المؤلفون: Gomez, Diego E., Dunkel, Bettina, Renaud, David L., Arroyo, Luis G., Schoster, Angelika, Kopper, Jamie J., Byrne, David, Toribio, Ramiro E., Pihl, Tina H.

المصدر: Gomez , D E , Dunkel , B , Renaud , D L , Arroyo , L G , Schoster , A , Kopper , J J , Byrne , D , The Multicenter Equine Diarrhea (MEDS) group , Toribio , R E & Pihl , T H 2024 , ' Survival rates and factors associated with survival and laminitis of horses with acute diarrhoea admitted to referral institutions ' , Equine Veterinary Journal . https://doi.org/10.1111/evj.14032Test

مصطلحات موضوعية: antimicrobial associated diarrhoea, Clostridiosis, horse, Potomac horse fever, sand diarrhoea

الوصف: Background Clinicopathological findings and their association with the outcome and development of laminitis in horses with acute diarrhoea has not been investigated in a multicentre study across different geographic regions. Objectives Describe and compare clinicopathologic findings of diarrhoeic horses between different geographic regions, survival rates and factors associated with non-survival and laminitis. Study design Multicentre retrospective case series. Methods Information from horses with acute diarrhoea presenting to participating institutions between 2016 and 2020 was collected, and clinicopathological data were compared between surviving and non-surviving horses and horses that did and did not develop laminitis. Survival rates and seasonal and geographic differences were also investigated. Results One thousand four hundred thirty-eight horses from 26 participating institutions from 4 continents were included; 76% survived to discharge with no differences identified between geographic regions. The survival proportion of horses with SIRS and creatinine concentrations > 159 μmol/L was 55% (154/279) compared with 81% (358/437) for those with SIRS and creatinine concentrations < 159 μmol/L (p < 0.001). The survival proportion of horses with SIRS that had an L-lactate concentration > 2.8 mmol/L was 59% (175/298) compared with 81% (240/296) in horses with SIRS and L-lactate concentration < 2.8 mmol/L (p < 0.001). The proportion of horses that developed laminitis was lower in Europe (4%, 19/479) compared with North America (8%, 52/619), Australia (8%, 12/138) and Latin America (11%, 16/146) (p < 0.05). More horses developed laminitis in the summer (46%, 39/85) compared with winter (18%, 15/85), spring (18%, 15/85) and fall (19%, 16/85) (p < 0.01). Horses with laminitis had greater odds of non-survival than those without laminitis (OR: 3.73, 95% CI: 2.47–5.65). Main limitations Not all variables were available for all horses due to the retrospective nature. Conclusions ...

الإتاحة: https://doi.org/10.1111/evj.14032Test
https://curis.ku.dk/portal/da/publications/survival-rates-and-factors-associated-with-survival-and-laminitis-of-horses-with-acute-diarrhoea-admitted-to-referral-institutionsTest(b6eacb1f-c905-43ac-b846-0bd6d2589a1c).html

المؤلفون: Gabriel, Vojtech, Zdyrski, Christopher, Sahoo, Dipak, Ralston, Abigail, Wickham, Hannah, Bourgois-Mochel, Agnes, Ahmed, Basant, Merodio, Maria, Paukner, Karel, Piñeyro, Pablo, Kopper, Jamie, Rowe, Eric, Smith, Jodi, Meyerholz, David, Kol, Amir, Viall, Austin, Elbadawy, Mohamed, Mochel, Jonathan, Allenspach, Karin

المصدر: International Journal of Molecular Sciences, vol 25, iss 2

مصطلحات موضوعية: biomedical, organoid, reverse translational research, veterinary medicine, Adult, Humans, Animals, Mice, One Health, Biomedical Research, Translational Research, Adult Stem Cells, Organoids

الوصف: Preclinical biomedical research is limited by the predictiveness of in vivo and in vitro models. While in vivo models offer the most complex system for experimentation, they are also limited by ethical, financial, and experimental constraints. In vitro models are simplified models that do not offer the same complexity as living animals but do offer financial affordability and more experimental freedom; therefore, they are commonly used. Traditional 2D cell lines cannot fully simulate the complexity of the epithelium of healthy organs and limit scientific progress. The One Health Initiative was established to consolidate human, animal, and environmental health while also tackling complex and multifactorial medical problems. Reverse translational research allows for the sharing of knowledge between clinical research in veterinary and human medicine. Recently, organoid technology has been developed to mimic the original organs epithelial microstructure and function more reliably. While human and murine organoids are available, numerous other organoids have been derived from traditional veterinary animals and exotic species in the last decade. With these additional organoid models, species previously excluded from in vitro research are becoming accessible, therefore unlocking potential translational and reverse translational applications of animals with unique adaptations that overcome common problems in veterinary and human medicine.

وصف الملف: application/pdf

العلاقة: qt66w5c60r; https://escholarship.org/uc/item/66w5c60rTest

الإتاحة: https://escholarship.org/uc/item/66w5c60rTest

المؤلفون: Gomez, Diego E, Dunkel, Bettina, Renaud, David L, Arroyo, Luis G, Schoster, Angelika, Kopper, Jamie J, Byrne, David, Toribio, Ramiro E

المصدر: Gomez, Diego E; Dunkel, Bettina; Renaud, David L; Arroyo, Luis G; Schoster, Angelika; Kopper, Jamie J; Byrne, David; Toribio, Ramiro E (2023). Survival rates and factors associated with survival and laminitis of horses with acute diarrhoea admitted to referral institutions. Equine Veterinary Journal:Epub ahead of print.

مصطلحات موضوعية: Equine Department, 570 Life sciences, biology, 630 Agriculture, General Medicine

الوصف: Background: Clinicopathological findings and their association with the outcome and development of laminitis in horses with acute diarrhoea has not been investigated in a multicentre study across different geographic regions.ObjectivesDescribe and compare clinicopathologic findings of diarrhoeic horses between different geographic regions, survival rates and factors associated with non‐survival and laminitis.Study designMulticentre retrospective case series. Methods: Information from horses with acute diarrhoea presenting to participating institutions between 2016 and 2020 was collected, and clinicopathological data were compared between surviving and non‐surviving horses and horses that did and did not develop laminitis. Survival rates and seasonal and geographic differences were also investigated. Results: One thousand four hundred thirty‐eight horses from 26 participating institutions from 4 continents were included; 76% survived to discharge with no differences identified between geographic regions. The survival proportion of horses with SIRS and creatinine concentrations > 159 μmol/L was 55% (154/279) compared with 81% (358/437) for those with SIRS and creatinine concentrations < 159 μmol/L (p < 0.001). The survival proportion of horses with SIRS that had an L‐lactate concentration > 2.8 mmol/L was 59% (175/298) compared with 81% (240/296) in horses with SIRS and L‐lactate concentration < 2.8 mmol/L (p < 0.001). The proportion of horses that developed laminitis was lower in Europe (4%, 19/479) compared with North America (8%, 52/619), Australia (8%, 12/138) and Latin America (11%, 16/146) (p < 0.05). More horses developed laminitis in the summer (46%, 39/85) compared with winter (18%, 15/85), spring (18%, 15/85) and fall (19%, 16/85) (p < 0.01). Horses with laminitis had greater odds of non‐survival than those without laminitis (OR: 3.73, 95% CI: 2.47–5.65). Main limitations: Not all variables were available for all horses due to the retrospective nature. Conclusions: ...

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/255246/1/Gomez_2023__EVJ__Colitis_multicenter_survival_laminitis_overall.pdfTest; info:pmid/38083907; urn:issn:0425-1644

الإتاحة: https://doi.org/10.5167/uzh-25524610.1111/evj.14032Test
https://www.zora.uzh.ch/id/eprint/255246Test/
https://www.zora.uzh.ch/id/eprint/255246/1/Gomez_2023__EVJ__Colitis_multicenter_survival_laminitis_overall.pdfTest

المؤلفون: Gomez, Diego E, Arroyo, Luis G, Schoster, Angelika, Renaud, David L, Kopper, Jamie J, Dunkel, Bettina, Byrne, David, Toribio, Ramiro E

المصدر: Gomez, Diego E; Arroyo, Luis G; Schoster, Angelika; Renaud, David L; Kopper, Jamie J; Dunkel, Bettina; Byrne, David; Toribio, Ramiro E (2023). Diagnostic approaches, aetiological agents and their associations with short-term survival and laminitis in horses with acute diarrhoea admitted to referral institutions. Equine Veterinary Journal:Epub ahead of print.

