المؤلفون: Messier, Stephen P., Callahan, Leigh F., Losina, Elena, Mihalko, Shannon L., Guermazi, Ali, Ip, Edward, Miller, Gary D., Katz, Jeffrey N., Loeser, Richard F., Pietrosimone, Brian G., Soto, Sandra, Cook, James L., Newman, Jovita J., DeVita, Paul, Spindler, Kurt P., Runhaar, Jos, Armitano-Lago, Cortney, Duong, Vicky, Selzer, Faith, Hill, Ryan, Love, Monica, Beavers, Daniel P., Saldana, Santiago, Stoker, Aaron M., Rice, Paige E., Hunter, David J.

المصدر: Messier , S P , Callahan , L F , Losina , E , Mihalko , S L , Guermazi , A , Ip , E , Miller , G D , Katz , J N , Loeser , R F , Pietrosimone , B G , Soto , S , Cook , J L , Newman , J J , DeVita , P , Spindler , K P , Runhaar , J , Armitano-Lago , C , Duong , V , Selzer , F , Hill , R , Love , M , Beavers , D P , ....

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: Background: Osteoarthritis (OA), the leading cause of disability among adults, has no cure and is associated with significant comorbidities. The premise of this randomized clinical trial is that, in a population at risk, a 48-month program of dietary weight loss and exercise will result in less incident structural knee OA compared to control. Methods/design: The Osteoarthritis Prevention Study (TOPS) is a Phase III, assessor-blinded, 48-month, parallel 2 arm, multicenter randomized clinical trial designed to reduce the incidence of structural knee OA. The study objective is to assess the effects of a dietary weight loss, exercise, and weight-loss maintenance program in preventing the development of structural knee OA in females at risk for the disease. TOPS will recruit 1230 ambulatory, community dwelling females with obesity (Body Mass Index (BMI) ≥ 30 kg/m 2 ) and aged ≥50 years with no radiographic (Kellgren-Lawrence grade ≤1) and no magnetic resonance imaging (MRI) evidence of OA in the eligible knee, with no or infrequent knee pain. Incident structural knee OA (defined as tibiofemoral and/or patellofemoral OA on MRI) assessed at 48-months from intervention initiation using the MRI Osteoarthritis Knee Score (MOAKS) is the primary outcome. Secondary outcomes include knee pain, 6-min walk distance, health-related quality of life, knee joint loading during gait, inflammatory biomarkers, and self-efficacy. Cost effectiveness and budgetary impact analyses will determine the value and affordability of this intervention. Discussion: This study will assess the efficacy and cost effectiveness of a dietary weight loss, exercise, and weight-loss maintenance program designed to reduce incident knee OA. Trial registration: ClinicalTrials.gov Identifier: NCT05946044.

وصف الملف: application/pdf

العلاقة: https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test

الإتاحة: https://doi.org/10.1016/j.ocarto.2023.100418Test
https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test
https://pure.eur.nl/ws/files/124162103/The_osteoarthritis_prevention_study_TOPS_-_A_randomized_controlled_trial_of_diet_and_exercise_to_prevent_Knee_Osteoarthritis.pdfTest
http://www.scopus.com/inward/record.url?scp=85179044965&partnerID=8YFLogxKTest

المؤلفون: McDermott, Gregory C., Monshadizeh, Armaan, Selzer, Faith, Zhao, Sizheng S., Ermann, Joerg, Katz, Jeffrey N.

