المؤلفون: Mohamed E. Shaker, Mohamed F. Hamed, Ahmed A. Shaaban

المصدر: Saudi Pharmaceutical Journal, Vol 30, Iss 3, Pp 291-299 (2022)

مصطلحات موضوعية: Sterile inflammation, DAMPs, NLRP3, RORγt, Therapeutics. Pharmacology, RM1-950

العلاقة: http://www.sciencedirect.com/science/article/pii/S131901642200007XTest; https://doaj.org/toc/1319-0164Test; https://doaj.org/article/204dfc1e551b4c87b29edadee2f08c56Test

الإتاحة: https://doi.org/10.1016/j.jsps.2022.01.007Test
https://doaj.org/article/204dfc1e551b4c87b29edadee2f08c56Test

المؤلفون: Zhihui Zhang, Kai Zhang, Mi Zhang, Xiaomin Zhang, Rongxin Zhang

المصدر: Frontiers in Immunology, Vol 13 (2022)

مصطلحات موضوعية: multiple sclerosis (MS) disease, T helper 17 cell (Th17 cell), parthenolide (PTL), nuclear factor kappa B (NF-κB), experimental autoimmune encephalomyelitis (EAE), retinoid-related orphan receptor-γt (RORγt), Immunologic diseases. Allergy, RC581-607

العلاقة: https://www.frontiersin.org/articles/10.3389/fimmu.2022.856694/fullTest; https://doaj.org/toc/1664-3224Test; https://doaj.org/article/80e193243f4b4521a85d8ef10a96abcfTest

الإتاحة: https://doi.org/10.3389/fimmu.2022.856694Test
https://doaj.org/article/80e193243f4b4521a85d8ef10a96abcfTest

المؤلفون: Tao Wang, Shanshan Cui, Ling Hao, Wen Liu, Lijing Wang, Mengwei Ju, Wenjing Feng, Rong Xiao

المصدر: International Journal of Molecular Sciences, Vol 23, Iss 4370, p 4370 (2022)

مصطلحات موضوعية: 27-hydroxycholesterol, 24S-hydroxycholesterol, RORγt, Th17/Treg, learning and memory ability, Biology (General), QH301-705.5, Chemistry, QD1-999

العلاقة: https://www.mdpi.com/1422-0067/23/8/4370Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/7f5462cbea2a4d33901a30c571d117d0Test

الإتاحة: https://doi.org/10.3390/ijms23084370Test
https://doaj.org/article/7f5462cbea2a4d33901a30c571d117d0Test

المؤلفون: Yana Yang, Wenhui Qi, Yanyan Zhang, Ruining Wang, Mingyue Bao, Mengyuan Tian, Xing Li, Yuan Zhang

المصدر: International Journal of Molecular Sciences, Vol 23, Iss 14547, p 14547 (2022)

مصطلحات موضوعية: chalcone derivant, RORγt, Th17 cell differentiation, experimental autoimmune encephalomyeliti, experimental colitis, skin allograft rejection, Biology (General), QH301-705.5, Chemistry, QD1-999

العلاقة: https://www.mdpi.com/1422-0067/23/23/14547Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/dc464ee36ab74ddfb604c8bb32506445Test

الإتاحة: https://doi.org/10.3390/ijms232314547Test
https://doaj.org/article/dc464ee36ab74ddfb604c8bb32506445Test

المؤلفون: Manman Wang, Tiantian Su, Hanfei Sun, Huijuan Cheng, Chunru Jiang, Paipai Guo, Zhenduo Zhu, Ruhong Fang, Feng He, Mingli Ge, Qiuyun Guan, Wei Wei, Qingtong Wang

المصدر: International Journal of Molecular Sciences, Vol 23, Iss 16105, p 16105 (2022)

مصطلحات موضوعية: rheumatoid arthritis, Th17/Treg, Ziyuglycoside I, mTOR, RORγt, Foxp3, Biology (General), QH301-705.5, Chemistry, QD1-999

العلاقة: https://www.mdpi.com/1422-0067/23/24/16105Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/1c450662483144f2bff00b247c3ec959Test

الإتاحة: https://doi.org/10.3390/ijms232416105Test
https://doaj.org/article/1c450662483144f2bff00b247c3ec959Test

المؤلفون: Zou, Hongye, Yang, Yatian, Shi, Zhenrui, Wu, Xuesong, Liu, Ruiwu, Yu, Ai-Ming, Chen, Hong-Wu

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Cholesterol, Chromatin, Humans, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Triple Negative Breast Neoplasms, ROR gamma t, Tissue-selective modulator, Chromatin accessibility, Breast cancer, Cholesterol biosynthesis, RORγt, Pharmacology & Pharmacy

