المؤلفون: Lakeman, Inge M M, van den Broek, Alexandra J, Vos, Juliën A M, Barnes, Daniel R, Adlard, Julian, Andrulis, Irene L, Arason, Adalgeir, Arnold, Norbert, Arun, Banu K, Balmaña, Judith, Barrowdale, Daniel, Benitez, Javier, Borg, Ake, Caldés, Trinidad, Caligo, Maria A, Chung, Wendy K, Claes, Kathleen B M, Collée, J Margriet, Couch, Fergus J, Daly, Mary B, Dennis, Joe, Dhawan, Mallika, Domchek, Susan M, Eeles, Ros, Engel, Christoph, Evans, D Gareth, Feliubadaló, Lidia, Foretova, Lenka, Friedman, Eitan, Frost, Debra, Ganz, Patricia A, Garber, Judy, Gayther, Simon A, Gerdes, Anne-Marie, Godwin, Andrew K, Goldgar, David E, Hahnen, Eric, Hake, Christopher R, Hamann, Ute, Hogervorst, Frans B L, Hooning, Maartje J, Hopper, John L, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Izatt, Louise, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jensen, Uffe Birk, Jiao, Yue, John, Esther M, Joseph, Vijai, Karlan, Beth Y, Kets, Carolien M, Konstantopoulou, Irene, Kwong, Ava, Legrand, Clémentine, Leslie, Goska, Lesueur, Fabienne, Loud, Jennifer T, Lubiński, Jan, Manoukian, Siranoush, McGuffog, Lesley, Miller, Austin, Gomes, Denise Molina, Montagna, Marco, Mouret-Fourme, Emmanuelle, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Olah, Edith, Olopade, Olufunmilayo I, Park, Sue K, Parsons, Michael T, Peterlongo, Paolo, Piedmonte, Marion, Radice, Paolo, Rantala, Johanna, Rennert, Gad, Risch, Harvey A, Schmutzler, Rita K, Sharma, Priyanka, Simard, Jacques, Singer, Christian F, Stadler, Zsofia, Stoppa-Lyonnet, Dominique, Sutter, Christian, Tan, Yen Yen, Teixeira, Manuel R, Teo, Soo Hwang, Teulé, Alex, Thomassen, Mads, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Tung, Nadine, van Rensburg, Elizabeth J, Vega, Ana, Wappenschmidt, Barbara, Devilee, Peter, van Asperen, Christi J, Bernstein, Jonine L, Offit, Kenneth, Easton, Douglas F, Rookus, Matti A, Chenevix-Trench, Georgia, Antoniou, Antonis C, Robson, Mark, Schmidt, Marjanka K

المساهمون: 1Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. 2Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. 3Division of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 4Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 5Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK. 6Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada. 7Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. 8Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland. 9BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 10Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 11Institute of Clinical Molecular Biology, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany. 12Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 13Hereditary cancer Genetics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain. 14Department of Medical Oncology, Vall d'Hebron Barcelona Hospital Campus, University Hospital of Vall d'Hebron, Barcelona, Spain. 15Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain. 16Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 17Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden. 18Molecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain. 19SOD Genetica Molecolare. University Hospital, Pisa, Italy. 20Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA. 21Centre for Medical Genetics, Ghent University, Ghent, Belgium. 22Department of Clinical Genetics, Erasmus University Medical Center, CA, Rotterdam, The Netherlands. 23Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 24Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA. 25Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, USA. 26Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. 27Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK. 28Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 29Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. 30North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. 31Hereditary Cancer Program, ONCOBELL-IDIBELL-IGTP, Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 32Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. 33The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel. 34Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. 35Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, USA. 36Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA. 37Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core. Cedars-Sinai Medical Center, Los Angeles, CA, USA. 38Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 39Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA. 40Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. 41Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 42Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 43Waukesha Memorial Hospital-Pro Health Care, Waukesha, WI, USA. 44Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. 45Family Cancer Clinic, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 46Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. 47Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia. 48Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA. 49The University of Chicago Pritzker School of Medicine, Chicago, IL, USA. 50N.N. Petrov Institute of Oncology, St. Petersburg, Russia. 51Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. 52Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK. 53Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 54Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland. 55Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, VIC, Australia. 56Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia. 57Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. 58State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. 59Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark. 60Genetic Epidemiology of Cancer team, Paris, France. 61Institut Curie, Paris, France. 62Mines ParisTech, Fontainebleau, France. 63Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA. 64Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. 65Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 66David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA. 67Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece. 68Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong. 69Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong. 70Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong. 71Département de Génétique, CHU de Grenoble, Grenoble, France. 72Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. 73Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. 74NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, USA. 75Service de Biologie de la reproduction, Cytogénétique et Génétique Médicale, CHI Poissy-Saint Germain, Poissy, France. 76Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. 77Service de Génétique, Institut Curie, Paris, France. 78Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. 79Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 80Cancer Genetics Service, National Cancer Centre, Singapore, Singapore. 81Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. 82Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 83Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA. 84Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. 85Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. 86Cancer Research Institute, Seoul National University, Seoul, Korea. 87Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. 88Genome Diagnostics Program, IFOM-the FIRC Institute of Molecular Oncology, Milan, Italy. 89Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy. 90Clinical Genetics, Karolinska Institutet, Stockholm, Sweden. 91Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel. 92Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA. 93Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 94Department of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Westwood, KS, USA. 95Genomics Center, Centre Hospitalier Universitaire de Québec-Université Laval Research Center, Québec City, QC, Canada. 96Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 97Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 98Department of Tumour Biology, INSERM U830, Paris, France. 99Université Paris Descartes, Paris, France. 100Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. 101Dept of OB/GYN, Medical University of Vienna, Vienna, Austria. 102Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 103Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. 104Breast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. 105Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. 106Department of Clinical Genetics, Odense University Hospital, Odence C, Denmark. 107Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 108Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada. 109Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge. Vol Box 134, Level 6 Addenbrooke's Treatment Centre, Addenbrooke's Hosptital, Cambridge, UK. 110Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA. 111Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA. 112Department of Genetics, University of Pretoria, Arcadia, South Africa. 113Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain. 114Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain. 115Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. 116Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 117Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. 118Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands. 119Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. mk.schmidt@nki.nl. 120Division of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. mk.schmidt@nki.nl. 121Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands. mk.schmidt@nki.nl. #Contributed equally.

المصدر: Genetics in medicine : official journal of the American College of Medical Genetics ; 23 ; 9 ; 1726 ; 1737 ; United Kingdom ; United States ; Canada

مصطلحات موضوعية: Brjóstakrabbamein, Gen, BRCA1 Protein, BRCA2 Protein, Breast Neoplasms, Risk Factors

العلاقة: https://www.nature.com/articles/s41436-021-01198-7Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460445Test/; Lakeman IMM, van den Broek AJ, Vos JAM, Barnes DR, Adlard J, Andrulis IL, Arason A, Arnold N, Arun BK, Balmaña J, Barrowdale D, Benitez J, Borg A, Caldés T, Caligo MA, Chung WK, Claes KBM; GEMO Study Collaborators; EMBRACE Collaborators, Collée JM, Couch FJ, Daly MB, Dennis J, Dhawan M, Domchek SM, Eeles R, Engel C, Evans DG, Feliubadaló L, Foretova L, Friedman E, Frost D, Ganz PA, Garber J, Gayther SA, Gerdes AM, Godwin AK, Goldgar DE, Hahnen E, Hake CR, Hamann U, Hogervorst FBL, Hooning MJ, Hopper JL, Hulick PJ, Imyanitov EN; OCGN Investigators; HEBON Investigators; KconFab Investigators, Isaacs C, Izatt L, Jakubowska A, James PA, Janavicius R, Jensen UB, Jiao Y, John EM, Joseph V, Karlan BY, Kets CM, Konstantopoulou I, Kwong A, Legrand C, Leslie G, Lesueur F, Loud JT, Lubiński J, Manoukian S, McGuffog L, Miller A, Gomes DM, Montagna M, Mouret-Fourme E, Nathanson KL, Neuhausen SL, Nevanlinna H, Yie JNY, Olah E, Olopade OI, Park SK, Parsons MT, Peterlongo P, Piedmonte M, Radice P, Rantala J, Rennert G, Risch HA, Schmutzler RK, Sharma P, Simard J, Singer CF, Stadler Z, Stoppa-Lyonnet D, Sutter C, Tan YY, Teixeira MR, Teo SH, Teulé A, Thomassen M, Thull DL, Tischkowitz M, Toland AE, Tung N, van Rensburg EJ, Vega A, Wappenschmidt B, Devilee P, van Asperen CJ, Bernstein JL, Offit K, Easton DF, Rookus MA, Chenevix-Trench G, Antoniou AC, Robson M, Schmidt MK. The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant. Genet Med. 2021 Sep;23(9):1726-1737. doi:10.1038/s41436-021-01198-7.; http://hdl.handle.net/2336/621933Test; Genetics in medicine : official journal of the American College of Medical Genetics

الإتاحة: https://doi.org/10.1038/s41436-021-01198-7Test
http://hdl.handle.net/2336/621933Test

المؤلفون: Coignard, Juliette, Lush, Michael, Beesley, Jonathan, O'Mara, Tracy A, Dennis, Joe, Tyrer, Jonathan P, Barnes, Daniel R, McGuffog, Lesley, Leslie, Goska, Bolla, Manjeet K, Adank, Muriel A, Agata, Simona, Ahearn, Thomas, Aittomäki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Arnold, Norbert, Aronson, Kristan J, Arun, Banu K, Augustinsson, Annelie, Azzollini, Jacopo, Barrowdale, Daniel, Baynes, Caroline, Becher, Heiko, Bermisheva, Marina, Bernstein, Leslie, Białkowska, Katarzyna, Blomqvist, Carl, Bojesen, Stig E, Bonanni, Bernardo, Borg, Ake, Brauch, Hiltrud, Brenner, Hermann, Burwinkel, Barbara, Buys, Saundra S, Caldés, Trinidad, Caligo, Maria A, Campa, Daniele, Carter, Brian D, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Chung, Wendy K, Claes, Kathleen B M, Clarke, Christine L, Collée, J Margriet, Conroy, Don M, Czene, Kamila, Daly, Mary B, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Domchek, Susan M, Dörk, Thilo, Dos-Santos-Silva, Isabel, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Eliassen, A Heather, Engel, Christoph, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Flyger, Henrik, Fostira, Florentia, Friedman, Eitan, Fritschi, Lin, Frost, Debra, Gago-Dominguez, Manuela, Gapstur, Susan M, Garber, Judy, Garcia-Barberan, Vanesa, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, Gayther, Simon A, Gehrig, Andrea, Georgoulias, Vassilios, Giles, Graham G, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, Gonzalez Neira, Anna, Greene, Mark H, Guénel, Pascal, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Harrington, Patricia A, Hart, Steven N, He, Wei, Hogervorst, Frans B L, Hollestelle, Antoinette, Hopper, John L, Horcasitas, Darling J, Hulick, Peter J, Hunter, David J, Imyanitov, Evgeny N, Jager, Agnes, Jakubowska, Anna, James, Paul A, Jensen, Uffe Birk, John, Esther M, Jones, Michael E, Kaaks, Rudolf, Kapoor, Pooja Middha, Karlan, Beth Y, Keeman, Renske, Khusnutdinova, Elza, Kiiski, Johanna I, Ko, Yon-Dschun, Kosma, Veli-Matti, Kraft, Peter, Kurian, Allison W, Laitman, Yael, Lambrechts, Diether, Le Marchand, Loic, Lester, Jenny, Lesueur, Fabienne, Lindstrom, Tricia, Lopez-Fernández, Adria, Loud, Jennifer T, Luccarini, Craig, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Martens, John W M, Mebirouk, Noura, Meindl, Alfons, Miller, Austin, Milne, Roger L, Montagna, Marco, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nielsen, Finn C, O'Brien, Katie M, Olopade, Olufunmilayo I, Olson, Janet E, Olsson, Håkan, Osorio, Ana, Ottini, Laura, Park-Simon, Tjoung-Won, Parsons, Michael T, Pedersen, Inge Sokilde, Peshkin, Beth, Peterlongo, Paolo, Peto, Julian, Pharoah, Paul D P, Phillips, Kelly-Anne, Polley, Eric C, Poppe, Bruce, Presneau, Nadege, Pujana, Miquel Angel, Punie, Kevin, Radice, Paolo, Rantala, Johanna, Rashid, Muhammad U, Rennert, Gad, Rennert, Hedy S, Robson, Mark, Romero, Atocha, Rossing, Maria, Saloustros, Emmanouil, Sandler, Dale P, Santella, Regina, Scheuner, Maren T, Schmidt, Marjanka K, Schmidt, Gunnar, Scott, Christopher, Sharma, Priyanka, Soucy, Penny, Southey, Melissa C, Spinelli, John J, Steinsnyder, Zoe, Stone, Jennifer, Stoppa-Lyonnet, Dominique, Swerdlow, Anthony, Tamimi, Rulla M, Tapper, William J, Taylor, Jack A, Terry, Mary Beth, Teulé, Alex, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Trainer, Alison H, Truong, Thérèse, Tung, Nadine, Vachon, Celine M, Vega, Ana, Vijai, Joseph, Wang, Qin, Wappenschmidt, Barbara, Weinberg, Clarice R, Wendt, Camilla, Weitzel, Jeffrey N, Wolk, Alicja, Yadav, Siddhartha, Yang, Xiaohong R, Yannoukakos, Drakoulis, Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K, Park, Sue K, Thomassen, Mads, Offit, Kenneth, Schmutzler, Rita K, Couch, Fergus J, Simard, Jacques, Chenevix-Trench, Georgia, Easton, Douglas F, Andrieu, Nadine, Antoniou, Antonis C

المساهمون: German Cancer Research Center, National Health and Medical Research Council (Australia), United States Department of Health and Human Services, National Institute for Health Research (Reino Unido), French National Cancer Institute, Ligue Nationale Contre le Cancer (Francia), Cancer Research UK (Reino Unido), Unión Europea. Comisión Europea, Canadian Institutes of Health Research, Cancer Council New South Wales (Australia), Dutch Cancer Society (Holanda), Instituto de Salud Carlos III, Xunta de Galicia (España), Ministerio de Sanidad, Política Social e Igualdad (España), Helmholtz Association, California Breast Cancer Research Program, Federal Ministry of Education & Research (Alemania), Government of Netherlands, Russian Foundation for Basic Research

مصطلحات موضوعية: Polymorphism, Single Nucleotide, Adult, Alleles, BRCA1 Protein, BRCA2 Protein, Breast Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Linkage Disequilibrium, Middle Aged, Mutation, Quantitative Trait Loci, Risk Factors

العلاقة: Nat Commun. 2021;12(1):1078.; http://hdl.handle.net/20.500.12105/13240Test; Nature communications

الإتاحة: https://doi.org/20.500.12105/13240Test
https://doi.org/10.1038/s41467-020-20496-3Test
https://hdl.handle.net/20.500.12105/13240Test

