دورية أكاديمية
Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma
| العنوان: | Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma |
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| المؤلفون: | Chen-chen Wang, Dan-dan Lu, Ming-hong Shen, Ru-lei Chen, Zhi-hong Zhang, Jing-huan Lv |
| المصدر: | Diagnostic Pathology, Vol 18, Iss 1, Pp 1-10 (2023) |
| بيانات النشر: | BMC |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Papillary thyroid carcinoma, Cyclin D1, P21, Thyroid tissue in cervical lymph nodes, Pathology, RB1-214 |
| الوصف: | Background With the continuous discovery of new borderline thyroid lesions and benign and malignant “gray areas”, coupled with the limitations of traditional immune indicators, the differential diagnosis of papillary thyroid carcinoma (PTC) has become more difficult. Cyclin D1 and P21 are cell cycle regulators involved in the occurrence and metastasis of multiple tumors, including PTC, but their specific functions are unclear. Methods In our study, immunohistochemical staining was used to explore the expression of Cyclin D1 and P21 in PTC, paracancerous tissue, follicular adenoma (FA) and papillary thyroid hyperplasia. In addition, their relationship with the clinicopathological features of PTC and their differential diagnostic value in distinguishing between intralymph node PTC metastases and intralymph node ectopic thyroid tissue were studied. Results Among 200 primary PTC lesions, Cyclin D1 and P21 were found to be expressed in 186 (93.00%) and 177 (88.50%), respectively, and their expression levels were significantly higher in PTC tissue than in adjacent tissue, FA tissue and papillary thyroid hyperplasia tissue (P < 0.05). The expression levels of Cyclin D1 and P21 were positively correlated with tumor size and lymph node metastasis (P < 0.05) but not with sex, age, number of tumor lesions, histological subtype, chronic lymphocytic thyroiditis or TNM stage (P < 0.05). The expression levels of Cyclin D1 and P21 were significantly correlated (P < 0.05). The positivity rates of Cyclin D1 and P21 in intralymph node PTC metastases were 97.96% (48/49) and 89.80% (44/49), respectively, which were significantly higher than those in intralymph node ectopic thyroid tissue (P < 0.05). The sensitivity (Se) and negative predictive value (NPV) of Cyclin D1 and P21 detection alone or in combination were higher than those of the combined detection of the classical antibody markers CK19, HBME-1 and Galectin-3. Besides, the Se, Sp, PPV and NPV of Cyclin D1 and P21 in differentiating intralymph node ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1746-1596 |
| العلاقة: | https://doi.org/10.1186/s13000-023-01410-zTest; https://doaj.org/toc/1746-1596Test; https://doaj.org/article/ddfa31b7b1434739bdb71411060212f3Test |
| DOI: | 10.1186/s13000-023-01410-z |
| الإتاحة: | https://doi.org/10.1186/s13000-023-01410-zTest https://doaj.org/article/ddfa31b7b1434739bdb71411060212f3Test |
| رقم الانضمام: | edsbas.903C672 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17461596 |
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| DOI: | 10.1186/s13000-023-01410-z |