دورية أكاديمية
Atg12–Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release
| العنوان: | Atg12–Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release |
|---|---|
| المؤلفون: | Lyndsay Murrow, Jayanta Debnath |
| المصدر: | Molecular & Cellular Oncology, Vol 5, Iss 5 (2018) |
| بيانات النشر: | Taylor & Francis Group |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | atg12, atg3, basal autophagy, exosome, late endosome, pdcd6ip/alix, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | We recently identified an interaction between Atg12–Atg3, a complex between 2 core autophagy regulators, and the ESCRT-associated protein Pdcd6ip (programmed cell death 6 interacting protein, commonly known as Alix), which coordinately regulates basal autophagy, late endosome-to-lysosome trafficking, and exosome release. Because these processes all serve fundamental roles in cancer progression and therapy, Atg12-Atg3 may be an attractive anticancer target. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2372-3556 |
| العلاقة: | http://dx.doi.org/10.1080/23723556.2015.1039191Test; https://doaj.org/toc/2372-3556Test; https://doaj.org/article/7e389170528f4bf7a4293b5a83ef291fTest |
| DOI: | 10.1080/23723556.2015.1039191 |
| الإتاحة: | https://doi.org/10.1080/23723556.2015.1039191Test https://doaj.org/article/7e389170528f4bf7a4293b5a83ef291fTest |
| رقم الانضمام: | edsbas.58A307C6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23723556 |
|---|---|
| DOI: | 10.1080/23723556.2015.1039191 |