المؤلفون: Longo V., Della Corte C. M., Russo A., Spinnato F., Ambrosio F., Ronga R., Marchese A., Del Giudice T., Sergi C., Casaluce F., Gilli M., Montrone M., Gristina V., Sforza V., Reale M. L., Di Liello R., Servetto A., Lipari H., Longhitano C., Vizzini L., Manzo A., Cristofano A., Paolelli L., Nardone A., De Summa S., Perrone A., Bisceglia C., Derosa C., Nardone V., Viscardi G., Galetta D., Vitiello F.

المساهمون: Longo V., Della Corte C.M., Russo A., Spinnato F., Ambrosio F., Ronga R., Marchese A., Del Giudice T., Sergi C., Casaluce F., Gilli M., Montrone M., Gristina V., Sforza V., Reale M.L., Di Liello R., Servetto A., Lipari H., Longhitano C., Vizzini L., Manzo A., Cristofano A., Paolelli L., Nardone A., De Summa S., Perrone A., Bisceglia C., Derosa C., Nardone V., Viscardi G., Galetta D., Vitiello F.

مصطلحات موضوعية: chemoimmunotherapy, consolidative radiotherapy, innate immunity, safety, SCLC - small cell lung cancer

الوصف: Background: Consolidative thoracic radiotherapy (TRT) has been commonly used in the management of extensive-stage small cell lung cancer (ES-SCLC). Nevertheless, phase III trials exploring first-line chemoimmunotherapy have excluded this treatment approach. However, there is a strong biological rationale to support the use of radiotherapy (RT) as a boost to sustain anti-tumor immune responses. Currently, the benefit of TRT after chemoimmunotherapy remains unclear. The present report describes the real-world experiences of 120 patients with ES-SCLC treated with different chemoimmunotherapy combinations. Preclinical data supporting the hypothesis of anti-tumor immune responses induced by RT are also presented. Methods: A total of 120 ES-SCLC patients treated with chemoimmunotherapy since 2019 in the South of Italy were retrospectively analyzed. None of the patients included in the analysis experienced disease progression after undergoing first-line chemoimmunotherapy. Of these, 59 patients underwent TRT after a multidisciplinary decision by the treatment team. Patient characteristics, chemoimmunotherapy schedule, and timing of TRT onset were assessed. Safety served as the primary endpoint, while efficacy measured in terms of overall survival (OS) and progression-free survival (PFS) was used as the secondary endpoint. Immune pathway activation induced by RT in SCLC cells was explored to investigate the biological rationale for combining RT and immunotherapy. Results: Preclinical data supported the activation of innate immune pathways, including the STimulator of INterferon pathway (STING), gamma-interferon-inducible protein (IFI-16), and mitochondrial antiviral-signaling protein (MAVS) related to DNA and RNA release. Clinical data showed that TRT was associated with a good safety profile. Of the 59 patients treated with TRT, only 10% experienced radiation toxicity, while no ≥ G3 radiation-induced adverse events occurred. The median time for TRT onset after cycles of chemoimmunotherapy was 62 days. Total radiation ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38304255; info:eu-repo/semantics/altIdentifier/wos/WOS:001154316800001; volume:14; firstpage:1; lastpage:9; numberofpages:9; journal:FRONTIERS IN IMMUNOLOGY; https://hdl.handle.net/10447/623973Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85183811990

الإتاحة: https://doi.org/10.3389/fimmu.2023.1289434Test
https://hdl.handle.net/10447/623973Test

المؤلفون: Doronzo, Domenico, Delle Donne, Dario, Bellucci Sessa, Eliana, Convertito, Vincenzo, de' Michieli Vitturi, Mattia, de Vita, Sandro, Di Traglia, Federico, Nappi, Rosa, Nardone, Lucia, Nave, Rosella, Sansivero, Fabio, Di Vito, Mauro Antonio

المساهمون: Istituto Nazionale di Geofisica e Vulcanologia (INGV), Sezione OV, Napoli, Italia, Istituto Nazionale di Geofisica e Vulcanologia (INGV), Sezione Pisa, Pisa, Italia