المؤلفون: Barnes, Daniel R, Rookus, Matti A, McGuffog, Lesley, Leslie, Goska, Mooij, Thea M, Dennis, Joe, Mavaddat, Nasim, Adlard, Julian, Ahmed, Munaza, Aittomäki, Kristiina, Andrieu, Nadine, Andrulis, Irene L, Arnold, Norbert, Arun, Banu K, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barrowdale, Daniel, Benitez, Javier, Berthet, Pascaline, Białkowska, Katarzyna, Blanco, Amie M, Blok, Marinus J, Bonanni, Bernardo, Boonen, Susanne E, Borg, Åke, Bozsik, Aniko, Bradbury, Angela R, Brennan, Paul, Brewer, Carole, Brunet, Joan, Buys, Saundra S, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Christensen, Lise Lotte, Chung, Wendy K, Claes, Kathleen B M, Colas, Chrystelle, Collonge-Rame, Marie-Agnès, Cook, Jackie, Daly, Mary B, Davidson, Rosemarie, de la Hoya, Miguel, de Putter, Robin, Delnatte, Capucine, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Domchek, Susan M, Dorfling, Cecilia M, Dumont, Martine, Eeles, Ros, Ejlertsen, Bent, Engel, Christoph, Evans, D Gareth, Faivre, Laurence, Foretova, Lenka, Fostira, Florentia, Friedlander, Michael, Friedman, Eitan, Frost, Debra, Ganz, Patricia A, Garber, Judy, Gehrig, Andrea, Gerdes, Anne-Marie, Gesta, Paul, Giraud, Sophie, Glendon, Gord, Godwin, Andrew K, Goldgar, David E, González-Neira, Anna, Greene, Mark H, Gschwantler-Kaulich, Daphne, Hahnen, Eric, Hamann, Ute, Hanson, Helen, Hentschel, Julia, Hogervorst, Frans B L, Hooning, Maartje J, Horvath, Judit, Hu, Chunling, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Izatt, Louise, Izquierdo, Angel, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, John, Esther M, Joseph, Vijai, Karlan, Beth Y, Kast, Karin, Koudijs, Marco, Kruse, Torben A, Kwong, Ava, Laitman, Yael, Lasset, Christine, Lazaro, Conxi, Lester, Jenny, Lesueur, Fabienne, Liljegren, Annelie, Loud, Jennifer T, Lubiński, Jan, Mai, Phuong L, Manoukian, Siranoush, Mari, Véronique, Mebirouk, Noura, Meijers-Heijboer, Hanne E J, Meindl, Alfons, Mensenkamp, Arjen R, Miller, Austin, Montagna, Marco, Mouret-Fourme, Emmanuelle, Mukherjee, Semanti, Mulligan, Anna Marie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Niederacher, Dieter, Nielsen, Finn Cilius, Nikitina-Zake, Liene, Noguès, Catherine, Olah, Edith, Olopade, Olufunmilayo I, Ong, Kai-ren, O'Shaughnessy-Kirwan, Aoife, Osorio, Ana, Ott, Claus-Eric, Papi, Laura, Park, Sue K, Parsons, Michael T, Pedersen, Inge Sokilde, Peissel, Bernard, Peixoto, Ana, Peterlongo, Paolo, Pfeiler, Georg, Phillips, Kelly-Anne, Prajzendanc, Karolina, Pujana, Miquel Angel, Radice, Paolo, Ramser, Juliane, Ramus, Susan J, Rantala, Johanna, Rennert, Gad, Risch, Harvey A, Robson, Mark, Rønlund, Karina, Salani, Ritu, Schuster, Hélène, Senter, Leigha, Shah, Payal D, Sharma, Priyanka, Side, Lucy E, Singer, Christian F, Slavin, Thomas P, Soucy, Penny, Southey, Melissa C, Spurdle, Amanda B, Steinemann, Doris, Steinsnyder, Zoe, Stoppa-Lyonnet, Dominique, Sutter, Christian, Tan, Yen Yen, Teixeira, Manuel R, Teo, Soo Hwang, Thull, Darcy L, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda E, Trainer, Alison H, Tung, Nadine, van Engelen, Klaartje, van Rensburg, Elizabeth J, Vega, Ana, Vierstraete, Jeroen, Wagner, Gabriel, Walker, Lisa, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weitzel, Jeffrey N, Yadav, Siddhartha, Yang, Xin, Yannoukakos, Drakoulis, Zimbalatti, Dario, Offit, Kenneth, Thomassen, Mads, Couch, Fergus J, Schmutzler, Rita K, Simard, Jacques, Easton, Douglas F, Chenevix-Trench, Georgia, Antoniou, Antonis C

المساهمون: 1Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. drb54@medschl.cam.ac.uk. 2The Netherlands Cancer Institute, Department of Epidemiology (PSOE), Amsterdam, The Netherlands. 3Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 4Chapel Allerton Hospital, Yorkshire Regional Genetics Service, Leeds, UK. 5Great Ormond Street Hospital for Children NHS Trust, North East Thames Regional Genetics Service, London, UK. 6University of Helsinki, Department of Clinical Genetics, Helsinki University Hospital, Helsinki, Finland. 7Inserm U900, Genetic Epidemiology of Cancer team, Paris, France. 8Institut Curie, Paris, France. 9Mines ParisTech, Fontainebleau, France. 10Department of Life & Health Sciences, PSL University, Paris, France. 11Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, Canada. 12University of Toronto, Department of Molecular Genetics, Toronto, ON, Canada. 13University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Department of Gynaecology and Obstetrics, Kiel, Germany. 14University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany. 15University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology, Houston, TX, USA. 16Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Unit of Medical Genetics, Department of Medical Oncology and Hematology, Milan, Italy. 17Vall d'Hebron Institute of Oncology, High Risk and Cancer Prevention Group, Barcelona, Spain. 18University Hospital of Vall d'Hebron, Department of Medical Oncology, Barcelona, Spain. 19Landspitali University Hospital, Department of Pathology, Reykjavik, Iceland. 20University of Iceland, BMC (Biomedical Centre), Faculty of Medicine, Reykjavik, Iceland. 21Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain. 22Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain. 23Centre François Baclesse, Département de Biopathologie, Caen, France. 24Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland. 25University of California San Francisco, Cancer Genetics and Prevention Program, San Francisco, CA, USA. 26Maastricht University Medical Center, Department of Clinical Genetics, Maastricht, The Netherlands. 27IEO, European Institute of Oncology IRCCS, Division of Cancer Prevention and Genetics, Milan, Italy. 28Zealand University Hospital, Clinical Genetic Unit, Department of Paediatrics, Roskilde, Denmark. 29Lund University, Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund, Sweden. 30National Institute of Oncology, Department of Molecular Genetics, Budapest, Hungary. 31Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Abramson Cancer Center, Philadelphia, PA, USA. 32Institute of Genetic Medicine, International Centre for Life, Northern Genetic Service, Newcastle upon Tyne, UK. 33Royal Devon & Exeter Hospital, Department of Clinical Genetics, Exeter, UK. 34ONCOBELL-IDIBELL-IDIBGI-IGTP, Catalan Institute of Oncology, CIBERONC, Hereditary Cancer Program, Barcelona, Spain. 35Huntsman Cancer Institute, Department of Medicine, Salt Lake City, UT, USA. 36CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Molecular Oncology Laboratory, Madrid, Spain. 37University Hospital, SOD Genetica Molecolare, Pisa, Italy. 38Peter MacCallum Cancer Center, Melbourne, VIC, Australia. 39The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC, Australia. 40Aarhus University Hospital, Department of Clinical Medicine,, Aarhus, Denmark. 41Columbia University, Departments of Pediatrics and Medicine, New York, NY, USA. 42Ghent University, Centre for Medical Genetics, Ghent, Belgium. 43Institut Curie, Service de Génétique, Paris, France. 44CHU de Besançon, Service de Génétique, Besançon, France. 45Sheffield Children's Hospital, Sheffield Clinical Genetics Service, Sheffield, UK. 46Fox Chase Cancer Center, Department of Clinical Genetics, Philadelphia, PA, USA. 47Queen Elizabeth University Hospitals, Department of Clinical Genetics, Glasgow, UK. 48CHU Nantes, Laboratoire de genetique moleculaire, Nantes, France. 49Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands. 50Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands. 51Vall dHebron Institute of Oncology (VHIO), Oncogenetics Group, Barcelona, Spain. 52University Hospital Vall dHebron, Clinical and Molecular Genetics Area, Barcelona, Spain. 53Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA. 54University of Pennsylvania, Basser Center for BRCA, Abramson Cancer Center, Philadelphia, PA, USA. 55University of Pretoria, Department of Genetics, Arcadia, South Africa. 56Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Genomics Center,, Québec City, QC, Canada. 57The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Oncogenetics Team, London, UK. 58Rigshospitalet, Copenhagen University Hospital, Department of Oncology, Copenhagen, Denmark. 59University of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany. 60The University of Manchester, Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St. Mary's Hospital, Genomic Medicine, Division of Evolution and Genomic Sciences, Manchester, UK. 61Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St. Mary's Hospital, Genomic Medicine, North West Genomics hub, Manchester, UK. 62Centre Georges-François Leclerc, Unité d'oncogénétique, Centre de Lutte Contre le Cancer, Dijon, France. 63DHU Dijon, Centre de Génétique, Dijon, France. 64Masaryk Memorial Cancer Institute, Department of Cancer Epidemiology and Genetics, Brno, Czech Republic. 65National Centre for Scientific Research 'Demokritos', Molecular Diagnostics Laboratory, INRASTES, Athens, Greece. 66NHMRC Clinical Trials, ANZ GOTG Coordinating Centre, Camperdown, NSW, Australia. 67Chaim Sheba Medical Center, The Susanne Levy Gertner Oncogenetics Unit, Ramat Gan, Israel. 68Tel Aviv University, Sackler Faculty of Medicine, Ramat Aviv, Israel. 69Jonsson Comprehensive Cancer Centre, UCLA, Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Los Angeles, CA, USA. 70Dana-Farber Cancer Institute, Cancer Risk and Prevention Clinic, Boston, MA, USA. 71University Würzburg, Department of Human Genetics, Würzburg, Germany. 72Rigshospitalet, Copenhagen University Hospital, Department of Clinical Genetics, Copenhagen, Denmark. 73CH Niort, Service Régional Oncogénétique Poitou-Charentes, Niort, France. 74Hospices Civils de Lyon, Department of Genetics, Bron, France. 75University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS, USA. 76Huntsman Cancer Institute, University of Utah School of Medicine, Department of Dermatology, Salt Lake City, UT, USA. 77Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. 78Medical University of Vienna, Dept of OB/GYN, Vienna, Austria. 79Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Familial Breast and Ovarian Cancer, Cologne, Germany. 80Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Integrated Oncology (CIO), Cologne, Germany. 81German Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany. 82St George's NHS Foundation Trust, Southwest Thames Regional Genetics Service, London, UK. 83University Hospital Leipzig, Institute of Human Genetics, Leipzig, Germany. 84The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Family Cancer Clinic, Amsterdam, The Netherlands. 85Erasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands. 86University of Münster, Institute of Human Genetics, Münster, Germany. 87Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, USA. 88NorthShore University HealthSystem, Center for Medical Genetics, Evanston, IL, USA. 89The University of Chicago Pritzker School of Medicine, Chicago, IL, USA. 90N.N. Petrov Institute of Oncology, St. Petersburg, Russia. 91Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. 92Guy's and St Thomas' NHS Foundation Trust, Clinical Genetics, London, UK. 93Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, Poland. 94Peter MacCallum Cancer Center, Parkville Familial Cancer Centre, Melbourne, VIC, Australia. 95Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania. 96State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. 97Stanford Cancer Institute, Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA, USA. 98Memorial Sloan-Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY, USA. 99University of California at Los Angeles, David Geffen School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, CA, USA. 100Cedars-Sinai Medical Center, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA. 101Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 102University Medical Center Utrecht, Department of Medical Genetics, Utrecht, The Netherlands. 103Odense University Hospital, Department of Clinical Genetics, Odense, Denmark. 104Cancer Genetics Centre, Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong. 105The University of Hong Kong, Department of Surgery, Pok Fu Lam, Hong Kong. 106Hong Kong Sanatorium and Hospital, Department of Surgery, Happy Valley, Hong Kong. 107Centre Léon Bérard, Unité de Prévention et d'Epidémiologie Génétique, Lyon, France. 108Lyon University, UMR CNRS 5558, Lyon, France. 109Karolinska Institutet, Department of Oncology, Stockholm, Sweden. 110Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 111Centre Antoine Lacassagne, Département d'Hématologie-Oncologie Médicale, Nice, France. 112Amsterdam UMC, location AMC, Department of Clinical Genetics, Amsterdam, The Netherlands. 113University of Munich, Campus Großhadern, Department of Gynecology and Obstetrics, Munich, Germany. 114Radboud University Medical Center, Department of Human Genetics, Nijmegen, The Netherlands. 115Roswell Park Cancer Institute, NRG Oncology, Statistics and Data Management Center, Buffalo, NY, USA. 116Veneto Institute of Oncology IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy. 117Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, USA. 118University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada. 119University Health Network, Laboratory Medicine Program, Toronto, ON, Canada. 120University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland. 121University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Department of Gynecology and Obstetrics, Düsseldorf, Germany. 122Rigshospitalet, Copenhagen University Hospital, Center for Genomic Medicine, Copenhagen, Denmark. 123Latvian Biomedical Research and Study Centre, Riga, Latvia. 124Oncogénétique Clinique and Aix Marseille Univ, INSERM, IRD, SESSTIM, Institut Paoli-Calmettes, Département d'Anticipation et de Suivi des Cancers, Marseille, France. 125The University of Chicago, Center for Clinical Cancer Genetics, Chicago, IL, USA. 126Birmingham Women's Hospital Healthcare NHS Trust, West Midlands Regional Genetics Service, Birmingham, UK. 127Cambridge University Hospitals NHS Foundation Trust, East Anglian Medical Genetics Service, Cambridge, UK. 128Campus Virchov Klinikum, Charite, Institute of Human Genetics, Berlin, Germany. 129University of Florence, Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, Florence, Italy. 130Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, Korea. 131Seoul National University Graduate School, Department of Biomedical Sciences, Seoul, Korea. 132Seoul National University, Cancer Research Institute, Seoul, Korea. 133QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD, Australia. 134Aalborg University Hospital, Molecular Diagnostics, Aalborg, Denmark. 135Aalborg University Hospital, Clinical Cancer Research Center, Aalborg, Denmark. 136Aalborg University, Department of Clinical Medicine, Aalborg, Denmark. 137Portuguese Oncology Institute, Department of Genetics, Porto, Portugal. 138IFOM - the FIRC Institute of Molecular Oncology, Genome Diagnostics Program, Milan, Italy. 139Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria. 140The University of Melbourne, Department of Medicine, St Vincent's Hospital, Fitzroy, VIC, Australia. 141The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC, Australia. 142IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, ProCURE, Barcelona, Spain. 143Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy. 144Klinikum rechts der Isar der Technischen Universität München, Department of Gynaecology and Obstetrics, Munich, Germany. 145University of NSW Sydney, School of Women's and Children's Health, Faculty of Medicine, Sydney, NSW, Australia. 146The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia. 147University of NSW Sydney, Adult Cancer Program, Lowy Cancer Research Centre, Sydney, NSW, Australia. 148Karolinska Institutet, Clinical Genetics, Stockholm, Sweden. 149Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel. 150Yale School of Medicine, Chronic Disease Epidemiology, New Haven, CT, USA. 151Region of Southern Denmark, Vejle Hospital, Department of Clinical Genetics, Vejle, Denmark. 152Wexner Medical Center, The Ohio State University, Department of Gynecology and Obstetrics, Columbus, OH, USA. 153Unité d'Oncogénétique Centre de Lutte contre le Cancer Paul Strauss, Strasbourg, France. 154Institut de Cancérologie Strasbourg Europe, ICANS, Strasbourg, France. 155Université de Strasbourg, Laboratoire d'ImmunoRhumatologie Moléculaire, Plateforme GENOMAX, INSERM UMR_S 1109, LabEx TRANSPLANTEX, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Faculté de Médecine, Strasbourg, France. 156The Ohio State University, Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, Columbus, OH, USA. 157University of Kansas Medical Center, Department of Internal Medicine, Division of Medical Oncology, Westwood, KS, USA. 158Princess Anne Hospital, Southampton, UK. 159City of Hope, Clinical Cancer Genomics, Duarte, CA, USA. 160Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC, Australia. 161The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC, Australia. 162Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC, Australia. 163Hannover Medical School, Institute of Human Genetics, Hannover, Germany. 164INSERM U830, Department of Tumour Biology, Paris, France. 165Université Paris Descartes, Paris, France. 166University Hospital Heidelberg, Institute of Human Genetics, Heidelberg, Germany. 167University of Porto, Biomedical Sciences Institute (ICBAS), Porto, Portugal. 168Cancer Research Malaysia, Breast Cancer Research Programme, Subang Jaya, Selangor, Malaysia. 169University of Malaya, Department of Surgery, Faculty of Medicine, Kuala Lumpur, Malaysia. 170Magee-Womens Hospital, University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA, USA. 171McGill University, Program in Cancer Genetics, Departments of Human Genetics and Oncology, Montréal, QC, Canada. 172University of Cambridge, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, UK. 173The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, USA. 174University Of Melbourne, Department of Medicine, Melbourne, VIC, Australia. 175Beth Israel Deaconess Medical Center, Department of Medical Oncology, Boston, MA, USA. 176Amsterdam UMC, location VUmc, Department of Clinical Genetics, Amsterdam, The Netherlands. 177Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain. 178Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain. 179Oxford University Hospitals, Oxford Centre for Genomic Medicine, Oxford, UK. 180University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, Germany. 181Mayo Clinic, Department of Oncology, Rochester, MN, USA. 182Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany. 183Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

