المؤلفون: Dy-Hollins, Marisela E., Carr, Samuel J., Essa, Angela, Osiecki, Lisa, Lackland, Daniel T., Voeks, Jenifer H., Mejia, Nicte I., Sharma, Nutan, Budman, Cathy L., Cath, Danielle C., Grados, Marco A., King, Robert A., Lyon, Gholson J., Rouleau, Guy A., Sandor, Paul, Singer, Harvey S., Chibnik, Lori B., Mathews, Carol A., Scharf, Jeremiah M.

المساهمون: National Institute of Neurological Disorders and Stroke, Tourette Association of America, NIH

المصدر: Pediatric Neurology ; volume 155, page 55-61 ; ISSN 0887-8994

مصطلحات موضوعية: Neurology (clinical), Developmental Neuroscience, Neurology, Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1016/j.pediatrneurol.2024.02.008Test
https://api.elsevier.com/content/article/PII:S0887899424000584?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0887899424000584?httpAccept=text/plainTest

المؤلفون: Martin, Seth S., Aday, Aaron W., Almarzooq, Zaid I., Anderson, Cheryl A.M., Arora, Pankaj, Avery, Christy L., Baker-Smith, Carissa M., Barone Gibbs, Bethany, Beaton, Andrea Z., Boehme, Amelia K., Commodore-Mensah, Yvonne, Currie, Maria E., Elkind, Mitchell S.V., Evenson, Kelly R., Generoso, Giuliano, Heard, Debra G., Hiremath, Swapnil, Johansen, Michelle C., Kalani, Rizwan, Kazi, Dhruv S., Ko, Darae, Liu, Junxiu, Magnani, Jared W., Michos, Erin D., Mussolino, Michael E., Navaneethan, Sankar D., Parikh, Nisha I., Perman, Sarah M., Poudel, Remy, Rezk-Hanna, Mary, Roth, Gregory A., Shah, Nilay S., St-Onge, Marie-Pierre, Thacker, Evan L., Tsao, Connie W., Urbut, Sarah M., Van Spall, Harriette G.C., Voeks, Jenifer H., Wang, Nae-Yuh, Wong, Nathan D., Wong, Sally S., Yaffe, Kristine, Palaniappan, Latha P.

المصدر: Circulation ; volume 149, issue 8 ; ISSN 0009-7322 1524-4539

الوصف: BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, brain health, complications of pregnancy, kidney disease, congenital heart disease, rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary heart disease, cardiomyopathy, heart failure, valvular disease, venous thromboembolism, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). METHODS: The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2024 AHA Statistical Update is the product of a full year’s worth of effort in 2023 by dedicated volunteer clinicians and scientists, committed government professionals, and AHA staff members. The AHA strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional global data, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. ...

الإتاحة: https://doi.org/10.1161/cir.0000000000001209Test

المؤلفون: Matsumura, Jon S., Hanlon, Bret M., Rosenfield, Kenneth, Voeks, Jenifer H., Howard, George, Roubin, Gary S., Brott, Thomas G.

المصدر: European Journal of Vascular and Endovascular Surgery ; volume 63, issue 4, page e70-e71 ; ISSN 1078-5884

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.ejvs.2022.03.031Test
https://api.elsevier.com/content/article/PII:S1078588422002088?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1078588422002088?httpAccept=text/plainTest

المؤلفون: Matsumura, Jon S., Hanlon, Bret M., Rosenfield, Kenneth, Voeks, Jenifer H., Howard, George, Roubin, Gary S., Brott, Thomas G.

المصدر: Journal of Vascular Surgery ; volume 75, issue 4, page 1276-1283.e1 ; ISSN 0741-5214

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.jvs.2021.10.020Test
https://api.elsevier.com/content/article/PII:S0741521421023375?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0741521421023375?httpAccept=text/plainTest

المؤلفون: Meschia, James F., Barrett, Kevin M., Brown, Robert D., Turan, Tanya N., Howard, Virginia J., Voeks, Jenifer H., Lal, Brajesh K., Howard, George, Brott, Thomas G.

المصدر: Neurology ; volume 95, issue 1, page 29-36 ; ISSN 0028-3878 1526-632X

الإتاحة: https://doi.org/10.1212/wnl.0000000000009698Test

المؤلفون: Turan, Tanya N., Voeks, Jenifer H., Chimowitz, Marc I., Roldan, Ana, LeMatty, Todd, Haley, William, Lopes-Virella, Maria, Chaturvedi, Seemant, Jones, Michael, Heck, Donald, Howard, George, Lal, Brajesh K., Meschia, James F., Brott, Thomas G.