مصطلحات موضوعية: Ischia island, landslide

الوصف: Lahars, landslides and debris flows are rapid natural phenomena that can heavily impact on and modify the environment, not only that from which they are triggered but also the one in which they propagate or leave deposits. In particular, lahars can reach significant runout distances from source areas (e.g., several km) and this can mainly depend, among other factors, on the morphology experienced by such propagation. There are cases in the recent history of natural occurrences in which lahars impacted catastrophically on rural and urban settings, such as for example at Nevado del Ruiz volcano (Colombia) in 1985 causing the death of thousands of people living around there. A more recent event occurred on November 26, 2022 at Ischia island (Italy), which is an active volcano particularly subjected to the recurrence of these phenomena. In this case, the emplacement of some lahars caused the death of a few tens of people and the damaging of tens of building, besides the direct impact on local agriculture and tourism. In the nearby Neapolitan volcanic area, several other lahar events occurred in the historical past, not only during but also after or well after explosive eruptions, as the evidence that these phenomena are still to be considered as complex and often unpredictable extreme natural events, also exacerbated by the climate changes, but also that they have some recurrence that cannot be neglected. Such kind of recurrence is mainly related to the local weather, which can even affect the intrinsic behavior of the flows that detach from the source areas and invade the territory. On the other hand, this is not a strictly statistical issue, as there are instrumental measurements that support the fact that heavy rains can exacerbate a landscape already prone to sliding, avalanching, and other catastrophic phenomena. For this, the November 26, 2022 Ischia case study was chosen with the goal of reconstructing the physical features that led to the lahar generation and invasion, which is something that might occur in ...

العلاقة: EGU General Assembly 2024; http://hdl.handle.net/2122/17178Test

الإتاحة: https://doi.org/10.5194/egusphere-egu24-10028Test
http://hdl.handle.net/2122/17178Test

المؤلفون: Ricciardi, Toni, Nardone, Marco, Cattacin, Sandro

المصدر: Placements et destinée. Décisions des autorités et conséquences sur les parcours de vie, (2024) p. 161-172

مصطلحات موضوعية: info:eu-repo/classification/ddc/301, Placements extrafamiliaux, Internements administratifs, Migration, Migration italienne, Trente Glorieuses, Clandestinité, Saisonniers, Saisonnières, Von Mentlen, Ospedale neuropsichiatrico cantonale, Mendrisio, Bellinzona, Tessin, Ticino, Droits des enfants, Diritti dei fanciulli, Psichiatria, Psychiatrie, Institution, Institut

الوصف: Le deuxième texte figurant dans la troisième partie de ce livre éclaire une réalité moins connue de la migration et, indirectement, du statut de saisonnier en Suisse. Les conditions strictes de ce statut visaient à empêcher le regroupement familial. Les couples de saisonniers ayant un ou plusieurs enfants ne pouvaient vivre en Suisse avec le reste de leur famille. Certains enfants en bas âge ont dès lors été placés en institution. D’autres sont demeurés au pays sous la garde du reste de la famille. Un nombre conséquent d’enfants a néanmoins été contraint d’habiter clandestinement en Suisse durant plusieurs années de leur existence. Ces enfants ne pouvaient que rarement être scolarisés lorsque les parents travaillaient avec le statut de saisonnier. Leur condition de clandestins leur valait de demeurer cachés et discrets autant durant l’absence de leurs parents partis travailler que lorsque la famille était réunie. Ils étaient très tôt familiarisés avec la discrétion, de façon à ne pas révéler leur existence. Des institutions spécifiques pour l’accueil et l’hébergement des enfants concernés avaient été créées dans les régions frontalières de la Suisse. Les résultats obtenus par Ricciardi et al. (2024) permettent d’interroger fondamentalement le rapport de force inégal entre les intérêts économiques et la protection des droits de l’enfance.