مصطلحات موضوعية: Equine Department, 570 Life sciences, biology, 630 Agriculture, General Medicine

الوصف: Background: An international description of the diagnostic approaches used in different institutions to diagnose acute equine diarrhoea and the pathogens detected is lacking. Objectives: To describe the diagnostic approach, aetiological agents, outcome, and development of laminitis for diarrhoeic horses worldwide. Study design: Multicentre retrospective case series. Methods: Information from horses with acute diarrhoea presenting to participating institutions between 2016 and 2020, including diagnostic approaches, pathogens detected and their associations with outcomes, were compared between institutions or geographic regions. Results: One thousand four hundred and thirty‐eight horses from 26 participating institutions from 4 continents were included. Overall, aetiological testing was limited (44% for Salmonella spp., 42% for Neorickettsia risticii [only North America], 40% for Clostridiodes difficile, and 29% for ECoV); however, 13% (81/633) of horses tested positive for Salmonella, 13% (35/262) for N. risticii, 9% (37/422) for ECoV, and 5% (27/578) for C. difficile. C. difficile positive cases had greater odds of non‐survival than horses negative for C. difficile (OR: 2.69, 95%CI: 1.23–5.91). In addition, horses that were positive for N. risticii had greater odds of developing laminitis than negative horses (OR: 2.76, 95%CI: 1.12–6.81; p = 0.029). Main limitations: Due to the study's retrospective nature, there are missing data. Conclusions: This study highlighted limited diagnostic investigations in cases of acute equine diarrhoea. Detection rates of pathogens are similar to previous reports. Non‐survival and development of laminitis are related to certain detected pathogens.

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/239100/1/Gomez_2023__EVJ__Colitis_multicenter_retrospective_aetiologic_agents.pdfTest; info:pmid/37984355; urn:issn:0425-1644

الإتاحة: https://doi.org/10.5167/uzh-23910010.1111/evj.14024Test
https://www.zora.uzh.ch/id/eprint/239100Test/
https://www.zora.uzh.ch/id/eprint/239100/1/Gomez_2023__EVJ__Colitis_multicenter_retrospective_aetiologic_agents.pdfTest

المؤلفون: Sellon, Debra C., Sanz, Macarena G., Kopper, Jamie J.

المصدر: Equine Veterinary Education ; volume 36, issue 3, page 133-139 ; ISSN 0957-7734 2042-3292

الوصف: Summary Background Analgesic protocols related to orchiectomy or castration of young horses vary widely depending on geographic location, educational background of the veterinarian, and other demographic factors. Specific practices of equine veterinarians in the United States (US) have not been reported. Objectives To determine perioperative pain management practices of equine veterinarians in the United States as they relate to castration of healthy yearling colts. Study design Cross‐sectional survey. Methods An internet‐based questionnaire included items related to analgesic drugs used in association with castration of healthy yearling colts. Demographic, educational, and experiential factors associated with routine recommendation of analgesic medications after castration were analysed with calculation of odds ratios (OR) with 95% confidence intervals (CI) and multivariable logistic regression. Results Responses from 146 equine veterinarians in the United States revealed that 112/146 (76.7%) administered a nonsteroidal anti‐inflammatory drug (NSAID) at the time of castration, and 107/143 respondents (73.3%) recommended administration of NSAIDs for a median of 3 days (IQR = 3–5) after surgery. Veterinarians who recommended NSAID analgesia after castration provided a higher pain severity score for horses at 24 h after a routine castration. Routine recommendation of post‐castration NSAID analgesia was associated with veterinarians who were employed in a multi‐veterinarian practice (OR = 2.7, 95% CI = 1.2–6.1) and completed their veterinary education in the year 2000 or more recently (OR = 2.6, 95% CI = 1.1–5.9). Main limitations Possible distribution, self‐selection, and response biases as a result of convenience sampling methodology and possible recall bias of respondents. Conclusions Perioperative pain management practices vary widely among US veterinarians but the majority of veterinarians, especially more recent graduates and those in multi‐veterinarian practices, recommend administration of an NSAID at the ...