المصدر: McDermott , G C , Monshadizeh , A , Selzer , F , Zhao , S S , Ermann , J & Katz , J N 2024 , ' Factors associated with diagnostic delay in axial spondyloarthritis: impact of clinical factors and social vulnerability ' , Arthritis Care & Research , vol. 76 , no. 4 , pp. 541-549 . https://doi.org/10.1002/acr.25264Test

مصطلحات موضوعية: axial spondyloarthritis, diagnostic delay, uveitis

الوصف: Objective: Axial spondyloarthritis (axSpA) patients often experience significant delay between symptom onset and diagnosis. Determinants of delay are incompletely understood. We investigated associations between demographic, medical, and socioeconomic factors and axSpA diagnostic delay. Methods: We identified axSpA patients diagnosed by rheumatologists in the Mass General Brigham health care system between December 1990 and October 2021. All patients met modified New York criteria for ankylosing spondylitis (AS) or 2009 Assessment of SpondloArthritis international Society (ASAS) criteria for axSpA. We determined the duration of diagnostic delay, defined as the duration of back pain symptoms reported at diagnosis, as well as extra-articular disease manifestations and specialty care received prior to diagnosis from the electronic health record. We obtained each patient’s social vulnerability index (SVI) by mapping their address to the US Centers for Disease Control SVI Atlas. We examined associations between disease manifestations, SVI, and diagnostic delay using ordinal logistic regression. Results: We identified 554 axSpA patients with mean diagnostic delay 6.8 (SD 8.5) years. In multivariable ordinal logistic regression analyses, peripheral arthritis (OR 0.65, 95%CI 0.45-0.93) and older age at symptom onset (OR 0.83, 95%CI 0.78-0.88 per 5 years) were associated with shorter delay. AS at diagnosis (OR 1.85, 95%CI 1.30-2.63), having a history of uveitis prior to diagnosis (OR 2.77, 95%CI 1.73-4.52), and higher social vulnerability (defined as being in the 80-99th percentile of SVI – OR 1.99, 95%CI 1.06-3.84) were associated with longer diagnostic delay. Conclusion: Older age at back pain onset and peripheral arthritis were associated with shorter delay while uveitis was associated with longer diagnostic delay. Patients with higher socioeconomic vulnerability had longer diagnostic delay independent of clinical factors.

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

العلاقة: https://research.manchester.ac.uk/en/publications/d0a4aea8-b9f2-4f29-99de-350c9741d068Test

الإتاحة: https://doi.org/10.1002/acr.25264Test
https://research.manchester.ac.uk/en/publications/d0a4aea8-b9f2-4f29-99de-350c9741d068Test
https://pure.manchester.ac.uk/ws/files/278740331/axspa_diagnostic_delay.docxTest

المؤلفون: Messier, Stephen P., Gill, Malia E., Mihalko, Shannon L., Beavers, Daniel P., Queen, Kate, Miller, Gary D., Losina, Elena, Katz, Jeffrey N., Loeser, Richard F., DeVita, Paul, Hunter, David J., Quandt, Sara A., Lyles, Mary F., Hudson, David, Callahan, Leigh F.

المساهمون: National Institute of Arthritis and Musculoskeletal and Skin Diseases

المصدر: Arthritis Care & Research ; volume 76, issue 4, page 503-510 ; ISSN 2151-464X 2151-4658

الوصف: Objective The purpose of this study was to determine whether clinical, health‐related quality of life (HRQL), and gait characteristics in adults with knee osteoarthritis (OA) differed by obesity category. Methods This cross‐sectional analysis of 823 older adults (mean age 64.6 years, SD 7.8 years) with knee OA and overweight or obesity compared clinical, HRQL, and gait outcomes among obesity classifications (overweight or class I, body mass index [BMI] 27.0–34.9; class II, BMI 35.0–39.9; class III BMI ≥40.0). Results Patients with class III obesity had worse Western Ontario McMasters Universities Arthritis Index knee pain (0–20) than the overweight or class I (mean 8.6 vs 7.0; difference 1.5; 95% confidence interval [CI] 1.0–2.1; P < 0.0001) and class II (mean 8.6 vs 7.4; difference 1.1; 95% CI 0.6–1.7; P = 0.0002) obesity groups. The Short Form 36 physical HRQL measure was lower in the class III obesity group compared to the overweight or class I (mean 31.0 vs 37.3; difference −6.2; 95% CI −7.8 to −4.7; P < 0.0001) and class II (mean 31.0 vs 35.0; difference −3.9; 95% CI −5.6 to −2.2; P < 0.0001) obesity groups. The class III obesity group had a base of support (cm) during gait that was wider than that for the overweight or class I (mean 14.0 vs 11.6; difference 3.3; 95% CI 2.6–4.0; P < 0.0001) and class II (mean 14.0 vs 11.6; difference 2.4; 95% CI 1.6–3.2; P < 0.0001) obesity groups. Conclusion Among adults with knee OA, those with class III obesity had significantly higher pain levels and worse physical HRQL and gait characteristics compared to adults with overweight or class I or class II obesity. image

