المؤلفون: Sakai K., Mizukami T., Leipsic J., Belmonte M., Sonck J., Norgaard B. L., Otake H., Ko B., Koo B. -K., Maeng M., Jensen J. M., Buytaert D., Munhoz D., Andreini D., Ohashi H., Shinke T., Taylor C. A., Barbato E., Johnson N. P., De Bruyne B., Collet C.

المساهمون: K. Sakai, T. Mizukami, J. Leipsic, M. Belmonte, J. Sonck, B.L. Norgaard, H. Otake, B. Ko, B.-. Koo, M. Maeng, J.M. Jensen, D. Buytaert, D. Munhoz, D. Andreini, H. Ohashi, T. Shinke, C.A. Taylor, E. Barbato, N.P. Johnson, B. De Bruyne, C. Collet

مصطلحات موضوعية: calcification, coronary computed tomography angiography, lipid-rich plaque, optical coherence tomography, pullback pressure gradient, thin-cap fibroatheromas, Settore MED/11 - Malattie dell'Apparato Cardiovascolare

الوصف: Background: The interplay between coronary hemodynamics and plaque characteristics remains poorly understood. Objectives: The aim of this study was to compare atherosclerotic plaque phenotypes between focal and diffuse coronary artery disease (CAD) defined by coronary hemodynamics. Methods: This multicenter, prospective, single-arm study was conducted in 5 countries. Patients with functionally significant lesions based on an invasive fractional flow reserve ≤0.80 were included. Plaque analysis was performed by using coronary computed tomography angiography and optical coherence tomography. CAD patterns were assessed using motorized fractional flow reserve pullbacks and quantified by pullback pressure gradient (PPG). Focal and diffuse CAD was defined according to the median PPG value. Results: A total of 117 patients (120 vessels) were included. The median PPG was 0.66 (IQR: 0.54-0.75). According to coronary computed tomography angiography analysis, plaque burden was higher in patients with focal CAD (87% ± 8% focal vs 82% ± 10% diffuse; P = 0.003). Calcifications were significantly more prevalent in patients with diffuse CAD (Agatston score per vessel: 51 [IQR: 11-204] focal vs 158 [IQR: 52-341] diffuse; P = 0.024). According to optical coherence tomography analysis, patients with focal CAD had a significantly higher prevalence of circumferential lipid-rich plaque (37% focal vs 4% diffuse; P = 0.001) and thin-cap fibroatheroma (TCFA) (47% focal vs 10% diffuse; P = 0.002). Focal disease defined by PPG predicted the presence of TCFA with an area under the curve of 0.73 (95% CI: 0.58-0.87). Conclusions: Atherosclerotic plaque phenotypes associate with intracoronary hemodynamics. Focal CAD had a higher plaque burden and was predominantly lipid-rich with a high prevalence of TCFA, whereas calcifications were more prevalent in diffuse CAD. (Precise Percutaneous Coronary Intervention Plan [P3]; NCT03782688)

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37480908; volume:16; issue:11; firstpage:1452; lastpage:1464; numberofpages:13; journal:JACC. CARDIOVASCULAR IMAGING; https://hdl.handle.net/2434/1018356Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85173698617

الإتاحة: https://doi.org/10.1016/j.jcmg.2023.05.018Test
https://hdl.handle.net/2434/1018356Test

المؤلفون: Sakai, K., Mizukami, T., Leipsic, J., Belmonte, M., Sonck, J., Nørgaard, B.L., Otake, H., Ko, B., Koo, B.K., Maeng, M., Jensen, J.M., Buytaert, D., Munhoz, D., Andreini, D., Ohashi, H., Shinke, T., Taylor, C.A., Barbato, E., Johnson, N.P., De Bruyne, B., Collet, C.

