دورية أكاديمية
Extent and prevalence of post-exercise and nocturnal hypoglycemia following peri-exercise bolus insulin adjustments in individuals with type 1 diabetes
| العنوان: | Extent and prevalence of post-exercise and nocturnal hypoglycemia following peri-exercise bolus insulin adjustments in individuals with type 1 diabetes |
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| المؤلفون: | McCarthy, Olivia, Deere, Rachel, Churm, Rachel, Dunseath, Gareth J., Jones, Charlotte, Eckstein, Max L., Williams, David M., Hayes, Jennifer, Pitt, Jason, Bain, Stephen C., Moser, Othmar, Bracken, Richard M. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Cardiff University: ORCA (Online Research @ Cardiff) |
| الوصف: | Aim: To detail the extent and prevalence of post-exercise and nocturnal hypoglycemiafollowing peri-exercise bolus insulin dose adjustments in individuals with type 1 diabetes (T1D)using multiple daily injections of insulins aspart (IAsp) and degludec (IDeg).Methods and results: Sixteen individuals with T1D, completed a single-centred, randomised, fourperiod crossover trial consisting of 23-h inpatient phases. Participants administered either a regular (100%) or reduced (50%) dose (100%; 5.1 2.4, 50%; 2.6 1.2 IU, p < 0.001) of individualisedIAsp 1 h before and after 45-min of evening exercise at 60 6% V_O2max. An unaltered dose ofIDeg was administered in the morning. Metabolic, physiological and hormonal responses duringexercise, recovery and nocturnal periods were characterised. The primary outcome was the number of trial day occurrences of hypoglycemia (venous blood glucose 3.9 mmol L 1). Inclusion ofa 50% IAsp dose reduction strategy prior to evening exercise reduced the occurrence of inexercise hypoglycemia (p Z 0.023). Mimicking this reductive strategy in the post-exercise perioddecreased risk of nocturnal hypoglycemia (p Z 0.045). Combining this strategy to reflect reductions either side of exercise resulted in higher glucose concentrations in the acute post-exercise(p Z 0.034), nocturnal (p Z 0.001), and overall (p < 0.001) periods. Depth of hypoglycemia(p Z 0.302), as well as ketonic and counter-regulatory hormonal profiles were similar.Conclusions: These findings demonstrate the glycemic safety of peri-exercise bolus dose reduction strategies in minimising the prevalence of acute and nocturnal hypoglycemia following evening exercise in people with T1D on MDI. Use of newer background insulins with current bolusinsulins demonstrates efficacy and advances current recommendations for safe performance ofexercise. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://orca.cardiff.ac.uk/id/eprint/162786/1/1-s2.0-S0939475320303343-main.pdfTest; McCarthy, Olivia, Deere, Rachel https://orca.cardiff.ac.uk/view/cardiffauthors/A2781135J.htmlTest, Churm, Rachel, Dunseath, Gareth J., Jones, Charlotte, Eckstein, Max L., Williams, David M., Hayes, Jennifer, Pitt, Jason, Bain, Stephen C., Moser, Othmar and Bracken, Richard M. 2021. Extent and prevalence of post-exercise and nocturnal hypoglycemia following peri-exercise bolus insulin adjustments in individuals with type 1 diabetes. Nutrition, Metabolism & Cardiovascular Diseases 31 (1) , pp. 227-236. 10.1016/j.numecd.2020.07.043 https://doi.org/10.1016/j.numecd.2020.07.043Test file https://orca.cardiff.ac.uk/id/eprint/162786/1/1-s2.0-S0939475320303343-main.pdfTest |
| DOI: | 10.1016/j.numecd.2020.07.043 |
| الإتاحة: | https://doi.org/10.1016/j.numecd.2020.07.043Test https://orca.cardiff.ac.uk/id/eprint/162786Test/ https://orca.cardiff.ac.uk/id/eprint/162786/1/1-s2.0-S0939475320303343-main.pdfTest |
| حقوق: | cc_by_nc_nd_4_0 |
| رقم الانضمام: | edsbas.B5D0CAB9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.numecd.2020.07.043 |
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