المؤلفون: Zhang, Lanlan, Wager, Tor, Koban, Leonie

المساهمون: Guangzhou Sport University, Dartmouth College Hanover, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1090-3801.

مصطلحات موضوعية: skin conductance, psychophysiology, empathy, social influence, pain, conformity, [SCCO]Cognitive science, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; Background Accurately perceiving other people's pain is important in both daily life and healthcare settings. However, judging other's pain is inherently difficult and can be biased by various social and cultural factors. Here, we examined whether perception of others' pain and pain management recommendations are socially influenced by seeing the opinions of other raters. Methods In Experiment 1 ( N = 50), participants rated pictures depicting injured hands or feet of pre‐selected high, medium and low intensities. Each picture was preceded by cues indicating ratings of 10 previous participants. Cues were randomized to indicate low (Social LOW ) or high (Social HIGH ) pain judgements and were not predictive of actual normative pain intensity. In Experiment 2 ( N = 209), participants viewed facial video clips of patients with chronic shoulder pain making painful movements. They estimated patients' pain intensity and provided pain management recommendations. Results Experiment 1 revealed that perceivers' pain estimates were significantly and substantially higher for stimuli following Social HIGH than Social LOW cues (Cohen's d = 1.26, p < 0.001) and paralleled by increased skin conductance responses. Experiment 2 replicated the effect of social cues on pain judgements ( d = 0.58, p < 0.001). However, social cues did not influence post‐study pain management recommendations, potentially due to memory limitations. Conclusions Together, these studies reveal that judgements of others' pain are robustly modulated by information about others' opinions. Future research could test the prevalence and strength of such effects in clinical settings. Significance The present study shows that even arbitrary opinions of other raters influence the perception of others' pain. This finding adds new insight into the growing evidence of social and cultural biases in pain estimation.

العلاقة: hal-04386306; https://hal.science/hal-04386306Test; https://hal.science/hal-04386306/documentTest; https://hal.science/hal-04386306/file/ZhangWagerKoban_2024_HAL.pdfTest

الإتاحة: https://doi.org/10.1002/ejp.2225Test
https://hal.science/hal-04386306Test
https://hal.science/hal-04386306/documentTest
https://hal.science/hal-04386306/file/ZhangWagerKoban_2024_HAL.pdfTest

المؤلفون: Zhang, Lanlan, Wager, Tor, Koban, Leonie

المساهمون: Guangzhou Sport University, Dartmouth College Hanover, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1090-3801.

مصطلحات موضوعية: skin conductance, psychophysiology, empathy, social influence, pain, conformity, [SCCO]Cognitive science, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; Background Accurately perceiving other people's pain is important in both daily life and healthcare settings. However, judging other's pain is inherently difficult and can be biased by various social and cultural factors. Here, we examined whether perception of others' pain and pain management recommendations are socially influenced by seeing the opinions of other raters. Methods In Experiment 1 ( N = 50), participants rated pictures depicting injured hands or feet of pre‐selected high, medium and low intensities. Each picture was preceded by cues indicating ratings of 10 previous participants. Cues were randomized to indicate low (Social LOW ) or high (Social HIGH ) pain judgements and were not predictive of actual normative pain intensity. In Experiment 2 ( N = 209), participants viewed facial video clips of patients with chronic shoulder pain making painful movements. They estimated patients' pain intensity and provided pain management recommendations. Results Experiment 1 revealed that perceivers' pain estimates were significantly and substantially higher for stimuli following Social HIGH than Social LOW cues (Cohen's d = 1.26, p < 0.001) and paralleled by increased skin conductance responses. Experiment 2 replicated the effect of social cues on pain judgements ( d = 0.58, p < 0.001). However, social cues did not influence post‐study pain management recommendations, potentially due to memory limitations. Conclusions Together, these studies reveal that judgements of others' pain are robustly modulated by information about others' opinions. Future research could test the prevalence and strength of such effects in clinical settings. Significance The present study shows that even arbitrary opinions of other raters influence the perception of others' pain. This finding adds new insight into the growing evidence of social and cultural biases in pain estimation.