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-3-7965-4883-3; https://archive-ouverte.unige.ch/unige:175813Test; unige:175813

الإتاحة: https://doi.org/10.24894/978-3-7965-4905-2Test
https://archive-ouverte.unige.ch/unige:175813Test

المؤلفون: Ricciardi, Toni, Nardone, Marco, Cattacin, Sandro

المصدر: Schicksale der Fremdplatzierung. Behördensntscheidungen und Auswirkungen auf den Lebenslauf, (2024) p. 165-178

مصطلحات موضوعية: info:eu-repo/classification/ddc/301, Ticino, Tessin, Ospedale neuropsichiatrico cantonale, ONC, Neuro, Mendrisio, Bellinzona, Heimkinder, Italienische Migration, Kinderrechte, Kinderschutz, Institution, Fremdplatzierungen, Administrative Versorgungen, Fürsorgerische Zwangsmassnahmen, Saisonniers

الوصف: Der zweite Text im dritten Teil dieses Bandes beleuchtet eine weniger bekannte Realität der Migration und indirekt auch des Saisonnierstatuts in der Schweiz. Die strengen Bedingungen dieses Status zielten unter anderem auch darauf ab, Familienzusammenführungen zu verhindern. Saisonarbeiterpaare mit einem oder mehreren Kindern konnten nicht mit dem Rest ihrer Familie in der Schweiz leben. Einige Kleinkinder wurden daher in Heimen untergebracht. Andere blieben unter der Obhut der restlichen Familie im Herkunftsland. Eine beträchtliche Anzahl von Kindern war jedoch gezwungen, mehrere Jahre illegal in der Schweiz zu leben. Waren die Eltern unter dem Saisonnierstatut tätig, konnten diese Kinder nur selten beschult werden. Als Illegale blieben sie versteckt und unauffällig, und zwar sowohl, wenn die Eltern wegen der Arbeit abwesend waren, als auch, wenn die Familie zusammenkam. Die Kinder waren schon sehr früh auf Unauffälligkeit sozialisiert worden, um ihr Vorhandensein nicht zu offenbaren. In den Grenzregio-nen der Schweiz waren sogar spezielle Einrichtungen für die Aufnahme und Unter-bringung der betroffenen Kinder geschaffen worden. Die Forschungsergebnisse des Teams Cattacin et al. (2024) erlauben es, das ungleiche Kräfteverhältnis zwischen wirtschaftlichen Interessen und dem Schutz der Kinderrechte grundlegend zu hinterfragen.

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-3-7965-4883-3; https://archive-ouverte.unige.ch/unige:175814Test; unige:175814

الإتاحة: https://doi.org/10.24894/978-3-7965-4883-3Test
https://archive-ouverte.unige.ch/unige:175814Test

