دورية أكاديمية
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
| العنوان: | A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization |
|---|---|
| المؤلفون: | Ong, JS, Dixon-Suen, SC, Han, X, An, J, Fitzgerald, R, Buas, M, Gammon, MD, Corley, DA, Shaheen, NJ, Hardie, LJ, Bird, NC, Reid, BJ, Chow, WH, Risch, HA, Ye, W, Liu, G, Romero, Y, Bernstein, L, Wu, AH, Whiteman, DE, Vaughan, T, Agee, M, Alipanahi, B, Auton, A, Bell, RK, Bryc, K, Elson, SL, Fontanillas, P, Furlotte, NA, Hinds, DA, Huber, KE, Kleinman, A, Litterman, NK, McIntyre, MH, Mountain, JL, Noblin, ES, Northover, CAM, Pitts, SJ, Sathirapongsasuti, JF, Sazonova, OV, Shelton, JF, Shringarpure, S, Tian, C, Tung, JY, Vacic, V, Wilson, CH, Liyanage, U, Dusingize, JC, Schumacher, J, Gockel, I, Böhmer, A, Jankowski, J, Palles, C, O’Mara, T, Spurdle, A, Law, MH, Iles, MM, Pharoah, P, Berchuck, A, Zheng, W, Thrift, AP, Olsen, C, Neale, RE, Gharahkhani, P, Webb, PM, MacGregor, S |
| المصدر: | Nature Communications , 12 , Article 246. (2021) |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Cancer epidemiology, Cancer genetics, Cancer prevention |
| الوصف: | Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89; 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16; 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10170841/1/A%20comprehensive%20re-assessment%20of%20the%20association%20between%20vitamin%20D%20and%20cancer%20susceptibility%20using%20Mendelian%20randomization.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10170841Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10170841/1/A%20comprehensive%20re-assessment%20of%20the%20association%20between%20vitamin%20D%20and%20cancer%20susceptibility%20using%20Mendelian%20randomization.pdfTest https://discovery.ucl.ac.uk/id/eprint/10170841Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.3AD91C34 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |