رسالة جامعية
Avaliação dos mecanismos determinantes dos efeitos cardiovasculares promovidos pelo IM-7 em ratos com hipertensão induzida pelo L-NAME : abordagens in vivo e in vitro ; Evaluation of determinant mechanisms involved in cardiovascular effects induced by IM-7 in L-NAME hypertensive rats: In vivo and in vitro approaches
| العنوان: | Avaliação dos mecanismos determinantes dos efeitos cardiovasculares promovidos pelo IM-7 em ratos com hipertensão induzida pelo L-NAME : abordagens in vivo e in vitro ; Evaluation of determinant mechanisms involved in cardiovascular effects induced by IM-7 in L-NAME hypertensive rats: In vivo and in vitro approaches |
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| المؤلفون: | Anjos, Raline Mendonça dos |
| المساهمون: | Medeiros, Isac Almeida de, http://lattes.cnpq.br/3412816427200150Test |
| بيانات النشر: | Universidade Federal da Paraíba BR Farmacologia Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos UFPB |
| سنة النشر: | 2010 |
| المجموعة: | Universidade Federal da Paraiba: Biblioteca Digital de Teses e Dissertações |
| مصطلحات موضوعية: | Hipotensão, Vasorrelaxamento, Óxido Nítrico - NO, Receptores muscarínicos, Hypotension, Vasorelaxant effect, Muscarinic receptors, CIENCIAS BIOLOGICAS::FARMACOLOGIA |
| الوصف: | Imidazolidinic derivates present a wide range of biological activities, such as anti-arrhythmic and anti-hypertensive. The vasorelaxant effect of six Imidazolinic compounds was evaluated in this study. Among of this, the cardiovascular effects induced by IM-7 were evaluated using in vivo and in vitro assays. HPA-01 and IM-3 produced a reduced relaxation of rat mesenteric artery rings contracted by phenylephrine (PHE) (MR = 43.15 ± 7.69%; MR = 54.08 ± 6.59%, respectively). IM-6 e IM-2 showed vasoconstictor effects in rigns with endothelium and vasorelaxant effect when endothelium was removed. Meanwhile, HPA-02 did not induce significant vasorelaxant effect. In normotensive non-anesthetized rats, the pretreatment with L-NAME or hexamethonium did not affect the hypotensive and bradicardic effects induced by IM-7. In isolated rat atrial preparations from normotensive, IM-7 (1pM-1 mM) produced negative chronotropic (MR = 65.45 ± 11.4%; pD2 = 3.94 ± 0.02) and inotropic (MR = 68.58 ± 8,0% ; pD2 = 6.74 ± 0.05) effects. which were attenuated by atropine. In hypertensive non-anesthetized rats IM-7 (1, 5, 10, 20 e 30 mg/Kg, i.v.) induced hypotensive and bradicardic effects. These effects were abolished after pre-treatment with atropine (2 mg/Kg, i.v.). In isolated hypertensive rat mesenteric artery rings IM-7 (1pM-1 mM), elicited concentration-dependent relaxation of PHE-induced contraction (pD2 = 5.64 0.09). After removal of the vascular endothelium IM-7 effects were significantly attenuated (pD2 = 3.8 ± 0.07 p < 0.001), suggesting the participation of endothelium derived relaxant factors in the IM-7 induced vasorelaxant effect. Similar results were obtained in the presence of L-NAME (100 M), ODQ (10μM), or atropine (100 nM). In endothelium denuded rings incubed with KCl 20 mM the relaxant response was not attenuated. Furthermore, in absence of extracellular calcium, IM-7 concentration-dependently depressed the vasoconstrictions derived from CaCl2. Similar results were obtained in contractions induced by 5-HT, ... |
| نوع الوثيقة: | thesis |
| وصف الملف: | application/pdf |
| اللغة: | Portuguese |
| العلاقة: | ANJOS, Raline Mendonça dos. Avaliação dos mecanismos determinantes dos efeitos cardiovasculares promovidos pelo IM-7 em ratos com hipertensão induzida pelo L-NAME : abordagens in vivo e in vitro. 2010. 145 f. Tese (Doutorado em Produtos Naturais e Sintéticos Bioativos) - Universidade Federal da Paraíba, João Pessoa, 2010.; https://repositorio.ufpb.br/jspui/handle/tede/6855Test |
| الإتاحة: | https://repositorio.ufpb.br/jspui/handle/tede/6855Test |
| حقوق: | Acesso aberto |
| رقم الانضمام: | edsbas.8AAD4F92 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |