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1مؤتمر
المؤلفون: Jean-Daubias, Stéphanie, Excoffier, Thierry, Azziz, Otman
المساهمون: Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Traces, Web, Education, Adaptation, Knowledge (TWEAK), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Modélisation Géométrique, Géométrie Algorithmique, Fractales (GeoMod), CVEC, IFRATH, Bousefsaf F., Thomann G., Morère Y., ANR-21-DMES-0005,INCLUDE (DMES),Inclusion des apprenants dans le supérieur: cultiver les diversités en transcendant les barrières spatiales, temporelles et cognitives grâce à la transformation numérique(2021)
المصدر: Handicap 2024 ; https://hal.science/hal-04618419Test ; Handicap 2024, IFRATH, Jun 2024, Aubervillers campus condorcet, France. pp.101-106 ; https://ifrath.fr/handicap2024Test/
مصطلحات موضوعية: application mobile, itinéraire intérieur, plus court chemin, adaptation, PMR, Troubles du Spectre Autistique, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC]
جغرافية الموضوع: France
الوقت: Aubervillers campus condorcet, France
الوصف: National audience ; OPALE is a multi-service mobile app for users of the Claude Bernard Lyon 1 University campuses, combining the discovery of practical, cultural and scientific resources with useful everyday functions. Points of interest are geolocated on a map of the campus and can be reached via an itinerary. But an itinerary to a building is not always enough to find your way around. The orientation problem often lies in the last few metres: between the entrance to the building and the room you are looking for. In this article we present OPALE, and the approach we have adopted to solve this problem of orienting users in a building. We will also show how we take into account the specific characteristics of users, particularly those with physical or cognitive disabilities. ; OPALE est une application mobile multi-services à destination des usagers des campus de l’Université Claude Bernard Lyon 1. Elle associe découverte des ressources pratiques, culturelles et scientifiques à des fonctionnalités utiles au quotidien. Les points d’intérêts sont géolocalisés sur une carte du campus et atteignables via un itinéraire. Mais un itinéraire vers un bâtiment ne suffit pas toujours à se repérer. Le problème d’orientation se situe en effet souvent dans les derniers mètres : entre l’entrée du bâtiment et la salle recherchée. Dans cet article nous présentons OPALE, ainsi que l’approche que nous avons adoptée pour résoudre ce problème d’orientation des usagers dans un bâtiment. Nous montrerons également comment nous prenons en compte les spécificités des usagers, tout particulièrement ceux porteurs de handicaps, qu’ils soient physiques ou cognitifs.
العلاقة: hal-04618419; https://hal.science/hal-04618419Test; https://hal.science/hal-04618419/documentTest; https://hal.science/hal-04618419/file/Handicap-2024_OPALE_finale.pdfTest
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2مؤتمر
المؤلفون: Jean-Daubias, Stéphanie, Excoffier, Thierry, Azziz, Otman
المساهمون: Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Traces, Web, Education, Adaptation, Knowledge (TWEAK), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Modélisation Géométrique, Géométrie Algorithmique, Fractales (GeoMod), CVEC, IFRATH, Bousefsaf F., Thomann G., Morère Y., ANR-21-DMES-0005,INCLUDE (DMES),Inclusion des apprenants dans le supérieur: cultiver les diversités en transcendant les barrières spatiales, temporelles et cognitives grâce à la transformation numérique(2021)
المصدر: Handicap 2024 ; https://hal.science/hal-04618419Test ; Handicap 2024, IFRATH, Jun 2024, Aubervillers campus condorcet, France. pp.101-106 ; https://ifrath.fr/handicap2024Test/
مصطلحات موضوعية: application mobile, itinéraire intérieur, plus court chemin, adaptation, PMR, Troubles du Spectre Autistique, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC]
جغرافية الموضوع: France
الوقت: Aubervillers campus condorcet, France
الوصف: National audience ; OPALE is a multi-service mobile app for users of the Claude Bernard Lyon 1 University campuses, combining the discovery of practical, cultural and scientific resources with useful everyday functions. Points of interest are geolocated on a map of the campus and can be reached via an itinerary. But an itinerary to a building is not always enough to find your way around. The orientation problem often lies in the last few metres: between the entrance to the building and the room you are looking for. In this article we present OPALE, and the approach we have adopted to solve this problem of orienting users in a building. We will also show how we take into account the specific characteristics of users, particularly those with physical or cognitive disabilities. ; OPALE est une application mobile multi-services à destination des usagers des campus de l’Université Claude Bernard Lyon 1. Elle associe découverte des ressources pratiques, culturelles et scientifiques à des fonctionnalités utiles au quotidien. Les points d’intérêts sont géolocalisés sur une carte du campus et atteignables via un itinéraire. Mais un itinéraire vers un bâtiment ne suffit pas toujours à se repérer. Le problème d’orientation se situe en effet souvent dans les derniers mètres : entre l’entrée du bâtiment et la salle recherchée. Dans cet article nous présentons OPALE, ainsi que l’approche que nous avons adoptée pour résoudre ce problème d’orientation des usagers dans un bâtiment. Nous montrerons également comment nous prenons en compte les spécificités des usagers, tout particulièrement ceux porteurs de handicaps, qu’ils soient physiques ou cognitifs.
