التفاصيل البيبلوغرافية
| العنوان: |
Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP |
| المؤلفون: |
Cantu, E, Suzuki, Y, Diamond, JM, Ellis, J, Tiwari, J, Beduhn, B, Nellen, JR, Shah, R, Meyer, NJ, Lederer, DJ, Kawut, SM, Palmer, SM, Snyder, LD, Hartwig, MG, Lama, VN, Bhorade, S, Crespo, M, Demissie, E, Wille, K, Orens, J, Shah, PD, Weinacker, A, Weill, D, Wilkes, D, Roe, D, Ware, LB, Wang, F, Feng, R, Christie, JD, Group, for the Lung Transplant Outcomes |
| المصدر: |
American Journal of Transplantation, vol 16, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2016 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Immunology, Clinical Research, Rare Diseases, Lung, Acute Respiratory Distress Syndrome, Genetics, Human Genome, Adult, Biomarkers, Female, Follow-Up Studies, Genetic Variation, Genotype, Humans, Intracellular Signaling Peptides and Proteins, Lung Transplantation, Male, Middle Aged, Phenotype, Plasminogen Activator Inhibitor 1, Primary Graft Dysfunction, Prognosis, Prospective Studies, Quantitative Trait Loci, translational research, science, pulmonology, ischemia reperfusion injury |
| جغرافية الموضوع: |
833 - 840 |
| الوصف: |
The authors previously identified plasma plasminogen activator inhibitor-1 (PAI-1) level as a quantitative lung injury biomarker in primary graft dysfunction (PGD). They hypothesized that plasma levels of PAI-1 used as a quantitative trait could facilitate discovery of genetic loci important in PGD pathogenesis. A two-stage cohort study was performed. In stage 1, they tested associations of loci with PAI-1 plasma level using linear modeling. Genotyping was performed using the Illumina CVD Bead Chip v2. Loci meeting a p < 5 × 10(-4) cutoff were carried forward and tested in stage 2 for association with PGD. Two hundred ninety-seven enrollees were evaluated in stage 1. Six loci, associated with PAI-1, were carried forward to stage 2 and evaluated in 728 patients. rs3168046 (Toll interacting protein [TOLLIP]) was significantly associated with PGD (p = 0.006). The increased risk of PGD for carrying at least one copy of this variant was 11.7% (95% confidence interval 4.9-18.5%). The false-positive rate for individuals with this genotype who did not have PGD was 6.1%. Variants in the TOLLIP gene are associated with higher circulating PAI-1 plasma levels and validate for association with clinical PGD. A protein quantitative trait analysis for PGD risk prioritizes genetic variations in TOLLIP and supports a role for Toll-like receptors in PGD pathogenesis. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt5352n17h; https://escholarship.org/uc/item/5352n17hTest |
| الإتاحة: |
https://escholarship.org/uc/item/5352n17hTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.D438BF04 |
| قاعدة البيانات: |
BASE |
