دورية أكاديمية
Insulin-induced hypoglycemia accelerates gastric emptying of solids and liquids in long-standing type 1 diabetes
| العنوان: | Insulin-induced hypoglycemia accelerates gastric emptying of solids and liquids in long-standing type 1 diabetes |
|---|---|
| المؤلفون: | Russo, A., Stevens, J., Chen, R., Gentilcore, D., Burnet, R., Horowitz, M., Jones, K. |
| المصدر: | http://dx.doi.org/10.1210/jc.2005-0513Test. |
| بيانات النشر: | Endocrine Society |
| سنة النشر: | 2005 |
| المجموعة: | The University of Adelaide: Digital Library |
| مصطلحات موضوعية: | Humans, Diabetes Mellitus, Type 1, Hypoglycemia, Technetium, Gallium Radioisotopes, Insulin, Hypoglycemic Agents, Glucose Clamp Technique, Blood Pressure, Heart Rate, Drinking, Eating, Gastric Emptying, Adult, Middle Aged, Female, Male |
| الوصف: | Copyright © 2005 by The Endocrine Society ; Context The rate of gastric emptying of carbohydrate is a major determinant of postprandial glycemia. In healthy subjects and patients with uncomplicated type 1 diabetes, there is evidence that gastric emptying may be accelerated by insulin-induced hypoglycemia. Objective The objective was to determine the effects of acute hypoglycemia on gastric emptying in long-standing type 1 diabetes and evaluate whether the response to hypoglycemia is influenced by the rate of gastric emptying during euglycemia and/or autonomic dysfunction. Design Gastric emptying of a solid/liquid meal (100 g (99m)Tc-minced beef and 150 ml 67Ga-EDTA-labeled water) was measured by scintigraphy on 2 separate days, during hypoglycemia and euglycemia. Setting These studies took place at the Department of Nuclear Medicine, Positron Emission Tomography, and Bone Densitometry at the Royal Adelaide Hospital. Patients Twenty type 1 patients (4 female, 16 male; age, 45.9 +/- 2.3 yr; duration of known diabetes, 18.0 +/- 2.7 yr) were recruited from outpatient clinics and the Diabetes Centre at the Royal Adelaide Hospital. Intervention Hypoglycemia (approximately 2.6 mmol/liter) was established 15 min before and maintained for 45 min after meal consumption. On one of the days, autonomic nerve function was evaluated using cardiovascular reflex tests. Main outcome measure The main outcome measure was gastric emptying during hypoglycemia when compared with euglycemia. Results Twelve of the 20 subjects had autonomic neuropathy. Gastric emptying of both solid (P < 0.001) and liquid (P < 0.05) was faster during hypoglycemia. The magnitude of this acceleration was greater when the rate of gastric emptying during euglycemia was slower (solid, percentage retention at 100 min, r = -0.52, P < 0.05; liquid, 50% emptying time, r = -0.82, P < 0.0001, but not influenced by autonomic nerve function). Conclusions Insulin-induced hypoglycemia accelerates gastric emptying of solids and liquids in long-standing type ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0021-972X 1945-7197 |
| العلاقة: | Journal of Clinical Endocrinology and Metabolism, 2005; 90(8):4489-4495; http://hdl.handle.net/2440/17471Test; Horowitz, M. [0000-0002-0942-0306]; Jones, K. [0000-0002-1155-5816] |
| DOI: | 10.1210/jc.2005-0513 |
| الإتاحة: | https://doi.org/10.1210/jc.2005-0513Test http://hdl.handle.net/2440/17471Test |
| رقم الانضمام: | edsbas.3900CD37 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0021972X 19457197 |
|---|---|
| DOI: | 10.1210/jc.2005-0513 |