التفاصيل البيبلوغرافية
| العنوان: |
Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial |
| المؤلفون: |
Statland, Jeffrey M, Moore, Dan, Wang, Yunxia, Walsh, Maureen, Mozaffar, Tahseen, Elman, Lauren, Nations, Sharon P, Mitsumoto, Hiroshi, Fernandes, J Americo, Saperstein, David, Hayat, Ghazala, Herbelin, Laura, Karam, Chafic, Katz, Jonathan, Wilkins, Heather M, Agbas, Abdulbaki, Swerdlow, Russell H, Santella, Regina M, Dimachkie, Mazen M, Barohn, Richard J, Consortium, The Rasagiline Investigators of the Muscle Study Group and Western ALS |
| المصدر: |
Muscle & Nerve, vol 59, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2019 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Clinical Research, Clinical Trials and Supportive Activities, ALS, Neurodegenerative, Neurosciences, Brain Disorders, Rare Diseases, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Neurological, Adult, Aged, 80 and over, Amyotrophic Lateral Sclerosis, DNA-Binding Proteins, Double-Blind Method, Female, Humans, Indans, Male, Middle Aged, Neuroprotective Agents, Outcome Assessment, Health Care, Quality of Life, Retrospective Studies, Severity of Illness Index, Treatment Outcome, United States, Young Adult |
| جغرافية الموضوع: |
201 - 207 |
| الوصف: |
Rasagiline is a monoamine oxidase B (MAO-B) inhibitor with possible neuroprotective effects in patients with amyotrophic lateral sclerosis (ALS). We performed a randomized, double-blind, placebo-controlled trial of 80 ALS participants with enrichment of the placebo group with historical controls (n = 177) at 10 centers in the United States. Participants were randomized in a 3:1 ratio to 2 mg/day rasagiline or placebo. The primary outcome was average slope of decline on the ALS Functional Rating Scale-Revised (ALSFRS-R). Secondary measures included slow vital capacity, survival, mitochondrial and molecular biomarkers, and adverse-event reporting. There was no difference in the average 12-month ALSFRS-R slope between rasagiline and the mixed placebo and historical control cohorts. Rasagiline did not show signs of drug-target engagement in urine and blood biomarkers. Rasagiline was well tolerated with no serious adverse events. Rasagiline did not alter disease progression compared with controls over 12 months of treatment. Muscle Nerve 59:201-207, 2019. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt83f5g5tb; https://escholarship.org/uc/item/83f5g5tbTest |
| الإتاحة: |
https://escholarship.org/uc/item/83f5g5tbTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.36871E12 |
| قاعدة البيانات: |
BASE |