المصدر: JACC. Cardiovascular imaging, vol. 16, no. 11, pp. 1452-1464

مصطلحات موضوعية: Humans, Coronary Artery Disease/diagnostic imaging, Coronary Artery Disease/pathology, Plaque, Atherosclerotic, Prospective Studies, Coronary Angiography/methods, Fractional Flow Reserve, Myocardial, Predictive Value of Tests, Phenotype, Lipids, calcification, coronary computed tomography angiography, lipid-rich plaque, optical coherence tomography, pullback pressure gradient, thin-cap fibroatheromas

الوصف: The interplay between coronary hemodynamics and plaque characteristics remains poorly understood. The aim of this study was to compare atherosclerotic plaque phenotypes between focal and diffuse coronary artery disease (CAD) defined by coronary hemodynamics. This multicenter, prospective, single-arm study was conducted in 5 countries. Patients with functionally significant lesions based on an invasive fractional flow reserve ≤0.80 were included. Plaque analysis was performed by using coronary computed tomography angiography and optical coherence tomography. CAD patterns were assessed using motorized fractional flow reserve pullbacks and quantified by pullback pressure gradient (PPG). Focal and diffuse CAD was defined according to the median PPG value. A total of 117 patients (120 vessels) were included. The median PPG was 0.66 (IQR: 0.54-0.75). According to coronary computed tomography angiography analysis, plaque burden was higher in patients with focal CAD (87% ± 8% focal vs 82% ± 10% diffuse; P = 0.003). Calcifications were significantly more prevalent in patients with diffuse CAD (Agatston score per vessel: 51 [IQR: 11-204] focal vs 158 [IQR: 52-341] diffuse; P = 0.024). According to optical coherence tomography analysis, patients with focal CAD had a significantly higher prevalence of circumferential lipid-rich plaque (37% focal vs 4% diffuse; P = 0.001) and thin-cap fibroatheroma (TCFA) (47% focal vs 10% diffuse; P = 0.002). Focal disease defined by PPG predicted the presence of TCFA with an area under the curve of 0.73 (95% CI: 0.58-0.87). Atherosclerotic plaque phenotypes associate with intracoronary hemodynamics. Focal CAD had a higher plaque burden and was predominantly lipid-rich with a high prevalence of TCFA, whereas calcifications were more prevalent in diffuse CAD. (Precise Percutaneous Coronary Intervention Plan [P3]; NCT03782688).

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37480908; info:eu-repo/semantics/altIdentifier/eissn/1876-7591; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_58FB3F4963E54; https://serval.unil.ch/notice/serval:BIB_58FB3F4963E5Test; urn:issn:1876-7591; https://serval.unil.ch/resource/serval:BIB_58FB3F4963E5.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_58FB3F4963E54Test

الإتاحة: https://doi.org/10.1016/j.jcmg.2023.05.018Test
https://serval.unil.ch/notice/serval:BIB_58FB3F4963E5Test
https://serval.unil.ch/resource/serval:BIB_58FB3F4963E5.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_58FB3F4963E54Test

المؤلفون: Narita, Y., Matsushima, T., Sakamoto, Y., Matsuoka, H., Tanioka, H., Kawakami, T., Shoji, H., Mizukami, T., Izawa, N., Nishina, T., Yamamoto, Y., Mitani, S., Nakamura, M., Misumi, T., Muro, K.

المصدر: ESMO Open ; volume 8, issue 6, page 102071 ; ISSN 2059-7029

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1016/j.esmoop.2023.102071Test
https://api.elsevier.com/content/article/PII:S2059702923013121?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2059702923013121?httpAccept=text/plainTest

المؤلفون: Mizukami T., Sonck J., Sakai K., Ko B., Maeng M., Otake H., Koo B. -K., Nagumo S., Norgaard B. L., Leipsic J., Shinke T., Munhoz D., Mileva N., Belmonte M., Ohashi H., Barbato E., Johnson N. P., De Bruyne B., Collet C.

المساهمون: Mizukami, T., Sonck, J., Sakai, K., Ko, B., Maeng, M., Otake, H., Koo, B. -K., Nagumo, S., Norgaard, B. L., Leipsic, J., Shinke, T., Munhoz, D., Mileva, N., Belmonte, M., Ohashi, H., Barbato, E., Johnson, N. P., De Bruyne, B., Collet, C.

