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1دورية أكاديمية
المؤلفون: Salvini, Catherine L. A., Darlot, Benoit, Davison, Jack, Martin, Mathew P., Tudhope, Susan J., Turberville, Shannon, Kawamura, Akane, Noble, Martin E. M., Wedge, Stephen R., Crawford, James J., Waring, Michael J.
المساهمون: Genentech, Engineering and Physical Sciences Research Council, Cancer Research UK, BD, Horizon 2020
المصدر: Chemical Science ; volume 14, issue 31, page 8288-8294 ; ISSN 2041-6520 2041-6539
الإتاحة: https://doi.org/10.1039/d3sc01171bTest
http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01171BTest -
2دورية أكاديمية
المؤلفون: Miller, Duncan C., Harnor, Suzannah J., Martin, Mathew P., Noble, Richard A., Wedge, Stephen R., Cano, Celine
المساهمون: Medical Research Council, Cancer Research UK
المصدر: Journal of Medicinal Chemistry ; volume 66, issue 7, page 4491-4502 ; ISSN 0022-2623 1520-4804
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3دورية أكاديمية
المؤلفون: Morese, Pasquale A., Anthony, Nahoum, Bodnarchuk, Michael, Jennings, Claire, Martin, Mathew P., Noble, Richard A., Phillips, Nicole, Thomas, Huw D., Wang, Lan Z., Lister, Andrew, Noble, Martin E. M., Ward, Richard A., Wedge, Stephen R., Stewart, Hannah L., Waring, Michael J.
المساهمون: AstraZeneca, Engineering and Physical Sciences Research Council, Cancer Research UK
المصدر: Journal of Medicinal Chemistry ; volume 66, issue 17, page 12324-12341 ; ISSN 0022-2623 1520-4804
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4دورية أكاديمية
المؤلفون: Miller, Duncan C, Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J, Edwards, Noel, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Hardcastle, Ian, Harnor, Suzannah J, Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P, Martin, Nick C, Myers, Stephanie, Newell, David R, Noble, Richard A, Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A, Wang, Lan-Zhen, Waring, Michael J, Wong, Ai-Ching, Wedge, Stephen R, Noble, Martin E, Cano, Celine
مصطلحات موضوعية: Chemistry
وصف الملف: application/pdf
العلاقة: http://sure.sunderland.ac.uk/id/eprint/14709/8/acs.jmedchem.1c01756.pdfTest; Miller, Duncan C , Reuillon, Tristan , Molyneux, Lauren , Blackburn, Timothy , Cook, Simon J , Edwards, Noel , Endicott, Jane A , Golding, Bernard T , Griffin, Roger J , Hardcastle, Ian , Harnor, Suzannah J , Heptinstall, Amy , Lochhead, Pamela , Martin, Mathew P , Martin, Nick C , Myers, Stephanie , Newell, David R , Noble, Richard A , Phillips, Nicole , Rigoreau, Laurent , Thomas, Huw , Tucker, Julie A , Wang, Lan-Zhen , Waring, Michael J , Wong, Ai-Ching , Wedge, Stephen R , Noble, Martin E and Cano, Celine (2022) Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. Journal of Medicinal Chemistry, 65 (9). pp. 6513-6540. ISSN 0022-2623
الإتاحة: http://sure.sunderland.ac.uk/id/eprint/14709Test/
http://sure.sunderland.ac.uk/id/eprint/14709/8/acs.jmedchem.1c01756.pdfTest -
5دورية أكاديمية
المؤلفون: Noble, Richard A., Thomas, Huw, Zhao, Yan, Herendi, Lili, Howarth, Rachel, Dragoni, Ilaria, Keun, Hector C., Vellano, Christopher P., Marszalek, Joseph R., Wedge, Stephen R.