الإتاحة: https://doi.org/10.1002/acr.25265Test

المؤلفون: Gottreich, Julia R., Katz, Jeffrey N., Jones, Morgan H.

المصدر: Orthopaedic Journal of Sports Medicine ; volume 12, issue 3 ; ISSN 2325-9671 2325-9671

مصطلحات موضوعية: Orthopedics and Sports Medicine

الوصف: Background: Biomarkers collected in synovial tissue and fluid have been identified as potential predictors of outcomes after arthroscopy. Purpose: To provide a narrative review of the current literature that assesses the associations between preoperative biomarkers in the synovial fluid or synovial tissue and patient outcomes after knee arthroscopy. Study Design: Narrative review. Methods: We searched the PubMed database with keywords, “biomarkers AND arthroscopy,” “biomarkers AND anterior cruciate ligament reconstruction,” and “biomarkers AND meniscectomy.” To be included, studies must have collected synovial fluid or synovial tissue from patients before or during arthroscopic knee surgery and analyzed the relationship of biomarkers to postoperative patient outcomes. Biomarkers were classified into 4 main categories: metabolism of aggrecan in cartilage, metabolism of collagen in cartilage (type II collagen), noncollagenous proteins in the knee, and other. When biomarker levels and outcomes were expressed with continuous variables, we abstracted the Pearson or Spearman correlation coefficients as the effect measure. If the biomarker values were continuous and the outcomes binary, we abstracted the mean or median biomarker values in those with favorable versus unfavorable outcomes. We calculated effect sizes as the difference between means of both groups divided by the standard deviation from the mean in the group with better outcomes. Results: Eight studies were included in the review. Each study reported different patient outcomes. Biomarkers associated with metabolism of aggrecan, type II collagen metabolism, and noncollagenous proteins as well as inflammatory biomarkers had statistically significant associations with a range of patient outcomes after knee arthroscopy. Difference across studies in sample size and outcome measures precluded choosing a single biomarker that best predicted patient outcomes. Conclusion: The findings suggest that biomarkers associated with metabolism of aggrecan, type II collagen ...

الإتاحة: https://doi.org/10.1177/23259671231193370Test

المؤلفون: Kumara, Mahima T., Cleveland, Rebecca J., Kostic, Aleksandra M., Weisner, Serena E., Allen, Kelli D., Golightly, Yvonne M., Welch, Heather, Dale, Melissa, Messier, Stephen P., Hunter, David J., Katz, Jeffrey N., Callahan, Leigh F., Losina, Elena

المساهمون: CDC, National Institute of Arthritis and Musculoskeletal and Skin Diseases

المصدر: Osteoarthritis and Cartilage Open ; volume 6, issue 2, page 100463 ; ISSN 2665-9131

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.ocarto.2024.100463Test
https://api.elsevier.com/content/article/PII:S266591312400030X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S266591312400030X?httpAccept=text/plainTest

المؤلفون: Messier, Stephen P., Callahan, Leigh F., Losina, Elena, Mihalko, Shannon L., Guermazi, Ali, Ip, Edward, Miller, Gary D., Katz, Jeffrey N., Loeser, Richard F., Pietrosimone, Brian G., Soto, Sandra, Cook, James L., Newman, Jovita J., DeVita, Paul, Spindler, Kurt P., Runhaar, Jos, Armitano-Lago, Cortney, Duong, Vicky, Selzer, Faith, Hill, Ryan, Love, Monica, Beavers, Daniel P., Saldana, Santiago, Stoker, Aaron M., Rice, Paige E., Hunter, David J.