المصدر: Genetics in medicine : official journal of the American College of Medical Genetics ; United States

مصطلحات موضوعية: BRCA1/2, PRS, breast cancer, genetics, ovarian cancer, Brjóstakrabbamein, Eggjastokkar, Gen, Breast Neoplasms, Genes, BRCA1, BRCA2, Ovarian Neoplasms

العلاقة: https://www.nature.com/articles/s41436-020-0862-xTest; Barnes DR, Rookus MA, McGuffog L, et al. Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants [published online ahead of print, 2020 Jul 15]. Genet Med. 2020;10.1038/s41436-020-0862-x. doi:10.1038/s41436-020-0862-x; http://hdl.handle.net/2336/621505Test; Genetics in medicine : official journal of the American College of Medical Genetics

الإتاحة: https://doi.org/10.1038/s41436-020-0862-xTest
http://hdl.handle.net/2336/621505Test

المؤلفون: Feng, Helian, Gusev, Alexander, Pasaniuc, Bogdan, Wu, Lang, Long, Jirong, Abu-Full, Zomoroda, Aittomäki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Arason, Adalgeir, Arndt, Volker, Aronson, Kristan J, Arun, Banu K, Asseryanis, Ella, Auer, Paul L, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barnes, Daniel R, Barrowdale, Daniel, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Białkowska, Katarzyna, Blanco, Ana, Blomqvist, Carl, Boeckx, Bram, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Borg, Ake, Brauch, Hiltrud, Brenner, Hermann, Briceno, Ignacio, Broeks, Annegien, Brüning, Thomas, Burwinkel, Barbara, Cai, Qiuyin, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Canisius, Sander, Campa, Daniele, Carter, Brian D, Carter, Jonathan, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Christiansen, Hans, Chung, Wendy K, Claes, Kathleen B M, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, de la Hoya, Miguel, De Leeneer, Kim, Dennis, Joe, Devilee, Peter, Diez, Orland, Domchek, Susan M, Dörk, Thilo, Dos-Santos-Silva, Isabel, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Ejlertsen, Bent, Ellberg, Carolina, Engel, Christoph, Eriksson, Mikael, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Fostira, Florentia, Friedman, Eitan, Fritschi, Lin, Frost, Debra, Gabrielson, Marike, Ganz, Patricia A, Gapstur, Susan M, Garber, Judy, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Greene, Mark H, Gronwald, Jacek, Guénel, Pascal, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hake, Christopher, He, Wei, Heyworth, Jane, Hogervorst, Frans B L, Hollestelle, Antoinette, Hooning, Maartje J, Hoover, Robert N, Hopper, John L, Huang, Guanmengqian, Hulick, Peter J, Humphreys, Keith, Imyanitov, Evgeny N, Isaacs, Claudine, Jakimovska, Milena, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Jankowitz, Rachel C, John, Esther M, Johnson, Nichola, Joseph, Vijai, Jung, Audrey, Karlan, Beth Y, Khusnutdinova, Elza, Kiiski, Johanna I, Konstantopoulou, Irene, Kristensen, Vessela N, Laitman, Yael, Lambrechts, Diether, Lazaro, Conxi, Leroux, Dominique, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Lindor, Noralane, Lindström, Sara, Lo, Wing-Yee, Loud, Jennifer T, Lubiński, Jan, Makalic, Enes, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martens, John W M, Martinez, Maria E, Matricardi, Laura, Maurer, Tabea, Mavroudis, Dimitrios, McGuffog, Lesley, Meindl, Alfons, Menon, Usha, Michailidou, Kyriaki, Kapoor, Pooja M, Miller, Austin, Montagna, Marco, Moreno, Fernando, Moserle, Lidia, Mulligan, Anna M, Muranen, Taru A, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nevelsteen, Ines, Nielsen, Finn C, Nikitina-Zake, Liene, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Olsson, Håkan, Osorio, Ana, Papp, Janos, Park-Simon, Tjoung-Won, Parsons, Michael T, Pedersen, Inge S, Peixoto, Ana, Peterlongo, Paolo, Peto, Julian, Pharoah, Paul D P, Phillips, Kelly-Anne, Plaseska-Karanfilska, Dijana, Poppe, Bruce, Pradhan, Nisha, Prajzendanc, Karolina, Presneau, Nadege, Punie, Kevin, Pylkäs, Katri, Radice, Paolo, Rantala, Johanna, Rashid, Muhammad Usman, Rennert, Gad, Risch, Harvey A, Robson, Mark, Romero, Atocha, Saloustros, Emmanouil, Sandler, Dale P, Santos, Catarina, Sawyer, Elinor J, Schmidt, Marjanka K, Schmidt, Daniel F, Schmutzler, Rita K, Schoemaker, Minouk J, Scott, Rodney J, Sharma, Priyanka, Shu, Xiao-Ou, Simard, Jacques, Singer, Christian F, Skytte, Anne-Bine, Soucy, Penny, Southey, Melissa C, Spinelli, John J, Spurdle, Amanda B, Stone, Jennifer, Swerdlow, Anthony J, Tapper, William J, Taylor, Jack A, Teixeira, Manuel R, Terry, Mary Beth, Teulé, Alex, Thomassen, Mads, Thöne, Kathrin, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Tollenaar, Rob A E M, Torres, Diana, Truong, Thérèse, Tung, Nadine, Vachon, Celine M, van Asperen, Christi J, van den Ouweland, Ans M W, van Rensburg, Elizabeth J, Vega, Ana, Viel, Alessandra, Vieiro-Balo, Paula, Wang, Qin, Wappenschmidt, Barbara, Weinberg, Clarice R, Weitzel, Jeffrey N, Wendt, Camilla, Winqvist, Robert, Yang, Xiaohong R, Yannoukakos, Drakoulis, Ziogas, Argyrios, Milne, Roger L, Easton, Douglas F, Chenevix-Trench, Georgia, Zheng, Wei, Kraft, Peter, Jiang, Xia

المساهمون: 1Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 2Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 3Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 4Dana-Farber Cancer Institute, Boston, Massachusetts. 5UCLA Path & Lab Med, Los Angeles, California. 6Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii. 7Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee. 8Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel. 9Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 10Fred A, Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. 11Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. 12Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, California. 13Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 14Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland. 15BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 16Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. 17Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, Ontario, Canada. 18Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. 19Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 20Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington. 21Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin. 22Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. 23High Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain. 24Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany. 25Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 26Centro de Investigaci-n en Red de Enfermedades Raras (CIBERER), Madrid, Spain. 27Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. 28Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia. 29Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 30Fundaci-n Pœblica Galega Medicina Xen-mica, Santiago De Compostela, Spain. 31Instituto de Investigacion Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain. 32Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 33Department of Oncology, University Hospital, Karolinska Institute, Stockholm, Sweden. 34VIB Center for Cancer Biology, VIB, Leuven, Belgium. 35Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium. 36Department of Radiation Oncology, Hannover Medical School, Hannover, Germany. 37Gynaecology Research Unit, Hannover Medical School, Hannover, Germany. 38NN Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus. 39Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. 40Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. 41Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 42Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy. 43Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden. 44Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany. 45iFIT-Cluster of Excellence, University of Tuebingen, Tuebingen, Germany. 46German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. 47Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany. 48Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia. 49Medical Faculty, Universidad de La Sabana, Bogota, Colombia. 50Division of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 51Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany. 52Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. 53Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, Heidelberg, Germany. 54Medical Oncology Department, Hospital Cl'nico San Carlos, Instituto de Investigaci-n Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain. 55Section of Molecular Genetics, Dept, of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy. 56Research Department, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 57Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. 58Division of Molecular Carcinogenesis, The Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands. 59Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. 60Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia. 61Department of Gynaecological Oncology, Chris OÕBrien Lifehouse and The University of Sydney, Camperdown, New South Wales, Australia. 62Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain. 63Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 64Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 65Departments of Pediatrics and Medicine, Columbia University, New York, New York. 66Centre for Medical Genetics, Ghent University, Gent, Belgium. 67Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia. 68Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. 69Department of Oncology and Metabolism, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield, Sheffield, UK. 70Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK. 71Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 72Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania. 73Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. 74Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. 75Hereditary Cancer Genetics Group, Area of Clinical and Molecular Genetics, Vall dHebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Barcelona, Spain. 76Clinical and Molecular Genetics Area, University Hospital Vall dHebron, Barcelona, Spain. 77Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. 78Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK. 79Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. 80Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK. 81Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK. 82Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 83Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden. 84Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 85LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 86David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California. 87The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. 88Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. 89Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritosဩ, Athens, Greece. 90The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel. 91Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. 92School of Public Health, Curtin University, Perth, Western Australia, Australia. 93Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, California. 94Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts. 95Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK. 96Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia. 97Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. 98Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. 99Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kanas. 100Department of Medicine, McGill University, Montreal, Quebec, Canada. 101Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada. 102Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah. 103Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. 104Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France. 105Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. 106Department of Oncology, Sšdersjukhuset, Stockholm, Sweden. 107Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. 108City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California. 109School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia. 110Family Cancer Clinic, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 111Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. 112Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois. 113The University of Chicago Pritzker School of Medicine, Chicago, Illinois. 114NN Petrov Institute of Oncology, St. Petersburg, Russia. 115Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia. 116Research Centre for Genetic Engineering and Biotechnology 'Georgi D, Efremov', Macedonian Academy of Sciences and Arts, Skopje Republic of North Macedonia, North Macedonia. 117Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland. 118Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 119State Research Institute Innovative Medicine Center, Vilnius, Lithuania. 120Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 121Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California. 122Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York. 123David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, California. 124Department of Genetics and Fundamental Medicine, Bashkir State Medical University, Ufa, Russia. 125Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 126Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. 127Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. 128Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, Spain. 129Departement de Ge netique, CHU de Grenoble, Grenoble, France. 130Institut Curie, Paris, France. 131Mines ParisTech, Fontainebleau, France. 132Genetic Epidemiology of Cancer Team, Inserm U900, Paris, France. 133Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona. 134Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington. 135Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. 136Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland. 137Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland. 138Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland. 139Department of Clinical Science and Education, Sšdersjukhuset, Karolinska Institutet, Stockholm, Sweden. 140Moores Cancer Center, University of California San Diego, La Jolla, California. 141Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California. 142Immunology and Molecular Oncology Unit, Veneto Institute of Oncology ÊIOV-IRCCS, Padua, Italy. 143Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece. 144Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany. 145MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, UK. 146Department of Electron Microscopy/Molecular Pathology and The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus. 147Faculty of Medicine, University of Heidelberg, Heidelberg, Germany. 148NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York. 149Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. 150Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada. 151Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California. 152Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium. 153Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 154Latvian Biomedical Research and Study Centre, Riga, Latvia. 155Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York. 156Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 157Center for Clinical Cancer Genetics, The University of Chicago, Chicago, Illinois. 158Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 159Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark. 160Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 161Genome Diagnostics Program, IFOM-The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. 162Department of Medicine Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. 163Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland. 164Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland. 165Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy. 166Clinical Genetics, Karolinska Institutet, Stockholm, Sweden. 167Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC), Lahore, Pakistan. 168Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut. 169Medical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain. 170Department of Oncology, University Hospital of Larissa, Larissa, Greece. 171Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. 172Research Oncology, GuyÕs Hospital, King's College London, London, UK. 173Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. 174Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia. 175Center for Hereditary Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 176Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 177Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia. 178Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia. 179Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia. 180Department of Internal Medicine, Division of Medical Oncology, University of Kansas Medical Center, Westwood, Kanas. 181Genomics Center, Centre Hospitalier Universitaire de Quebec-Universite Laval, Research Center, Quebec City, Qubec, Canada. 182Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark. 183Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. 184Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia. 185Population Oncology, BC Cancer, Vancouver, British of Columbia, Canada. 186School of Population and Public Health, University of British Columbia, Vancouver, British of Columbia, Canada. 187The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, Western Australia, Australia. 188Division of Breast Cancer Research, The Institute of Cancer Research, London, UK. 189Faculty of Medicine, University of Southampton, Southampton, UK. 190Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. 191Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. 192Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. 193Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain. 194Department of Clinical Genetics, Odense University Hospital, Odence C, Denmark. 195Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 196Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada. 197Department of Medical Genetics, University of Cambridge, Cambridge, UK. 198Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio. 199Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands. 200Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts. 201Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota. 202Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. 203Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands. 204Department of Genetics, University of Pretoria, Arcadia, South Africa. 205Division of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy. 206Hospital Clínico Universitario (SERGAS), Universidad de Santiago de Compostela, CIMUS, Santiago de Compostela, España. 207Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina. 208Clinical Cancer Genomics, City of Hope, Duarte, California.

