دورية أكاديمية
Effect of GLP-1 Receptor Activation on Offspring Kidney Health in a Rat Model of Maternal Obesity
| العنوان: | Effect of GLP-1 Receptor Activation on Offspring Kidney Health in a Rat Model of Maternal Obesity |
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| المؤلفون: | Glastras, SJ, Chen, H, McGrath, RT, Zaky, AA, Gill, AJ, Pollock, CA, Saad, S |
| المصدر: | urn:ISSN:2045-2322 ; Scientific Reports, 6, 1, 23525 |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2016 |
| المجموعة: | UNSW Sydney (The University of New South Wales): UNSWorks |
| مصطلحات موضوعية: | Pediatric, Obesity, Nutrition, Prevention, Kidney Disease, Diabetes, 5.1 Pharmaceuticals, 5 Development of treatments and therapeutic interventions, 2 Aetiology, 2.1 Biological and endogenous factors, Renal and urogenital, Reproductive health and childbirth, Metabolic and endocrine, Cardiovascular, 3 Good Health and Well Being, Animals, Newborn, Body Weight, Diet, High-Fat, Disease Models, Animal, Exenatide, Female, Glucagon-Like Peptide-1 Receptor, Humans, Kidney, Kidney Diseases, Maternal Nutritional Physiological Phenomena, Oxidative Stress |
| الوصف: | Maternal obesity is associated with an increased risk of chronic disease in offspring, including type 2 diabetes (T2D). Exendin-4 (Exd-4) activates the glucagon like peptide-1 (GLP-1) receptor thereby decreasing serum glucose levels and body weight. In addition, Exd-4 has been shown to reduce renal and cardiac complications in experimental models of T2D. We hypothesized that treatment with Exd-4 would ameliorate the detrimental effects of maternal and diet-induced obesity on renal characteristics in offspring. Female Sprague-Dawley rats were fed either normal or high-fat diet (HFD) for 6 weeks prior to pregnancy, during pregnancy and lactation, and their offspring were weaned to normal or HFD. The offspring were randomized to Exd-4 or placebo from weaning and their kidneys harvested at Week 9. We found that the kidneys of offspring from obese mothers, regardless of postnatal diet, had significantly increased markers of inflammation, oxidative stress and fibrosis. Exd-4 ameliorated the negative renal effects of maternal obesity and in particular, reduced renal inflammation, oxidative stress and fibrosis. In conclusion, maternal obesity has persisting effects on renal structure in the offspring. GLP-1 analogues are potentially useful for protecting against the deleterious effects of maternal obesity on renal physiology in offspring. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://hdl.handle.net/1959.4/unsworks_53465Test; https://doi.org/10.1038/srep23525Test |
| DOI: | 10.1038/srep23525 |
| الإتاحة: | https://doi.org/10.1038/srep23525Test http://hdl.handle.net/1959.4/unsworks_53465Test |
| حقوق: | open access ; https://purl.org/coar/access_right/c_abf2Test ; CC BY ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.3DE4B457 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/srep23525 |
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