المؤلفون: Ankit Kumar, Anoop Singh Negi, Ashutosh Chauhan, Ravindra Semwal, Rajnish Kumar, Ruchi Badoni Semwal, Randhir Singh, Tushar Joshi, Subhash Chandra, Sunil Kumar Joshi, Deepak Kumar Semwal

المصدر: Journal of Traditional and Complementary Medicine, Vol 12, Iss 5, Pp 477-487 (2022)

مصطلحات موضوعية: Diabetes mellitus, Polyherbal formulation, Molecular docking, Liver function test, Histopathology, SGLT2 protein, Medicine

الوصف: Background and aim: The ingredients viz., Artemisia roxburghiana, Cissampelos pareira, Stephania glabra, Drimia indica, Roylea cinerea, Tinospora sinensis and Curcuma longa of the present formulation are used to treat diabetes in the Indian traditional medical system. Adopting the concept of multiple herbal mixtures for better therapeutic effects from the ancient Ayurvedic text Sarangdhar Samhita, the present study aimed to develop a polyherbal formulation (PHF) of seven herbs and to evaluate its sodium-glucose cotransporter protein-2 (SGLT2) inhibitory effect on type 2 diabetic rats. Experimental procedure: Streptozotocin (STZ) (60 mg/kg) and nicotinamide (NAM) (120 mg/kg) were intraperitoneally administered to induce type 2 diabetes in Wistar rats. The animals were divided into 5 groups viz. normal control, diabetic control, positive control (dapagliflozin at 0.1 mg/kg) and two test groups (PHF at 250 and 500 mg/kg). Various parameters including blood glucose, serum glutamic pyruvic transaminase (SGPT), serum glutamic-oxaloacetic transaminase (SGOT), bilirubin, triglycerides and creatinine were measured. Results and conclusion: The treatment with PHF (250 and 500 mg/kg) showed a significant (p < 0.05) decrease in blood glucose levels by 56.37% and 58.17%, respectively. The levels of SGOT, SGPT and bilirubin were significantly reduced in PHF-fed diabetic rats. Histopathological examination revealed no major changes in the treated groups as compared to the normal control. The molecular docking study showed strong binding of β-sitosterol, insulanoline, warifteine, dehydrocorydalmine, taraxerol acetate, lupeol, corydalmine and luteolin to SGLT2 protein. The present study concludes that PHF has promising antidiabetic activity via inhibiting SGLT2 protein without showing any adverse effects.

العلاقة: http://www.sciencedirect.com/science/article/pii/S222541102200030XTest; https://doaj.org/toc/2225-4110Test; https://doaj.org/article/54fd241c947a4edca3f7306257ca64dfTest

الإتاحة: https://doi.org/10.1016/j.jtcme.2022.03.003Test
https://doaj.org/article/54fd241c947a4edca3f7306257ca64dfTest

المؤلفون: Ankit Kumar, Ravindra Semwal, Ashutosh Chauhan, Ruchi Badoni Semwal, Subhash Chandra, Debabrata Sircar, Partha Roy, Deepak Kumar Semwal

المصدر: Phytomedicine Plus, Vol 2, Iss 4, Pp 100374- (2022)

مصطلحات موضوعية: Diabetes mellitus, Lipid profile, Liver function test, Kidney function test, Ayurveda, Other systems of medicine, RZ201-999

