دورية أكاديمية
Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7
العنوان: | Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7 |
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المؤلفون: | Ana Dios-Esponera, Nicolas Melis, Bhagawat C. Subramanian, Roberto Weigert, Lawrence E. Samelson |
المصدر: | Frontiers in Immunology, Vol 10 (2019) |
بيانات النشر: | Frontiers Media S.A. |
سنة النشر: | 2019 |
المجموعة: | Directory of Open Access Journals: DOAJ Articles |
مصطلحات موضوعية: | Pak1 kinase, L-selectin, CCR7, lymph node trafficking, L-selectin shedding, Immunologic diseases. Allergy, RC581-607 |
الوصف: | Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, which is mediated by the dynamic re-arrangement of the actin cytoskeleton. Pak1 plays a central role in cell morphology, adhesion and migration in various cell types. Here we demonstrate that Pak1 is required for activated CD4+ T cell trafficking to lymph nodes. Pak1 deficiency in T cells causes a defect in the transcription of CCR7 and L-selectin, thereby altering lymphocyte trafficking. Additionally, we report an increase in L-selectin shedding in Pak1-deficient T cells, which correlates with a decrease in the recruitment of calmodulin to the cytoplasmic tail of L-selectin during T cell activation. Overall, our findings demonstrate that by regulating the expression of two major lymph node homing molecules, L-selectin and CCR7, Pak1 mediates activated CD4+ T cell trafficking. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
تدمد: | 1664-3224 |
العلاقة: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00370/fullTest; https://doaj.org/toc/1664-3224Test; https://doaj.org/article/8153e5895b47424b8d23e08bf4895a2dTest |
DOI: | 10.3389/fimmu.2019.00370 |
الإتاحة: | https://doi.org/10.3389/fimmu.2019.00370Test https://doaj.org/article/8153e5895b47424b8d23e08bf4895a2dTest |
رقم الانضمام: | edsbas.D8B290E3 |
قاعدة البيانات: | BASE |
تدمد: | 16643224 |
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DOI: | 10.3389/fimmu.2019.00370 |