المساهمون: Arthritis Foundation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Office of Disease Prevention, Office of Behavioral and Social Sciences Research, Wake Forest University, University of Missouri, Centers for Disease Control and Prevention, National Center for Complementary and Integrative Health, Office of Research on Women's Health, University of Missouri School of Medicine

المصدر: Osteoarthritis and Cartilage Open ; volume 6, issue 1, page 100418 ; ISSN 2665-9131

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.ocarto.2023.100418Test
https://api.elsevier.com/content/article/PII:S2665913123000857?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2665913123000857?httpAccept=text/plainTest

المؤلفون: Cheema, Haadiya, Brophy, Robert, Collins, Jamie, Cox, Charles L., Guermazi, Ali, Kumara, Mahima, Levy, Bruce A., MacFarlane, Lindsey, Mandl, Lisa A., Marx, Robert, Selzer, Faith, Spindler, Kurt, Katz, Jeffrey N., Murray, Eleanor J.

المساهمون: National Institute of Arthritis and Musculoskeletal and Skin Diseases

المصدر: Osteoarthritis and Cartilage ; volume 32, issue 3, page 319-328 ; ISSN 1063-4584

مصطلحات موضوعية: Orthopedics and Sports Medicine, Biomedical Engineering, Rheumatology

الإتاحة: https://doi.org/10.1016/j.joca.2023.10.007Test
https://api.elsevier.com/content/article/PII:S1063458423009597?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1063458423009597?httpAccept=text/plainTest

المؤلفون: Kwon, Youngho, Rösner, Heike, Zhao, Weixing, Selemenakis, Platon, He, Zhuoling, Kawale, Ajinkya S, Katz, Jeffrey N, Rogers, Cody M, Neal, Francisco E, Badamchi Shabestari, Aida, Petrosius, Valdemaras, Singh, Akhilesh K, Joel, Marina Z, Lu, Lucy, Holloway, Stephen P, Burma, Sandeep, Mukherjee, Bipasha, Hromas, Robert, Mazin, Alexander, Wiese, Claudia, Sørensen, Claus S., Sung, Patrick

المصدر: Kwon , Y , Rösner , H , Zhao , W , Selemenakis , P , He , Z , Kawale , A S , Katz , J N , Rogers , C M , Neal , F E , Badamchi Shabestari , A , Petrosius , V , Singh , A K , Joel , M Z , Lu , L , Holloway , S P , Burma , S , Mukherjee , B , Hromas , R , Mazin , A , Wiese , C , Sørensen , C S & Sung , P 2023 , ' ....

مصطلحات موضوعية: DNA Replication, Rad51 Recombinase/genetics, DNA Repair, BRCA2 Protein/metabolism, DNA, Homologous Recombination

الوصف: The tumor suppressor BRCA2 participates in DNA double-strand break repair by RAD51-dependent homologous recombination and protects stressed DNA replication forks from nucleolytic attack. We demonstrate that the C-terminal Recombinase Binding (CTRB) region of BRCA2, encoded by gene exon 27, harbors a DNA binding activity. CTRB alone stimulates the DNA strand exchange activity of RAD51 and permits the utilization of RPA-coated ssDNA by RAD51 for strand exchange. Moreover, CTRB functionally synergizes with the Oligonucleotide Binding fold containing DNA binding domain and BRC4 repeat of BRCA2 in RPA-RAD51 exchange on ssDNA. Importantly, we show that the DNA binding and RAD51 interaction attributes of the CTRB are crucial for homologous recombination and protection of replication forks against MRE11-mediated attrition. Our findings shed light on the role of the CTRB region in genome repair, reveal remarkable functional plasticity of BRCA2, and help explain why deletion of Brca2 exon 27 impacts upon embryonic lethality.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1038/s41467-023-36211-xTest
https://curis.ku.dk/portal/da/publications/dna-binding-and-rad51-engagement-by-the-brca2-cterminus-orchestrate-dna-repair-and-replication-fork-preservationTest(95674b82-f17e-4821-8f1d-29a05bec874a).html
https://curis.ku.dk/ws/files/336597181/s41467_023_36211_x.pdfTest

المؤلفون: Peters, Susan E., Gundersen, Daniel A., Katz, Jeffrey N., Sorensen, Glorian, Wagner, Gregory R.

