دورية أكاديمية
MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis
| العنوان: | MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis |
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| المؤلفون: | Debao Fang, Hao Hu, Kailiang Zhao, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu, Yide Mei |
| المصدر: | Advanced Science, Vol 10, Iss 26, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | colorectal cancer, myeloid leukemia factor 2 (MLF2), p53, ubiquitin‐specific protease 7 (USP7), Science |
| الوصف: | Inactivation of the p53 pathway is linked to a variety of human cancers. As a critical component of the p53 pathway, ubiquitin‐specific protease 7 (USP7) acts as a deubiquitinase for both p53 and its ubiquitin E3 ligase mouse double minute 2 homolog. Here, myeloid leukemia factor 2 (MLF2) is reported as a new negative regulator of p53. MLF2 interacts with both p53 and USP7. Via these interactions, MLF2 inhibits the binding of USP7 to p53 and antagonizes USP7‐mediated deubiquitination of p53, thereby leading to p53 destabilization. Functionally, MLF2 plays an oncogenic role in colorectal cancer, at least partially, via the negative regulation of p53. Clinically, MLF2 is elevated in colorectal cancer and its high expression is associated with poor prognosis in patients with colorectal cancer. In wild‐type‐p53‐containing colorectal cancer, MLF2 and p53 expressions are inversely correlated. These findings establish MLF2 as an important suppressor of p53 function. The study also reveals a critical role for the MLF2–p53 axis in promoting colorectal carcinogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2198-3844 |
| العلاقة: | https://doi.org/10.1002/advs.202303336Test; https://doaj.org/toc/2198-3844Test; https://doaj.org/article/b7701baaa11b471394c969ff6a562443Test |
| DOI: | 10.1002/advs.202303336 |
| الإتاحة: | https://doi.org/10.1002/advs.202303336Test https://doaj.org/article/b7701baaa11b471394c969ff6a562443Test |
| رقم الانضمام: | edsbas.D5FF38F4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21983844 |
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| DOI: | 10.1002/advs.202303336 |