العلاقة: hal-04618419; https://hal.science/hal-04618419Test; https://hal.science/hal-04618419/documentTest; https://hal.science/hal-04618419/file/Handicap-2024_OPALE_finale.pdfTest
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3مؤتمر
المؤلفون: Jean-Daubias, Stéphanie, Excoffier, Thierry, Azziz, Otman
المساهمون: Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Traces, Web, Education, Adaptation, Knowledge (TWEAK), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Modélisation Géométrique, Géométrie Algorithmique, Fractales (GeoMod), CVEC, IFRATH, Bousefsaf F., Thomann G., Morère Y., ANR-21-DMES-0005,INCLUDE (DMES),Inclusion des apprenants dans le supérieur: cultiver les diversités en transcendant les barrières spatiales, temporelles et cognitives grâce à la transformation numérique(2021), ANR-17-NCUN-0017,Atypie-Friendly,Building an(2017)
المصدر: Handicap 2024 ; https://hal.science/hal-04618419Test ; Handicap 2024, IFRATH, Jun 2024, Aubervillers campus condorcet, France. pp.101-106 ; https://ifrath.fr/handicap2024Test/
مصطلحات موضوعية: application mobile, itinéraire intérieur, plus court chemin, adaptation, PMR, Troubles du Spectre Autistique, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC]
جغرافية الموضوع: France
الوقت: Aubervillers campus condorcet, France
الوصف: National audience ; OPALE is a multi-service mobile app for users of the Claude Bernard Lyon 1 University campuses, combining the discovery of practical, cultural and scientific resources with useful everyday functions. Points of interest are geolocated on a map of the campus and can be reached via an itinerary. But an itinerary to a building is not always enough to find your way around. The orientation problem often lies in the last few metres: between the entrance to the building and the room you are looking for. In this article we present OPALE, and the approach we have adopted to solve this problem of orienting users in a building. We will also show how we take into account the specific characteristics of users, particularly those with physical or cognitive disabilities. ; OPALE est une application mobile multi-services à destination des usagers des campus de l’Université Claude Bernard Lyon 1. Elle associe découverte des ressources pratiques, culturelles et scientifiques à des fonctionnalités utiles au quotidien. Les points d’intérêts sont géolocalisés sur une carte du campus et atteignables via un itinéraire. Mais un itinéraire vers un bâtiment ne suffit pas toujours à se repérer. Le problème d’orientation se situe en effet souvent dans les derniers mètres : entre l’entrée du bâtiment et la salle recherchée. Dans cet article nous présentons OPALE, ainsi que l’approche que nous avons adoptée pour résoudre ce problème d’orientation des usagers dans un bâtiment. Nous montrerons également comment nous prenons en compte les spécificités des usagers, tout particulièrement ceux porteurs de handicaps, qu’ils soient physiques ou cognitifs.
