التفاصيل البيبلوغرافية
| العنوان: |
Matrilin-2 Is a Widely Distributed Extracellular Matrix Protein and a Potential Biomarker in the Early Stage of Osteoarthritis in Articular Cartilage |
| المؤلفون: |
Shukun Zhang, Jinwu Peng, Yan Guo, Sara Javidiparsijani, Guirong Wang, Yichun Wang, Honggang Liu, Jingshi Liu, Junming Luo |
| بيانات النشر: |
BioMed Research International |
| سنة النشر: |
2014 |
| المجموعة: |
Hindawi Publishing Corporation |
| مصطلحات موضوعية: |
Orthopedics |
| الوصف: |
In this study, we first generated and characterized a polyclonal antibody against unique domain of matrlin-2 and then used this specific antibody to assess the expression pattern of matrilin-2 by immunohistochemistry. We found that marilin-2 is widely distributed in the connective tissues of many mouse tissues including heart, colon, penis, esophagus, lung, kidney, tracheal cartilage, developmental bone, and adult bone. The expression level of matrilin-2 was remarkably increased in the tissues of osteoarthritis developmental articular cartilage, compared to normal healthy tissues. Furthermore, we determined matrilin-2 expression in specific epithelial cells in stomach and ductal epithelial cells of salivary gland. In other tissues, the positive signals were mainly located around cardiac muscle cells and Purkinje fibers in the heart; corpus spongiosum in the penis; submucosa in the colon and esophagus; extracellular matrix of cartilage in the tracheal cartilage; and, glomerulus, the basement membrane of distal convoluted tubule and renal matrix in kidney. These observations indicated that the distribution pattern of matrilin-2 is heterogeneous in each tissue. Matrilin-2 may play an important role in the communication of matrix to matrix and matrix to cells and will be used as a potential biomarker in the early stage of osteoarthritis of articular cartilage. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.1155/2014/986127Test |
| DOI: |
10.1155/2014/986127 |
| الإتاحة: |
https://doi.org/10.1155/2014/986127Test |
| حقوق: |
Copyright © 2014 Shukun Zhang et al. |
| رقم الانضمام: |
edsbas.582D8A98 |
| قاعدة البيانات: |
BASE |