المصدر: Stroke ; volume 51, issue 10, page 2960-2971 ; ISSN 0039-2499 1524-4628

الوصف: Background and Purpose: The CREST2 trial (Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis) is comparing intensive medical management (IMM) alone to IMM plus revascularization with carotid endarterectomy or transfemoral carotid artery stenting for preventing stroke or death within 44 days after randomization or ipsilateral ischemic stroke thereafter. There are extensive clinical trial data on outcomes after revascularization of asymptomatic carotid stenosis, but not for IMM. As such, the experimental treatment in CREST2 is IMM, which is described in this article. Methods: IMM consists of aspirin 325 mg/day and intensive risk factor management, primarily targeting systolic blood pressure <130 mm Hg (initially systolic blood pressure <140 mm Hg) and LDL (low-density lipoprotein) cholesterol <70 mg/dL. Secondary risk factor targets focus on tobacco smoking, non-HDL (high-density lipoprotein), HbA1c (hemoglobin A1c), physical activity, and weight. Risk factor management is performed by site personnel and a lifestyle coaching program delivered by telephone. We report interim risk factor data on 1618 patients at baseline and last follow-up through 24 months. Results: The mean baseline LDL of 80.5 mg/dL improved to 66.7 mg/dL. The mean baseline systolic blood pressure of 139.7 mm Hg improved to 130.3 mm Hg. The proportion of patients in-target improved from 43% to 61% for systolic blood pressure <130 mm Hg and from 45% to 67% for LDL<70 mg/dL (both changes P <0.001). Conclusions: The rigorous multimodal approach to intensive stroke risk factor management in CREST2 has resulted in significant improvements in risk factor control that will enable a comparison of cutting-edge medical care to revascularization in patients with asymptomatic carotid stenosis. Registration: URL: https://www.clinicaltrials.govTest . Unique identifier: NCT02089217.

الإتاحة: https://doi.org/10.1161/strokeaha.120.030730Test

المؤلفون: Lal, Brajesh K., Meschia, James F., Roubin, Gary S., Jankowitz, Brian, Heck, Donald, Jovin, Tudor, White, Christopher J., Rosenfield, Kenneth, Katzen, Barry, Dabus, Guilherme, Gray, William, Matsumura, Jon, Hopkins, L. Nelson, Luke, Sothear, Sharma, Jashank, Voeks, Jenifer H., Howard, George, Brott, Thomas G.

المساهمون: National Institute of Neurological Disorders and Stroke

المصدر: Journal of Vascular Surgery ; volume 71, issue 3, page 854-861 ; ISSN 0741-5214

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.jvs.2019.05.035Test
https://api.elsevier.com/content/article/PII:S0741521419314491?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0741521419314491?httpAccept=text/plainTest

المؤلفون: Tsao, Connie W., Aday, Aaron W., Almarzooq, Zaid I., Anderson, Cheryl A.M., Arora, Pankaj, Avery, Christy L., Baker-Smith, Carissa M., Beaton, Andrea Z., Boehme, Amelia K., Buxton, Alfred E., Commodore-Mensah, Yvonne, Elkind, Mitchell S.V., Evenson, Kelly R., Eze-Nliam, Chete, Fugar, Setri, Generoso, Giuliano, Heard, Debra G., Hiremath, Swapnil, Ho, Jennifer E., Kalani, Rizwan, Kazi, Dhruv S., Ko, Darae, Levine, Deborah A., Liu, Junxiu, Ma, Jun, Magnani, Jared W., Michos, Erin D., Mussolino, Michael E., Navaneethan, Sankar D., Parikh, Nisha I., Poudel, Remy, Rezk-Hanna, Mary, Roth, Gregory A., Shah, Nilay S., St-Onge, Marie-Pierre, Thacker, Evan L., Virani, Salim S., Voeks, Jenifer H., Wang, Nae-Yuh, Wong, Nathan D., Wong, Sally S., Yaffe, Kristine, Martin, Seth S.

المصدر: Circulation ; volume 147, issue 8 ; ISSN 0009-7322 1524-4539

الوصف: Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). Methods: The American Heart Association, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2023 Statistical Update is the product of a full year’s worth of effort in 2022 by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. The American Heart Association strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year’s edition includes additional COVID-19 (coronavirus disease 2019) publications, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains. Results: Each of the chapters in the Statistical Update focuses on a different topic ...