العلاقة: hal-04386306; https://hal.science/hal-04386306Test; https://hal.science/hal-04386306/documentTest; https://hal.science/hal-04386306/file/ZhangWagerKoban_2024_HAL.pdfTest

الإتاحة: https://doi.org/10.1002/ejp.2225Test
https://hal.science/hal-04386306Test
https://hal.science/hal-04386306/documentTest
https://hal.science/hal-04386306/file/ZhangWagerKoban_2024_HAL.pdfTest

المؤلفون: Zhang, Lanlan, Wager, Tor, Koban, Leonie

المساهمون: Guangzhou Sport University, Dartmouth College Hanover, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1090-3801.

مصطلحات موضوعية: skin conductance, psychophysiology, empathy, social influence, pain, conformity, [SCCO]Cognitive science, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; Background Accurately perceiving other people's pain is important in both daily life and healthcare settings. However, judging other's pain is inherently difficult and can be biased by various social and cultural factors. Here, we examined whether perception of others' pain and pain management recommendations are socially influenced by seeing the opinions of other raters. Methods In Experiment 1 ( N = 50), participants rated pictures depicting injured hands or feet of pre‐selected high, medium and low intensities. Each picture was preceded by cues indicating ratings of 10 previous participants. Cues were randomized to indicate low (Social LOW ) or high (Social HIGH ) pain judgements and were not predictive of actual normative pain intensity. In Experiment 2 ( N = 209), participants viewed facial video clips of patients with chronic shoulder pain making painful movements. They estimated patients' pain intensity and provided pain management recommendations. Results Experiment 1 revealed that perceivers' pain estimates were significantly and substantially higher for stimuli following Social HIGH than Social LOW cues (Cohen's d = 1.26, p < 0.001) and paralleled by increased skin conductance responses. Experiment 2 replicated the effect of social cues on pain judgements ( d = 0.58, p < 0.001). However, social cues did not influence post‐study pain management recommendations, potentially due to memory limitations. Conclusions Together, these studies reveal that judgements of others' pain are robustly modulated by information about others' opinions. Future research could test the prevalence and strength of such effects in clinical settings. Significance The present study shows that even arbitrary opinions of other raters influence the perception of others' pain. This finding adds new insight into the growing evidence of social and cultural biases in pain estimation.

العلاقة: hal-04386306; https://hal.science/hal-04386306Test; https://hal.science/hal-04386306/documentTest; https://hal.science/hal-04386306/file/ZhangWagerKoban_2024_HAL.pdfTest

الإتاحة: https://doi.org/10.1002/ejp.2225Test
https://hal.science/hal-04386306Test
https://hal.science/hal-04386306/documentTest
https://hal.science/hal-04386306/file/ZhangWagerKoban_2024_HAL.pdfTest

المؤلفون: Zhang, Lanlan, Wager, Tor, Koban, Leonie

المساهمون: Guangzhou Sport University, Dartmouth College Hanover, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1090-3801.

مصطلحات موضوعية: skin conductance, psychophysiology, empathy, social influence, pain, conformity, [SCCO]Cognitive science, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; Background Accurately perceiving other people's pain is important in both daily life and healthcare settings. However, judging other's pain is inherently difficult and can be biased by various social and cultural factors. Here, we examined whether perception of others' pain and pain management recommendations are socially influenced by seeing the opinions of other raters. Methods In Experiment 1 ( N = 50), participants rated pictures depicting injured hands or feet of pre‐selected high, medium and low intensities. Each picture was preceded by cues indicating ratings of 10 previous participants. Cues were randomized to indicate low (Social LOW ) or high (Social HIGH ) pain judgements and were not predictive of actual normative pain intensity. In Experiment 2 ( N = 209), participants viewed facial video clips of patients with chronic shoulder pain making painful movements. They estimated patients' pain intensity and provided pain management recommendations. Results Experiment 1 revealed that perceivers' pain estimates were significantly and substantially higher for stimuli following Social HIGH than Social LOW cues (Cohen's d = 1.26, p < 0.001) and paralleled by increased skin conductance responses. Experiment 2 replicated the effect of social cues on pain judgements ( d = 0.58, p < 0.001). However, social cues did not influence post‐study pain management recommendations, potentially due to memory limitations. Conclusions Together, these studies reveal that judgements of others' pain are robustly modulated by information about others' opinions. Future research could test the prevalence and strength of such effects in clinical settings. Significance The present study shows that even arbitrary opinions of other raters influence the perception of others' pain. This finding adds new insight into the growing evidence of social and cultural biases in pain estimation.