مصطلحات موضوعية: CAD pattern, diffuse disease, percutaneous coronary intervention, pullback pressure gradient

الوصف: BACKGROUND: Coronary artery disease (CAD) patterns play an essential role in the decision-making process about revasculari-zation. The pullback pressure gradient (PPG) quantifies CAD patterns as either focal or diffuse based on fractional flow reserve (FFR) pullbacks. The objective of this study was to evaluate the impact of CAD patterns on acute percutaneous coronary intervention (PCI) results considered surrogates of clinical outcomes. METHODS AND RESULTS: This was a prospective, multicenter study of patients with hemodynamically significant CAD undergoing PCI. Motorized FFR pullbacks and optical coherence tomography (OCT) were performed before and after PCI. Post-PCI FFR >0.90 was considered an optimal result. Focal disease was defined as PPG >0.73 (highest PPG tertile). Overall, 113 patients (116 vessels) were included. Patients with focal disease were younger than those with diffuse CAD (61.4±9.9 versus 65.1±8.7 years, P=0.042). PCI in vessels with high PPG (focal CAD) resulted in higher post-PCI FFR (0.91±0.07 in the focal group versus 0.86±0.05 in the diffuse group, P<0.001) and larger minimal stent area (6.3±2.3 mm2 in focal versus 5.3±1.8 mm2 in diffuse CAD, P=0.015) compared withvessels with low PPG (diffuse CAD). The PPG was associated with the change in FFR after PCI (R2=0.51, P<0.001). The PPG significantly improved the capacity to predict optimal PCI results compared with an angiographic assessment of CAD patterns (area under the curvePPG 0.81 [95% CI, 0.73– 0.88] versus area under the curveangio 0.51 [95% CI, 0.42– 0.60]; P<0.001). CONCLUSIONS: PCI in vessels with focal disease defined by the PPG resulted in greater improvement in epicardial conductance and larger minimal stent area compared with diffuse disease. PPG, but not angiographically defined CAD patterns, distin-guished patients attaining superior procedural outcomes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36444858; info:eu-repo/semantics/altIdentifier/wos/WOS:000893866000022; volume:11; issue:23; numberofpages:19; journal:JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE; https://hdl.handle.net/11573/1699873Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85143586900

الإتاحة: https://doi.org/10.1161/JAHA.122.026960Test
https://hdl.handle.net/11573/1699873Test

المؤلفون: Mileva N., Nagumo S., Mizukami T., Sonck J., Berry C., Gallinoro E., Monizzi G., Candreva A., Munhoz D., Vassilev D., Penicka M., Barbato E., De Bruyne B., Collet C.

المساهمون: Mileva, N., Nagumo, S., Mizukami, T., Sonck, J., Berry, C., Gallinoro, E., Monizzi, G., Candreva, A., Munhoz, D., Vassilev, D., Penicka, M., Barbato, E., De Bruyne, B., Collet, C.

مصطلحات موضوعية: angina with nonobstructive coronary artery disease, ischemia with no obstructive coronary artery disease, vasospastic angina

الوصف: Background A relevant proportion of patients with suspected coronary artery disease undergo invasive coronary angiography showing normal or nonobstructive coronary arteries. However, the prevalence of coronary microvascular disease (CMD) and coronary spasm in patients with nonobstructive coronary artery disease remains to be determined. The objective of this study was to determine the prevalence of coronary CMD and coronary vasospastic angina in patients with no obstructive coronary artery disease. METHODS AND RESULTS: A systematic review and meta-analysis of studies assessing the prevalence of CMD and vasospastic angina in patients with no obstructive coronary artery disease was performed. Random-effects models were used to determine the prevalence of these 2 disease entities. Fifty-six studies comprising 14 427 patients were included. The pooled prevalence of CMD was 0.41 (95% CI, 0.36–0.47), epicardial vasospasm 0.40 (95% CI, 0.34–0.46) and microvascular spasm 24% (95% CI, 0.21–0.28). The prevalence of combined CMD and vasospastic angina was 0.23 (95% CI, 0.17–0.31). Female patients had a higher risk of presenting with CMD compared with male patients (risk ratio, 1.45 [95% CI, 1.11–1.90]). CMD prevalence was similar when assessed using noninvasive or invasive diagnostic methods. CONCLUSIONS: In patients with no obstructive coronary artery disease, approximately half of the cases were reported to have CMD and/or coronary spasm. CMD was more prevalent among female patients. Greater awareness among physicians of ischemia with no obstructive coronary arteries is urgently needed for accurate diagnosis and patient-tailored management.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35301851; info:eu-repo/semantics/altIdentifier/wos/WOS:000778262600073; volume:11; issue:7; firstpage:1; lastpage:34; numberofpages:34; journal:JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE; https://hdl.handle.net/11573/1699868Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85128245421

