دورية أكاديمية
Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer.
| العنوان: | Monitoring of RAS mutant clones in plasma of patients with RAS mutant metastatic colorectal cancer. |
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| المؤلفون: | Fernández Montes, A, Élez, E, Vivancos, A, Martínez, N, González, P, Covela, M, de la Cámara, J, Cousillas, A, Méndez, J C, Graña, B, Aranda, E |
| سنة النشر: | 2022 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Circulating tumor DNA, EGFR inhibitors, Liquid biopsy, Metastatic colorectal cancer, RAS mutant, Antineoplastic Combined Chemotherapy Protocols, Clone Cells, Colonic Neoplasms, Colorectal Neoplasms, Fluorouracil, Humans, Mutation, Panitumumab |
| الوصف: | Some patients with histologically confirmed primary mCRC and mutated RAS reported undetectable RAS mutant clones in plasma after receiving anti-VEGF treatment. The aim was to prospectively assess it with its potential therapeutic implications. RAS mutant genes in solid biopsy (before first-line treatment: FOLFOX/CAPOX + bevacizumab) were compared in liquid biopsy (before second-line treatment: panitumumab + FOLFIRI), using Idylla™ system. Discordant results between solid/liquid biopsies were assessed by the next-generation sequencing (NGS) test (solid/liquid biopsies). Twenty-three patients were assessed (seven had RAS mutant discrepancies between solid/liquid biopsies). The NGS test confirmed that 3/23 (13%) patients had undetectable RAS mutant clones in liquid biopsy and 3/23 (13%) presented discrepancies in solid biopsy (Idylla™ system vs. NGS test). Thirteen percentage of patients had undetectable RAS mutant clones in liquid biopsy after first-line treatment. However, some discrepancies between solid and liquid biopsies have been observed. These results suggest a need to improve accuracy of RAS analyses, especially in solid biopsies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 34997474 1699-3055 |
| العلاقة: | http://hdl.handle.net/10668/21019Test; PMC9107427; https://link.springer.com/content/pdf/10.1007/s12094-021-02767-7.pdfTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107427/pdfTest |
| DOI: | 10.1007/s12094-021-02767-7 |
| DOI: | 10.1007/s12094-021-02767-7.pdf |
| الإتاحة: | https://doi.org/10.1007/s12094-021-02767-7Test http://hdl.handle.net/10668/21019Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107427/pdfTest |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.53B44A62 |
| قاعدة البيانات: | BASE |
| تدمد: | 34997474 16993055 |
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| DOI: | 10.1007/s12094-021-02767-7 |