المؤلفون: Phelps, Nowell H, Singleton, Rosie K, Zhou, Bin, Heap, Rachel A, Mishra, Anu, Bennett, James E, Paciorek, Christopher J, Lhoste, Victor PF, Carrillo-Larco, Rodrigo M, Stevens, Gretchen A, Rodriguez-Martinez, Andrea, Bixby, Honor, Bentham, James, Di Cesare, Mariachiara, Danaei, Goodarz, Rayner, Archie W, Barradas-Pires, Ana, Cowan, Melanie J, Savin, Stefan, Riley, Leanne M, Aguilar-Salinas, Carlos A, Baker, Jennifer L, Barkat, Amina, Bhutta, Zulfiqar A, Branca, Francesco, Caixeta, Roberta B, Cuschieri, Sarah, Farzadfar, Farshad, Ganapathy, Shubash, Ikeda, Nayu, Iotova, Violeta, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Lin, Hsien-Ho, Ma, Jun, Mbanya, Jean Claude N, Miranda, J Jaime, Pradeepa, Rajendra, Rodríguez-Artalejo, Fernando, Sorić, Maroje, Turley, Maria, Wang, Limin, Webster-Kerr, Karen, Aarestrup, Julie, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdeen, Ziad A, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Abubakar Garba, Jamila, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J, Adu-Afarwuah, Seth, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Ågren, Åsa, Aguenaou, Hassan, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lahou, Badreya, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Al Qaoud, Nawal M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Aldwairji, Maryam A, Alexius, Sylvia, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkerwi, Ala'a, Alkhatib, Buthaina M, Allin, Kristine, Alomary, Shaker A, Alomirah, Husam F, Alshangiti, Arwa M, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Ängquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assefa, Nega, Aspelund, Thor, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Aung, May Soe, Aurélio de Valois, Correia Júnior Marco, Auvinen, Juha, Avdičová, Mária, Avi, Shina, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Babu, Bontha V, Bacopoulou, Flora, Bæksgaard Jørgensen, Maja, Baharudin, Azli, Bahijri, Suhad, Bajramovic, Izet, Bakacs, Marta, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Banegas, José R, Baran, Joanna, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, Joao Luiz, Bata, Iqbal, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berhane, Yemane, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Berrios Carrasola, Ximena, Bettiol, Heloísa, Beutel, Manfred E, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Biasch, Katia, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Anne A, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Blychfeld Magnazu, Moran, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boer, Jolanda MA, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Botomba, Steve, Bourne, Rupert RA, Bovet, Pascal, Boymatova, Khadichamo, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Braithwaite, Tasanee, Brajkovich, Imperia, Breckenkamp, Juergen, Breda, João, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brophy, Sinead, Brug, Johannes, Bruno, Graziella, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de León, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, José, Can, Günay, Cândido, Ana Paula c, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajús, José A, Casanueva, Felipe F, Casas, Maribel, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Angelique, Chan, Queenie, Charchar, Fadi J, Charles, Marie-Aline, Chaturvedi, Himanshu K, Chaturvedi, Nish, Che Abdul Rahim, Norsyamlina, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Cojocaru, Cosmin R, Colorado-Yohar, Sandra, Compañ-Gabucio, Laura-María, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Cortés, Lilia Yadira, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Csányi, Tamás, Csilla, Semánová, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, Czenczek-Lewandowska, Ewelina, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva, Alanna G, Dacica, Liliana, Dahm, Christina C, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Backer, Guy, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, De Neve, Jan-Walter, Duarte de Oliveira, Paula, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, de Sá, Ana Carolina MGN, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent Jr, Delisle, Hélène, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Dereń, Katarzyna, Deschamps, Valérie, Devrishov, Ruslan D, Dhimal, Meghnath, Di Castelnuovo, Augusto, Dias-da-Costa, Juvenal Soares, Díaz-Sánchez, María Elena, Diaz, Alejandro, Díaz Fernández, Pedro, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Dong, Yanhui, Donoso, Silvana P, Döring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Dörr, Marcus, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duleva, Vesselka L, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dwyer, Terence, Dyussupova, Azhar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ammari, Laila, El Ati, Jalila, Eldemire-Shearer, Denise, Elliott, Paul, Enang, Ofem, Endevelt, Ronit, Engle-Stone, Reina, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Evans, Roger G, Faeh, David, Fagherazzi, Guy, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farrugia Sant'Angelo, Victoria, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Fawzi, Wafaie W, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Gerson, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferreira, Haroldo S, Ferrer, Eldridge, Ferrieres, Jean, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Fras, Zlatko, Fraser, Brooklyn, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Gafencu, Mihai, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Gao, Pei, Garcia-de-la-Hera, Manoli, García Mérida, María José, García Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, George, Ronnie, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gieger, Christian, Gill, Tiffany K, Giovannelli, Jonathan, 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Slazhnyova, Tatyana, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Söderberg, Stefan, Soekatri, Moesijanti YE, Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Solovieva, Yuliya V, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Soofi, Sajid, Sørensen, Thorkild IA, Sørgjerd, Elin P, Sossa Jérome, Charles, Soto-Rojas, Victoria E, Soumaré, Aïcha, Sousa-Poza, Alfonso, Sovic, Slavica, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Spencer, Phoebe R, Spinelli, Angela, Spiroski, Igor, Staessen, Jan A, Stamm, Hanspeter, Stang, Andreas, Starc, Gregor, Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Steinsbekk, Silje, Stergiou, George S, Stessman, Jochanan, Stevanović, Ranko, Stieber, Jutta, Stöckl, Doris, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Strufaldi, Maria Wany, Sturua, Lela, Suárez-Medina, Ramón, Suarez-Ortegón, Milton F, Suebsamran, Phalakorn, Sugiyama, Mindy, Suka, Machi, Sulo, Gerhard, Sun, Chien-An, Sun, Liang, Sund, Malin, Sundström, Johan, Sung, Yn-Tz, Sunyer, Jordi, Suriyawongpaisal, Paibul, Sweis, Nabil William G, Swinburn, Boyd A, Sy, Rody G, Sylva, René Charles, Szponar, Lucjan, Tabone, Lorraine, Tai, E Shyong, Takuro, Furusawa, Tambalis, Konstantinos D, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanrygulyyeva, Maya, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Taxová Braunerová, Radka, Taylor, Anne, Taylor, Julie, Tchibindat, Félicité, Te Velde, Saskia, Tebar, William R, Tell, Grethe S, Tello, Tania, Tessema, Masresha, Tham, Yih Chung, Thankappan, KR, Theobald, Holger, Theodoridis, Xenophon, Thomas, Nihal, Thorand, Barbara, Thrift, Amanda G, Tichá, Ľubica, Timmermans, Erik J, Tjandrarini, Dwi Hapsari, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Tomaszewski, Maciej, Topbas, Murat, Topór-Mądry, Roman, Torheim, Liv Elin, Tornaritis, Michael J, Torrent, Maties, Torres-Collado, Laura, Toselli, Stefania, Touloumi, Giota, Traissac, Pierre, Tran, Thi Tuyet-Hanh, Tremblay, Mark S, Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsigga, Maria, Tsintavis, Panagiotis, Tsugane, Shoichiro, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Twig, Gilad, Tynelius, Per, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Udoji, Nwannedimma, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Ulmer, Hanno, Unal, Belgin, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Varona-Pérez, Patricia, Vasan, Senthil K, Vasques, Daniel G, Vatasescu, Radu, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Viriyautsahakul, Napaphan, Virtanen, Jyrki K, Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Völzke, Henry, Vourli, Georgia, Voutilainen, Ari, Vrijheid, Martine, Vrijkotte, Tanja GM, Vuletić, Silvije, Wade, Alisha N, Waldhör, Thomas, Walton, Janette, Wambiya, Elvis OA, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D, Whincup, Peter H, Wichstrøm, Lars, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wild, Philipp S, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wirth, James P, Wojtyniak, Bogdan, Woldeyohannes, Meseret, Wolf, Kathrin, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Li, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, Yépez García, Martha, Yiallouros, Panayiotis K, Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, Yotov, Yoto, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zentai, Andrea, Zhang, Bing, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, Zuziak, Monika, Ezzati, Majid