العلاقة: hal-04386306; https://hal.science/hal-04386306Test; https://hal.science/hal-04386306/documentTest; https://hal.science/hal-04386306/file/ZhangWagerKoban_2024_HAL.pdfTest

الإتاحة: https://doi.org/10.1002/ejp.2225Test
https://hal.science/hal-04386306Test
https://hal.science/hal-04386306/documentTest
https://hal.science/hal-04386306/file/ZhangWagerKoban_2024_HAL.pdfTest

المؤلفون: Noe-Steinmüller, Niklas, Scherbakov, Dmitry, Zhuravlyova, Alexandra, Wager, Tor D., Goldstein, Pavel, Tesarz, Jonas

المساهمون: Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung

المصدر: Pain ; ISSN 0304-3959 1872-6623

الوصف: Understanding, measuring, and mitigating pain-related suffering is a key challenge for both clinical care and pain research. However, there is no consensus on what exactly the concept of pain-related suffering includes, and it is often not precisely operationalized in empirical studies. Here, we (1) systematically review the conceptualization of pain-related suffering in the existing literature, (2) develop a definition and a conceptual framework, and (3) use machine learning to cross-validate the results. We identified 111 articles in a systematic search of Web of Science, PubMed, PsychINFO, and PhilPapers for peer-reviewed articles containing conceptual contributions about the experience of pain-related suffering. We developed a new procedure for extracting and synthesizing study information based on the cross-validation of qualitative analysis with an artificial intelligence–based approach grounded in large language models and topic modeling. We derived a definition from the literature that is representative of current theoretical views and describes pain-related suffering as a severely negative, complex, and dynamic experience in response to a perceived threat to an individual's integrity as a self and identity as a person. We also offer a conceptual framework of pain-related suffering distinguishing 8 dimensions: social, physical, personal, spiritual, existential, cultural, cognitive, and affective. Our data show that pain-related suffering is a multidimensional phenomenon that is closely related to but distinct from pain itself. The present analysis provides a roadmap for further theoretical and empirical development.

الإتاحة: https://doi.org/10.1097/j.pain.0000000000003195Test

المؤلفون: BOGAERTS, Katleen, VAN DEN HOUTE, Maaike, Jongen, Daniëlle, Ly, Huynh Giao, Coppens, Eline, Schruers, Koen, Van Diest, Ilse, Tack, Jan, Van Wambeke, Peter, Petre, Bogdan, Kragel, Philip A., Lindquist, Martin A., Wager, Tor D., Van Oudenhove, Lukas, Van den Bergh, Omer

المساهمون: BOGAERTS, Katleen, VAN DEN HOUTE, Maaike, Jongen, Daniëlle, Ly, Huynh Giao, Coppens, Eline, Schruers, Koen, Van Diest, Ilse, Tack, Jan, Van Wambeke, Peter, Petre, Bogdan, Kragel, Philip A., Lindquist, Martin A., Wager, Tor D., Van Oudenhove, Lukas, Van den Bergh, Omer

