التفاصيل البيبلوغرافية
| العنوان: |
Role of Statin in Atrial Fibrillation-Related Stroke: An Angiographic Study for Collateral Flow |
| المؤلفون: |
Lee, Mi Ji, Bang, Oh Young, Kim, Suk Jae, Kim, Gyeong Moon, Chung, Chin Sang, Lee, Kwang Ho, Ovbiagele, Bruce, Liebeskind, David S, Saver, Jeffrey L |
| المصدر: |
Cerebrovascular Diseases, vol 37, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2014 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Heart Disease, Clinical Research, Aging, Brain Disorders, Stroke, Cardiovascular, Neurosciences, Adult, Aged, 80 and over, Atrial Fibrillation, Brain Ischemia, Cerebral Angiography, Collateral Circulation, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Retrospective Studies, Collateral flow, Statin, Arteriogenesis, Clinical Sciences, Neurology & Neurosurgery |
| جغرافية الموضوع: |
77 - 84 |
| الوصف: |
BackgroundCurrently, intensive lipid lowering is recommended in patients with atherosclerotic ischemic stroke or transient ischemic attack. However, the role of statin in cardioembolic stroke is unclear. We investigated the association of statin with pretreatment collateral status in cardioembolic stroke.MethodsA collaborative study from two stroke centers in distinct geographic regions included consecutive patients with acute middle cerebral artery (MCA) infarction due to atrial fibrillation (AF) who underwent cerebral angiography. The relationship between pretreatment collateral grade and the use/dose of statin at stroke onset was assessed. The angiographic collateral grade was evaluated according to the ASITN/SIR Collateral Flow Grading System.ResultsNinety-eight patients (76 statin-naïve, 22 statin users) were included. Compared with statin-naïve patients, statin users were older and more frequently had hypertension, hyperlipidemia and coronary heart disease. Excellent collaterals (grade 3-4) were more frequently observed in statin users (11 patients, 50%) than in statin-naïve patients (21 patients, 27.6%; p = 0.049). The use of atorvastatin 10 mg equivalent or higher doses of statin was associated with excellent collaterals (p for trend = 0.025). In multiple regression analysis, prestroke statin use was independently associated with excellent collaterals (odds ratio, 7.841; 95% confidence interval, CI, 1.96-31.363; p = 0.004).ConclusionsPremorbid use of statin in AF patients is associated with excellent collateral flow. Although most statin trials excluded patients with cardioembolic stroke, our data suggests the possibility that statin may be beneficial in AF-related stroke |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt0n88g524; https://escholarship.org/uc/item/0n88g524Test |
| الإتاحة: |
https://escholarship.org/uc/item/0n88g524Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.4D5F3CA4 |
| قاعدة البيانات: |
BASE |
