دورية أكاديمية
Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation
العنوان: | Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation |
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المؤلفون: | Ulrich Baumann, Johannes H. Schulte, Jonathan P. Groß, Rita Beier, Marius Ludwig, Volker Wahn, Jörg Hofmann, Britta Maecker-Kolhoff, Martin Sauer, Petra Kaiser-Labusch, Negin Karimian, Ulrike Blume-Peytavi, Franziska Ghoreschi, Hagen Ott, Ludmila Perelygina, Christian Klemann, Oliver Blankenstein, Horst von Bernuth, Renate Krüger |
المصدر: | Frontiers in Immunology, Vol 13 (2022) |
بيانات النشر: | Frontiers Media S.A. |
سنة النشر: | 2022 |
المجموعة: | Directory of Open Access Journals: DOAJ Articles |
مصطلحات موضوعية: | inborn errors of immunity, primary immunodeficiency, Ataxia telangiectasia, Artemis deficiency, rubella virus vaccine strain, granuloma formation, Immunologic diseases. Allergy, RC581-607 |
الوصف: | We report two patients with DNA repair disorders (Artemis deficiency, Ataxia telangiectasia) with destructive skin granulomas, presumably triggered by live-attenuated rubella vaccinations. Both patients showed reduced naïve T cells. Rapid resolution of skin lesions was observed following hematopoietic stem cell transplantation. However, the patient with AT died due to complications of severe hepatic veno-occlusive disease 6 month after HSCT. Dried blood spots obtained after birth were available from this patient and showed absent T-cell receptor excision circles (TRECs). Therefore, newborn screening may help to prevent patients with moderate T-cell deficiency from receiving live-attenuated rubella vaccine potentially causing granulomas. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
تدمد: | 1664-3224 |
العلاقة: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.886540/fullTest; https://doaj.org/toc/1664-3224Test; https://doaj.org/article/74676d116b12464bbeaa7e1f70c43e0fTest |
DOI: | 10.3389/fimmu.2022.886540 |
الإتاحة: | https://doi.org/10.3389/fimmu.2022.886540Test https://doaj.org/article/74676d116b12464bbeaa7e1f70c43e0fTest |
رقم الانضمام: | edsbas.687FE9F4 |
قاعدة البيانات: | BASE |
تدمد: | 16643224 |
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DOI: | 10.3389/fimmu.2022.886540 |