الإتاحة: https://doi.org/10.1161/cir.0000000000001123Test

المؤلفون: Brott, Thomas G, Calvet, David, Howard, George, Gregson, John, Algra, Ale, Becquemin, Jean-Pierre, de Borst, Gert J, Bulbulia, Richard, Eckstein, Hans-Henning, Fraedrich, Gustav, Greving, Jacoba P, Halliday, Alison, Hendrikse, Jeroen, Jansen, Olav, Voeks, Jenifer H, Ringleb, Peter A, Mas, Jean-Louis, Brown, Martin M, Bonati, Leo H, Carotid Stenosis Trialists' Collaboration

الوصف: BACKGROUND: The risk of periprocedural stroke or death is higher after carotid artery stenting (CAS) than carotid endarterectomy (CEA) for the treatment of symptomatic carotid stenosis. However, long-term outcomes have not been sufficiently assessed. We sought to combine individual patient-level data from the four major randomised controlled trials of CAS versus CEA for the treatment of symptomatic carotid stenosis to assess long-term outcomes. METHODS: We did a pooled analysis of individual patient-level data, acquired from the four largest randomised controlled trials assessing the relative efficacy of CAS and CEA for treatment of symptomatic carotid stenosis (Endarterectomy versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis trial, Stent-Protected Percutaneous Angioplasty of the Carotid Artery versus Endarterectomy trial, International Carotid Stenting Study, and Carotid Revascularization Endarterectomy versus Stenting Trial). The risk of ipsilateral stroke was assessed between 121 days and 1, 3, 5, 7, 9, and 10 years after randomisation. The primary outcome was the composite risk of stroke or death within 120 days after randomisation (periprocedural risk) or subsequent ipsilateral stroke up to 10 years after randomisation (postprocedural risk). Analyses were intention-to-treat, with the risk of events calculated using Kaplan-Meier methods and Cox proportional hazards analysis with adjustment for trial. FINDINGS: In the four trials included, 4775 patients were randomly assigned, of whom a total of 4754 (99·6%) patients were followed up for a maximum of 12·4 years. 21 (0·4%) patients immediately withdrew consent after randomisation and were excluded. Median length of follow-up across the studies ranged from 2·0 to 6·9 years. 129 periprocedural and 55 postprocedural outcome events occurred in patients allocated CEA, and 206 and 57 for those allocated CAS. After the periprocedural period, the annual rates of ipsilateral stroke per person-year were similar for the two treatments: 0·60% (95% CI ...

وصف الملف: text

العلاقة: https://researchonline.lshtm.ac.uk/id/eprint/4652575/2/Brown_Long-term%20outcomes%20of%20stenting%20and%20endarterectomy%20for%20symptomatic%20carotid%20stenosis.%20A%20preplanned%20pooled%20analysis%20of%20individual%20patient%20data_AAM.pdfTest; https://researchonline.lshtm.ac.uk/id/eprint/4652575/1/Brown_Long-term%20outcomes%20of%20stenting%20and%20endarterectomy%20for%20symptomatic%20carotid%20stenosis.%20A%20preplanned%20pooled%20analysis%20of%20individual%20patient%20data_Suppl.pdfTest; Brott, Thomas G; Calvet, David; Howard, George; Gregson, John ; Algra, Ale; Becquemin, Jean-Pierre; de Borst, Gert J; Bulbulia, Richard; Eckstein, Hans-Henning; Fraedrich, Gustav; +10 more. Greving, Jacoba P; Halliday, Alison; Hendrikse, Jeroen; Jansen, Olav; Voeks, Jenifer H; Ringleb, Peter A; Mas, Jean-Louis; Brown, Martin M; Bonati, Leo H; Carotid Stenosis Trialists' Collaboration; (2019) Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient data. LANCET NEUROLOGY, 18 (4). pp. 348-356. ISSN 1474-4422 DOI: https://doi.org/10.1016/S1474-4422Test(19)30028-6

الإتاحة: https://doi.org/10.1016/S1474-4422Test(19)30028-6
https://researchonline.lshtm.ac.uk/id/eprint/4652575Test/
https://researchonline.lshtm.ac.uk/id/eprint/4652575/2/Brown_Long-term%20outcomes%20of%20stenting%20and%20endarterectomy%20for%20symptomatic%20carotid%20stenosis.%20A%20preplanned%20pooled%20analysis%20of%20individual%20patient%20data_AAM.pdfTest
https://researchonline.lshtm.ac.uk/id/eprint/4652575/1/Brown_Long-term%20outcomes%20of%20stenting%20and%20endarterectomy%20for%20symptomatic%20carotid%20stenosis.%20A%20preplanned%20pooled%20analysis%20of%20individual%20patient%20data_Suppl.pdfTest

المؤلفون: Moore, Wesley S., Voeks, Jenifer H., Roubin, Gary S., Clark, Wayne M., Howard, Virginia J., Jones, Michael R., Brott, Thomas G.

المساهمون: National Institute of Neurological Disorders and Stroke, Abbott Vascular

المصدر: Journal of Vascular Surgery ; volume 69, issue 6, page 1797-1800 ; ISSN 0741-5214

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.jvs.2018.09.054Test
https://api.elsevier.com/content/article/PII:S0741521418324686?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0741521418324686?httpAccept=text/plainTest