الإتاحة: https://doi.org/10.1161/JAHA.121.023207Test
https://hdl.handle.net/11573/1699868Test

المؤلفون: G. Toth G., Collet C., Langhoff Thuesen A., Mizukami T., Casselman F., Riber L. P., Van Praet F., Junker A., Nagumo S., De Bruyne B., Okkels Jensen L., Barbato E.

المساهمون: G. Toth, G., Collet, C., Langhoff Thuesen, A., Mizukami, T., Casselman, F., Riber, L. P., Van Praet, F., Junker, A., Nagumo, S., De Bruyne, B., Okkels Jensen, L., Barbato, E.

مصطلحات موضوعية: coronary artery bypass surgery, fractional flow reserve, graft patency

الوصف: Objective: To investigate the impact of invasive functional guidance for coronary artery bypass graft surgery (CABG) on graft failure. Background: Data on the impact of fractional flow reserve (FFR) in guiding CABG are still limited. Methods: Systematic review and individual patient data meta-analysis were performed. Primary objective was the risk of graft failure, stratified by FFR. Risk estimates are reported as odds ratios (ORs) derived from the aggregated data using random-effects models. Individual patient data were analyzed using mixed effect model to assess relationship between FFR and graft failure. This meta-analysis is registered in PROSPERO (CRD42020180444). Results: Four prospective studies comprising 503 patients referred for CABG, with 1471 coronaries, assessed by FFR were included. Graft status was available for 1039 conduits at median of 12.0 [IQR 6.6; 12.0] months. Risk of graft failure was higher in vessels with preserved FFR (OR 5.74, 95% CI 1.71–19.29). Every 0.10 FFR units decrease in the coronaries was associated with 56% risk reduction of graft failure (OR 0.44, 95% CI 0.34 to 0.59). FFR cut-off to predict graft failure was 0.79. Conclusion: Surgical grafting of coronaries with functionally nonsignificant stenoses was associated with higher risk of graft failure.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34233071; info:eu-repo/semantics/altIdentifier/wos/WOS:000670365700001; volume:99; issue:3; firstpage:730; lastpage:735; numberofpages:6; journal:CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS; https://hdl.handle.net/11573/1699870Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85109733169

الإتاحة: https://doi.org/10.1002/ccd.29864Test
https://hdl.handle.net/11573/1699870Test

المؤلفون: Sonck J., Nagumo S., Norgaard B. L., Otake H., Ko B., Zhang J., Mizukami T., Maeng M., Andreini D., Takahashi Y., Jensen J. M., Ihdayhid A., Heggermont W., Barbato E., Mileva N., Munhoz D., Bartunek J., Updegrove A., Collinsworth A., Penicka M., Van Hoe L., Leipsic J., Koo B. -K., De Bruyne B., Collet C.

المساهمون: Sonck, J., Nagumo, S., Norgaard, B. L., Otake, H., Ko, B., Zhang, J., Mizukami, T., Maeng, M., Andreini, D., Takahashi, Y., Jensen, J. M., Ihdayhid, A., Heggermont, W., Barbato, E., Mileva, N., Munhoz, D., Bartunek, J., Updegrove, A., Collinsworth, A., Penicka, M., Van Hoe, L., Leipsic, J., Koo, B. -K., De Bruyne, B., Collet, C.

