دورية أكاديمية

The Intricate Crosstalk Between Insulin and Pancreatic Ductal Adenocarcinoma: A Review From Clinical to Molecular

التفاصيل البيبلوغرافية
العنوان: The Intricate Crosstalk Between Insulin and Pancreatic Ductal Adenocarcinoma: A Review From Clinical to Molecular
المؤلفون: Junyuan Deng, Yujie Guo, Jiali Du, Jichun Gu, Lei Kong, Boan Tao, Ji Li, Deliang Fu
المصدر: Frontiers in Cell and Developmental Biology, Vol 10 (2022)
بيانات النشر: Frontiers Media S.A.
سنة النشر: 2022
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: Insulin, diabetes mellitus, cancer metabolism, pancreatic ductal adenocarcinoma, hyperinsulinemia, Biology (General), QH301-705.5
الوصف: Increased insulin level (or “hyperinsulinemia”) is a common phenomenon in pancreatic ductal adenocarcinoma (PDA) patients and signals poor clinical outcomes. Insulin is safe in low PDA risk population, while insulin significantly promotes PDA risk in high PDA risk population. The correlation between insulin and PDA is a reciprocal self-reinforcing relationship. On the one hand, pancreatic cancer cells synthesize multiple molecules to cause elevated peripheral insulin resistance, thus enhancing hyperinsulinemia. On the other hand, insulin promotes pancreatic cancer initiation and sustains PDA development by eliciting tumorigenic inflammation, regulating lipid and glucose metabolic reprogram, overcoming apoptosis through the crosstalk with IGF-1, stimulating cancer metastasis, and activating tumor microenvironment formation (inflammation, fibrosis, and angiogenesis). Currently, taking glucose sensitizing agents, including metformin, SGLT-2 inhibitor, and GLP-1 agonist, is an effective way of lowering insulin levels and controlling PDA development at the same time. In the future, new drugs targeting insulin-related signal pathways may pave a novel way for suppressing PDA initiation and progression.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2296-634X
العلاقة: https://www.frontiersin.org/articles/10.3389/fcell.2022.844028/fullTest; https://doaj.org/toc/2296-634XTest; https://doaj.org/article/33132f18981b45f6a089da4f7cf76fcaTest
DOI: 10.3389/fcell.2022.844028
الإتاحة: https://doi.org/10.3389/fcell.2022.844028Test
https://doaj.org/article/33132f18981b45f6a089da4f7cf76fcaTest
رقم الانضمام: edsbas.5358E19A
قاعدة البيانات: BASE
الوصف
تدمد:2296634X
DOI:10.3389/fcell.2022.844028