دورية أكاديمية
HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey
| العنوان: | HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey |
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| المؤلفون: | Sargin, F., Sayan, M., Inan, D., Sevgi, D.Y., Celikbas, A.K., Yasar, K., Kaptan, F. |
| بيانات النشر: | Mary Ann Liebert Inc. |
| سنة النشر: | 2016 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | nonnucleoside reverse transcriptase inhibitor, antivirus agent, RNA directed DNA polymerase inhibitor, thymidine derivative, anti human immunodeficiency virus agent, Female, Human immunodeficiency virus proteinase, Human immunodeficiency virus proteinase inhibitor, RNA directed DNA polymerase, virus RNA, antiviral resistance, Article, child, cohort analysis, human, Human immunodeficiency virus 1, Human immunodeficiency virus 1 infection, Human immunodeficiency virus infected patient, major clinical study, male, preschool child, prevalence, priority journal, Turkey (republic), virus mutation, virus transmission, world health organization, adult, CD4 lymphocyte count, drug effects |
| الوصف: | HIV-1 replication is rapid and highly error-prone. Transmission of a drug-resistant HIV-1 strain is possible and occurs within the HIV-1-infected population. In this study, we aimed to determine the prevalence of transmitted drug resistance mutations (TDRMs) in 1,306 newly diagnosed untreated HIV-1-infected patients from 21 cities across six regions of Turkey between 2010 and 2015. TDRMs were identified according to the criteria provided by the World Health Organization's 2009 list of surveillance drug resistance mutations. The HIV-1 TDRM prevalence was 10.1% (133/1,306) in Turkey. Primary drug resistance mutations (K65R, M184V) and thymidine analogue-associated mutations (TAMs) were evaluated together as nucleos(t)ide reverse transcriptase inhibitor (NRTI) mutations. NRTI TDRMs were found in 8.1% (107/1,306) of patients. However, TAMs were divided into three categories and M41L, L210W, and T215Y mutations were found for TAM1 in 97 (7.4%) patients, D67N, K70R, K219E/Q/N/R, T215F, and T215C/D/S mutations were detected for TAM2 in 52 (3.9%) patients, and M41L + K219N and M41L + T215C/D/S mutations were detected for the TAM1 + TAM2 profile in 22 (1.7%) patients, respectively. Nonnucleoside reverse transcriptase inhibitor-associated TDRMs were detected in 3.3% (44/1,306) of patients (L100I, K101E/P, K103N/S, V179F, Y188H/L/M, Y181I/C, and G190A/E/S) and TDRMs to protease inhibitors were detected in 2.3% (30/1,306) of patients (M46L, I50V, I54V, Q58E, L76V, V82A/C/L/T, N83D, I84V, and L90M). In conclusion, long-term and large-scale monitoring of regional levels of HIV-1 TDRMs informs treatment guidelines and provides feedback on the success of HIV-1 prevention and treatment efforts. © Copyright 2016, Mary Ann Liebert, Inc. 2016. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0889-2229 |
| العلاقة: | AIDS Research and Human Retroviruses; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/9948Test; https://doi.org/10.1089/aid.2015.0110Test; 32; 26; 31; 2-s2.0-84954092536; WOS:000367335100005 |
| DOI: | 10.1089/aid.2015.0110 |
| الإتاحة: | https://doi.org/10.1089/aid.2015.0110Test https://hdl.handle.net/11499/9948Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.CBE78185 |
| قاعدة البيانات: | BASE |
| تدمد: | 08892229 |
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| DOI: | 10.1089/aid.2015.0110 |