المصدر: Genetic epidemiology ; 44 ; 5 ; 442 ; 468 ; United Kingdom ; United States

مصطلحات موضوعية: GWAS, TWAS, breast cancer subtype, causal gene, Brjóstakrabbamein, Gen, Genome-Wide Association Study, Breast Neoplasms

العلاقة: Feng H, Gusev A, Pasaniuc B, et al. Transcriptome-wide association study of breast cancer risk by estrogen-receptor status. Genet Epidemiol. 2020;44(5):442-468. doi:10.1002/gepi.22288; http://hdl.handle.net/2336/621480Test; Genetic epidemiology

الإتاحة: https://doi.org/10.1002/gepi.22288Test
http://hdl.handle.net/2336/621480Test

المؤلفون: Fachal, Laura, Aschard, Hugues, Beesley, Jonathan, Barnes, Daniel R, Allen, Jamie, Kar, Siddhartha, Pooley, Karen A, Dennis, Joe, Michailidou, Kyriaki, Turman, Constance, Soucy, Penny, Lemaçon, Audrey, Lush, Michael, Tyrer, Jonathan P, Ghoussaini, Maya, Moradi Marjaneh, Mahdi, Jiang, Xia, Agata, Simona, Aittomäki, Kristiina, Alonso, M Rosario, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arason, Adalgeir, Arndt, Volker, Aronson, Kristan J, Arun, Banu K, Auber, Bernd, Auer, Paul L, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barrowdale, Daniel, Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Białkowska, Katarzyna, Blanco, Amie M, Blomqvist, Carl, Blot, William, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Borg, Ake, Bosse, Kristin, Brauch, Hiltrud, Brenner, Hermann, Briceno, Ignacio, Brock, Ian W, Brooks-Wilson, Angela, Brüning, Thomas, Burwinkel, Barbara, Buys, Saundra S, Cai, Qiuyin, Caldés, Trinidad, Caligo, Maria A, Camp, Nicola J, Campbell, Ian, Canzian, Federico, Carroll, Jason S, Carter, Brian D, Castelao, Jose E, Chiquette, Jocelyne, Christiansen, Hans, Chung, Wendy K, Claes, Kathleen B M, Clarke, Christine L, Collée, J Margriet, Cornelissen, Sten, Couch, Fergus J, Cox, Angela, Cross, Simon S, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, de la Hoya, Miguel, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Dite, Gillian S, Domchek, Susan M, Dörk, Thilo, Dos-Santos-Silva, Isabel, Droit, Arnaud, Dubois, Stéphane, Dumont, Martine, Duran, Mercedes, Durcan, Lorraine, Dwek, Miriam, Eccles, Diana M, Engel, Christoph, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Fletcher, Olivia, Floris, Giuseppe, Flyger, Henrik, Foretova, Lenka, Foulkes, William D, Friedman, Eitan, Fritschi, Lin, Frost, Debra, Gabrielson, Marike, Gago-Dominguez, Manuela, Gambino, Gaetana, Ganz, Patricia A, Gapstur, Susan M, Garber, Judy, García-Sáenz, José A, Gaudet, Mia M, Georgoulias, Vassilios, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Tibiletti, Maria Grazia, Greene, Mark H, Grip, Mervi, Gronwald, Jacek, Grundy, Anne, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Harrington, Patricia A, Hartikainen, Jaana M, Hartman, Mikael, He, Wei, Healey, Catherine S, Heemskerk-Gerritsen, Bernadette A M, Heyworth, Jane, Hillemanns, Peter, Hogervorst, Frans B L, Hollestelle, Antoinette, Hooning, Maartje J, Hopper, John L, Howell, Anthony, Huang, Guanmengqian, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Iwasaki, Motoki, Jager, Agnes, Jakimovska, Milena, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jankowitz, Rachel C, John, Esther M, Johnson, Nichola, Jones, Michael E, Jukkola-Vuorinen, Arja, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Kapoor, Pooja Middha, Karlan, Beth Y, Keeman, Renske, Kerin, Michael J, Khusnutdinova, Elza, Kiiski, Johanna I, Kirk, Judy, Kitahara, Cari M, Ko, Yon-Dschun, Konstantopoulou, Irene, Kosma, Veli-Matti, Koutros, Stella, Kubelka-Sabit, Katerina, Kwong, Ava, Kyriacou, Kyriacos, Laitman, Yael, Lambrechts, Diether, Lee, Eunjung, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Lindblom, Annika, Lo, Wing-Yee, Long, Jirong, Lophatananon, Artitaya, Loud, Jennifer T, Lubiński, Jan, MacInnis, Robert J, Maishman, Tom, Makalic, Enes, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martinez, Maria Elena, Matsuo, Keitaro, Maurer, Tabea, Mavroudis, Dimitrios, Mayes, Rebecca, McGuffog, Lesley, McLean, Catriona, Mebirouk, Noura, Meindl, Alfons, Miller, Austin, Miller, Nicola, Montagna, Marco, Moreno, Fernando, Muir, Kenneth, Mulligan, Anna Marie, Muñoz-Garzon, Victor M, Muranen, Taru A, Narod, Steven A, Nassir, Rami, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Neven, Patrick, Nielsen, Finn C, Nikitina-Zake, Liene, Norman, Aaron, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Olsson, Håkan, Orr, Nick, Osorio, Ana, Pankratz, V Shane, Papp, Janos, Park, Sue K, Park-Simon, Tjoung-Won, Parsons, Michael T, Paul, James, Pedersen, Inge Sokilde, Peissel, Bernard, Peshkin, Beth, Peterlongo, Paolo, Peto, Julian, Plaseska-Karanfilska, Dijana, Prajzendanc, Karolina, Prentice, Ross, Presneau, Nadege, Prokofyeva, Darya, Pujana, Miquel Angel, Pylkäs, Katri, Radice, Paolo, Ramus, Susan J, Rantala, Johanna, Rau-Murthy, Rohini, Rennert, Gad, Risch, Harvey A, Robson, Mark, Romero, Atocha, Rossing, Maria, Saloustros, Emmanouil, Sánchez-Herrero, Estela, Sandler, Dale P, Santamariña, Marta, Saunders, Christobel, Sawyer, Elinor J, Scheuner, Maren T, Schmidt, Daniel F, Schmutzler, Rita K, Schneeweiss, Andreas, Schoemaker, Minouk J, Schöttker, Ben, Schürmann, Peter, Scott, Christopher, Scott, Rodney J, Senter, Leigha, Seynaeve, Caroline M, Shah, Mitul, Sharma, Priyanka, Shen, Chen-Yang, Shu, Xiao-Ou, Singer, Christian F, Slavin, Thomas P, Smichkoska, Snezhana, Southey, Melissa C, Spinelli, John J, Spurdle, Amanda B, Stone, Jennifer, Stoppa-Lyonnet, Dominique, Sutter, Christian, Swerdlow, Anthony J, Tamimi, Rulla M, Tan, Yen Yen, Tapper, William J, Taylor, Jack A, Teixeira, Manuel R, Tengström, Maria, Teo, Soo Hwang, Terry, Mary Beth, Teulé, Alex, Thomassen, Mads, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Tollenaar, Rob A E M, Tomlinson, Ian, Torres, Diana, Torres-Mejía, Gabriela, Troester, Melissa A, Truong, Thérèse, Tung, Nadine, Tzardi, Maria, Ulmer, Hans-Ulrich, Vachon, Celine M, van Asperen, Christi J, van der Kolk, Lizet E, van Rensburg, Elizabeth J, Vega, Ana, Viel, Alessandra, Vijai, Joseph, Vogel, Maartje J, Wang, Qin, Wappenschmidt, Barbara, Weinberg, Clarice R, Weitzel, Jeffrey N, Wendt, Camilla, Wildiers, Hans, Winqvist, Robert, Wolk, Alicja, Wu, Anna H, Yannoukakos, Drakoulis, Zhang, Yan, Zheng, Wei, Hunter, David, Pharoah, Paul D P, Chang-Claude, Jenny, García-Closas, Montserrat, Schmidt, Marjanka K, Milne, Roger L, Kristensen, Vessela N, French, Juliet D, Edwards, Stacey L, Antoniou, Antonis C, Chenevix-Trench, Georgia, Simard, Jacques, Easton, Douglas F, Kraft, Peter, Dunning, Alison M

المساهمون: Véronique Mari, Pascaline Berthet, Laurent Castera, Dominique Vaur, Hakima Lallaoui, Yves-Jean Bignon, Nancy Uhrhammer, Valérie Bonadona, Christine Lasset, Françoise Révillion, Paul Vennin, Daniele Muller, Denise Molina Gomes, Olivier Ingster, Isabelle Coupier, Pascal Pujol, Marie-Agnès Collonge-Rame, Isabelle Mortemousque, Odile Bera, Mickaelle Rose, Amandine Baurand, Geoffrey Bertolone, Laurence Faivre, Hélène Dreyfus, Dominique Leroux, Laurence Venat-Bouvet, Stéphane Bézieau, Capucine Delnatte, Jean Chiesa, Brigitte Gilbert-Dussardier, Paul Gesta, Fabienne Prieur Prieur, Myriam Bronner, Johanna Sokolowska, Florence Coulet, Nadia Boutry-Kryza, Alain Calender, Sophie Giraud, Mélanie Leone, Sandra Fert-Ferrer, Dominique Stoppa-Lyonnet, Yue Jiao, Fabienne Lesueur Lesueur, Noura Mebirouk, Emmanuelle Barouk-Simonet, Virginie Bubien, Michel Longy, Nicolas Sevenet, Laurence Gladieff, Christine Toulas, Audrey Reimineras, Hagay Sobol, Brigitte Bressac-de Paillerets, Odile Cabaret, Olivier Caron, Marine Guillaud-Bataille, Etienne Rouleau, Muriel Belotti, Bruno Buecher, Sandrine Caputo, Chrystelle Colas, Antoine De Pauw, Emmanuelle Fourme, Marion Gauthier-Villars, Lisa Golmard, Virginie Moncoutier, Claire Saule, Alan Donaldson, Alex Murray, Angela Brady, Carole Brewer, Caroline Pottinger, Clare Miller, David Gallagher, Helen Gregory, Jackie Cook, Jacqueline Eason, Julian Adlard, Julian Barwell, Kai-Ren Ong, Katie Snape, Lisa Walker, Louise Izatt, Lucy Side, Marc Tischkowitz, Mark T Rogers, Mary E Porteous, Munaza Ahmed, Patrick J Morrison, Paul Brennan, Ros Eeles, Rosemarie Davidson, Adrienne Sexton, Alice Christian, Alison Trainer, Allan Spigelman, Andrew Fellows, Andrew Shelling, Anna De Fazio, Anneke Blackburn, Ashley Crook, Bettina Meiser, Briony Patterson, Christine Clarke, Christobel Saunders, Clare Hunt, Clare Scott, David Amor, Deb Marsh, Edward Edkins, Elizabeth Salisbury, Eric Haan, Eveline Neidermayr, Finlay Macrea, Gelareh Farshid, Geoff Lindeman, Georgia Trench, Graham Mann, Graham Giles, Grantley Gill, Heather Thorne, Ian Campbell, Ian Hickie, Ingrid Winship, James Flanagan, James Kollias, Jane Visvader, Jennifer Stone, Jessica Taylor, Jo Burke, Jodi Saunus, John Forbes, John Hopper, Jonathan Beesley, Judy Kirk, Juliet French, Kathy Tucker, Kathy Wu, Kelly Phillips, Lara Lipton, Leslie Andrews, Lizz Lobb, Logan Walker, Maira Kentwell, Mandy Spurdle, Margaret Cummings, Margaret Gleeson, Marion Harris, Mark Jenkins, Mary Anne Young, Martin Delatycki, Mathew Wallis, Matthew Burgess, Melanie Price, Melissa Brown, Melissa Southey, Michael Bogwitz, Michael Field, Michael Friedlander, Michael Gattas, Mona Saleh, Nick Hayward, Nick Pachter, Paul Cohen, Pascal Duijf, Paul James, Pete Simpson, Peter Fong, Phyllis Butow, Rachael Williams, Rick Kefford, Rodney Scott, Roger Milne, Rosemary Balleine, Sarah-Jane Dawson, Sheau Lok, Shona O'Connell, Sian Greening, Sophie Nightingale, Stacey Edwards, Stephen Fox, Sue-Anne McLachlan, Sunil Lakhani, Yoland Antill, Cora Aalfs, Hanne Meijers-Heijboer, Klaartje van Engelen, Hans Gille, Ingrid Boere, Margriet Collée, Carolien van Deurzen, Maartje Hooning, Inge-Marie Obdeijn, Ans van den Ouweland, Caroline Seynaeve, Sabine Siesling, Janneke Verloop, Christi van Asperen, Peter Devilee, Twiggy van Cronenburg, Rien Blok, Maaike de Boer, Encarna Gómez Garcia, Muriel Adank, Frans Hogervorst, Denise Jenner, Flora van Leeuwen, Matti Rookus, Nicola Russell, Marjanka Schmidt, Sandra van den Belt-Dusebout, Carolien Kets, Arjen Mensenkamp, Truuske de Bock, Annemieke van der Hout, Marian Mourits, Jan Oosterwijk, Margreet Ausems, Marco Koudijs, Christine Clarke, Deborah Marsh, Rodney Scott, Robert Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter Simpson, Dinny Graham, Mythily Sachchithananthan

المصدر: Nature genetics ; 52 ; 1 ; 56 ; 73 ; United Kingdom ; United States

مصطلحات موضوعية: Brjóstakrabbamein, Gen, Genome-Wide Association Study, Breast Neoplasms

العلاقة: https://www.nature.com/articles/s41588-019-0537-1Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974400Test/; Fachal L, Aschard H, Beesley J, et al. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nat Genet. 2020;52(1):56-73. doi:10.1038/s41588-019-0537-1; http://hdl.handle.net/2336/621477Test; Nature genetics

الإتاحة: https://doi.org/10.1038/s41588-019-0537-1Test
http://hdl.handle.net/2336/621477Test