الوصف: Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced physical symptoms in FSS patients. Thirty patients with fibromyalgia and/or IBS and 30 healthy controls (all women) watched neutral, positive and negative affective picture blocks during functional MRI scanning and rated negative affect and physical symptoms after every block. We compared brain-wide activation during negative versus neutral picture viewing in FSS patients versus controls using robust general linear model analysis. Further, we compared neurologic pain signature (NPS), stimulus intensityindependent pain signature (SIIPS) and picture-induced negative emotion signature (PINES) responses to the negative versus neutral affect contrast and investigated whether they mediated between-group differences in affective picture-induced physical symptom reporting. More physical symptoms were reported after viewing negative compared to neutral pictures, and this effect was larger in patients than controls (p=0.025). Accordingly, patients showed stronger activation in somatosensory regions during negative versus neutral picture viewing. NPS, but not SIIPS nor PINES, responses were higher in patients than controls during negative versus neutral pictures (p=0.026). These differential NPS responses partially mediated between-group differences in physical symptoms. In conclusion, pictureinduced negative affect elicits physical symptoms in FSS patients as a result of activation of somatosensory and nociceptive brain patterns, supporting the idea that affect-driven alterations in processing of somatic signals is a critical mechanism underlying FSS.

وصف الملف: application/pdf

العلاقة: Translational psychiatry, 13(1), Art N° 285; http://hdl.handle.net/1942/40629Test; 13

الإتاحة: https://doi.org/10.1038/s41398-023-02567-3Test
http://hdl.handle.net/1942/40629Test

المؤلفون: Branco, Paulo, Vachon-Presseau, Etienne, Hall, Kathryn T., Wager, Tor D., Vania Apkarian, A.

المساهمون: Colloca, Luana, Noel, Jason, Franklin, Patricia D., Seneviratne, Chamindi

المصدر: Placebo Effects Through the Lens of Translational Research ; page 57-C2.1P101 ; ISBN 0197645445 9780197645444 9780197645475

الوصف: The bulk of research on the mechanisms underlying placebo effects has been conducted for painful stimuli in laboratory settings. Such studies identify a long list of learning mechanisms that can explain observed effects, as well as provide evidence that placebo analgesia is associated with reproducible patterns of brain activity. These studies also show that placebo effects are unstable across contexts, and the magnitude of a participant’s response in one setting does not generalize following subtle manipulations of the procedure, suggesting that placebo effects are primarily driven by immediate, context-specific expectations and, thus, remain essentially unpredictable. Recent studies challenge this notion by finding that clinical placebo effects in chronic pain patients can be predicted by genetics, brain properties and language use. If replicated, latter results suggest that placebo effects can be understood and harnessed in clinical treatment of chronic pain conditions and beyond.

الإتاحة: https://doi.org/10.1093/med/9780197645444.003.0005Test
https://academic.oup.com/book/54240/chapter/422451733Test

المؤلفون: Koban, Leonie, Wager, Tor, D, Kober, Hedy

المساهمون: Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Dartmouth College Hanover, Yale University New Haven

المصدر: ISSN: 1097-6256.

مصطلحات موضوعية: craving, fMRI, machine-learning, brainmarker, signature, addiction, food, drug, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SCCO]Cognitive science, [SDV]Life Sciences [q-bio], [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition

الوصف: International audience ; Craving is a core feature of substance use disorders. It is a strong predictor of substance use and relapse and is linked to overeating, gambling, and other maladaptive behaviors. Craving is measured via self-report, which is limited by introspective access and sociocultural contexts. Neurobiological markers of craving are both needed and lacking, and it remains unclear whether craving for drugs and food involve similar mechanisms. Across three functional magnetic resonance imaging studies (n = 99), we used machine learning to identify a cross-validated neuromarker that predicts self-reported intensity of cue-induced drug and food craving (P < 0.0002). This pattern, which we term the Neurobiological Craving Signature (NCS), includes ventromedial prefrontal and cingulate cortices, ventral striatum, temporal/parietal association areas, mediodorsal thalamus and cerebellum. Importantly, NCS responses to drug versus food cues discriminate drug users versus non-users with 82% accuracy. The NCS is also modulated by a self-regulation strategy. Transfer between separate neuromarkers for drug and food craving suggests shared neurobiological mechanisms. Future studies can assess the discriminant and convergent validity of the NCS and test whether it responds to clinical interventions and predicts long-term clinical outcomes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36536243; hal-03857887; https://hal.science/hal-03857887Test; https://hal.science/hal-03857887/documentTest; https://hal.science/hal-03857887/file/Koban_2023_NCS_forHAL.pdfTest; PUBMED: 36536243