المساهمون: Cancer Research UK
المصدر: British Journal of Cancer ; volume 127, issue 5, page 937-947 ; ISSN 0007-0920 1532-1827
مصطلحات موضوعية: Cancer Research, Oncology
الإتاحة: https://doi.org/10.1038/s41416-022-01848-wTest
https://www.nature.com/articles/s41416-022-01848-w.pdfTest
https://www.nature.com/articles/s41416-022-01848-wTest -
6دورية أكاديمية
المؤلفون: Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian, Harnor, Suzannah J., Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P., Martin, Nick C., Myers, Stephanie, Newell, David R., Noble, Richard A., Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A., Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
المساهمون: Astex Pharmaceuticals, Medical Research Council, Cancer Research UK
المصدر: Journal of Medicinal Chemistry ; volume 65, issue 9, page 6513-6540 ; ISSN 0022-2623 1520-4804
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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7دورية أكاديمية
المؤلفون: Willoughby, Catherine E., Jiang, Yanyan, Thomas, Huw D., Willmore, Elaine, Kyle, Suzanne, Wittner, Anita, Phillips, Nicole, Zhao, Yan, Tudhope, Susan J., Prendergast, Lisa, Junge, Gesa, Lourenco, Luiza Madia, Finlay, M. Raymond V., Turner, Paul, Munck, Joanne M., Griffin, Roger J., Rennison, Tommy, Pickles, James, Cano, Celine, Newell, Herbie, Reeves, Helen L., Ryan, Anderson J., Wedge, Stephen R.
وصف الملف: application/pdf
العلاقة: http://sure.sunderland.ac.uk/id/eprint/12742/1/Selective%20DNA-PKcs.pdfTest; Willoughby, Catherine E., Jiang, Yanyan, Thomas, Huw D., Willmore, Elaine, Kyle, Suzanne, Wittner, Anita, Phillips, Nicole, Zhao, Yan, Tudhope, Susan J., Prendergast, Lisa, Junge, Gesa, Lourenco, Luiza Madia, Finlay, M. Raymond V., Turner, Paul, Munck, Joanne M., Griffin, Roger J., Rennison, Tommy, Pickles, James, Cano, Celine, Newell, Herbie, Reeves, Helen L., Ryan, Anderson J. and Wedge, Stephen R. (2019) Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy. Journal of Clinical Investigation, 130 (1). pp. 258-271. ISSN 0021-9738
الإتاحة: https://doi.org/10.1172/JCI127483Test
http://sure.sunderland.ac.uk/id/eprint/12742Test/
http://sure.sunderland.ac.uk/id/eprint/12742/1/Selective%20DNA-PKcs.pdfTest -
8دورية أكاديمية
المؤلفون: Tucker, Julie Ann, Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine
وصف الملف: text
العلاقة: https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest; Tucker, Julie Ann orcid.org/0000-0002-6119-676X , Myers, Stephanie M., Miller, Duncan C. et al. (27 more authors) (2019) Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. European Journal of Medicinal Chemistry. pp. 530-543. ISSN 0223-5234
الإتاحة: https://doi.org/10.1016/j.ejmech.2019.05.057Test
https://eprints.whiterose.ac.uk/148098Test/
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest -
9دورية أكاديمية
المؤلفون: Sharma, Ricky A., Plummer, Ruth, Stock, Julie K., Greenhalgh, Tessa A., Ataman, Ozlem, Kelly, Stephen, Clay, Robert, Adams, Richard A., Baird, Richard D., Billingham, Lucinda, Brown, Sarah R., Buckland, Sean, Bulbeck, Helen, Chalmers, Anthony J., Clack, Glen, Cranston, Aaron N., Damstrup, Lars, Ferraldeschi, Roberta, Forster, Martin D., Golec, Julian, Hagan, Russell M., Hall, Emma, Hanauske, Axel-R., Harrington, Kevin J., Haswell, Tom, Hawkins, Maria A., Illidge, Tim, Jones, Hazel, Kennedy, Andrew S., McDonald, Fiona, Melcher, Thorsten, O'Connor, James P. B., Pollard, John R., Saunders, Mark P., Sebag-Montefiore, David, Smitt, Melanie, Staffurth, John, Stratford, Ian J., Wedge, Stephen R.
وصف الملف: text
العلاقة: http://eprints.gla.ac.uk/168118/1/168118.pdfTest; Sharma, R. A. et al. (2018) Clinical development of new drug–radiotherapy combinations. Nature Reviews Clinical Oncology , 13(10), pp. 627-642. (doi:10.1038/nrclinonc.2016.79 ) (PMID:27245279)
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10دورية أكاديمية
المؤلفون: Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine
المساهمون: Cancer Research UK
المصدر: Organic & Biomolecular Chemistry ; volume 16, issue 11, page 1843-1850 ; ISSN 1477-0520 1477-0539
الإتاحة: https://doi.org/10.1039/c8ob00099aTest
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00099ATest