الإتاحة: https://doi.org/10.1111/eve.13861Test

المؤلفون: Gomez, Diego E., Dunkel, Bettina, Renaud, David L., Arroyo, Luis G., Schoster, Angelika, Kopper, Jamie J., Byrne, David, Toribio, Ramiro E.

المصدر: Equine Veterinary Journal ; ISSN 0425-1644 2042-3306

الوصف: Background Clinicopathological findings and their association with the outcome and development of laminitis in horses with acute diarrhoea has not been investigated in a multicentre study across different geographic regions. Objectives Describe and compare clinicopathologic findings of diarrhoeic horses between different geographic regions, survival rates and factors associated with non‐survival and laminitis. Study design Multicentre retrospective case series. Methods Information from horses with acute diarrhoea presenting to participating institutions between 2016 and 2020 was collected, and clinicopathological data were compared between surviving and non‐surviving horses and horses that did and did not develop laminitis. Survival rates and seasonal and geographic differences were also investigated. Results One thousand four hundred thirty‐eight horses from 26 participating institutions from 4 continents were included; 76% survived to discharge with no differences identified between geographic regions. The survival proportion of horses with SIRS and creatinine concentrations > 159 μmol/L was 55% (154/279) compared with 81% (358/437) for those with SIRS and creatinine concentrations < 159 μmol/L ( p < 0.001). The survival proportion of horses with SIRS that had an L‐lactate concentration > 2.8 mmol/L was 59% (175/298) compared with 81% (240/296) in horses with SIRS and L‐lactate concentration < 2.8 mmol/L ( p < 0.001). The proportion of horses that developed laminitis was lower in Europe (4%, 19/479) compared with North America (8%, 52/619), Australia (8%, 12/138) and Latin America (11%, 16/146) ( p < 0.05). More horses developed laminitis in the summer (46%, 39/85) compared with winter (18%, 15/85), spring (18%, 15/85) and fall (19%, 16/85) ( p < 0.01). Horses with laminitis had greater odds of non‐survival than those without laminitis (OR: 3.73, 95% CI: 2.47–5.65). Main limitations Not all variables were available for all horses due to the retrospective nature. Conclusions ...

الإتاحة: https://doi.org/10.1111/evj.14032Test

المؤلفون: Gomez, Diego E., Arroyo, Luis G., Schoster, Angelika, Renaud, David L., Kopper, Jamie J., Dunkel, Bettina, Byrne, David, Toribio, Ramiro E.

المصدر: Equine Veterinary Journal ; ISSN 0425-1644 2042-3306

الوصف: Background An international description of the diagnostic approaches used in different institutions to diagnose acute equine diarrhoea and the pathogens detected is lacking. Objectives To describe the diagnostic approach, aetiological agents, outcome, and development of laminitis for diarrhoeic horses worldwide. Study design Multicentre retrospective case series. Methods Information from horses with acute diarrhoea presenting to participating institutions between 2016 and 2020, including diagnostic approaches, pathogens detected and their associations with outcomes, were compared between institutions or geographic regions. Results One thousand four hundred and thirty‐eight horses from 26 participating institutions from 4 continents were included. Overall, aetiological testing was limited (44% for Salmonella spp., 42% for Neorickettsia risticii [only North America], 40% for Clostridiodes difficile , and 29% for ECoV); however, 13% (81/633) of horses tested positive for Salmonella , 13% (35/262) for N. risticii , 9% (37/422) for ECoV, and 5% (27/578) for C. difficile . C. difficile positive cases had greater odds of non‐survival than horses negative for C. difficile (OR: 2.69, 95%CI: 1.23–5.91). In addition, horses that were positive for N. risticii had greater odds of developing laminitis than negative horses (OR: 2.76, 95%CI: 1.12–6.81; p = 0.029). Main limitations Due to the study's retrospective nature, there are missing data. Conclusions This study highlighted limited diagnostic investigations in cases of acute equine diarrhoea. Detection rates of pathogens are similar to previous reports. Non‐survival and development of laminitis are related to certain detected pathogens.