الوصف: Background: Cissampelos pareira L. (Menispermaceae) has been used in Indian traditional medicine for a variety of human ailments including diabetes mellitus. Although its anti-hyperglycemic activity has been validated by previous studies, a detailed mechanism of action and the responsible components are still unknown. Purpose: The present study aimed to evaluate the antidiabetic effect of aqueous-ethanolic extract of C. pareira roots in streptozotocin-nicotinamide (STZ-NAM)-induced diabetic rats via targeting SGLT2 inhibition. Methods: In vitro α-amylase and α-glucosidase inhibitory assays were conducted using Epoch Microplate Spectrophotometer. A-498 cells viability assay and SGLT2 protein expression study were conducted using MTT assay and western blot respectively. STZ-NAM-induced diabetic rats were used as a model to evaluate the antidiabetic effect of the extract. Selected bioactive compounds reported earlier from the plant were studied for their in silico SGLT2 inhibitory activity. Results: The extract showed α-amylase and α-glucosidase inhibitory effects with IC50 values of 18.0 ± 1.01 and 4.87±0.54 mg/mL, respectively. A-498 cells viability assay showed its CC50 value of 0.8 mg/mL. The extract showed a notable effect on SGLT2 protein expression. The in vivo study revealed that the extract significantly (p<0.05) reduced the glucose levels in rats at the dose of 500 mg/kg, b.w. in a 28-days study. The molecular docking studies revealed insulanoline and warifteine as the most active compounds with docking scores of -10 and -9.9 kcal mol−1, respectively. Conclusion: The study showed that the extract has the potential to reduce STZ-induced elevated blood glucose without affecting liver and kidney functions.

العلاقة: http://www.sciencedirect.com/science/article/pii/S2667031322001531Test; https://doaj.org/toc/2667-0313Test; https://doaj.org/article/2984e4f8d1d245e5a8f9e19047e581a9Test

الإتاحة: https://doi.org/10.1016/j.phyplu.2022.100374Test
https://doaj.org/article/2984e4f8d1d245e5a8f9e19047e581a9Test

المؤلفون: Sonali Aswal, Ankit Kumar, Ruchi Badoni Semwal, Ashutosh Chauhan, Abhimanyu Kumar, Jörg Lehmann, Deepak Kumar Semwal

المصدر: Medicina; Volume 55; Issue 6; Pages: 255

مصطلحات موضوعية: Bufadienolides, cardiotonic, Indian squill, Kolkanda, traditional medicine

الوصف: Drimia indica (Roxb.) Jessop (Asparagaceae) is a reputed Ayurvedic medicine for a number of therapeutic benefits, including for cardiac diseases, indigestion, asthma, dropsy, rheumatism, leprosy, and skin ailments. The present work aimed to critically and extensively review its traditional uses, phytochemistry, pharmacology, toxicology, and taxonomy together with the mechanisms of action of selected extracts of D. indica. A systematic literature survey from scientific databases such as PubMed, Scopus, and Web of Science as well as from some textbooks and classical texts was conducted. The plant, mainly its bulb, contains various bioactive constituents, such as alkylresorcinols, bufadienolides, phytosterols, and flavonoids. Various scientific studies have proven that the plant has anthelmintic, anticancer, antidiabetic, antimicrobial, antioxidant, and wound healing activities. The present work concludes that D. indica has the potential to treat various diseases, mainly microbial infections. This review also suggests that bufadienolides, flavonoids, and steroids might be responsible for its bioactive potential.

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/medicina55060255Test

الإتاحة: https://doi.org/10.3390/medicina55060255Test

المؤلفون: Sonali Aswal, Ankit Kumar, Ruchi Badoni Semwal, Ashutosh Chauhan, Abhimanyu Kumar, Jörg Lehmann, Deepak Kumar Semwal

المصدر: Medicina, Vol 55, Iss 6, p 255 (2019)

مصطلحات موضوعية: Bufadienolides, cardiotonic, Indian squill, Kolkanda, traditional medicine, Medicine (General), R5-920

الوصف: Drimia indica (Roxb.) Jessop (Asparagaceae) is a reputed Ayurvedic medicine for a number of therapeutic benefits, including for cardiac diseases, indigestion, asthma, dropsy, rheumatism, leprosy, and skin ailments. The present work aimed to critically and extensively review its traditional uses, phytochemistry, pharmacology, toxicology, and taxonomy together with the mechanisms of action of selected extracts of D. indica . A systematic literature survey from scientific databases such as PubMed, Scopus, and Web of Science as well as from some textbooks and classical texts was conducted. The plant, mainly its bulb, contains various bioactive constituents, such as alkylresorcinols, bufadienolides, phytosterols, and flavonoids. Various scientific studies have proven that the plant has anthelmintic, anticancer, antidiabetic, antimicrobial, antioxidant, and wound healing activities. The present work concludes that D. indica has the potential to treat various diseases, mainly microbial infections. This review also suggests that bufadienolides, flavonoids, and steroids might be responsible for its bioactive potential.