مصطلحات موضوعية: coronary computed tomography angiography, ffr, ct, planner, fractional flow reserve, invasive coronary angiography, optical coherence tomography, percutaneous coronary intervention

الوصف: Background: Low fractional flow reserve (FFR) values after percutaneous coronary intervention (PCI) carry a worse prognosis than high post-PCI FFR values. Therefore, the ability to predict post-PCI FFR might play an important role in procedural planning. Post-PCI FFR values can now be computed from pre-PCI coronary computed tomography angiography (CTA) using the fractional flow reserve derived from coronary computed tomography angiography revascularization planner (FFRCT Planner). Objectives: The aim of this study was to validate the accuracy of the FFRCT Planner. Methods: In this multicenter, investigator-initiated, prospective study, patients with chronic coronary syndromes and significant lesions based on invasive FFR ≤0.80 were recruited. The FFRCT Planner was applied to the fractional flow reserve derived from coronary computed tomography angiography (FFRCT) model, simulating PCI. The primary objective was the agreement between the predicted post-PCI FFR by the FFRCT Planner and measured post-PCI FFR. Accuracy of the FFRCT Planner's luminal dimensions was assessed by using post-PCI optical coherence tomography as the reference. Results: Overall, 259 patients were screened, with 120 patients (123 vessels) included in the final analysis. The mean patient age was 64 ± 9 years, and 24% had diabetes. Measured FFR post-PCI was 0.88 ± 0.06, and the FFRCT Planner FFR was 0.86 ± 0.06 (mean difference: 0.02 ± 0.07 FFR unit; limits of agreement: –0.12 to 0.15). Optical coherence tomography minimal stent area was 5.60 ± 2.01 mm2, and FFRCT Planner minimal stent area was 5.0 ± 2.2 mm2 (mean difference: 0.66 ± 1.21 mm2; limits of agreement: –1.7 to 3.0). The accuracy and precision of the FFRCT Planner remained high in cases with focal and diffuse disease and with low and high calcium burden. Conclusions: The FFRCT-based technology was accurate and precise for predicting FFR after PCI. (Precise Percutaneous Coronary Intervention Plan Study [P3]; NCT03782688).

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35798401; info:eu-repo/semantics/altIdentifier/wos/WOS:000861792700009; volume:15; issue:7; firstpage:1242; lastpage:1255; numberofpages:14; journal:JACC. CARDIOVASCULAR IMAGING; https://hdl.handle.net/11573/1700095Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85132732464

الإتاحة: https://doi.org/10.1016/j.jcmg.2022.02.003Test
https://hdl.handle.net/11573/1700095Test

المؤلفون: Belmonte, M., Gallinoro, E., Pijls, N.H., Bertolone, D.T., Keulards, D.C.J., Viscusi, M.M., Storozhenko, T., Mizukami, T., Mahendiran, T., Seki, R., Fournier, S., Vos, Annemiek de, Adjedj, J., Barbato, E., Sonck, J., Damman, P., Keeble, T., Fawaz, S., Gutiérrez-Barrios, A., Paradies, V., Bouisset, F., Kern, M.J., Fearon, W.F., Collet, C., Bruyne, B. de

المصدر: Journal of the American College of Cardiology, 83, 6, pp. 699-709

مصطلحات موضوعية: Radboudumc 16: Vascular damage Cardiology

الوصف: Item does not contain fulltext ; Diagnosing coronary microvascular dysfunction remains challenging, primarily due to the lack of direct measurements of absolute coronary blood flow (Q) and microvascular resistance (R(μ)). However, there has been recent progress with the development and validation of continuous intracoronary thermodilution, which offers a simplified and validated approach for clinical use. This technique enables direct quantification of Q and R(μ), leading to precise and accurate evaluation of the coronary microcirculation. To ensure consistent and reliable results, it is crucial to follow a standardized protocol when performing continuous intracoronary thermodilution measurements. This document aims to summarize the principles of thermodilution-derived absolute coronary flow measurements and propose a standardized method for conducting these assessments. The proposed standardization serves as a guide to ensure the best practice of the method, enhancing the clinical assessment of the coronary microcirculation.