المؤلفون: Ferreira, Manuel A, Gamazon, Eric R, Al-Ejeh, Fares, Aittomäki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Arason, Adalgeir, Arndt, Volker, Aronson, Kristan J, Arun, Banu K, Asseryanis, Ella, Azzollini, Jacopo, Balmaña, Judith, Barnes, Daniel R, Barrowdale, Daniel, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Białkowska, Katarzyna, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Borg, Ake, Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Burwinkel, Barbara, Caldés, Trinidad, Caligo, Maria A, Campa, Daniele, Campbell, Ian, Canzian, Federico, Carter, Jonathan, Carter, Brian D, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Christiansen, Hans, Chung, Wendy K, Claes, Kathleen B M, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, De la Hoya, Miguel, Dennis, Joe, Devilee, Peter, Diez, Orland, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Ejlertsen, Bent, Ellberg, Carolina, Engel, Christoph, Eriksson, Mikael, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Friedman, Eitan, Frost, Debra, Gabrielson, Marike, Gago-Dominguez, Manuela, Ganz, Patricia A, Gapstur, Susan M, Garber, Judy, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Greene, Mark H, Gronwald, Jacek, Guénel, Pascal, Haiman, Christopher A, Hall, Per, Hamann, Ute, He, Wei, Heyworth, Jane, Hogervorst, Frans B L, Hollestelle, Antoinette, Hoover, Robert N, Hopper, John L, Hulick, Peter J, Humphreys, Keith, Imyanitov, Evgeny N, Isaacs, Claudine, Jakimovska, Milena, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jankowitz, Rachel C, John, Esther M, Johnson, Nichola, Joseph, Vijai, Karlan, Beth Y, Khusnutdinova, Elza, Kiiski, Johanna I, Ko, Yon-Dschun, Jones, Michael E, Konstantopoulou, Irene, Kristensen, Vessela N, Laitman, Yael, Lambrechts, Diether, Lazaro, Conxi, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Lindström, Sara, Long, Jirong, Loud, Jennifer T, Lubiński, Jan, Makalic, Enes, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Maurer, Tabea, Mavroudis, Dimitrios, McGuffog, Lesley, Meindl, Alfons, Menon, Usha, Michailidou, Kyriaki, Miller, Austin, Montagna, Marco, Moreno, Fernando, Moserle, Lidia, Mulligan, Anna Marie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nevelsteen, Ines, Nielsen, Finn C, Nikitina-Zake, Liene, Nussbaum, Robert L, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Olsson, Håkan, Osorio, Ana, Papp, Janos, Park-Simon, Tjoung-Won, Parsons, Michael T, Pedersen, Inge Sokilde, Peixoto, Ana, Peterlongo, Paolo, Pharoah, Paul D P, Plaseska-Karanfilska, Dijana, Poppe, Bruce, Presneau, Nadege, Radice, Paolo, Rantala, Johanna, Rennert, Gad, Risch, Harvey A, Saloustros, Emmanouil, Sanden, Kristin, Sawyer, Elinor J, Schmidt, Marjanka K, Schmutzler, Rita K, Sharma, Priyanka, Shu, Xiao-Ou, Simard, Jacques, Singer, Christian F, Soucy, Penny, Southey, Melissa C, Spinelli, John J, Spurdle, Amanda B, Stone, Jennifer, Swerdlow, Anthony J, Tapper, William J, Taylor, Jack A, Teixeira, Manuel R, Terry, Mary Beth, Teulé, Alex, Thomassen, Mads, Thöne, Kathrin, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Truong, Thérèse, Tung, Nadine, Vachon, Celine M, van Asperen, Christi J, van den Ouweland, Ans M W, van Rensburg, Elizabeth J, Vega, Ana, Viel, Alessandra, Wang, Qin, Wappenschmidt, Barbara, Weitzel, Jeffrey N, Wendt, Camilla, Winqvist, Robert, Yang, Xiaohong R, Yannoukakos, Drakoulis, Ziogas, Argyrios, Kraft, Peter, Antoniou, Antonis C, Zheng, Wei, Easton, Douglas F, Milne, Roger L, Beesley, Jonathan, Chenevix-Trench, Georgia

المساهمون: 1 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. Manuel.Ferreira@qimr.edu.au. 2 Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, 37235, USA. 3 Clare Hall, University of Cambridge, Cambridge, CB3 9AL, UK. 4 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. 5 Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, 00290, Helsinki, Finland. 6 Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada. 7 Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. 8 Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA, 92617. 9 Department of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland. 10 BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland. 11 Division of Clinical Epidemiology and Aging Research, C070, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 12 Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON, K7L 3N6, Canada. 13 Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. 14 Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, 1090, Vienna, Austria. 15 Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133, Milan, Italy. 16 Oncogenetics Group, Vall dHebron Institute of Oncology (VHIO), 8035, Barcelona, Spain. 17 Department of Medical Oncology, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, 08035, Barcelona, Spain. 18 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. 19 Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, 91054, Erlangen, Germany. 20 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 21 Centro de Investigación en Red de Enfermedades Raras (CIBERER), 46010, Valencia, Spain. 22 Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain. 23 Institute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences, 450054, Ufa, Russia. 24 Department of Genetics and Pathology, Pomeranian Medical University, 71-252, Szczecin, Poland. 25 Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, 00290, Finland. 26 Department of Oncology, Örebro University Hospital, 70185, Örebro, Sweden. 27 Department of Radiation Oncology, Hannover Medical School, 30625, Hannover, Germany. 28 Gynaecology Research Unit, Hannover Medical School, 30625, Hannover, Germany. 29 N.N. Alexandrov Research Institute of Oncology and Medical Radiology, 223040, Minsk, Belarus. 30 Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark. 31 Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark. 32 Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark. 33 Department of Oncology, Lund University and Skåne University Hospital, 222 41, Lund, Sweden. 34 Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376, Stuttgart, Germany. 35 University of Tübingen, 72074, Tübingen, Germany. 36 German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 37 Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120, Heidelberg, Germany. 38 Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands. 39 Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 40 Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, 69120, Heidelberg, Germany. 41 Molecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), 28040, Madrid, Spain. 42 Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa, 56126, Pisa, Italy. 43 Department of Biology, University of Pisa, 56126, Pisa, Italy. 44 Research Department, Peter MacCallum Cancer Center, Melbourne, VIC, 3000, Australia. 45 Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, 3000, Australia. 46 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 47 Department of Gynaecological Oncology, Chris O'Brien Lifehouse and The University of Sydney, Camperdown, NSW, 2050, Australia. 48 Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA, 30303. 49 Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, 36312, Vigo, Spain. 50 Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. 51 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20850, USA. 52 Departments of Pediatrics and Medicine, Columbia University, New York, NY, 10032, USA. 53 Centre for Medical Genetics, Ghent University, Gent, 9000, Belgium. 54 Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, 2145, Australia. 55 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. 56 Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, S10 2TN, UK. 57 Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, S10 2TN, UK. 58 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65, Stockholm, Sweden. 59 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. 60 Department of Pathology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. 61 Department of Human Genetics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. 62 Clinical and Molecular Genetics Area, University Hospital Vall dHebron, Barcelona, 08035, Spain. 63 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK. 64 Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, W1B 2HW, UK. 65 Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK. 66 Department of Oncology, Rigshospitalet, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark. 67 Department of Cancer Epidemiology, Clinical Sciences, Lund University, 222 42, Lund, Sweden. 68 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany. 69 David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, 90095, USA. 70 The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW7 3RP, UK. 71 Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark. 72 The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, 52621, Ramat Gan, Israel. 73 Sackler Faculty of Medicine, Tel Aviv University, 69978, Ramat Aviv, Israel. 74 Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, 15706, Santiago de Compostela, Spain. 75 Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA. 76 Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, 90096-6900, USA. 77 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. 78 Division of Genetics and Epidemiology, Institute of Cancer Research, London, SM2 5NG, UK. 79 Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), 28040, Madrid, Spain. 80 Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC, 3004, Australia. 81 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3010, Australia. 82 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia. 83 Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, 66160, USA. 84 Department of Medicine, McGill University, Montréal, QC, H4A 3J1, Canada. 85 Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montréal, QC, H4A 3J1, Canada. 86 Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA. 87 Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20850-9772, USA. 88 Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, 94805, Villejuif, France. 89 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. 90 Department of Oncology, Södersjukhuset, 118 83, Stockholm, Sweden. 91 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 92 School of Population and Global Health, The University of Western Australia, Perth, WA, 6009, Australia. 93 Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands. 94 Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, 3015 CN, The Netherlands. 95 Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, 60201, USA. 96 The University of Chicago Pritzker School of Medicine, Chicago, IL, 60637, USA. 97 N.N. Petrov Institute of Oncology. St., Petersburg, 197758, Russia. 98 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20007, USA. 99 Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, 1000, Republic of Macedonia. 100 Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, 71-252, Poland. 101 Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, VIC, 3000, Australia. 102 Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, 08410, Lithuania. 103 Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15232, USA. 104 Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94304, USA. 105 Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA. 106 David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, 90095, USA. 107 Department of Genetics and Fundamental Medicine, Bashkir State Medical University, 450076, Ufa, Russia. 108 Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, 00290, Finland. 109 Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, 53177, Germany. 110 Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK. 111 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, 15310, Greece. 112 Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, 0379, Norway. 113 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 0450, Norway. 114 VIB Center for Cancer Biology, VIB, Leuven, 3001, Belgium. 115 Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, 3000, Belgium. 116 Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, 08908, Spain. 117 Genetic Epidemiology of Cancer team, Inserm U900, Paris, 75005, France. 118 Institut Curie, Paris, 75005, France. 119 Mines ParisTech, Fontainebleau, 77305, France. 120 Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, 98195, USA. 121 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. 122 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA. 123 Translational Cancer Research Area, University of Eastern Finland, Kuopio, 70210, Finland. 124 Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, 70210, Finland. 125 Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, 70210, Finland. 126 Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden. 127 Department of Medical Oncology, University Hospital of Heraklion, Heraklion, 711 10, Greece. 128 Department of Gynecology and Obstetrics, University of Munich, Campus Großhadern, Munich, 81377, Germany. 129 MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, WC1V 6LJ, UK. 130 Department of Electron Microscopy/Molecular Pathology and The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology & Genetics, Nicosia, 1683, Cyprus. 131 NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA. 132 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, 35128, Italy. 133 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A8, Canada. 134 Laboratory Medicine Program, University Health Network, Toronto, ON, M5G 2C4, Canada. 135 Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19066, USA. 136 Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA. 137 Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, 3000, Belgium. 138 Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, DK-2100, Denmark. 139 Latvian Biomedical Research and Study Centre, Riga, LV-1067, Latvia. 140 Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, 94143-1714, USA. 141 Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA. 142 Department of Molecular Genetics, National Institute of Oncology, Budapest, 1122, Hungary. 143 Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, 60637, USA. 144 Molecular Diagnostics, Aalborg University Hospital, Aalborg, 9000, Denmark. 145 Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, 9000, Denmark. 146 Department of Clinical Medicine, Aalborg University, Aalborg, 9000, Denmark. 147 Department of Genetics, Portuguese Oncology Institute, Porto, 4220-072, Portugal. 148 Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, 20139, Italy. 149 Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, 20133, Italy. 150 Clinical Genetics, Karolinska Institutet, Stockholm, 171 76, Sweden. 151 Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, 35254, Israel. 152 Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, 06510, USA. 153 Department of Oncology, University Hospital of Larissa, Larissa, 411 10, Greece. 154 City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, 91010, USA. 155 Research Oncology, Guy's Hospital, King's College London, London, SE1 9RT, UK. 156 Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands. 157 Center for Hereditary Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, 50937, Germany. 158 Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany. 159 Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, KS, 66205, USA. 160 Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Québec City, QC, G1V 4G2, Canada. 161 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia. 162 Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia. 163 Population Oncology, BC Cancer, Vancouver, BC, V5Z 1G1, Canada. 164 School of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. 165 The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, WA, 6000, Australia. 166 Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK. 167 Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA. 168 Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA. 169 Biomedical Sciences Institute (ICBAS), University of Porto, Porto, 4050-013, Portugal. 170 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA. 171 Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, CIBERONC, Barcelona, 08908, Spain. 172 Department of Clinical Genetics, Odense University Hospital, Odence C, 5000, Denmark. 173 Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. 174 Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, H4A 3J1, Canada. 175 Department of Medical Genetics, University of Cambridge, Cambridge, CB2 0QQ, UK. 176 Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, 43210, USA. 177 Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, 110231, Colombia. 178 Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA. 179 Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, 55905, USA. 180 Department of Clinical Genetics, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands. 181 Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, 3015 CN, The Netherlands. 182 Department of Genetics, University of Pretoria, Arcadia, 0007, South Africa. 183 Fundación Pública galega Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela, Spain. 184 Division of Functional onco-genomics and genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, 33081, Italy. 185 Clinical Cancer Genomics, City of Hope, Duarte, CA, 91010, USA. 186 Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, 90570, Finland. 187 Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, 90570, Finland. 188 Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA. 189 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

المصدر: Nature communications

مصطلحات موضوعية: Brjóstakrabbamein, Gen, Breast Neoplasms, Genome-Wide Association Study, Genetics

العلاقة: https://www.nature.com/articles/s41467-018-08053-5Test; Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. 2019, 10(1):1741. doi:10.1038/s41467-018-08053-5.; http://hdl.handle.net/2336/621016Test; Nature Communications

الإتاحة: https://doi.org/10.1038/s41467-018-08053-5Test
http://hdl.handle.net/2336/621016Test

المؤلفون: Ferreira, Manuel A, Gamazon, Eric R, Al-Ejeh, Fares, Aittomäki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Arason, Adalgeir, Arndt, Volker, Aronson, Kristan J, Arun, Banu K, Asseryanis, Ella, Azzollini, Jacopo, Balmaña, Judith, Barnes, Daniel R, Barrowdale, Daniel, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Białkowska, Katarzyna, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Borg, Ake, Brauch, Hiltrud, Brenner, Hermann, Broeks, Annegien, Burwinkel, Barbara, Caldés, Trinidad, Caligo, Maria A, Campa, Daniele, Campbell, Ian, Canzian, Federico, Carter, Jonathan, Carter, Brian D, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Christiansen, Hans, Chung, Wendy K, Claes, Kathleen B M, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, De la Hoya, Miguel, Dennis, Joe, Devilee, Peter, Diez, Orland, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Ejlertsen, Bent, Ellberg, Carolina, Engel, Christoph, Eriksson, Mikael, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Friedman, Eitan, Frost, Debra, Gabrielson, Marike, Gago-Dominguez, Manuela, Ganz, Patricia A, Gapstur, Susan M, Garber, Judy, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Greene, Mark H, Gronwald, Jacek, Guénel, Pascal, Haiman, Christopher A, Hall, Per, Hamann, Ute, He, Wei, Heyworth, Jane, Hogervorst, Frans B L, Hollestelle, Antoinette, Hoover, Robert N, Hopper, John L, Hulick, Peter J, Humphreys, Keith, Imyanitov, Evgeny N, Isaacs, Claudine, Jakimovska, Milena, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jankowitz, Rachel C, John, Esther M, Johnson, Nichola, Joseph, Vijai, Karlan, Beth Y, Khusnutdinova, Elza, Kiiski, Johanna I, Ko, Yon-Dschun, Jones, Michael E, Konstantopoulou, Irene, Kristensen, Vessela N, Laitman, Yael, Lambrechts, Diether, Lazaro, Conxi, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Lindström, Sara, Long, Jirong, Loud, Jennifer T, Lubiński, Jan, Makalic, Enes, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Maurer, Tabea, Mavroudis, Dimitrios, McGuffog, Lesley, Meindl, Alfons, Menon, Usha, Michailidou, Kyriaki, Miller, Austin, Montagna, Marco, Moreno, Fernando, Moserle, Lidia, Mulligan, Anna Marie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nevelsteen, Ines, Nielsen, Finn C, Nikitina-Zake, Liene, Nussbaum, Robert L, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Olsson, Håkan, Osorio, Ana, Papp, Janos, Park-Simon, Tjoung-Won, Parsons, Michael T, Pedersen, Inge Sokilde, Peixoto, Ana, Peterlongo, Paolo, Pharoah, Paul D P, Plaseska-Karanfilska, Dijana, Poppe, Bruce, Presneau, Nadege, Radice, Paolo, Rantala, Johanna, Rennert, Gad, Risch, Harvey A, Saloustros, Emmanouil, Sanden, Kristin, Sawyer, Elinor J, Schmidt, Marjanka K, Schmutzler, Rita K, Sharma, Priyanka, Shu, Xiao-Ou, Simard, Jacques, Singer, Christian F, Soucy, Penny, Southey, Melissa C, Spinelli, John J, Spurdle, Amanda B, Stone, Jennifer, Swerdlow, Anthony J, Tapper, William J, Taylor, Jack A, Teixeira, Manuel R, Terry, Mary Beth, Teulé, Alex, Thomassen, Mads, Thöne, Kathrin, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Truong, Thérèse, Tung, Nadine, Vachon, Celine M, van Asperen, Christi J, van den Ouweland, Ans M W, van Rensburg, Elizabeth J, Vega, Ana, Viel, Alessandra, Wang, Qin, Wappenschmidt, Barbara, Weitzel, Jeffrey N, Wendt, Camilla, Winqvist, Robert, Yang, Xiaohong R, Yannoukakos, Drakoulis, Ziogas, Argyrios, Kraft, Peter, Antoniou, Antonis C, Zheng, Wei, Easton, Douglas F, Milne, Roger L, Beesley, Jonathan, Chenevix-Trench, Georgia