العلاقة: https://www.mdpi.com/1010-660X/55/6/255Test; https://doaj.org/toc/1010-660XTest; https://doaj.org/article/80410eff53814b47bb623e6258666ca0Test

الإتاحة: https://doi.org/10.3390/medicina55060255Test
https://doaj.org/article/80410eff53814b47bb623e6258666ca0Test

المؤلفون: Ankit Kumar, Sonali Aswal, Ashutosh Chauhan, Ruchi Badoni Semwal, Abhimanyu Kumar, Deepak Kumar Semwal

المصدر: Natural Products and Bioprospecting, Vol 9, Iss 3, Pp 175-200 (2019)

مصطلحات موضوعية: Ayurveda, Diabetes, Herbal formulations, Traditional healers, Folk medicine, Botany, QK1-989

الوصف: The Himalayan region is the treasure house of natural wealth, particularly of medicinal and aromatic plants. These plants are used by the Indian traditional healers for the past many centuries to treat various ailments such as skin disorders, asthma, diabetes, snake bite, fever, pain, eye diseases, diarrhoea, indigestion, jaundice, burn, wound, liver disorder, CNS disorders and urinary tract infection. The indigenous traditional knowledge of medicinal plants and therapies of various local communities has been lost due to changes in traditional culture and the introduction of modern technologies. Therefore, it is essential to explore the traditional knowledge of the indigenous medicinal plants mainly in such areas where there is a severe threat to natural vegetation owing to human inhabitation. The present study aimed to explore the medicinal plants of Chakrata region (Jaunsar–Bawar Hills), Uttarakhand, India used in the folk medicine for the management of diabetes by Jaunsari Tribe. In a comprehensive field survey, the information about the medicinal plants have been mainly collected from the traditional healers and other elderly people belong to the tribal community. All the information about the medicinal plants of the study area was documented in a field book. Various tools have been used to collect the samples for identification purpose and the authentication of the plants was done with the help of taxonomists. The literature on these plants was also searched from online (PubMed and Scopus) as well as from some textbooks and Ayurvedic classical texts. The present survey-based work described a total of 54 plants belonging to 47 genera and 30 families used in the traditional medicine for the management of diabetes in Chakrata region. The information gathered from the local community revealed that the plants are effective in diabetes and one can use most of them without consulting a practitioner or traditional healer. The literature revealed that most of the surveyed plants are already used in the ...

العلاقة: http://link.springer.com/article/10.1007/s13659-019-0202-5Test; https://doaj.org/toc/2192-2195Test; https://doaj.org/toc/2192-2209Test; https://doaj.org/article/985a2507f76a4e21be25c6829f8b8db7Test

الإتاحة: https://doi.org/10.1007/s13659-019-0202-5Test
https://doaj.org/article/985a2507f76a4e21be25c6829f8b8db7Test

المؤلفون: Ashutosh Chauhan, Deepak Kumar Semwal, Satyendra Prasad Mishra, Ruchi Badoni Semwal

المصدر: International Journal of Yoga, Vol 10, Iss 2, Pp 103-106 (2017)

مصطلحات موضوعية: Body mass index, hypertension, pranayama, systolic and diastolic blood pressure, yoga practice, Miscellaneous systems and treatments, RZ409.7-999

الوصف: Background: Yoga, an ancient Indian system of exercise and therapy is an art of good living or an integrated system for the benefit of the body, mind, and inner spirit. Regular practice of yoga can help to increase blood flow to the brain, reduce stress, have a calming effect on the nervous system, and greatly help in reducing hypertension. Aim: Aim of the present study is to evaluate the effect of 1-month yoga practice on body mass index (BMI), and blood pressure (BP). Materials and Methods: The present study was conducted to determine the effect of yoga practice on 64 participants (age 53.6 ± 13.1 years) (experimental group) whereas the results were compared with 26 healthy volunteers (control group). We examined the effects of yoga on physiological parameters in a 1-month pilot study. Most of the participants were learner and practiced yoga for 1 h daily in the morning for 1 month. BMI and BP (systolic and diastolic) were studied before and after 1 month of yoga practice. Results: Yoga practice causes decreased BMI (26.4 ± 2.5–25.22 ± 2.4), systolic BP (136.9 ± 22.18 mmHg to 133 ± 21.38 mmHg), and diastolic BP (84.7 ± 6.5 mmHg to 82.34 ± 7.6 mmHg). On the other hand, no significant changes were observed in BMI and BP of control group. Conclusion: This study concludes that yoga practice has potential to control BMI and BP without taking any medication.

العلاقة: http://www.ijoy.org.in/article.asp?issn=0973-6131;year=2017;volume=10;issue=2;spage=103;epage=106;aulastTest=Chauhan; https://doaj.org/toc/0973-6131Test; https://doaj.org/article/f82e8a0c98a149fc8771c012af2e0a8aTest

الإتاحة: https://doi.org/10.4103/ijoy.IJOY_46_16Test
https://doaj.org/article/f82e8a0c98a149fc8771c012af2e0a8aTest

المؤلفون: Ashutosh Chauhan, Deepak Semwal, Satyendra Mishra, Sandeep Goyal, Rajendra Marathe, Ruchi Semwal

المصدر: Medical Sciences; Volume 4; Issue 4; Pages: 16

مصطلحات موضوعية: renal cell carcinoma, mammalian target of rapamycin, mitogen activated protein kinase, target therapy

الوصف: Renal cell carcinoma (RCC) is the most common neoplasm that occurs in the kidney and is marked by a unique biology, with a long history of poor response to conventional cancer treatments. In the past few years, there have been significant advancements to understand the biology of RCC. This has led to the introduction of novel targeted therapies in the management of patients with metastatic disease. Patients treated with targeted therapies for RCC had shown positive impact on overall survival, however, no cure is possible and patients need to undergo treatment for long periods of time, which raises challenges to manage the associated adverse events. Moreover, many patients may not respond to it and even response may not last long enough in the responders. Many inhibitors of the Mammalian target of Rapamycin (mTOR) signaling pathway are currently being used in treatment of advanced RCC. Studies showed that inhibitions of mTOR pathways induce Mitogen-Activated Protein Kinase (MAPK) escape cell death and cells become resistant to mTOR inhibitors. Because of this, there is a need to inhibit both pathways with their inhibitors comparatively for a better outcome and treatment of patients with RCC.

وصف الملف: application/pdf

العلاقة: Cancer and Cancer-Related Research; https://dx.doi.org/10.3390/medsci4040016Test

الإتاحة: https://doi.org/10.3390/medsci4040016Test

المؤلفون: Ashutosh Chauhan, Deepak Kumar Semwal, Satyendra Prasad Mishra, Sandeep Goyal, Rajendra Marathe, Ruchi Badoni Semwal

المصدر: Medical Sciences, Vol 4, Iss 4, p 16 (2016)

مصطلحات موضوعية: renal cell carcinoma, mammalian target of rapamycin, mitogen activated protein kinase, target therapy, Medicine

الوصف: Renal cell carcinoma (RCC) is the most common neoplasm that occurs in the kidney and is marked by a unique biology, with a long history of poor response to conventional cancer treatments. In the past few years, there have been significant advancements to understand the biology of RCC. This has led to the introduction of novel targeted therapies in the management of patients with metastatic disease. Patients treated with targeted therapies for RCC had shown positive impact on overall survival, however, no cure is possible and patients need to undergo treatment for long periods of time, which raises challenges to manage the associated adverse events. Moreover, many patients may not respond to it and even response may not last long enough in the responders. Many inhibitors of the Mammalian target of Rapamycin (mTOR) signaling pathway are currently being used in treatment of advanced RCC. Studies showed that inhibitions of mTOR pathways induce Mitogen-Activated Protein Kinase (MAPK) escape cell death and cells become resistant to mTOR inhibitors. Because of this, there is a need to inhibit both pathways with their inhibitors comparatively for a better outcome and treatment of patients with RCC.