العلاقة: https://repository.ubn.ru.nl/handle/2066/305502Test

الإتاحة: https://doi.org/10.1016/j.jacc.2023.12.014Test
https://repository.ubn.ru.nl/handle/2066/305502Test

المؤلفون: Sonck J., Nagumo S., Norgaard B. L., Otake H., Ko B., Zhang J., Mizukami T., Maeng M., Andreini D., Takahashi Y., Jensen J. M., Ihdayhid A., Heggermont W., Barbato E., Mileva N., Munhoz D., Bartunek J., Updegrove A., Collinsworth A., Penicka M., Van Hoe L., Leipsic J., Koo B. -K., De Bruyne B., Collet C.

المساهمون: J. Sonck, S. Nagumo, B.L. Norgaard, H. Otake, B. Ko, J. Zhang, T. Mizukami, M. Maeng, D. Andreini, Y. Takahashi, J.M. Jensen, A. Ihdayhid, W. Heggermont, E. Barbato, N. Mileva, D. Munhoz, J. Bartunek, A. Updegrove, A. Collinsworth, M. Penicka, L. Van Hoe, J. Leipsic, B.-. Koo, B. De Bruyne, C. Collet

مصطلحات موضوعية: coronary computed tomography angiography, FFR, CT, Planner, fractional flow reserve, invasive coronary angiography, optical coherence tomography, percutaneous coronary intervention, Settore MED/11 - Malattie dell'Apparato Cardiovascolare

الوصف: Background: Low fractional flow reserve (FFR) values after percutaneous coronary intervention (PCI) carry a worse prognosis than high post-PCI FFR values. Therefore, the ability to predict post-PCI FFR might play an important role in procedural planning. Post-PCI FFR values can now be computed from pre-PCI coronary computed tomography angiography (CTA) using the fractional flow reserve derived from coronary computed tomography angiography revascularization planner (FFRCT Planner). Objectives: The aim of this study was to validate the accuracy of the FFRCT Planner. Methods: In this multicenter, investigator-initiated, prospective study, patients with chronic coronary syndromes and significant lesions based on invasive FFR ≤0.80 were recruited. The FFRCT Planner was applied to the fractional flow reserve derived from coronary computed tomography angiography (FFRCT) model, simulating PCI. The primary objective was the agreement between the predicted post-PCI FFR by the FFRCT Planner and measured post-PCI FFR. Accuracy of the FFRCT Planner's luminal dimensions was assessed by using post-PCI optical coherence tomography as the reference. Results: Overall, 259 patients were screened, with 120 patients (123 vessels) included in the final analysis. The mean patient age was 64 ± 9 years, and 24% had diabetes. Measured FFR post-PCI was 0.88 ± 0.06, and the FFRCT Planner FFR was 0.86 ± 0.06 (mean difference: 0.02 ± 0.07 FFR unit; limits of agreement: –0.12 to 0.15). Optical coherence tomography minimal stent area was 5.60 ± 2.01 mm2, and FFRCT Planner minimal stent area was 5.0 ± 2.2 mm2 (mean difference: 0.66 ± 1.21 mm2; limits of agreement: –1.7 to 3.0). The accuracy and precision of the FFRCT Planner remained high in cases with focal and diffuse disease and with low and high calcium burden. Conclusions: The FFRCT-based technology was accurate and precise for predicting FFR after PCI. (Precise Percutaneous Coronary Intervention Plan Study [P3]; NCT03782688)

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35798401; info:eu-repo/semantics/altIdentifier/wos/WOS:000861792700009; volume:15; issue:7; firstpage:1242; lastpage:1255; numberofpages:14; journal:JACC. CARDIOVASCULAR IMAGING; https://hdl.handle.net/2434/1001779Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85132732464