المساهمون: 1 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. Manuel.Ferreira@qimr.edu.au. 2 Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, 37235, USA. 3 Clare Hall, University of Cambridge, Cambridge, CB3 9AL, UK. 4 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia. 5 Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, 00290, Helsinki, Finland. 6 Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada. 7 Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. 8 Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA, 92617. 9 Department of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland. 10 BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland. 11 Division of Clinical Epidemiology and Aging Research, C070, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 12 Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON, K7L 3N6, Canada. 13 Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. 14 Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, 1090, Vienna, Austria. 15 Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), 20133, Milan, Italy. 16 Oncogenetics Group, Vall dHebron Institute of Oncology (VHIO), 8035, Barcelona, Spain. 17 Department of Medical Oncology, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, 08035, Barcelona, Spain. 18 Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. 19 Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, 91054, Erlangen, Germany. 20 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 21 Centro de Investigación en Red de Enfermedades Raras (CIBERER), 46010, Valencia, Spain. 22 Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029, Madrid, Spain. 23 Institute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences, 450054, Ufa, Russia. 24 Department of Genetics and Pathology, Pomeranian Medical University, 71-252, Szczecin, Poland. 25 Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, 00290, Finland. 26 Department of Oncology, Örebro University Hospital, 70185, Örebro, Sweden. 27 Department of Radiation Oncology, Hannover Medical School, 30625, Hannover, Germany. 28 Gynaecology Research Unit, Hannover Medical School, 30625, Hannover, Germany. 29 N.N. Alexandrov Research Institute of Oncology and Medical Radiology, 223040, Minsk, Belarus. 30 Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark. 31 Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark. 32 Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark. 33 Department of Oncology, Lund University and Skåne University Hospital, 222 41, Lund, Sweden. 34 Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376, Stuttgart, Germany. 35 University of Tübingen, 72074, Tübingen, Germany. 36 German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 37 Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120, Heidelberg, Germany. 38 Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands. 39 Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 40 Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, 69120, Heidelberg, Germany. 41 Molecular Oncology Laboratory, CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), 28040, Madrid, Spain. 42 Section of Molecular Genetics, Dept. of Laboratory Medicine, University Hospital of Pisa, 56126, Pisa, Italy. 43 Department of Biology, University of Pisa, 56126, Pisa, Italy. 44 Research Department, Peter MacCallum Cancer Center, Melbourne, VIC, 3000, Australia. 45 Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, 3000, Australia. 46 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 47 Department of Gynaecological Oncology, Chris O'Brien Lifehouse and The University of Sydney, Camperdown, NSW, 2050, Australia. 48 Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA, 30303. 49 Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, 36312, Vigo, Spain. 50 Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. 51 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20850, USA. 52 Departments of Pediatrics and Medicine, Columbia University, New York, NY, 10032, USA. 53 Centre for Medical Genetics, Ghent University, Gent, 9000, Belgium. 54 Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, 2145, Australia. 55 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. 56 Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, S10 2TN, UK. 57 Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, S10 2TN, UK. 58 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65, Stockholm, Sweden. 59 Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. 60 Department of Pathology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. 61 Department of Human Genetics, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. 62 Clinical and Molecular Genetics Area, University Hospital Vall dHebron, Barcelona, 08035, Spain. 63 Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK. 64 Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, W1B 2HW, UK. 65 Faculty of Medicine, University of Southampton, Southampton, SO17 1BJ, UK. 66 Department of Oncology, Rigshospitalet, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark. 67 Department of Cancer Epidemiology, Clinical Sciences, Lund University, 222 42, Lund, Sweden. 68 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany. 69 David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, 90095, USA. 70 The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW7 3RP, UK. 71 Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730, Herlev, Denmark. 72 The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, 52621, Ramat Gan, Israel. 73 Sackler Faculty of Medicine, Tel Aviv University, 69978, Ramat Aviv, Israel. 74 Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, 15706, Santiago de Compostela, Spain. 75 Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA. 76 Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Los Angeles, CA, 90096-6900, USA. 77 Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. 78 Division of Genetics and Epidemiology, Institute of Cancer Research, London, SM2 5NG, UK. 79 Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), 28040, Madrid, Spain. 80 Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC, 3004, Australia. 81 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3010, Australia. 82 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia. 83 Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, 66160, USA. 84 Department of Medicine, McGill University, Montréal, QC, H4A 3J1, Canada. 85 Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montréal, QC, H4A 3J1, Canada. 86 Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA. 87 Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20850-9772, USA. 88 Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, 94805, Villejuif, France. 89 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. 90 Department of Oncology, Södersjukhuset, 118 83, Stockholm, Sweden. 91 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. 92 School of Population and Global Health, The University of Western Australia, Perth, WA, 6009, Australia. 93 Family Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands. 94 Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, 3015 CN, The Netherlands. 95 Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, 60201, USA. 96 The University of Chicago Pritzker School of Medicine, Chicago, IL, 60637, USA. 97 N.N. Petrov Institute of Oncology. St., Petersburg, 197758, Russia. 98 Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20007, USA. 99 Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, 1000, Republic of Macedonia. 100 Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, 71-252, Poland. 101 Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, VIC, 3000, Australia. 102 Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, 08410, Lithuania. 103 Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15232, USA. 104 Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94304, USA. 105 Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA. 106 David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, 90095, USA. 107 Department of Genetics and Fundamental Medicine, Bashkir State Medical University, 450076, Ufa, Russia. 108 Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, 00290, Finland. 109 Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, 53177, Germany. 110 Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SM2 5NG, UK. 111 Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, 15310, Greece. 112 Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, 0379, Norway. 113 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 0450, Norway. 114 VIB Center for Cancer Biology, VIB, Leuven, 3001, Belgium. 115 Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, 3000, Belgium. 116 Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Bellvitge Biomedical Research Institute, Catalan Institute of Oncology), CIBERONC, Barcelona, 08908, Spain. 117 Genetic Epidemiology of Cancer team, Inserm U900, Paris, 75005, France. 118 Institut Curie, Paris, 75005, France. 119 Mines ParisTech, Fontainebleau, 77305, France. 120 Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, 98195, USA. 121 Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA. 122 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA. 123 Translational Cancer Research Area, University of Eastern Finland, Kuopio, 70210, Finland. 124 Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, 70210, Finland. 125 Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, 70210, Finland. 126 Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden. 127 Department of Medical Oncology, University Hospital of Heraklion, Heraklion, 711 10, Greece. 128 Department of Gynecology and Obstetrics, University of Munich, Campus Großhadern, Munich, 81377, Germany. 129 MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, WC1V 6LJ, UK. 130 Department of Electron Microscopy/Molecular Pathology and The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology & Genetics, Nicosia, 1683, Cyprus. 131 NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA. 132 Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, 35128, Italy. 133 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A8, Canada. 134 Laboratory Medicine Program, University Health Network, Toronto, ON, M5G 2C4, Canada. 135 Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19066, USA. 136 Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA. 137 Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, 3000, Belgium. 138 Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, DK-2100, Denmark. 139 Latvian Biomedical Research and Study Centre, Riga, LV-1067, Latvia. 140 Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA, 94143-1714, USA. 141 Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA. 142 Department of Molecular Genetics, National Institute of Oncology, Budapest, 1122, Hungary. 143 Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, 60637, USA. 144 Molecular Diagnostics, Aalborg University Hospital, Aalborg, 9000, Denmark. 145 Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, 9000, Denmark. 146 Department of Clinical Medicine, Aalborg University, Aalborg, 9000, Denmark. 147 Department of Genetics, Portuguese Oncology Institute, Porto, 4220-072, Portugal. 148 Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, 20139, Italy. 149 Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, 20133, Italy. 150 Clinical Genetics, Karolinska Institutet, Stockholm, 171 76, Sweden. 151 Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, 35254, Israel. 152 Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, 06510, USA. 153 Department of Oncology, University Hospital of Larissa, Larissa, 411 10, Greece. 154 City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, 91010, USA. 155 Research Oncology, Guy's Hospital, King's College London, London, SE1 9RT, UK. 156 Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands. 157 Center for Hereditary Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, 50937, Germany. 158 Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany. 159 Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, KS, 66205, USA. 160 Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Center, Québec City, QC, G1V 4G2, Canada. 161 Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia. 162 Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia. 163 Population Oncology, BC Cancer, Vancouver, BC, V5Z 1G1, Canada. 164 School of Population and Public Health, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. 165 The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, WA, 6000, Australia. 166 Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK. 167 Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA. 168 Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, 27709, USA. 169 Biomedical Sciences Institute (ICBAS), University of Porto, Porto, 4050-013, Portugal. 170 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, 10032, USA. 171 Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, CIBERONC, Barcelona, 08908, Spain. 172 Department of Clinical Genetics, Odense University Hospital, Odence C, 5000, Denmark. 173 Department of Medicine, Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. 174 Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, H4A 3J1, Canada. 175 Department of Medical Genetics, University of Cambridge, Cambridge, CB2 0QQ, UK. 176 Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, 43210, USA. 177 Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, 110231, Colombia. 178 Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA. 179 Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, 55905, USA. 180 Department of Clinical Genetics, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands. 181 Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, 3015 CN, The Netherlands. 182 Department of Genetics, University of Pretoria, Arcadia, 0007, South Africa. 183 Fundación Pública galega Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela, Spain. 184 Division of Functional onco-genomics and genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, 33081, Italy. 185 Clinical Cancer Genomics, City of Hope, Duarte, CA, 91010, USA. 186 Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, 90570, Finland. 187 Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, 90570, Finland. 188 Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, USA. 189 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

المصدر: Nature communications

مصطلحات موضوعية: Brjóstakrabbamein, Gen, Breast Neoplasms, Genome-Wide Association Study, Genetic Loci

العلاقة: https://www.nature.com/articles/s41467-018-08053-5Test; Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. 2019, 10(1):1741 Nat Commun; http://hdl.handle.net/2336/620930Test; Nature Communications

الإتاحة: https://doi.org/10.1038/s41467-018-08053-5Test
http://hdl.handle.net/2336/620930Test

المؤلفون: Shu, Xiang, Wu, Lang, Khankari, Nikhil K, Shu, Xiao-Ou, Wang, Thomas J, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Milne, Roger L, Schmidt, Marjanka K, Pharoah, Paul DP, Andrulis, Irene L, Hunter, David J, Simard, Jacques, Easton, Douglas F, Zheng, Wei, Alicia, Beeghly-Fadiel J, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Auer, Paul L, Barrdahl, Myrto, Baynes, Caroline, Beane Freeman, Laura E, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brinton, Louise, Broberg, Per, Brucker, Sara Y, Brüning, Thomas, Burwinkel, Barbara, Cai, Qiuyin, Caldés, Trinidad, Canzian, Federico, Carter, Brian D, Castelao, Jose E, Chang-Claude, Jenny, Chenevix-Trench, Georgia, David Cheng, Ting-Yuan, Clarke, Christine L, Conroy, Don M, Couch, Fergus J, Cox, David G, Cox, Angela, Cross, Simon S, Cunningham, Julie M, Czene, Kamila, Daly, Mary B, Doheny, Kimberly F, Dörk, Thilo, dos-Santos-Silva, Isabel, Dumont, Martine, Dunning, Alison M, Dwek, Miriam, Earp, H Shelton, Eccles, Diana M, Heather Eliassen, A, Engel, Christoph, Eriksson, Mikael, Gareth Evans, D, Fachal, Laura, Fasching, Peter A, Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, Gapstur, Susan M, García-Closas, Montserrat, Gaudet, Mia M, Ghoussaini, Maya, Giles, Graham G, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hallberg, Emily, Hamann, Ute, Harrington, Patricia, He, Wei, Hein, Alexander, Hicks, Belynda, Hillemanns, Peter, Hogervorst, Frans B, Hollestelle, Antoinette, Hoover, Robert N

المصدر: International Journal of Epidemiology, vol 48, iss 3

مصطلحات موضوعية: Clinical Research, Diabetes, Prevention, Nutrition, Obesity, Cancer, Aging, Breast Cancer, Genetics, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Adult, Aged, Blood Glucose, Body Mass Index, Breast Neoplasms, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Mendelian Randomization Analysis, Middle Aged, Abdominal, Waist-Hip Ratio, glucose, Breast Cancer Association Consortium, Statistics, Public Health and Health Services

