as up-regulation of IκBα. In conclusion, the administration of rhoifolin attenuated cisplatin-induced renal damage, oxidative stress and inflammatory response through inhibition of the NF-κB signaling pathway, suggesting a potential adjunct candidate for cisplatin in tumor treatment. [ABSTRACT FROM AUTHOR] |
|
Copyright of Current Topics in Nutraceutical Research is the property of New Century Health Publishers, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Business Source Index |