الإتاحة: https://doi.org/10.1016/j.jcmg.2022.02.003Test
https://hdl.handle.net/2434/1001779Test

المؤلفون: Sonck, J., Nagumo, S., Norgaard, B.L., Otake, H., Ko, B., Zhang, J., Mizukami, T., Maeng, M., Andreini, D., Takahashi, Y., Jensen, J.M., Ihdayhid, A., Heggermont, W., Barbato, E., Mileva, N., Munhoz, D., Bartunek, J., Updegrove, A., Collinsworth, A., Penicka, M., Van Hoe, L., Leipsic, J., Koo, B.K., De Bruyne, B., Collet, C.

المصدر: JACC. Cardiovascular imaging, vol. 15, no. 7, pp. 1242-1255

مصطلحات موضوعية: Aged, Computed Tomography Angiography, Coronary Angiography/methods, Coronary Artery Disease/diagnostic imaging, Coronary Artery Disease/therapy, Coronary Stenosis/diagnostic imaging, Coronary Stenosis/therapy, Coronary Vessels/diagnostic imaging, Fractional Flow Reserve, Myocardial, Humans, Middle Aged, Percutaneous Coronary Intervention, Predictive Value of Tests, Prospective Studies, Tomography, X-Ray Computed, FFR(CT) Planner, coronary computed tomography angiography, invasive coronary angiography, optical coherence tomography

الوصف: Low fractional flow reserve (FFR) values after percutaneous coronary intervention (PCI) carry a worse prognosis than high post-PCI FFR values. Therefore, the ability to predict post-PCI FFR might play an important role in procedural planning. Post-PCI FFR values can now be computed from pre-PCI coronary computed tomography angiography (CTA) using the fractional flow reserve derived from coronary computed tomography angiography revascularization planner (FFR CT Planner). The aim of this study was to validate the accuracy of the FFR CT Planner. In this multicenter, investigator-initiated, prospective study, patients with chronic coronary syndromes and significant lesions based on invasive FFR ≤0.80 were recruited. The FFR CT Planner was applied to the fractional flow reserve derived from coronary computed tomography angiography (FFR CT ) model, simulating PCI. The primary objective was the agreement between the predicted post-PCI FFR by the FFR CT Planner and measured post-PCI FFR. Accuracy of the FFR CT Planner's luminal dimensions was assessed by using post-PCI optical coherence tomography as the reference. Overall, 259 patients were screened, with 120 patients (123 vessels) included in the final analysis. The mean patient age was 64 ± 9 years, and 24% had diabetes. Measured FFR post-PCI was 0.88 ± 0.06, and the FFR CT Planner FFR was 0.86 ± 0.06 (mean difference: 0.02 ± 0.07 FFR unit; limits of agreement: -0.12 to 0.15). Optical coherence tomography minimal stent area was 5.60 ± 2.01 mm 2 , and FFR CT Planner minimal stent area was 5.0 ± 2.2 mm 2 (mean difference: 0.66 ± 1.21 mm 2 ; limits of agreement: -1.7 to 3.0). The accuracy and precision of the FFR CT Planner remained high in cases with focal and diffuse disease and with low and high calcium burden. The FFR CT -based technology was accurate and precise for predicting FFR after PCI. (Precise Percutaneous Coronary Intervention Plan Study [P3]; NCT03782688).

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35798401; info:eu-repo/semantics/altIdentifier/eissn/1876-7591; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_0C1B5E0E96EA7; https://serval.unil.ch/notice/serval:BIB_0C1B5E0E96EATest; urn:issn:1876-7591; https://serval.unil.ch/resource/serval:BIB_0C1B5E0E96EA.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_0C1B5E0E96EA7Test

الإتاحة: https://doi.org/10.1016/j.jcmg.2022.02.003Test
https://serval.unil.ch/notice/serval:BIB_0C1B5E0E96EATest
https://serval.unil.ch/resource/serval:BIB_0C1B5E0E96EA.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_0C1B5E0E96EA7Test