جغرافية الموضوع: 795 - 806

وصف الملف: application/pdf

العلاقة: qt9706z1b3; https://escholarship.org/uc/item/9706z1b3Test

الإتاحة: https://escholarship.org/uc/item/9706z1b3Test

المؤلفون: Hamdi, Yosr, Soucy, Penny, Kuchenbaeker, Karoline B, Pastinen, Tomi, Droit, Arnaud, Lemaçon, Audrey, Adlard, Julian, Aittomäki, Kristiina, Andrulis, Irene L, Arason, Adalgeir, Arnold, Norbert, Arun, Banu K, Azzollini, Jacopo, Bane, Anita, Barjhoux, Laure, Barrowdale, Daniel, Benitez, Javier, Berthet, Pascaline, Blok, Marinus J, Bobolis, Kristie, Bonadona, Valérie, Bonanni, Bernardo, Bradbury, Angela R, Brewer, Carole, Buecher, Bruno, Buys, Saundra S, Caligo, Maria A, Chiquette, Jocelyne, Chung, Wendy K, Claes, Kathleen B M, Daly, Mary B, Damiola, Francesca, Davidson, Rosemarie, De la Hoya, Miguel, De Leeneer, Kim, Diez, Orland, Ding, Yuan Chun, Dolcetti, Riccardo, Domchek, Susan M, Dorfling, Cecilia M, Eccles, Diana, Eeles, Ros, Einbeigi, Zakaria, Ejlertsen, Bent, Engel, Christoph, Gareth Evans, D, Feliubadalo, Lidia, Foretova, Lenka, Fostira, Florentia, Foulkes, William D, Fountzilas, George, Friedman, Eitan, Frost, Debra, Ganschow, Pamela, Ganz, Patricia A, Garber, Judy, Gayther, Simon A, Gerdes, Anne-Marie, Glendon, Gord, Godwin, Andrew K, Goldgar, David E, Greene, Mark H, Gronwald, Jacek, Hahnen, Eric, Hamann, Ute, Hansen, Thomas V O, Hart, Steven, Hays, John L, Hogervorst, Frans B L, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Izatt, Louise, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Jensen, Uffe Birk, John, Esther M, Joseph, Vijai, Just, Walter, Kaczmarek, Katarzyna, Karlan, Beth Y, Kets, Carolien M, Kirk, Judy, Kriege, Mieke, Laitman, Yael, Laurent, Maïté, Lazaro, Conxi, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Liljegren, Annelie, Loman, Niklas, Loud, Jennifer T, Manoukian, Siranoush, Mariani, Milena, Mazoyer, Sylvie, McGuffog, Lesley, Meijers-Heijboer, Hanne E J, Meindl, Alfons, Miller, Austin, Montagna, Marco, Mulligan, Anna Marie, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nussbaum, Robert L, Olah, Edith, Olopade, Olufunmilayo I, Ong, Kai-Ren, Oosterwijk, Jan C, Osorio, Ana, Papi, Laura, Park, Sue Kyung, Pedersen, Inge Sokilde, Peissel, Bernard, Segura, Pedro Perez, Peterlongo, Paolo, Phelan, Catherine M, Radice, Paolo, Rantala, Johanna, Rappaport-Fuerhauser, Christine, Rennert, Gad, Richardson, Andrea, Robson, Mark, Rodriguez, Gustavo C, Rookus, Matti A, Schmutzler, Rita Katharina, Sevenet, Nicolas, Shah, Payal D, Singer, Christian F, Slavin, Thomas P, Snape, Katie, Sokolowska, Johanna, Sønderstrup, Ida Marie Heeholm, Southey, Melissa, Spurdle, Amanda B, Stadler, Zsofia, Stoppa-Lyonnet, Dominique, Sukiennicki, Grzegorz, Sutter, Christian, Tan, Yen, Tea, Muy-Kheng, Teixeira, Manuel R, Teulé, Alex, Teo, Soo-Hwang, Terry, Mary Beth, Thomassen, Mads, Tihomirova, Laima, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda Ewart, Tung, Nadine, van den Ouweland, Ans M W, van der Luijt, Rob B, van Engelen, Klaartje, van Rensburg, Elizabeth J, Varon-Mateeva, Raymonda, Wappenschmidt, Barbara, Wijnen, Juul T, Rebbeck, Timothy, Chenevix-Trench, Georgia, Offit, Kenneth, Couch, Fergus J, Nord, Silje, Easton, Douglas F, Antoniou, Antonis C, Simard, Jacques

المساهمون: Show the Organization-Enhanced name(s) 1 Ctr Hosp Univ Quebec, Res Ctr, Genom Ctr, 2705 Laurier Blvd, Quebec City, PQ G1V 4G2, Canada Show the Organization-Enhanced name(s) 2 Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Ctr Canc Genet Epidemiol, Worts Causeway, Cambridge, England Show the Organization-Enhanced name(s) 3 Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1HH, England Show the Organization-Enhanced name(s) 4 McGill Univ, Dept Human Genet, Montreal, PQ H3A 1B1, Canada Show the Organization-Enhanced name(s) 5 McGill Univ, Montreal, PQ H3A 0G1, Canada 6 Chapel Allerton Hosp, Yorkshire Reg Genet Serv, Leeds LS7 4SA, W Yorkshire, England Show the Organization-Enhanced name(s) 7 Helsinki Univ Hosp, Dept Clin Genet, Meilahdentie 2,POB 160, Helsinki 00029, Finland Show the Organization-Enhanced name(s) 8 Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G IX5, Canada Show the Organization-Enhanced name(s) 9 Univ Toronto, Dept Mol Genet, Toronto, ON, Canada 10 Landspitali LSH V Hringbraut, Dept Pathol Hus 9, IS-101 Reykjavik, Iceland Show the Organization-Enhanced name(s) 11 Univ Iceland, Fac Med, BMC Biomed Ctr, Vatnsmyrarvegi 16, IS-101 Reykjavik, Iceland Show the Organization-Enhanced name(s) 12 Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Obstet & Gynaecol, Campus Kiel, D-24105 Kiel, Germany Show the Organization-Enhanced name(s) 13 Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, 1515 Pressler St CBP 5, Houston, TX 77030 USA 14 Fdn IRCCS Ist Ric Cura & Carattere Sci, Dept Prevent & Predict Med, Unit Med Genet, INT, Via Giacomo Venezian 1, I-20133 Milan, Italy Show the Organization-Enhanced name(s) 15 McMaster Univ, Juravinski Hosp & Canc Ctr, Dept Pathol Mol Med, 711 Concess St, Hamilton, ON L8V 1C3, Canada Show the Organization-Enhanced name(s) 16 Ctr Leon Berard, Bat Cheney D,28 Rue Laennec, F-69373 Lyon, France Show the Organization-Enhanced name(s) 17 Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain 18 Biomed Network Rare Dis CIBERER, Madrid 28029, Spain Show the Organization-Enhanced name(s) 19 Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Program, Human Genotyping CEGEN Unit, Madrid, Spain Show the Organization-Enhanced name(s) 20 Ctr Francois Baclesse, 3 Ave Gen Harris, F-14076 Caen, France Show the Organization-Enhanced name(s) 21 Maastricht Univ, Dept Clin Genet, Med Ctr, POB 5800, NL-6202 AZ Maastricht, Netherlands Show the Organization-Enhanced name(s) 22 City Hope Natl Med Ctr, Clin Canc Genom Community Res Network, 1500 East Duarte Rd, Duarte, CA 91010 USA Show the Organization-Enhanced name(s) 23 Ctr Leon Berard, Unite Prevent & Epidemiol Genet, 28 Rue Laennec, F-69373 Lyon, France Show the Organization-Enhanced name(s) 24 IEO, Div Canc Prevent & Genet, Via Ripamonti 435, I-20141 Milan, Italy Show the Organization-Enhanced name(s) 25 Univ Penn, Dept Med, Abramson Canc Ctr, Perelman Sch Med, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA Show the Organization-Enhanced name(s) 26 Royal Devon & Exeter Hosp, Dept Clin Genet, Exeter EX1 2ED, Devon, England Show the Organization-Enhanced name(s) 27 Inst Curie, Serv Genet Oncol, 26 Rue Ulm, F-75248 Paris 05, France 28 Huntsman Canc Inst, Dept Med, 2000 Circle Hope, Salt Lake City, UT 84112 USA 29 Univ & Univ Hosp Pisa, Sect Genet Oncol, Dept Lab Med, Pisa, Italy Show the Organization-Enhanced name(s) 30 Hop St Sacrement, Ctr Malad Sein Deschenes Fabia, Unite Rech Sante Populat, 1050 Chemin Sainte Foy, Quebec City, PQ G1S 4L8, Canada Show the Organization-Enhanced name(s) 31 Columbia Univ, Dept Pediat, 1150 St Nicholas Ave, New York, NY 10032 USA Show the Organization-Enhanced name(s) 32 Univ Ghent, Ctr Med Genet, De Pintelaan 185, Ghent, Belgium Show the Organization-Enhanced name(s) 33 Fox Chase Canc Ctr, Div Populat Sci, 333 Cottman Ave, Philadelphia, PA 19111 USA 34 South Glasgow Univ Hosp, Dept Clin Genet, Glasgow G51 4TF, Lanark, Scotland Show the Organization-Enhanced name(s) 35 IdISSC Inst Invest Sanitaria Hosp Clin San Carlos, Hosp Clinico San Carlos, Mol Oncol Lab, Martin Lagos S-N, Madrid, Spain Show the Organization-Enhanced name(s) 36 Vall dHebron Univ Hosp, Clin & Mol Genet Area, Oncogenet Grp, Vall dHebron Inst Oncol VHIO, Passeig Vall dHebron 119-129, Barcelona 08035, Spain Show the Organization-Enhanced name(s) 37 City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA Show the Organization-Enhanced name(s) 38 IRCCS Ist Ric & Cura Carattere Sci, Dept Med Oncol, Canc Bioimmunotherapy Unit, Ctr Riferimento Oncol,Natl Canc Inst, Via Franco Gallini 2, I-33081 Aviano, PN, Italy Show the Organization-Enhanced name(s) 39 Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia Show the Organization-Enhanced name(s) 40 Univ Pretoria, Dept Genet, Canc Genet Lab, Private Bag X323, ZA-0007 Arcadia, South Africa Show the Organization-Enhanced name(s) 41 Univ Southampton, Southampton Univ Hosp NHS Trust, Fac Med, Southampton, Hants, England Show the Organization-Enhanced name(s) 42 Inst Canc Res, Oncogenet Team, Sutton SM2 5NG, Surrey, England Show the Organization-Enhanced name(s) 43 Sahlgrens Univ Hosp, Dept Oncol, S-41345 Gothenburg, Sweden Show the Organization-Enhanced name(s) 44 Copenhagen Univ Hosp, Dept Oncol, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark Show the Organization-Enhanced name(s) 45 Univ Leipzig, Inst Med Informat Stat & Epidemiol, D-04107 Leipzig, Germany Show the Organization-Enhanced name(s) 46 Univ Leipzig, Leipzig Res Ctr Civilizat Dis, LIFE, Leipzig, Germany Show the Organization-Enhanced name(s) 47 Univ Manchester, Manchester Acad Hlth Sci Ctr, Inst Human Dev, NHS Fdn Trust,Cent Manchester Univ Hosp,Genom Med, Manchester M13 9WL, Lancs, England 48 IDIBELL Bellvitge Biomed Res Inst, Catalan Inst Oncol, Hereditary Canc Program, Mol Diagnost Unit, Gran Via Hosp 199-203, Barcelona 08908, Spain 49 Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Zluty Kopec 7, Brno 65653, Czech Republic 50 INRASTES Inst Nucl & Radiol Sci & Technol, Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, Patriarchou Gregoriou & Neapoleos Str, Athens, Greece Show the Organization-Enhanced name(s) 51 McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ, Canada Show the Organization-Enhanced name(s) 52 Aristotle Univ Thessaloniki, Papageorgiou Hosp, Dept Med Oncol, Sch Med, Thessaloniki, Greece Show the Organization-Enhanced name(s) 53 Chaim Sheba Med Ctr, Inst Human Genet, Susanne Levy Gertner Oncogenet Unit, IL-52621 Ramat Gan, Israel Show the Organization-Enhanced name(s) 54 Tel Aviv Univ, Sackler Fac Med, IL-69978 Ramat Aviv, Israel Show the Organization-Enhanced name(s) 55 City Hope Natl Med Ctr, Clin Canc Genet, 1500 East Duarte Rd, Duarte, CA 91010 USA Show the Organization-Enhanced name(s) 56 UCLA, Div Canc Prevent Control Res, Jonsson Comprehens Canc Ctr, Sch Med, 650 Charles Young Dr South,Room A2-125 HS, Los Angeles, CA 90095 USA Show the Organization-Enhanced name(s) 57 Dana Farber Canc Inst, Canc Risk & Prevent Clin, 450 Brookline Ave, Boston, MA 02115 USA 58 Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA Show the Organization-Enhanced name(s) 59 Inst Curie, Dept Tumour Biol, Paris, France Show the Organization-Enhanced name(s) 60 Inst Curie, INSERM, U830, Paris, France Show the Organization-Enhanced name(s) 61 Univ Paris 05, Sorbonne Paris Cite, Paris, France Show the Organization-Enhanced name(s) 62 Rigshosp, Dept Clincial Genet, Blegdamsvej 9, DK-4062 Copenhagen, Denmark Show the Organization-Enhanced name(s) 63 Univ Kansas, Med Ctr, Dept Pathol & Lab Med, 3901 Rainbow Blvd,4019 Wahl Hall East,MS 3040, Kansas City, KS 66103 USA Show the Organization-Enhanced name(s) 64 Univ Utah, Sch Med, Dept Dermatol, 30 North 1900 East,SOM 4B454, Salt Lake City, UT 84132 USA Show the Organization-Enhanced name(s) 65 NCI, Clin Genet Branch, DCEG, NIH, 9609 Med Ctr Dr,Room 6E-454, Bethesda, MD 20892 USA 66 Pomeranian Med Univ, Dept Genet & Pathol, Polabska 4, PL-70115 Szczecin, Poland Show the Organization-Enhanced name(s) 67 Univ Hosp Cologne, Dept Gynaecol & Obstet, Ctr Familial Breast & Ovarian Canc, Ctr Mol Med Cologne CMMC, D-50931 Cologne, Germany Show the Organization-Enhanced name(s) 68 German Canc Res Ctr, Mol Genet Breast Canc, Neuenheimer Feld 580, D-69120 Heidelberg, Germany Show the Organization-Enhanced name(s) 69 Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark Show the Organization-Enhanced name(s) 70 Mayo Clin, Dept Hlth Sci Res, 200 First St SW, Rochester, MN 55905 USA Show the Organization-Enhanced name(s) 71 Ohio State Univ, Div Med Oncol, Dept Internal Med, Columbus, OH 43210 USA Show the Organization-Enhanced name(s) 72 Ohio State Univ, Div Gynecol Oncol, Dept Obstet & Gynecol, Columbus, OH 43210 USA 73 Ctr Comprehens Canc, Arthur C James Canc Hosp & Richard J Solove Res I, Columbus, OH 43210 USA 74 Netherlands Canc Inst, Hereditary Breast & Ovarian Canc Res Grp Netherla, Coordinating Ctr, Amsterdam, Netherlands 75 Netherlands Canc Inst, Family Canc Clin, POB 90203, NL-1006 BE Amsterdam, Netherlands Show the Organization-Enhanced name(s) 76 Univ Chicago, Pritzker Sch Med, NorthShore Univ HealthSyst, Ctr Med Genet, 1000 Cent St,Suite 620, Evanston, IL 60201 USA 77 NN Petrov Inst Oncol, St Petersburg 197758, Russia Show the Organization-Enhanced name(s) 78 Georgetown Univ, Lombardi Comprehens Canc Ctr, 3800 Reservoir Rd NW, Washington, DC 20007 USA Show the Organization-Enhanced name(s) 79 Guys & St Thomas NHS Fdn Trust, Clin Genet, London SE1 9RT, England 80 Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic 3000, Australia Show the Organization-Enhanced name(s) 81 Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia Show the Organization-Enhanced name(s) 82 Vilnius Univ Hosp, Santariskiu Clin, Dept Mol & Regenerat Med, Hematol Oncol & Transfus Med Ctr, Santariskiu St 2, LT-08661 Vilnius, Lithuania Show the Organization-Enhanced name(s) 83 State Res Inst Ctr Innovat Med, Zygymantu St 9, Vilnius, Lithuania Show the Organization-Enhanced name(s) 84 Aarhus Univ Hosp, Dept Clin Genet, Brendstrupgaardsvej 21C, Aarhus N, Denmark Show the Organization-Enhanced name(s) 85 Canc Prevent Inst Calif, Dept Epidemiol, 2201 Walnut Ave Suite 300, Fremont, CA 94538 USA Show the Organization-Enhanced name(s) 86 Stanford Univ, Sch Med, Dept Hlth Res & Policy Epidemiol, Stanford, CA 94305 USA Show the Organization-Enhanced name(s) 87 Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Res Lab, 1275 York Ave, New York, NY 10044 USA Show the Organization-Enhanced name(s) 88 Univ Ulm, Inst Human Genet, D-89091 Ulm, Germany Show the Organization-Enhanced name(s) 89 Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, 8700 Beverly Blvd,Suite 290W, Los Angeles, CA 90048 USA 90 Peter MacCallum Canc Ctr, Res Dept, Melbourne, Vic 8006, Australia Show the Organization-Enhanced name(s) 91 Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands Show the Organization-Enhanced name(s) 92 Westmead Hosp, Familial Canc Serv, Hawkebury Rd,POB 533, Westmead, NSW 2145, Australia Show the Organization-Enhanced name(s) 93 Erasmus Univ, Med Ctr, Family Canc Clin, Dept Med Oncol, POB 5201, NL-3008 AE Rotterdam, Netherlands Show the Organization-Enhanced name(s) 94 PSL Univ, Inst Curie Mines ParisTech, Genet Epidemiol Canc Team, INSERM,U900, 26 Rue Ulm, F-75248 Paris 05, France Show the Organization-Enhanced name(s) 95 Karolinska Univ Hosp, Dept Oncol, S-17176 Stockholm, Sweden Show the Organization-Enhanced name(s) 96 Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden Show the Organization-Enhanced name(s) 97 Univ Lyon, Lyon Neurosci Res Ctr CRNL, INSERM, CNRS,UMR5292,U1028, Lyon, France Show the Organization-Enhanced name(s) 98 Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet, POB 7057, NL-1007 MB Amsterdam, Netherlands 99 Roswell Pk Canc Inst, NRG Oncol Stat & Data Management Ctr, Elm St & Carlton St, Buffalo, NY 14263 USA Show the Organization-Enhanced name(s) 100 Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Via Gattamelata 64, I-35128 Padua, Italy Show the Organization-Enhanced name(s) 101 St Michaels Hosp, Dept Lab Med, Toronto, ON, Canada Show the Organization-Enhanced name(s) 102 Univ Helsinki, Dept Obstet & Gynecol, Haartmaninkatu 8,POB 700, Helsinki 00029, Finland Show the Organization-Enhanced name(s) 103 Univ Calif San Francisco, Dept Med & Genet, 513 Parnassus Ave,HSE 901E, San Francisco, CA 94143 USA Show the Organization-Enhanced name(s) 104 Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary Show the Organization-Enhanced name(s) 105 Univ Chicago, Dept Med, 5841 South Maryland Ave,MC 2115, Chicago, IL 60637 USA 106 Birmingham Womens Hosp Healthcare NHS Trust, West Midlands Reg Genet Serv, Birmingham, W Midlands, England Show the Organization-Enhanced name(s) 107 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands Show the Organization-Enhanced name(s) 108 Univ Florence, Dept Biomed Expt & Clin Sci, Unit Med Genet, Viale Morgagni 50, I-50134 Florence, Italy Show the Organization-Enhanced name(s) 109 Seoul Natl Univ, Dept Prevent Med, Coll Med, 103 Daehak Ro, Seoul 110799, South Korea Show the Organization-Enhanced name(s) 110 Aalborg Univ Hosp, Sect Mol Diagnost, Dept Biochem, Reberbansgade 15, Aalborg, Denmark Show the Organization-Enhanced name(s) 111 IdISSC Inst Investigacin Sanitaria Hosp Clin, Hosp Clinico San Carlos, Dept Oncol, Martin Lagos S-N, Madrid, Spain Show the Organization-Enhanced name(s) 112 IFOM, IFOM IEO Campus,Via Adamello 16, I-20139 Milan, Italy Show the Organization-Enhanced name(s) 113 H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL 33612 USA Show the Organization-Enhanced name(s) 114 Fdn IRCCS Ist Ric & Cura Carattere Sci, Dept Prevent & Predicted Med, Unit Mol Bases Genet Risk & Genet Testing, Ist Nazl Tumori, Amaedeolab Via GA Amadeo 42, I-20133 Milan, Italy Show the Organization-Enhanced name(s) 115 Karolinska Univ Hosp, Dept Clin Genet, Hosp L5 03, S-17176 Stockholm, Sweden Show the Organization-Enhanced name(s) 116 Med Univ Vienna, Dept OB GYN, Waehringer Guertel 18-20, A-1090 Vienna, Austria 117 Carmel Hosp, Clalit Natl Israeli Canc Control Ctr, 7 Michal St, IL-34362 Haifa, Israel Show the Organization-Enhanced name(s) 118 Johns Hopkins Univ, Dept Pathol, Sch Med, Baltimore, MD 21205 USA Show the Organization-Enhanced name(s) 119 Mem Sloan Kettering Canc Ctr, Serv Dept Med, Clin Genet, 1275 York Ave, New York, NY USA Show the Organization-Enhanced name(s) 120 Univ Chicago, NorthShore Univ HealthSyst, Div Gynecol Oncol, 2650 Ridge Ave,Suite 1507, Evanston, IL 60201 USA 121 Netherlands Canc Inst, Dept Epidemiol, POB 90203, NL-1006 BE Amsterdam, Netherlands Show the Organization-Enhanced name(s) 122 Univ Hosp Cologne, Fac Med, Ctr Hereditary Breast & Ovarian Canc, D-50931 Cologne, Germany Show the Organization-Enhanced name(s) 123 Univ Hosp Cologne, Fac Med, Ctr Integrated Oncol CIO, Cologne, Germany Show the Organization-Enhanced name(s) 124 Inst Bergonie, Oncogenet, 229 Cours Argonne, F-33076 Bordeaux, France Show the Organization-Enhanced name(s) 125 St Georges Univ London, Med Genet Unit, London SW17 0RE, England Show the Organization-Enhanced name(s) 126 Nancy Univ, Lab Genet Med, Ctr Hosp Reg & Univ, Rue Morvan, F-54511 Vandoeuvre Les Nancy 1, France 127 Slagelse Hosp, Dept Pathol Reg Zealand Sect Slagelse, Ingemannsvej 18, Slagelse, Cpoenhagen, Denmark Show the Organization-Enhanced name(s) 128 Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3010, Australia Show the Organization-Enhanced name(s) 129 QIMR Berghofer Med Res Inst, Genet & Computat Biol Dept, Herston Rd, Herston, Qld 4006, Australia Show the Organization-Enhanced name(s) 130 Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA Show the Organization-Enhanced name(s) 131 Univ Heidelberg Hosp, Inst Human Genet, Dept Human Genet, Heidelberg, Germany Show the Organization-Enhanced name(s) 132 Portuguese Oncol Inst, Dept Genet, Rua Dr Antonio Bernardino Almeida, P-4200072 Oporto, Portugal Show the Organization-Enhanced name(s) 133 Univ Porto, Biomed Sci Inst ICBAS, Oporto, Portugal 134 IDIBELL Bellvitge Biomed Res Inst, Catalan Inst Oncol, Hereditary Canc Program, Genet Counseling Unit, Gran Via Hosp 199-203, Barcelona 08908, Spain 135 Canc Res Initiat Fdn, Sime Darby Med Ctr, 1 Jalan SS12-1A, Subang Jaya 47500, Malaysia Show the Organization-Enhanced name(s) 136 Univ Malaya, Univ Malaya Canc Res Inst, 1 Jalan SS12-1A, Kuala Lumpur 50603, Malaysia Show the Organization-Enhanced name(s) 137 Columbia Univ, Dept Epidemiol, New York, NY USA 138 Odense Univ Hosp, Dept Clin Genet, Sonder Blvd 29, Odense C, Denmark 139 Latvian Biomed Res & Study Ctr, Ratsupites Str 1, Riga, Latvia Show the Organization-Enhanced name(s) 140 Addenbrookes Hosp, Dept Med Genet, Addenbrookes Treatment Ctr, Level 6,Hills Rd,Box 134, Cambridge CB2 0QQ, England Show the Organization-Enhanced name(s) 141 Ohio State Univ, Div Human Genet, Dept Internal Med, 998 Biomedical Res Tower, Columbus, OH 43210 USA Show the Organization-Enhanced name(s) 142 Beth Israel Deaconess Med Ctr, Dept Med Oncol, 330 Brookline Ave, Boston, MA 02215 USA Show the Organization-Enhanced name(s) 143 Erasmus Univ, Med Ctr, Family Canc Clin, Dept Clin Genet, 330 Brookline Ave,POB 2040, NL-3000 CA Rotterdam, Netherlands Show the Organization-Enhanced name(s) 144 Univ Med Ctr Utrecht, Dept Med Genet, NL-3584 EA Utrecht, Netherlands 145 Acad Med Ctr, Dept Clin Genet, POB 22700, NL-1100 DE Amsterdam, Netherlands Show the Organization-Enhanced name(s) 146 Charite, Inst Human Genet, Campus Virchov Klinikum, D-13353 Berlin, Germany Show the Organization-Enhanced name(s) 147 Leiden Univ, Med Ctr, Dept Human Genet, NL-2300 RC Leiden, Netherlands Show the Organization-Enhanced name(s) 148 Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Philadelphia, PA 19104 USA Show the Organization-Enhanced name(s) 149 Mayo Clin, Dept Lab Med & Pathol, 200 First St SW, Rochester, MN 55905 USA Show the Organization-Enhanced name(s) 150 Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Radiumhosp, N-0372 Oslo, Norway Show the Organization-Enhanced name(s) 151 Univ Laval, 2705 Laurier Blvd, Quebec City, PQ G1V 4G2, Canada 152 Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada Show the Organization-Enhanced name(s) 153 Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Show the Organization-Enhanced name(s) 154 Univ Texas MD Anderson Canc Ctr, Clin Canc Genet Program, 1515 Pressler St CBP 5, Houston, TX 77030 USA Show the Organization-Enhanced name(s) 155 Columbia Univ, Dept Med, 1150 St Nicholas Ave, New York, NY 10032 USA Show the Organization-Enhanced name(s) 156 Royal Marsden NHS Fdn Trust, Sutton SM2 5NG, Surrey, England Show the Organization-Enhanced name(s) 157 McGill Univ, Dept Oncol, Program Canc Genet, Montreal, PQ, Canada Show the Organization-Enhanced name(s) 158 UCLA, Div Canc Prevent Control Res, Jonsson Comprehens Canc Ctr, Sch Publ Hlth, 650 Charles Young Dr South,Room A2-125 HS, Los Angeles, CA 90095 USA Show the Organization-Enhanced name(s) 159 Univ Hosp Cologne, Ctr Mol Med Cologne CMMC, Ctr Integrated Oncol CIO, D-50931 Cologne, Germany Show the Organization-Enhanced name(s) 160 Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA Show the Organization-Enhanced name(s) 161 St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON, Canada Show the Organization-Enhanced name(s) 162 Helsinki Univ Hosp, Biomedicum Helsinki, Haartmaninkatu 8,POB 700, Helsinki 00029, Finland 163 Carmel Hosp, Dept Community Med & Epidemiol, 7 Michal St, IL-34362 Haifa, Israel Show the Organization-Enhanced name(s) 164 B Rappaport Fac Med, 7 Michal St, IL-34362 Haifa, Israel Show the Organization-Enhanced name(s) 165 Ohio State Univ, Div Human Genet, Dept Canc Biol, 998 Biomedical Res Tower, Columbus, OH 43210 USA Show the Organization-Enhanced name(s) 166 Ohio State Univ, Genet Comprehens Canc Ctr, 998 Biomedical Res Tower, Columbus, OH 43210 USA Show the Organization-Enhanced name(s) 167 Leiden Univ, Med Ctr, Dept Clin Genet, NL-2300 RC Leiden, Netherlands

