دورية أكاديمية
Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes.
| العنوان: | Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes. |
|---|---|
| المؤلفون: | Doria, Alessandro, Galecki, Andrzej T, Spino, Cathie, Pop-Busui, Rodica, Cherney, David Z, Lingvay, Ildiko, Parsa, Afshin, Rossing, Peter, Sigal, Ronald J, Afkarian, Maryam, Aronson, Ronnie, Caramori, M Luiza, Crandall, Jill P, de Boer, Ian H, Elliott, Thomas G, Goldfine, Allison B, Haw, J Sonya, Hirsch, Irl B, Karger, Amy B, Maahs, David M, McGill, Janet B, Molitch, Mark E, Perkins, Bruce A, Polsky, Sarit, Pragnell, Marlon, Robiner, William N, Rosas, Sylvia E, Senior, Peter, Tuttle, Katherine, Umpierrez, Guillermo E, Wallia, Amisha, Weinstock, Ruth S, Wu, Chunyi, Mauer, Michael, PERL Study Group, Alicic, PERL Study Group Collaborator: Radica |
| المصدر: | Articles, Abstracts, and Reports |
| بيانات النشر: | Providence St. Joseph Health Digital Commons |
| سنة النشر: | 2020 |
| المجموعة: | Providence St. Joseph Health Digital Commons |
| مصطلحات موضوعية: | Adult, Aged, Allopurinol, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Double-Blind Method, Enzyme Inhibitors, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Renin-Angiotensin System, Treatment Failure, Uric Acid, Xanthine Oxidase, Endocrinology, Diabetes, and Metabolism |
| الوصف: | BACKGROUND: Higher serum urate levels are associated with an increased risk of diabetic kidney disease. Lowering of the serum urate level with allopurinol may slow the decrease in the glomerular filtration rate (GFR) in persons with type 1 diabetes and early-to-moderate diabetic kidney disease. METHODS: In a double-blind trial, we randomly assigned participants with type 1 diabetes, a serum urate level of at least 4.5 mg per deciliter, an estimated GFR of 40.0 to 99.9 ml per minute per 1.73 m RESULTS: A total of 267 patients were assigned to receive allopurinol and 263 to receive placebo. The mean age was 51.1 years, the mean duration of diabetes 34.6 years, and the mean glycated hemoglobin level 8.2%. The mean baseline iohexol-based GFR was 68.7 ml per minute per 1.73 m CONCLUSIONS: We found no evidence of clinically meaningful benefits of serum urate reduction with allopurinol on kidney outcomes among patients with type 1 diabetes and early-to-moderate diabetic kidney disease. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; PERL ClinicalTrials.gov number, NCT02017171.). |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.psjhealth.org/publications/3311Test; https://pubmed.ncbi.nlm.nih.gov/32579810Test |
| الإتاحة: | https://digitalcommons.psjhealth.org/publications/3311Test https://pubmed.ncbi.nlm.nih.gov/32579810Test |
| رقم الانضمام: | edsbas.B1C155B8 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |