دورية أكاديمية
The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas
| العنوان: | The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas |
|---|---|
| المؤلفون: | D'Andrea A., Gritti I., Nicoli P., Giorgio M., Doni M., Conti A., Bianchi V., Casoli L., Sabo A., Mironov A., Beznoussenko G. V., Amati B. |
| المساهمون: | D'Andrea, A., Gritti, I., Nicoli, P., Giorgio, M., Doni, M., Conti, A., Bianchi, V., Casoli, L., Sabo, A., Mironov, A., Beznoussenko, G. V., Amati, B. |
| بيانات النشر: | Impact Journals LLC |
| سنة النشر: | 2016 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Lymphoma, Mitochondria, Mitochondrial translation, Myc, Tigecycline, Animal, Arabidopsis Protein, Burkitt Lymphoma, Cell Line, Tumor, Human, Mice, Transgenic, Minocycline, Protein Biosynthesi, Proto-Oncogene Proteins c-myc, RNA-Binding Protein, Xenograft Model Antitumor Assays |
| الوصف: | The oncogenic transcription factor Myc is required for the progression and maintenance of diverse tumors. This has led to the concept that Myc itself, Myc-activated gene products, or associated biological processes might constitute prime targets for cancer therapy. Here, we present an in vivo reverse-genetic screen targeting a set of 241 Myc-activated mRNAs in mouse B-cell lymphomas, unraveling a critical role for the mitochondrial ribosomal protein (MRP) Ptcd3 in tumor maintenance. Other MRP-coding genes were also up regulated in Myc-induced lymphoma, pointing to a coordinate activation of the mitochondrial translation machinery. Inhibition of mitochondrial translation with the antibiotic Tigecycline was synthetic-lethal with Myc activation, impaired respiratory activity and tumor cell survival in vitro, and significantly extended lifespan in lymphoma-bearing mice. We have thus identified a novel Myc-induced metabolic dependency that can be targeted by common antibiotics, opening new therapeutic perspectives in Myc-overexpressing tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27635472; info:eu-repo/semantics/altIdentifier/wos/WOS:000387452100003; volume:7; issue:45; firstpage:72415; lastpage:72430; numberofpages:16; journal:ONCOTARGET; http://hdl.handle.net/11577/3339100Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84995769193 |
| DOI: | 10.18632/oncotarget.11719 |
| الإتاحة: | https://doi.org/10.18632/oncotarget.11719Test http://hdl.handle.net/11577/3339100Test |
| رقم الانضمام: | edsbas.BEED947C |
| قاعدة البيانات: | BASE |
| DOI: | 10.18632/oncotarget.11719 |
|---|