مصطلحات موضوعية: ddc:330

الوصف: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.

العلاقة: Journal: The Lancet; Volume: 403; Year: 2024; Issue: 10431; Pages: 1027-1050; Amsterdam: Elsevier BV; https://hdl.handle.net/10419/295105Test; RePEc:zbw:ifwkie:295105

الإتاحة: https://doi.org/10.1016/S0140-6736Test(23)02750-2
https://hdl.handle.net/10419/295105Test

المؤلفون: Richard, S., Tasso, D., Rajana, M., Saker, A., Ramirez Santos, A., Makhloufi, C., Meynet, N., Hary, B., Nardone, S., Marino, G., Thomas, M., Italiano, C., Vita, A., Gallucci, F.

المصدر: Richard , S , Tasso , D , Rajana , M , Saker , A , Ramirez Santos , A , Makhloufi , C , Meynet , N , Hary , B , Nardone , S , Marino , G , Thomas , M , Italiano , C , Vita , A & Gallucci , F 2024 , ' Comparison of thermo-hydraulic performance among different 3D printed periodic open cellular structures ' , Chemical Engineering Journal , vol. 492 , 152005 . https://doi.org/10.1016/j.cej.2024.152005Test

مصطلحات موضوعية: Additive manufacturing, CFD, Heat transfer, LPBF, POCS, Pressure drop, Process intensification, Thermo-hydraulic

الوصف: As additive manufacturing of periodic open cellular structures (POCS) is gaining interest in structured catalytic reactor research, this work seeks to thermohydraulically compare the well-known Kelvin lattice structure with the lesser-researched BCC and gyroid lattice structures. Using a combined CFD (Computational Fluid Dynamic) and experimental approach, the selected POCS are fabricated through Laser Powder Bed Fusion (LPBF), characterized, and subsequently subjected to numerical analysis. From the manufacturability point of view, the 3D printed samples closely matched their CAD designs, showing a maximum porosity deviation of 15% below design values. A CFD model, validated through pressure drop experiment, was employed to compare the POCS designs on shared geometric attributes such as specific surface area and porosity. While all structures exhibited comparable performance in term of heat and momentum transfer, our findings suggest that the Gyroid lattice may provide the optimal balance between momentum and heat transfer rates in low-velocity region. Conversely, the BCC configuration may be more favourable at higher velocity. An Ergun-like correlation was also developed and validated for each lattice type, with a Mean Absolute Percentage Error (MAPE) below 10%. Our pressure drop results align quite well with existing literature correlations, showing a MAPE under 20%. Concerning heat transfer, the values forecasted in this research show a reasonable alignment with literature's results, though they tend to be on the lower spectrum.

وصف الملف: application/pdf

العلاقة: https://research.tue.nl/en/publications/ac9a15a8-7d20-4124-bae1-20e10bbcdc82Test

الإتاحة: https://doi.org/10.1016/j.cej.2024.152005Test
https://research.tue.nl/en/publications/ac9a15a8-7d20-4124-bae1-20e10bbcdc82Test
https://pure.tue.nl/ws/files/331613306/1-s2.0-S1385894724034922-main.pdfTest
http://www.scopus.com/inward/record.url?scp=85193903751&partnerID=8YFLogxKTest

المؤلفون: NARDONE, STEFANO

العلاقة: https://dx.doi.org/10.5281/zenodo.11117040Test

الإتاحة: https://doi.org/10.5281/zenodo.1111703910.5281/zenodo.11117040Test

المؤلفون: NARDONE, STEFANO

العلاقة: https://dx.doi.org/10.5281/zenodo.11117039Test

الإتاحة: https://doi.org/10.5281/zenodo.1111704010.5281/zenodo.11117039Test

المؤلفون: Wen, Ruishan, Huang, Xiulian, Long, Jinyu, Guo, Yuxin, Wei, Yilun, Lin, Ping, Xie, Siting, Zhao, Zhongquan, Zhang, Lei, Fan, Arthur Yin, Barbalho, Sandra M, Nardone, Valerio, Alzeer, Jawad, Chen, Ying, Yu, Zongyang

المصدر: Wen, Ruishan; Huang, Xiulian; Long, Jinyu; Guo, Yuxin; Wei, Yilun; Lin, Ping; Xie, Siting; Zhao, Zhongquan; Zhang, Lei; Fan, Arthur Yin; Barbalho, Sandra M; Nardone, Valerio; Alzeer, Jawad; Chen, Ying; Yu, Zongyang (2024). Advances in traditional Chinese herbal medicine and their pharmacodynamic mechanisms in cancer immunoregulation: a narrative review. Translational Cancer Research, 13(2):1166-1187.

