دورية أكاديمية
أعرض في EDS

Hypophysitis induced by immune checkpoint inhibitors in a Scottish melanoma population

التفاصيل البيبلوغرافية
العنوان: Hypophysitis induced by immune checkpoint inhibitors in a Scottish melanoma population
المؤلفون: Khor Zhong Wei, Mark Baxter, Richard Casasola
المصدر: Melanoma Management, Vol 6, Iss 1 (2019)
بيانات النشر: Future Medicine Ltd
سنة النشر: 2019
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: adverse effects, hypophysitis, immunotherapy, ipilimumab, melanoma, nivolumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Aim: This study aims to determine the incidence of all immune-mediated adverse events (IMAEs) with a focus on hypophysitis in patients with metastatic melanoma receiving immune checkpoint inhibitors (ICI). Methods: 51 patients with metastatic melanoma who received immune checkpoint inhibitors (ipilimumab, pembrolizumab and nivolumab) in Ninewells Hospital, Dundee between 2014 and 2018 were identified. Patient demographic data and outcomes were recorded retrospectively. Results: A total of 6 patients (11.7%) developed hypophysitis, while 15 patients (29.4%) developed IMAEs. A significant improvement in overall survival (p = 0.03) and progression-free survival (p = 0.041) was seen in patients who developed IMAEs compared with those who did not. Conclusion: This study demonstrates a high rate of hypophysitis in melanoma patients receiving ipilimumab. Careful monitoring of symptoms is crucial to detect and appropriately manage IMAEs.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2045-0893
2045-0885
العلاقة: https://doaj.org/toc/2045-0885Test; https://doaj.org/toc/2045-0893Test; https://doaj.org/article/6936a0979dc94b459061f6458b8b7094Test
DOI: 10.2217/mmt-2018-0009
الإتاحة: https://doi.org/10.2217/mmt-2018-0009Test
https://doaj.org/article/6936a0979dc94b459061f6458b8b7094Test
رقم الانضمام: edsbas.E6503CBC
قاعدة البيانات: BASE
الوصف
تدمد:20450893
20450885
DOI:10.2217/mmt-2018-0009