العلاقة: hal-04618419; https://hal.science/hal-04618419Test; https://hal.science/hal-04618419/documentTest; https://hal.science/hal-04618419/file/Handicap-2024_OPALE_finale.pdfTest
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4مؤتمر
المؤلفون: Óscar Fernández Fernández, Lucienne Costa-Frossard, Maria Luisa Martínez Ginés, Paloma Montero Escribano, José María Prieto González, Lluís Ramió-Torrentà, Yolanda Aladro, Ana Alonso Torres, Elena Álvarez Rodríguez, Andrés Labiano-Fontcuberta, Lamberto Landete Pascual, Ambrosio Miralles Martínez, Ester Moral Torres, Pedro Oliva-Nacarino
مصطلحات موضوعية: Neurology and Neuromuscular Diseases, Neurogenetics, multiple sclerosis, spasticity, Spasticity-Plus Syndrome, conjoint analysis, nabiximols, bladder dysfunction
الوصف: Introduction The Spasticity-Plus Syndrome (SPS) in multiple sclerosis (MS) refers to a combination of spasticity and other signs/symptoms such as spasms, cramps, bladder dysfunction, tremor, sleep disorder, pain, and fatigue. The main purpose is to develop a user-friendly tool that could help neurologists to detect SPS in MS patients as soon as possible. Methods A survey research based on a conjoint analysis approach was used. An orthogonal factorial design was employed to form 12 patient profiles combining, at random, the eight principal SPS signs/symptoms. Expert neurologists evaluated in a survey and a logistic regression model determined the weight of each SPS sign/symptom, classifying profiles as SPS or not. Results 72 neurologists participated in the survey answering the conjoint exercise. Logistic regression results of the survey showed the relative contribution of each sign/symptom to the classification as SPS. Spasticity was the most influential sign, followed by spasms, tremor, cramps, and bladder dysfunction. The goodness of fit of the model was appropriate (AUC = 0.816). Concordance between the experts’ evaluation vs. model estimation showed strong Pearson’s (r = 0.936) and Spearman’s (r = 0.893) correlation coefficients. The application of the algorithm provides with a probability of showing SPS and the following ranges are proposed to interpret the results: high (> 60%), moderate (30–60%), or low (< 30%) probability of SPS. Discussion This study offers an algorithmic tool to help healthcare professionals to identify SPS in MS patients. The use of this tool could simplify the management of SPS, reducing side effects related with polypharmacotherapy.
الإتاحة: https://doi.org/10.3389/fneur.2024.1371644.s001Test
https://figshare.com/articles/presentation/Presentation_1_Practical_tool_to_identify_Spasticity-Plus_Syndrome_amongst_patients_with_multiple_sclerosis_Algorithm_development_based_on_a_conjoint_analysis_PDF/25650066Test -
5دورية أكاديمية
المؤلفون: Mualifah, Siti, Zuhdi, Rasyid
المصدر: JURNAL KRIDATAMA SAINS DAN TEKNOLOGI; Vol. 6 No. 01 (2024): JURNAL KRIDATAMA SAINS DAN TEKNOLOGI; 350-358 ; JURNAL KRIDATAMA SAINS DAN TEKNOLOGI; Vol 6 No 01 (2024): JURNAL KRIDATAMA SAINS DAN TEKNOLOGI; 350-358 ; 2685-6921 ; 2656-6966 ; 10.53863/kst.v6i01
مصطلحات موضوعية: menulis puisi, strategi pikir plus, outdoor study, writing poetry, think-plus strategy
الوصف: Writing ability is one of the skills that must be mastered by grade VIII students in Indonesian language learning. Students’ ability to master the vocabulary and spelling of the words they use to express their ideas is very important in writing poetry. Based on the results of observations at Darul Hikam Junior High School, it shows that there are still student obstacles in writing poetry in class so that students feel less effective in expressing their ideas and objects. In addition, teachers still use traditional Indonesian language learning methods with teacher-related approaches in daily teaching and learning activities. A teacher’s skill in choosing effective learning strategies and methods can improve students’ poetry writing skills. Learning methods and strategies that increase students’ poetry writing skills are the Think Plus Strategy with the Outdoor Study Method. This study aims to find and explain the impact of thinking and strategies using the outdoor study method on grade VIII students of Smp Darul Hikam Kuwarasan in the 2023/2024 academic year. The method applied in this research is experimental method with one group pretest and posttest design. The sample in this study was formed from 24 students. Normality and homogeneity testing using the SPSS application illustrates the significance value of Sig. 0.571 > 0.05 and 0.412 > 0.05 illustrating that the class is normally distributed and homogeneous. Data on learning outcomes were analyzed using paired sample t-test with 5% confidence level. Based on the results of the SPSS test, the Sig (two-tailed) significance value is 0.032 <0.05, so it can be said that the strategy of thinking plus with the outdoor study method has a significant effect on improving the poetry writing skills of students in grade VIII of Darul Hikam Kuwarasan Junior High School in the 2023/2024 academic year. ; Kemampuan menulis yaitu salah satu keterampilan yang wajib dikuasai siswa kelas VIII pada pembelajaran bahasa Indonesia. Kemampuan siswa dalam menguasai kosakata ...