مصطلحات موضوعية: Brjóstakrabbamein, Gen, Breast Neoplasms, Genes, BRCA1, BRCA2, Genetic Predisposition to Disease

العلاقة: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222911/pdf/10549_2016_Article_4018.pdfTest; Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3. 2017, 161 (1):117-134 Breast Cancer Res. Treat.; http://hdl.handle.net/2336/620128Test; Breast cancer research and treatment

الإتاحة: https://doi.org/10.1007/s10549-016-4018-2Test
http://hdl.handle.net/2336/620128Test

المؤلفون: Shimelis, Hermela, Mesman, Romy LS, Von Nicolai, Catharina, Ehlen, Asa, Guidugli, Lucia, Martin, Charlotte, Calléja, Fabienne MGR, Meeks, Huong, Hallberg, Emily, Hinton, Jamie, Lilyquist, Jenna, Hu, Chunling, Aalfs, Cora M, Aittomäki, Kristiina, Andrulis, Irene, Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W, Benitez, Javier, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Borresen-Dale, Anne-Lise, Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Broeks, Annegien, Brouwers, Barbara, Brüning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Cheng, Ching-Yu, Choi, Ji-Yeob, Collée, J Margriet, Cox, Angela, Cross, Simon S, Czene, Kamila, Darabi, Hatef, Dennis, Joe, Dörk, Thilo, dos-Santos-Silva, Isabel, Dunning, Alison M, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, García-Closas, Montserrat, Giles, Graham G, Glendon, Gord, Guénel, Pascal, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hartman, Mikael, Hogervorst, Frans B, Hollestelle, Antoinette, Hopper, John L, Ito, Hidemi, Jakubowska, Anna, Kang, Daehee, Kosma, Veli-Matti, Kristensen, Vessela, Lai, Kah-Nyin, Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Machackova, Eva, Mannermaa, Arto, Margolin, Sara, Marme, Frederik, Matsuo, Keitaro, Miao, Hui, Michailidou, Kyriaki, Milne, Roger L, Muir, Kenneth, Neuhausen, Susan L, Nevanlinna, Heli, Olson, Janet E, Olswold, Curtis, Oosterwijk, Jan JC, Osorio, Ana, Peterlongo, Paolo, Peto, Julian, Pharoah, Paul DP, Pylkäs, Katri, Radice, Paolo, Rashid, Muhammad Usman, Rhenius, Valerie, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J, Schmidt, Marjanka K, Schoemaker, Minouk J, Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shrubsole, Martha

المصدر: Cancer Research, vol 77, iss 11

مصطلحات موضوعية: Breast Cancer, Cancer, Genetics, 2.1 Biological and endogenous factors, Aetiology, Aged, Amino Acid Substitution, Animals, BRCA2 Protein, Breast Neoplasms, Case-Control Studies, Female, Genotype, Germ-Line Mutation, Humans, Mice, Mutation, Missense, Risk, for kConFab/AOCS Investigators, for NBCS Collaborators, Oncology and Carcinogenesis, Oncology & Carcinogenesis

الوقت: 2789 - 2799

وصف الملف: application/pdf

العلاقة: qt3wp0r87g; https://escholarship.org/uc/item/3wp0r87gTest

الإتاحة: https://escholarship.org/uc/item/3wp0r87gTest