دورية أكاديمية
LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival
| العنوان: | LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival |
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| المؤلفون: | Yi Que, Zhixin Fang, Yuanxiang Guan, Wei Xiao, Bushu Xu, Jingjing Zhao, Huoying Chen, Xinke Zhang, Musheng Zeng, Yao Liang, Xing Zhang |
| المصدر: | Cancer Biology & Medicine, Vol 16, Iss 2, Pp 331-340 (2019) |
| بيانات النشر: | China Anti-Cancer Association |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Soft tissue sarcoma, LAG-3, expression, prognosis, tumor-infiltrating lymphocytes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Objective To elucidate the role and prognostic significance of lymphocyte activation-gene-3 (LAG-3) in soft tissue sarcoma (STS). Methods The expression of LAG-3 in patient and matched normal blood samples was analyzed by flow cytometry. The localization and prognostic values of LAG-3 + cells in 163 STS patients were analyzed by immunohistochemistry. In addition, the expression of tumor-infiltrating CD3 + T, CD4 + T, and CD8 + T cells and their role in the prognosis of STS were evaluated by immunohistochemistry. The effect of LAG-3 blockade was evaluated in an immunocompetent MCA205 fibrosarcoma mouse model. Results Peripheral CD8 + and CD4 + T cells from STS patients expressed higher levels of LAG-3 than those from healthy donors. LAG-3 expression in STS was significantly associated with a poor clinical outcome ( P = 0.038 ) and was correlated with high pathological grade ( P < 0.001), advanced tumor stage ( P = 0.016). Additionally, LAG-3 expression was highly correlated with CD8 + T-cell infiltration ( r = 0.7034, P < 0.001). LAG-3 was expressed in murine tumor-infiltrating lymphocytes, and its blockade decreased tumor growth and enhanced secretion of interferon-gamma by CD8 + and CD4 + T cells. Conclusions LAG-3 blockade may be a promising strategy to improve the effects of targeted therapy in STS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2095-3941 |
| العلاقة: | http://www.cancerbiomed.org/index.php/cocr/article/view/1427Test; https://doaj.org/toc/2095-3941Test; https://doaj.org/article/4794621709514320bd4aa8ddc6bcbcfdTest |
| DOI: | 10.20892/j.issn.2095-3941.2018.0306 |
| الإتاحة: | https://doi.org/10.20892/j.issn.2095-3941.2018.0306Test https://doaj.org/article/4794621709514320bd4aa8ddc6bcbcfdTest |
| رقم الانضمام: | edsbas.770E3D47 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20953941 |
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| DOI: | 10.20892/j.issn.2095-3941.2018.0306 |