الإتاحة: https://doi.org/10.1038/s41593-022-01228-wTest
https://hal.science/hal-03857887Test
https://hal.science/hal-03857887/documentTest
https://hal.science/hal-03857887/file/Koban_2023_NCS_forHAL.pdfTest

المؤلفون: Perszyk, Emily, Davis, Xue, Djordjevic, Jelena, Jones-Gotman, Marilyn, Trinh, Jessica, Hutelin, Zach, Veldhuizen, Maria, Koban, Leonie, Wager, Tor, Kober, Hedy, Small, Dana

المساهمون: Department of Psychiatry, Yale University School of Medicine, Yale School of Medicine New Haven, Connecticut (YSM), Montreal Neurological Institute and Hospital, McGill University = Université McGill Montréal, Canada, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Dartmouth College Hanover, Yale University New Haven

المصدر: EISSN: 2522-5812 ; Nature Metabolism ; https://hal.science/hal-04197726Test ; Nature Metabolism, In press, ⟨10.1038/s42255-023-00874-z⟩

مصطلحات موضوعية: [SCCO]Cognitive science, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

العلاقة: hal-04197726; https://hal.science/hal-04197726Test; https://hal.science/hal-04197726/documentTest; https://hal.science/hal-04197726/file/Perszyk_Manuscript_July25_2023_HAL.pdfTest

الإتاحة: https://doi.org/10.1038/s42255-023-00874-zTest
https://hal.science/hal-04197726Test
https://hal.science/hal-04197726/documentTest
https://hal.science/hal-04197726/file/Perszyk_Manuscript_July25_2023_HAL.pdfTest

المؤلفون: Koban, Leonie, Andrews-Hanna, Jessica, R, Ives, Lindsay, Wager, Tor, D, Arch, Joanna, J

المساهمون: Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Arizona, University of Colorado Boulder, Dartmouth College Hanover

المصدر: ISSN: 2158-3188.

مصطلحات موضوعية: fMRI, social influence, social anxiety disorder, bias, affect, emotion regulation, frontoparietal, [SCCO]Cognitive science, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; Abstract Social anxiety disorder (SAD) is characterized by an excessive fear of social evaluation and a persistently negative view of the self. Here we test the hypothesis that negative biases in brain responses and in social learning of self-related information contribute to the negative self-image and low self-esteem characteristic of SAD. Adult participants diagnosed with social anxiety ( N = 21) and matched controls ( N = 23) rated their performance and received social feedback following a stressful public speaking task. We investigated how positive versus negative social feedback altered self-evaluation and state self-esteem and used functional Magnetic Resonance Imaging (fMRI) to characterize brain responses to positive versus negative feedback. Compared to controls, participants with SAD updated their self-evaluation and state self-esteem significantly more based on negative compared to positive social feedback. Responses in the frontoparietal network correlated with and mirrored these behavioral effects, with greater responses to positive than negative feedback in non-anxious controls but not in participants with SAD. Responses to social feedback in the anterior insula and other areas mediated the effects of negative versus positive feedback on changes in self-evaluation. In non-anxious participants, frontoparietal brain areas may contribute to a positive social learning bias. In SAD, frontoparietal areas are less recruited overall and less attuned to positive feedback, possibly reflecting differences in attention allocation and cognitive regulation. More negatively biased brain responses and social learning could contribute to maintaining a negative self-image in SAD and other internalizing disorders, thereby offering important new targets for interventions.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37660045; hal-04196109; https://hal.science/hal-04196109Test; https://hal.science/hal-04196109/documentTest; https://hal.science/hal-04196109/file/Koban_etal2023_SAD_TranslPsychiatry.pdfTest; PUBMED: 37660045; PUBMEDCENTRAL: PMC10475036

الإتاحة: https://doi.org/10.1038/s41398-023-02587-zTest
https://hal.science/hal-04196109Test
https://hal.science/hal-04196109/documentTest
https://hal.science/hal-04196109/file/Koban_etal2023_SAD_TranslPsychiatry.pdfTest