التفاصيل البيبلوغرافية
| العنوان: |
Inflammation Is a Mediating Factor in the Association between Lifestyle and Fatigue in Colorectal Cancer Patients |
| المؤلفون: |
Evertine Wesselink, Harm van Baar, Moniek van Zutphen, Meilissa Tibosch, Ewout A. Kouwenhoven, Eric T.P. Keulen, Dieuwertje Kok, Henk K. van Halteren, Stephanie O. Breukink, Johannes H. W. de Wilt, Matty P. Weijenberg, Marlou-Floor Kenkhuis, Michiel G. J. Balvers, Renger F. Witkamp, Fränzel J. B. van Duijnhoven, Ellen Kampman, Sandra Beijer, Martijn J. L. Bours, Renate M. Winkels |
| المصدر: |
Cancers; Volume 12; Issue 12; Pages: 3701 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2020 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
fatigue, colorectal cancer, inflammation markers, lifestyle, mediation analyses |
| الوصف: |
Fatigue is very common among colorectal cancer (CRC) patients. We examined the association between adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations and fatigue among stage I-III CRC patients, and whether inflammation mediated this association. Data from two prospective cohort studies were used. Adherence to the WCRF/AICR recommendations was expressed as a score ranging from 0–7, and assessed shortly after diagnosis. Six months post-diagnosis, fatigue was assessed with the European Organization for Research and Treatment of Cancer quality of life questionnaire C30 (EORTC QLQ-C30), and in a subpopulation, the plasma levels of inflammation markers (IL6, IL8, TNFα, and hsCRP) were assessed. Multiple linear regression analyses were performed to investigate the association between adherence to the WCRF/AICR recommendations and fatigue. To test mediation by inflammation, the PROCESS analytic tool developed by Hayes was used. A higher WCRF/AICR adherence score was associated with less fatigue six months after diagnosis (n = 1417, β −2.22, 95%CI −3.65; −0.78). In the population of analysis for the mediation analyses (n = 551), the total association between lifestyle and fatigue was (β −2.17, 95% CI −4.60; 0.25). A statistically significant indirect association via inflammation was observed (β −0.97, 95% CI −1.92; −0.21), explaining 45% of the total association between lifestyle and fatigue (−0.97/−2.17 × 100). Thus, inflammation is probably one of the underlying mechanisms linking lifestyle to fatigue. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Cancer Causes, Screening and Diagnosis; https://dx.doi.org/10.3390/cancers12123701Test |
| DOI: |
10.3390/cancers12123701 |
| الإتاحة: |
https://doi.org/10.3390/cancers12123701Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.8565AA03 |
| قاعدة البيانات: |
BASE |