وصف الملف: application/pdf
العلاقة: http://jurnal.umnu.ac.id/index.php/kst/article/view/1152/501Test; http://jurnal.umnu.ac.id/index.php/kst/article/view/1152Test
الإتاحة: https://doi.org/10.53863/kst.v6i01.115210.53863/kst.v6i01Test
http://jurnal.umnu.ac.id/index.php/kst/article/view/1152Test -
6دورية أكاديمية
المؤلفون: Abidi, S. H., Aboulhorma, A., Sultansoy, S., Aad, G., Abeling, K., Abicht, N. J., Abbott, B.
مصطلحات موضوعية: Hadron-Hadron Scattering, Hadron Colliders, Pair Production, Pp Collisions, Plus Plus, Strahlung, Program
الوصف: A search for a heavy CP-odd Higgs boson, A, decaying into a Z boson and a heavy CP-even Higgs boson, H, is presented. It uses the full LHC Run 2 dataset of pp collisions at root s = 13TeV collected with the ATLAS detector, corresponding to an integrated luminosity of 140 fb(-1). The search for A -> ZH is performed in the l(+)l(-)t (t) over bar t and nu(nu) over barb (b) over bar final states and surpasses the reach of previous searches in different final states in the region with m(H) > 350 GeV and m(A) > 800 GeV. No significant deviation from the Standard Model expectation is found. Upper limits are placed on the production cross-section times the decay branching ratios. Limits with less model dependence are also presented as functions of the reconstructed m(t (t) over bar) and m(b (b) over bar) distributions in the l(+)l(-)t (t) over bar and nu(nu) over barb (b) over bar channels, respectively. In addition, the results are interpreted in the context of two-Higgs-doublet models.
العلاقة: Journal of High Energy Physics; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1007/JHEP02Test(2024)197; https://hdl.handle.net/20.500.11851/11546Test; WOS:001185484300001; 2-s2.0-85190986940
الإتاحة: https://doi.org/20.500.11851/1154610.1007/JHEP02Test(2024)197
https://hdl.handle.net/20.500.11851/11546Test -
7دورية أكاديمية
المؤلفون: Hayrapetyan, A., Adam, W., Andrejkovic, J. W., Chatterjee, S., Damanakis, K., Tumasyan, A., Bergauer, T.
