التفاصيل البيبلوغرافية
| العنوان: |
Arabidopsis Transcription Regulatory Factor Domain/Domain Interaction Analysis Tool—Liquid/Liquid Phase Separation, Oligomerization, GO Analysis: A Toolkit for Interaction Data-Based Domain Analysis |
| المؤلفون: |
Jee Eun Kang, Ji Hae Jun, Jung Hyun Kwon, Ju-Hyun Lee, Kidong Hwang, Sungjong Kim, Namhee Jeong |
| المصدر: |
Genes; Volume 14; Issue 7; Pages: 1476 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
liquid–liquid phase separation, protein oligomerization, GO, domain–domain interaction, domain linker, intrinsically disordered regions, domain–peptide interaction, beta sheet, transmembrane helices, post-translational modification |
| جغرافية الموضوع: |
agris |
| الوصف: |
Although a large number of databases are available for regulatory elements, a bottleneck has been created by the lack of bioinformatics tools to predict the interaction modes of regulatory elements. To reduce this gap, we developed the Arabidopsis Transcription Regulatory Factor Domain/Domain Interaction Analysis Tool–liquid/liquid phase separation (LLPS), oligomerization, GO analysis (ART FOUNDATION-LOG), a useful toolkit for protein–nucleic acid interaction (PNI) and protein–protein interaction (PPI) analysis based on domain–domain interactions (DDIs). LLPS, protein oligomerization, the structural properties of protein domains, and protein modifications are major components in the orchestration of the spatiotemporal dynamics of PPIs and PNIs. Our goal is to integrate PPI/PNI information into the development of a prediction model for identifying important genetic variants in peaches. Our program unified interdatabase relational keys based on protein domains to facilitate inference from the model species. A key advantage of this program lies in the integrated information of related features, such as protein oligomerization, LOG analysis, structural characterizations of domains (e.g., domain linkers, intrinsically disordered regions, DDIs, domain–motif (peptide) interactions, beta sheets, and transmembrane helices), and post-translational modification. We provided simple tests to demonstrate how to use this program, which can be applied to other eukaryotic organisms. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Bioinformatics; https://dx.doi.org/10.3390/genes14071476Test |
| DOI: |
10.3390/genes14071476 |
| الإتاحة: |
https://doi.org/10.3390/genes14071476Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.FC0230A2 |
| قاعدة البيانات: |
BASE |
