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1دورية أكاديمية
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s001Test
https://figshare.com/articles/journal_contribution/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591888Test -
2دورية أكاديمية
المؤلفون: Ji-An Chen (9305742), Hui Ma (290168), Zehui Liu (4023659), Jinlong Tian (5878574), Sisi Lu (6916592), Wenqing Fang (11879351), Shuyin Ze (11879354), Weiqiang Lu (165510), Qiong Xie (709001), Jin Huang (146235), Yonghui Wang (287491)
مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Space Science, Chemical Sciences not elsewhere classified, present study provides, multifactorial autoimmune disease, major clinical challenge, dextran sulfate sodium, may enhance anti, 50 sub, 14d b, potent dual rorγt, vivo <, therapeutic agents, taken together, reduce rorγt, novel framework, inflammatory effects, inflammatory activity, exhibited remarkable, dual rorγt, dihydroorotate dehydrogenase, dependently alleviated, aminobenzothiazole hit, 297 μm, 110 μm
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3دورية أكاديمية
المؤلفون: William P. Gallagher (1508725), John R. Coombs (1334916), Carlos A. Guerrero (1264551), Boguslaw M. Mudryk (11714298), Kishta Katipally (1695961), Candice L. Joe (1588000), Sanjeewa Rupasinghe (11714301), Jason Zhu (2042095), Francisco González-Bobes (1508401)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Infectious Diseases, Plant Biology, Virology, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, dynamic kinetic resolution, 1 kg scale, 2 b, 1 b, synthesized starting, rorγt inhibitor, overall 51, optimized process, hagemann ’, hageman ’, dkr ), cyclohexyl fragment, catalyzed carbonylation, asymmetric synthesis, 7 steps, 5 isolations
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4
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s003Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591894Test -
5
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s004Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591897Test -
6
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s002Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591891Test -
7
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s005Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591900Test -
8
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s006Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591903Test -
9
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s007Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591909Test -
10
المؤلفون: Ji-An Chen (9305742), Hui Ma (290168), Zehui Liu (4023659), Jinlong Tian (5878574), Sisi Lu (6916592), Wenqing Fang (11879351), Shuyin Ze (11879354), Weiqiang Lu (165510), Qiong Xie (709001), Jin Huang (146235), Yonghui Wang (287491)
مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Space Science, Chemical Sciences not elsewhere classified, present study provides, multifactorial autoimmune disease, major clinical challenge, dextran sulfate sodium, may enhance anti, 50 sub, 14d b, potent dual rorγt, vivo <, therapeutic agents, taken together, reduce rorγt, novel framework, inflammatory effects, inflammatory activity, exhibited remarkable, dual rorγt, dihydroorotate dehydrogenase, dependently alleviated, aminobenzothiazole hit, 297 μm, 110 μm