الوصف: The first search for scalar leptoquarks produced in z-lepton-quark collisions is presented. It is based on a set of proton-proton collision data recorded with the CMS detector at the LHC at a center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 138 fb-1. The reconstructed final state consists of a jet, significant missing transverse momentum, and a z lepton reconstructed through its hadronic or leptonic decays. Limits are set on the product of the leptoquark production cross section and branching fraction and interpreted as exclusions in the plane of the leptoquark mass and the leptoquark-z-quark coupling strength. ; BMBWF, (Austria); FWF (Austria); FNRS, (Belgium); FWO (Belgium); CNPq, (Brazil); CAPES, (Brazil); FAPERJ, (Brazil); FAPERGS, (Brazil); FAPESP,(Brazil); MES, (Bulgaria); CONACYT; BNSF (Bulgaria); LNS; CERN, (China); SEP; CAS, (China); UASLP-FAI (Mexico); MoST, (China); MOS (Montenegro); NSFC, (China); MBIE (New Zealand); MINCIENCIAS (Colombia); PAEC (Pakistan); MSES, (Croatia); MES,(Poland); CSF (Croatia); NSC (Poland); RIF (Cyprus); FCT (Portugal); SENESCYT (Ecuador); MESTD (Serbia); MoER, (Estonia); MCIN/AEI,(Spain); ERC PUT, (Estonia); PCTI (Spain); ERDF, (Estonia); MOSTR (Sri Lanka); Academy of Finland; Swiss Funding Agencies (Switzerland); MEC, (Finland); MST (Taipei); HIP, (Finland); MHESI, (Thailand); CEA, (France); NSTDA, (Thailand); CNRS/IN2P3 (France); TUBITAK, (Turkey); BMBF, (Germany); TENMAK (Turkey); DFG, (Germany); NASU (Ukraine); HGF, (Germany); STFC (United Kingdom); DOE, (USA); GSRI (Greece); NSF (USA); NKFIH (Hungary); DAE, (India); DST, (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP, (Republic of Korea); NRF (Republic of Korea); MES (Latvia); LAS (Lithuania); MOE, (Malaysia); UM, (Malaysia); BUAP; CINVESTAV ; We congratulate our colleagues in the CERN accelerator departments for the excellent performance of the LHC and thank the technical and administrative staffs at CERN and at other CMS institutes for their contributions to the success of the CMS ...
العلاقة: Physical Review Letters; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1103/PhysRevLett.132.061801Test; https://hdl.handle.net/20.500.13091/5601Test; 132; WOS:001190823600002
الإتاحة: https://doi.org/20.500.13091/560110.1103/PhysRevLett.132.061801Test
https://hdl.handle.net/20.500.13091/5601Test -
8دورية أكاديمية
المؤلفون: Irene Falgas-Bague, Maria Melero-Dominguez, Daniela de Vernisy-Romero, Thandiwe Tembo, Mpela Chembe, Theresa Lubozha, Ravi Paul, Doug Parkerson, Peter C. Rockers, Dorothy Sikazwe, Günther Fink
مصطلحات موضوعية: Medicine, Biotechnology, Sociology, Science Policy, Biological Sciences not elsewhere classified, world health organization, public healthcare offers, mental health treatments, mental health needs, mental health distress, locally adapted version, distress among women, community health workers, closely supervised wellbeing, adequate support system, address mother anxiety, strong communities intervention, adapted psychosocial intervention, zambia &# 8217, problem management plus, management plus, psychosocial intervention, strong minds, &# 8220, intervention group, innovative intervention, treatment gap, treat approach, specific parts, randomly assigned
الوصف: SPIRIT 2013 checklist: Recommended items to address in a clinical trial protocol and related documents*.
الإتاحة: https://doi.org/10.1371/journal.pone.0287269.s001Test
https://figshare.com/articles/journal_contribution/SPIRIT_2013_checklist_Recommended_items_to_address_in_a_clinical_trial_protocol_and_related_documents_/24951619Test -
9دورية أكاديمية
المؤلفون: Irene Falgas-Bague, Maria Melero-Dominguez, Daniela de Vernisy-Romero, Thandiwe Tembo, Mpela Chembe, Theresa Lubozha, Ravi Paul, Doug Parkerson, Peter C. Rockers, Dorothy Sikazwe, Günther Fink
مصطلحات موضوعية: Medicine, Biotechnology, Sociology, Science Policy, Biological Sciences not elsewhere classified, world health organization, public healthcare offers, mental health treatments, mental health needs, mental health distress, locally adapted version, distress among women, community health workers, closely supervised wellbeing, adequate support system, address mother anxiety, strong communities intervention, adapted psychosocial intervention, zambia &# 8217, problem management plus, management plus, psychosocial intervention, strong minds, &# 8220, intervention group, innovative intervention, treatment gap, treat approach, specific parts, randomly assigned
الوصف: Mental health disorders are one of the most common causes that limit the ability of mothers to care for themselves and for their children. Recent data suggest high rates of distress among women in charge of young children in Zambia. Nevertheless, Zambia’s public healthcare offers very limited treatment for common mental health distress. To address this treatment gap, this study aims to test the feasibility, acceptability, and potential efficacy of a context-adapted psychosocial intervention. A total of 265 mothers with mental health needs (defined as SRQ-20 scores above 7) were randomly assigned with equal probability to the intervention or control group. The intervention group will receive a locally adapted version of the Problem-Management Plus and “Thinking Healthy” interventions developed by the World Health Organization (WHO), combined with specific parts of the Strong Minds-Strong Communities intervention. Trained and closely supervised wellbeing-community health workers will provide the psychosocial intervention. Mental health distress and attendance to the intervention will be assessed at enrollment and 6 months after the intervention. We will estimate the impact of the intervention on mental health distress using an intention-to-treat approach. We previously found that there is a large necessity for interventions that aim to address mother anxiety/depression problems. In this study, we tested the feasibility and efficacy of an innovative intervention, demonstrating that implementing these mental health treatments in low-income settings, such as Zambia, is viable with an adequate support system. If successful, larger studies will be needed to test the effectiveness of the intervention with increased precision. Trial registration: This study is registered at clinicaltrials.gov as NCT05627206 .
