دورية أكاديمية
Relationship between Carotid Intima-Media Thickness and Osteoporosis in Type 2 Diabetic Patients: Cross-Sectional Study in the Third-Level Center
| العنوان: | Relationship between Carotid Intima-Media Thickness and Osteoporosis in Type 2 Diabetic Patients: Cross-Sectional Study in the Third-Level Center |
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| المؤلفون: | Güneş M., Kara Z., Yavuzer S., Yavuzer H., Bolayirli I.M., Oşar Siva Z. |
| بيانات النشر: | Mary Ann Liebert Inc. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | bone turnover, osteoporosis, subclinical atherosclerosis, alkaline phosphatase, carboxy terminal telopeptide, collagen type 1, glucose, hemoglobin A1c, osteocalcin, 4-toluenesulfonyl fluoride, adult, age, aged, Article, body mass, bone density, carotid intima-media thickness, controlled study, cross-sectional study, diabetic patient, fasting blood glucose level, female, femur, human, hyperlipidemia, hypertension, lumbar region, major clinical study, male, non insulin dependent diabetes mellitus |
| الوصف: | Aim: Although atherosclerosis and osteoporosis (OP) are seen in elderly patients, it is still a matter of research whether there is an age-independent relationship between them. In our study, we planned to investigate the relationship between carotid intima-media thickness (CIMT), OP, and bone turnover parameters in patients with type 2 diabetes mellitus (DM2) of both sexes. Materials and Methods: A total of 69 patients and 40 healthy volunteers with chronic diseases such as DM2, hypertension, hyperlipidemia, and OP. Group 1 had 27 patients with DM2 and OP, group 2 had 42 patients with DM2 and no OP, and group 3 had 40 healthy volunteers without DM2 and OP. Results: In the control group, CIMT was measured lower than the patients with DM2 (0.8 + 0.1 and 1.1 + 0.3, P < 0.001, respectively). Femur T score and lumbar T score values of patients with DM2 were lower than the control group (-0.48 + 1.1 and 0.7 + 0.6, P < 0.001, and -1.3 + 1.5 and 0.6 + 0.5, P < 0.001, respectively). Bone turnover markers in DM2 compared to the control group (C-terminal telopeptide of type 1 collagen: 240.9 ± 211.1 and 606.5 ± 200.8, P < 0.001; bone-specific alkaline phosphatase: 47.9 ± 15.5 and 431.5 ± 140, P < 0.001; and osteocalcin: 13.2 ± 5.0 and 19.7 ± 9.2, P < 0.001, respectively) were lower. Patients with femoral region (TSF) T score and lumbar region (TSL) T score below -2.5 were found to have higher CIMT values than those without (1.2 ± 0.23 mm and 0.9 ± 0.23 mm, P = 0.006, and 1.1 ± 0.28 mm and 0.95 ± 0.21 mm, P = 0.003, respectively). In linear regression analysis, age (? = 0.01, P < 0.001), OP (? = 0.166, P = 0.001), and DDM2 (? = 0.222, P = 0.04) were found to be effective on CIMT, while DM2 (?) = -0.754, P < 0.001), CIMT (? = -0.258, P = 0.021), body mass index (? = 0.355, P = 0.028), and age (? = -0.229, P = 0.029) were found to be independent factors on TSF. Conclusion: Bone turnover and bone mineral density are decreased in DM2 patients. In addition, subclinical atherosclerosis is more common in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 15404196 |
| العلاقة: | Metabolic Syndrome and Related Disorders; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1089/met.2022.0008Test; https://hdl.handle.net/20.500.12831/12845Test; 20; 10; 592; 598; 2-s2.0-85144589431 |
| DOI: | 10.1089/met.2022.0008 |
| الإتاحة: | https://doi.org/10.1089/met.2022.0008Test https://doi.org/20.500.12831/12845Test https://hdl.handle.net/20.500.12831/12845Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.85E784AE |
| قاعدة البيانات: | BASE |
| تدمد: | 15404196 |
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| DOI: | 10.1089/met.2022.0008 |