التفاصيل البيبلوغرافية
| العنوان: |
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment |
| المؤلفون: |
Wu, Chien-Ting, Lidsky, Peter V, Xiao, Yinghong, Lee, Ivan T, Cheng, Ran, Nakayama, Tsuguhisa, Jiang, Sizun, Demeter, Janos, Bevacqua, Romina J, Chang, Charles A, Whitener, Robert L, Stalder, Anna K, Zhu, Bokai, Chen, Han, Goltsev, Yury, Tzankov, Alexandar, Nayak, Jayakar V, Nolan, Garry P, Matter, Matthias S, Andino, Raul, Jackson, Peter K |
| المصدر: |
Cell Metabolism, vol 33, iss 8 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2021 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Diabetes, Pneumonia & Influenza, Prevention, Lung, Autoimmune Disease, Pneumonia, Infectious Diseases, Emerging Infectious Diseases, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Good Health and Well Being, A549 Cells, Adult, Aged, 80 and over, Angiotensin-Converting Enzyme 2, Antigens, CD, Apoptosis, Apoptosis Regulatory Proteins, COVID-19, Case-Control Studies, Diabetes Mellitus, Female, Host-Pathogen Interactions, Humans, Insulin, Insulin-Secreting Cells |
| الوقت: |
1565 - 1576.e5 |
| الوصف: |
Emerging evidence points toward an intricate relationship between the pandemic of coronavirus disease 2019 (COVID-19) and diabetes. While preexisting diabetes is associated with severe COVID-19, it is unclear whether COVID-19 severity is a cause or consequence of diabetes. To mechanistically link COVID-19 to diabetes, we tested whether insulin-producing pancreatic β cells can be infected by SARS-CoV-2 and cause β cell depletion. We found that the SARS-CoV-2 receptor, ACE2, and related entry factors (TMPRSS2, NRP1, and TRFC) are expressed in β cells, with selectively high expression of NRP1. We discovered that SARS-CoV-2 infects human pancreatic β cells in patients who succumbed to COVID-19 and selectively infects human islet β cells invitro. We demonstrated that SARS-CoV-2 infection attenuates pancreatic insulin levels and secretion and induces β cell apoptosis, each rescued by NRP1 inhibition. Phosphoproteomic pathway analysis of infected islets indicates apoptotic β cell signaling, similar to that observed in type 1 diabetes (T1D). In summary, our study shows SARS-CoV-2 can directly induce β cell killing. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt0jt3m3tq; https://escholarship.org/uc/item/0jt3m3tqTest |
| الإتاحة: |
https://escholarship.org/uc/item/0jt3m3tqTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.7DFF22FB |
| قاعدة البيانات: |
BASE |
