دورية أكاديمية
In vitro activity of tigecycline alone and antimicrobial combinations against clinical Neisseria gonorrhoeae isolates
| العنوان: | In vitro activity of tigecycline alone and antimicrobial combinations against clinical Neisseria gonorrhoeae isolates |
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| المساهمون: | College of Medicine, Dept. of Laboratory Medicine, Hyukmin Lee, Hyunsoo Kim, Young Hee Seo, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee, Younsop Chong, Yong, Dong Eun, Lee, Kyung Won, Lee, Hyuk Min, Jeong, Seok Hoon |
| بيانات النشر: | Elsevier Biomedical United States |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Anti-Bacterial Agents/pharmacology, Drug Synergism, Gonorrhea/microbiology, Humans, Microbial Sensitivity Tests, Minocycline/analogs & derivatives, Minocycline/pharmacology, Neisseria gonorrhoeae/drug effects, Neisseria gonorrhoeae/isolation & purification, Combination treatment, Gonorrhea, In vitro activity, Moxifloxacin, Synergy, Tigecycline |
| الوصف: | In this study, we determined the in vitro activity of various combinations of antimicrobial agents against 54 Neisseria gonorrhoeae isolates. The combined activity of ceftriaxone (CRO) and azithromycin (AZM), CRO and doxycycline (DOX), CRO and spectinomycin (SPT), cefixime (CFX) and AZM, CFX and DOX, and CFX and SPT was determined using a checkerboard method. The fractional inhibitory concentration index (FICI) values for all combinations were either additive or indifferent, and no synergistic or antagonistic effects were found. The FICI comparison in each combination did not show any difference according to the N.gonorrhoeae-resistant phenotypes and genotypic characteristics, including penicillinase-producing N. gonorrhoeae, tetracycline-resistant N. gonorrhoeae, stratified MIC of all antibiotics, and N. gonorrhoeae multiantigen sequence typing. MIC50 and MIC90 of tigecycline by agar dilution were 0.5 mg/L and 0.5 mg/L, respectively, which were lower than that of tetracycline and DOX. Additive/indifference results could suggest that combinations that include CRO may be used safely without a significant likelihood of generating resistance. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-7328-8931-9 0-7328-8931-6 |
| تدمد: | 0732-8893 1879-0070 |
| العلاقة: | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; J00731; OAK-2017-02626; https://ir.ymlib.yonsei.ac.kr/handle/22282913/154282Test; http://www.sciencedirect.com/science/article/pii/S0732889316303650Test; T201702194; DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.87 : 160-162, 2017 |
| DOI: | 10.1016/j.diagmicrobio.2016.10.022 |
| الإتاحة: | https://doi.org/10.1016/j.diagmicrobio.2016.10.022Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/154282Test http://www.sciencedirect.com/science/article/pii/S0732889316303650Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.9A440A45 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780732889319 0732889316 |
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| تدمد: | 07328893 18790070 |
| DOI: | 10.1016/j.diagmicrobio.2016.10.022 |