العلاقة: http://www.mdpi.com/2076-3271/4/4/16Test; https://doaj.org/toc/2076-3271Test; https://doaj.org/article/0dd34a977186405cb99f90e168f3680cTest

الإتاحة: https://doi.org/10.3390/medsci4040016Test
https://doaj.org/article/0dd34a977186405cb99f90e168f3680cTest

المؤلفون: Sangeeta Tiwari, Ashutosh Chauhan, Pallab Chaterjee, Mohammed T Alam

المصدر: Journal of Minimal Access Surgery, Vol 9, Iss 2, Pp 65-71 (2013)

مصطلحات موضوعية: General anaesthesia, laparoscopic cholecystectomy, spinal anaesthesia, Surgery, RD1-811, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Context: Spinal anaesthesia has been reported as an alternative to general anaesthesia for performing laparoscopic cholecystectomy (LC). Aims: Study aimed to evaluate efficacy, safety and cost benefit of conducting laparoscopic cholecystectomy under spinal anaesthesia (SA) in comparison to general anaesthesia(GA) Settings and Design: A prospective, randomised study conducted over a two year period at an urban, non teaching hospital. Materials and Methods: Patients meeting inclusion criteria e randomised into two groups .Group A and Group B received general and spinal anaesthesia by standardised techniques. Both groups underwent standard four port laparoscopic cholecystectomy. Mean anaesthesia time, pneumoperitoneum time and surgery time defined primary outcome measures. Intraoperative events and post operative pain score were secondary outcome measure. Statistical Analysis Used: The Student t test, Pearson′s chi-square test and Fisher exact test. Results: Out of 235 cases enrolled in the study, 114 cases in Group A and 110 in Group B analysed. Mean anaesthesia time appeared to be more in the GA group (49.45 vs. 40.64, P = 0.02) while pneumoperitoneum time and corresponding the total surgery time was slightly longer in the SA group. 27/117 cases who received SA experienced intraoperative events, four significant enough to convert to GA. No postoperative complications noted in either group. Pain relief significantly more in SA group in immediate post operative period (06 and 12 hours) but same as GA group at time of discharge (24 hours). No late postoperative complication or readmission noted in either group. Conclusion: Laparoscopic cholecystectomy done under spinal anaesthesia as a routine anaesthesia of choice is feasible and safe. Spinal anaesthesia can be recommended to be the anaesthesia technique of choice for conducting laparoscopic cholecystectomy in hospital setups in developing countries where cost factor is a major factor.

العلاقة: http://www.journalofmas.com/article.asp?issn=0972-9941;year=2013;volume=9;issue=2;spage=65;epage=71;aulast=TiwariTest; https://doaj.org/toc/0972-9941Test; https://doaj.org/toc/1998-3921Test; https://doaj.org/article/6269dbac7cce43b6884073769a889fb5Test

الإتاحة: https://doi.org/10.4103/0972-9941.110965Test
https://doaj.org/article/6269dbac7cce43b6884073769a889fb5Test

المؤلفون: Ashutosh Chauhan

المصدر: Indian Journal of Anaesthesia, Vol 52, Iss 3, Pp 337-339 (2008)

مصطلحات موضوعية: Central venous catheter, Subclavian, Malpositioning, Anesthesiology, RD78.3-87.3

الوصف: Malpositioning of central venous catheter inserted into subclavian vein is a known and dreaded complication. Malpositioning of catheter tip into contralateral subclavian is an extremely unusual occurrence. The author describes two cases, one of subclavian central venous catheter and another of a peripherally inserted central catheter, in which the catheter malpositioned into contralateral subclavian vein.

العلاقة: http://www.ijaweb.org/article.asp?issn=0019-5049;year=2008;volume=52;issue=3;spage=337;epage=339;aulastTest=Chauhan; https://doaj.org/toc/0019-5049Test; https://doaj.org/article/c3886deb4992483786f5b36155711b9dTest

الإتاحة: https://doaj.org/article/c3886deb4992483786f5b36155711b9dTest