المصدر: American Journal of Industrial Medicine ; volume 66, issue 4, page 281-296 ; ISSN 0271-3586 1097-0274

الوصف: Introduction Thriving from Work is defined as the state of positive mental, physical, and social functioning in which workers' experiences of their work and working conditions enable them to thrive in their overall lives, contributing to their ability to achieve their full potential at work, at home, and in the community. The purpose of this study was to develop a psychometrically‐sound questionnaire measuring the positive contribution that work can have on one's well‐being both at, and outside of, their work. Methods We used both a qualitative and quantitative approach of item reduction, domain mapping dimensionality testing, development of “long‐” and “short‐” versions of the questionnaire, reliability, and construct and criterion validity testing. This was established in two independent online samples of US based workers ( n = 1550, n = 500). Results We developed a bi‐factor model 30‐item long‐form and a uni‐factorial 8‐item short‐version. The long‐form measures both the latent construct of Thriving from Work and six domains (psychological/emotional; work‐life integration; social; experience of work; basic needs; health). Both long‐ and short‐ forms were found to have high empirical reliability (0.93 and 0.87 respectively). The short‐form captures 94% of variance of the long‐form. Construct and criterion validity were supported. Test‐retest reliability was high. Conclusions The Thriving from Work Questionnaire appears to be a valid and reliable measure of work‐related well‐being in United States workers. Further testing is needed to refine and test the instrument in specific industries, unique worker populations, and across geographic regions.

الإتاحة: https://doi.org/10.1002/ajim.23465Test

المؤلفون: Goldhaber, Nicole H., Qudsi, Rameez A., Polinsky, Samuel, Stupay, Kristen L., Katz, Jeffrey N., Stetson, William B., Dyer, George S. M., Investigators, Co-Principal

المصدر: Global Surgical Education - Journal of the Association for Surgical Education ; volume 2, issue 1 ; ISSN 2731-4588

الوصف: Purpose Arthroscopy is an efficacious and popular treatment modality in developed nations for a variety of musculoskeletal conditions. However, arthroscopy requires specialized training, complex infrastructure, and expensive equipment, occasionally causing barriers to use in developing countries. Consequently, the utilization of resources to perform and teach arthroscopy in low- and middle-income countries (LMICs) is controversial. Through this investigation, we assessed the current capacity and barriers to arthroscopy use and training in these settings. Methods Focused interviews were conducted with surgeons from Haiti (low-income) and Romania (middle-income) regarding their experience with arthroscopy. Based on responses, a multiple-choice survey was developed and administered to orthopaedic trainees and practicing orthopaedic surgeons during national orthopaedics conferences in each country. Results Fifty-eight orthopaedists in Haiti, and 29 in Romania completed the survey. Most (91% from Haiti; 79% from Romania) reported that learning arthroscopy is essential or important for orthopaedic training in their country. Yet only 17% from Haiti compared to 69% from Romania indicated their primary hospital has the equipment necessary for arthroscopy. In Haiti, equipment was the main barrier to use of arthroscopy, followed by training, while in Romania, the main barrier was training, followed by equipment. Simulations and telemedicine were ranked as top choices of effective methods for learning arthroscopy. Conclusions Regardless of their country’s resource limitations, most participants place high value on the practice of arthroscopy and arthroscopic training. The results from this study highlight a hierarchy of needs in developing nations. Furthermore, local providers report a strong belief in the need for arthroscopic treatment to benefit their patients, and a clear desire for further training and development of these techniques. By identifying similarities and differences by location, we may better ...

الإتاحة: https://doi.org/10.1007/s44186-023-00109-5Test