العلاقة: qt2q2371d3; https://escholarship.org/uc/item/2q2371d3Test

الإتاحة: https://escholarship.org/uc/item/2q2371d3Test

المؤلفون: Ji-An Chen (9305742), Hui Ma (290168), Zehui Liu (4023659), Jinlong Tian (5878574), Sisi Lu (6916592), Wenqing Fang (11879351), Shuyin Ze (11879354), Weiqiang Lu (165510), Qiong Xie (709001), Jin Huang (146235), Yonghui Wang (287491)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Space Science, Chemical Sciences not elsewhere classified, present study provides, multifactorial autoimmune disease, major clinical challenge, dextran sulfate sodium, may enhance anti, 50 , 14d , potent dual rorγt, vivo <, therapeutic agents, taken together, reduce rorγt, novel framework, inflammatory effects, inflammatory activity, exhibited remarkable, dual rorγt, dihydroorotate dehydrogenase, dependently alleviated, aminobenzothiazole hit, 297 μm, 110 μm

العلاقة: https://figshare.com/articles/journal_contribution/Discovery_of_Orally_Available_Retinoic_Acid_Receptor-Related_Orphan_Receptor_t_Dihydroorotate_Dehydrogenase_Dual_Inhibitors_for_the_Treatment_of_Refractory_Inflammatory_Bowel_Disease/17694968Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01746.s001Test

المؤلفون: Meijer, Femke A., van den Oetelaar, M.C.M., Doveston, R.G., Sampers, E.N.R., Brunsveld, Lucas

المصدر: Meijer , F A , van den Oetelaar , M C M , Doveston , R G , Sampers , E N R & Brunsveld , L 2021 , ' Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site ' , ACS Medicinal Chemistry Letters , vol. 12 , no. 4 , pp. 631-639 . https://doi.org/10.1021/acsmedchemlett.1c00029Test

مصطلحات موضوعية: Nuclear receptors, RORγt, allosteric modulators, covalent probes

العلاقة: https://research.tue.nl/en/publications/f2123ce0-8a26-4073-92e2-dd92e65e640aTest

الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00029Test
https://research.tue.nl/en/publications/f2123ce0-8a26-4073-92e2-dd92e65e640aTest
http://www.scopus.com/inward/record.url?scp=85103476297&partnerID=8YFLogxKTest

المؤلفون: Bhawna Yadav (172612), Charles A. Specht (10326563), Chrono K. Lee (11362104), Maria Pokrovskii (11362107), Jun R. Huh (2004790), Dan R. Littman (82), Stuart M. Levitz (10326566)

مصطلحات موضوعية: Medicine, Genetics, Ecology, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, sup >-/-, mcherry reporter mouse, master transcription factor, >- challenged wild, utilized murine models, lung eosinophils elicited, comparing lung eosinophils, div >< p, acute pulmonary aspergillosis, eosinophil rorγt expression, acute models, pulmonary aspergillosis, eosinophil il, western blotting, positively correlated, live conidia, immunocompetent persons, former predominated, flow cytometry, cytoplasmic localization, confocal microscopy, atopic individuals, adverse consequences

العلاقة: https://figshare.com/articles/journal_contribution/Intracellular_expression_of_ROR_t_in_lung_eosinophils_and_CD4_sup_sup_T_cells_from_wild-type_versus_IL-23p19_sup_-_-_sup_mice_with_allergic_aspergillosis_/16549956Test

الإتاحة: https://doi.org/10.1371/journal.ppat.1009891.s005Test

المؤلفون: Bhawna Yadav (172612), Charles A. Specht (10326563), Chrono K. Lee (11362104), Maria Pokrovskii (11362107), Jun R. Huh (2004790), Dan R. Littman (82), Stuart M. Levitz (10326566)

مصطلحات موضوعية: Medicine, Genetics, Ecology, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, sup >-/-, mcherry reporter mouse, master transcription factor, >- challenged wild, utilized murine models, lung eosinophils elicited, comparing lung eosinophils, div >< p, acute pulmonary aspergillosis, eosinophil rorγt expression, acute models, pulmonary aspergillosis, eosinophil il, western blotting, positively correlated, live conidia, immunocompetent persons, former predominated, flow cytometry, cytoplasmic localization, confocal microscopy, atopic individuals, adverse consequences

العلاقة: https://figshare.com/articles/journal_contribution/Immunoblotting_for_ROR_t_in_thymic_cells_from_wild-type_and_ROR_t_sup_-_-_sup_mice_/16549938Test

الإتاحة: https://doi.org/10.1371/journal.ppat.1009891.s002Test