الإتاحة: https://doi.org/10.1111/evj.14024Test

المؤلفون: Johnson, Katheryn, Peterson, Jackie, Kopper, Jamie, Dembek, Katarzyna

المساهمون: Iowa State University

المصدر: Journal of Veterinary Internal Medicine ; volume 37, issue 1, page 292-301 ; ISSN 0891-6640 1939-1676

الوصف: Background The hypothalamic‐pituitary‐adrenocortical axis (HPAA) response to sepsis can be impaired in critical illness. Corticotropin‐releasing hormone (CRH) stimulation test might assess HPAA function in foals. Objective To evaluate plasma cortisol, ACTH, arginine vasopressin (AVP), and endogenous CRH (eCRH) response to different doses of ovine CRH (oCRH). Animals Healthy (n = 14) and hospitalized (n = 15) foals <7 days of age. Methods In this prospective randomized study, oCRH (0.1, 0.3, and 1 μg/kg) was administered intravenously and blood samples were collected before, 15, 30, 60, and 90 minutes after administration of oCRH to determine plasma hormone concentrations. The hormonal response was evaluated as the difference (Delta; μg/dL or pg/mL) or percent change between baseline hormone concentration and each time point after oCRH stimulation. Results Cortisol concentrations increased from baseline at 15 minutes with 0.1 and 0.3 μg/kg and at 30 and 60 minutes from baseline with 1 μg/kg oCRH ( P < .05) in healthy and hospitalized foals. ACTH concentrations increased from baseline at 15 minutes with 0.1 μg/kg and at 30 minutes with 1 μg/kg oCRH ( P < .05) in hospitalized foals. Delta cortisol 0 – 30, ACTH 0 – 30, and eCRH 0 – 30 was higher for the 1 μg/kg compared with 0.1 μg/kg oCRH in healthy foals ( P < .05). Delta ACTH 0 – 15 and eCRH 0 – 30 was higher for the 1 μg/kg compared with the lower doses of oCRH in hospitalized foals ( P < .05). Conclusions and Clinical Importance Cortisol, ACTH, and eCRH concentrations increased in response to administration of all doses of oCRH. One microgram per kilogram of oCRH appears to be optimal for the assessment of HPAA in healthy and hospitalized foals.

الإتاحة: https://doi.org/10.1111/jvim.16604Test

المؤلفون: Walton, Rebecca, Riha, Julie, Swor, Tamara, Kopper, Jamie, Yuan, Lingnan, Mochel, Jonathan, t Hoen, Meredith, Blong, April

المصدر: Journal of Veterinary Medical Education ; volume 51, issue 1, page 38-43 ; ISSN 0748-321X 1943-7218

مصطلحات موضوعية: General Veterinary, Education, General Medicine

الوصف: Cardiopulmonary resuscitation (CPR) is a critical skill for veterinarians, but the most effective training methods and techniques are still unknown. In human medicine, simulation training enhances both knowledge and performance of basic life support CPR. This study evaluated the comparative effectiveness of didactic versus a combination of didactic and simulation training on performance and understanding of basic life support techniques in second-year veterinary medical students.

الإتاحة: https://doi.org/10.3138/jvme-2022-0121Test

المؤلفون: Monroe, Lindsay C., Troy, Jarrod R., Kogan, Clark, Kopper, Jamie J.

المساهمون: Iowa State University

المصدر: Journal of Equine Veterinary Science ; volume 133, page 104989 ; ISSN 0737-0806

مصطلحات موضوعية: Equine

الإتاحة: https://doi.org/10.1016/j.jevs.2023.104989Test
https://api.elsevier.com/content/article/PII:S0737080623008055?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0737080623008055?httpAccept=text/plainTest