مصطلحات موضوعية: 540 Chemistry, Cancer Research, Radiology, Nuclear Medicine and imaging, Oncology

الوصف: Background and Objective: The cancer-immunity cycle (CIC) is defined as a series of progressive events that cause an anticancer immune response leading to the killing of the cancer cell. The concept of CIC has important guiding significance for the clinical and basic tumor immunotherapy research. As one of the methods of traditional Chinese medicine (TCM), Chinese herbal medicine (CHM) has shown unique advantages in multitarget and multipathway immune regulation. However, the tumor immune circulation targeted by CHM is generally unclear at present. To provide reference for future clinical and basic research, we systematically reviewed the existing literature on CHM (including CHM monomers, CHM compounds, and CHM patent medicines) and the mechanisms related to its efficacy. Methods: We searched the PubMed and China National Knowledge Infrastructure (CNKI) databases for relevant Chinese-language and English-language literature published from January 1988 to October 2022. The literature was screened manually at three levels: title, abstract, and full text, to identify articles related to CHM and their mechanism of regulating tumor immunity. Key Content and Findings: By further classifying the CIC, it was confirmed that CHM can regulate the activation of dendritic cells (DCs) and macrophages and promote the presentation of tumor antigens. Meanwhile, CHM can also reverse tumor-immune escape by enhancing T-cell proliferation and infiltration. In addition, CHM can also enhance the antitumor ability of the body by regulating the killing process of tumor cells. Conclusions: The theory of a CIC is of guiding significance to regulating tumor immunity via CHM

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/257549/1/82623_PB4_5720_R2.pdfTest; urn:issn:2218-676X

الإتاحة: https://doi.org/10.5167/uzh-25754910.21037/tcr-23-1983Test
https://www.zora.uzh.ch/id/eprint/257549Test/
https://www.zora.uzh.ch/id/eprint/257549/1/82623_PB4_5720_R2.pdfTest

المؤلفون: Patricia H. Alvarenga, Thiago Luiz Alves e Silva, Motoshi Suzuki, Glenn Nardone, Pedro Cecilio, Joel Vega-Rodriguez, Jose M.C. Ribeiro, John F. Andersen

مصطلحات موضوعية: Biochemistry, Microbiology, Physiology, Ecology, Immunology, Inorganic Chemistry, Biological Sciences not elsewhere classified, free quantification approaches, families classically described, applied mass spectrometry, aedes aegypti <, 2 %, respectively, comprehensive proteomics analysis, also highly abundant, 102 serine proteases, based absolute quantification, serine protease, comprehensive catalogue, also provides, transports nutrients, relative abundances, proteins belonging, physiological importance, mosquito physiology, male mosquitoes, immune response, future studies, future research, disease transmission

الوصف: In arthropods, hemolymph carries immune cells and solubilizes and transports nutrients, hormones, and other molecules that are involved in diverse physiological processes including immunity, metabolism, and reproduction. However, despite such physiological importance, little is known about its composition. We applied mass spectrometry-based label-free quantification approaches to study the proteome of hemolymph perfused from sugar-fed female and male Aedes aegypti mosquitoes. A total of 1403 proteins were identified, out of which 447 of them were predicted to be extracellular. In both sexes, almost half of these extracellular proteins were predicted to be involved in defense/immune response, and their relative abundances (based on their intensity-based absolute quantification, iBAQ) were 37.9 and 33.2%, respectively. Interestingly, among them, 102 serine proteases/serine protease-homologues were identified, with almost half of them containing CLIP regulatory domains. Moreover, proteins belonging to families classically described as chemoreceptors, such as odorant-binding proteins (OBPs) and chemosensory proteins (CSPs), were also highly abundant in the hemolymph of both sexes. Our data provide a comprehensive catalogue of A. aegypti hemolymph basal protein content, revealing numerous unexplored targets for future research on mosquito physiology and disease transmission. It also provides a reference for future studies on the effect of blood meal and infection on hemolymph composition.

العلاقة: https://figshare.com/articles/journal_contribution/Comprehensive_Proteomics_Analysis_of_the_Hemolymph_Composition_of_Sugar-Fed_i_Aedes_aegypti_i_Female_and_Male_Mosquitoes/25342872Test

الإتاحة: https://doi.org/10.1021/acs.jproteome.3c00918.s001Test
https://figshare.com/articles/journal_contribution/Comprehensive_Proteomics_Analysis_of_the_Hemolymph_Composition_of_Sugar-Fed_i_Aedes_aegypti_i_Female_and_Male_Mosquitoes/25342872Test