الإتاحة: https://doi.org/10.1371/journal.pone.0287269.s003Test
https://figshare.com/articles/journal_contribution/Clinical_study_protocol_/24951625Test -
10دورية أكاديمية
المؤلفون: Karim S. Ladha, Jiwon Lee, Gabriella F. Mattina, Janneth Pazmino-Canizares, Duminda N. Wijeysundera, Fatemeh Gholamali Nezhad, Kaylyssa Philip, Vanessa K. Tassone, Fathima Adamsahib, Venkat Bhat
مصطلحات موضوعية: Cell Biology, Pharmacology, Biotechnology, Immunology, Science Policy, Mental Health, Infectious Diseases, Virology, sustained mood improvement, plus intravenous saline, plus intravenous midazolam, montgomery -&# 197, laughing gas exposure, 6 weeks starting, 4 consecutive weeks, 10 ), response, future definitive trial, 4 week course, first treatment visit, madrs score ), controlled pilot trial, pilot trial, week follow, per week,
%22">xlink ">, withdrawal rate, shown potentially, resistant depression, repeated administration الوصف: Background Nitrous oxide has shown potentially as an efficacious intervention for treatment-resistant depression, yet there remains insufficient evidence pertaining to repeated administration of nitrous oxide over time and active placebo-controlled studies with optimal blinding. Thus, we aim to examine the feasibility and preliminary efficacy of a six-week follow up study examining the effects of a 4 week course of weekly administered nitrous oxide as compared to the active placebo, midazolam. Methods In this randomized, active placebo-controlled, pilot trial, 40 participants with treatment-resistant depression will receive either inhaled nitrous oxide (1 hour at 50% concentration) plus intravenous saline (100mL) or inhaled oxygen (1 hour at 50% concentration) plus intravenous midazolam (0.02 mg/kg in 100mL, up to 2mg) once per week, for 4 consecutive weeks. Participants will be followed up for 6 weeks starting from the first treatment visit. Primary feasibility outcomes include recruitment rate, withdrawal rate, adherence, missing data, and adverse events. The primary exploratory clinical outcome is change in Montgomery-Åsberg Depression Rating Scale (MADRS) score at day 42 of the study. Other exploratory clinical outcomes include remission (defined as MADRS score <10), response (defined as ≥ 50% reduction in MADRS score), and adverse side effects. Discussion This pilot study will provide valuable information regarding the feasibility and preliminary efficacy of repeated nitrous oxide administration over time for treatment-resistant depression. If feasible, this study will inform the design of a future definitive trial of nitrous oxide as an efficacious and fast-acting treatment for treatment-resistant depression. Trial registration ClinicalTrials.gov NCT04957368 . Registered on July 12, 2021.
الإتاحة: https://doi.org/10.1371/journal.pone.0297330.s001Test
https://figshare.com/articles/journal_contribution/SPIRIT_checklist_/25030492Test
النص الكامل