دورية أكاديمية
Oxybutynin transdermal system improves the quality of life in adults with overactive bladder: a multicentre, community-based, randomized study.
| العنوان: | Oxybutynin transdermal system improves the quality of life in adults with overactive bladder: a multicentre, community-based, randomized study. |
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| المؤلفون: | Sand, Peter, Zinner, Norman, Newman, Diane, Lucente, Vincent, Dmochowski, Roger, Kelleher, Con, Dahl, Naomi V |
| المصدر: | Department of Obstetrics & Gynecology |
| بيانات النشر: | LVHN Scholarly Works |
| سنة النشر: | 2007 |
| المجموعة: | Lehigh Valley Health Network: LVHN Scholarly Works |
| مصطلحات موضوعية: | Administration, Cutaneous, Adolescent, Adult, Aged, 80 and over, Female, Humans, Male, Mandelic Acids, Middle Aged, Muscarinic Antagonists, Quality of Life, Severity of Illness Index, Treatment Outcome, Urinary Bladder, Overactive, Urinary Incontinence, Department of Obstetrics and Gynecology, Medicine and Health Sciences |
| الوصف: | OBJECTIVE: To assess health-related quality-of-life (HRQoL) and safety with the oxybutynin transdermal system (OXY-TDS) (Oxytrol), Watson Pharma, Corona, CA, USA) in the Multicentre Assessment of Transdermal Therapy in Overactive Bladder With Oxybutynin (MATRIX) study, as HRQoL measurements are increasingly important in evaluating pharmacotherapy for overactive bladder (OAB). PATIENTS AND METHODS: This randomized, open-label, community-based study enrolled 2878 participants aged >/=18 years who had been given a diagnosis of OAB. The 327 study sites were representative of various practice types. All participants were treated with OXY-TDS 3.9 mg/day for RESULTS: Most enrolees (2052/2625; 78.2%) had moderate to severe OAB at baseline (Patient Perception of Bladder Condition score >/= 4 on a scale of 1-6), and most (1632/2859; 57.1%) had been given previous drug treatment for OAB. Of 2592 with evaluable baseline KHQ scores, 92.2% reported urgency and 88.2% reported urge urinary incontinence. The most impaired domains at baseline were Incontinence Impact (69.3), Symptom Severity (55.9), and Sleep/Energy (54.2). There were clinically meaningful and statistically significant improvements in nine of 10 domains at the study end; the greatest improvements were in Incontinence Impact (-13.5), Symptom Severity (-12.4), and Role Limitations (-13.3). The treatment was well tolerated, with low incidences of drug-related anticholinergic adverse effects such as dry mouth (75; 2.6%), constipation (44; 1.5%), and dizziness (21; 0.7%). There were drug-related application-site reactions, including pruritus, erythema, dermatitis and irritation, in 14.0% of participants. CONCLUSIONS: OXY-TDS treatment was well tolerated in this diverse, community-based population, and resulted in clinically significant improvements in HRQoL, regardless of baseline characteristics. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholarlyworks.lvhn.org/obstetrics-gynecology/1172Test; https://pubmed.ncbi.nlm.nih.gov/17187655Test/ |
| الإتاحة: | https://scholarlyworks.lvhn.org/obstetrics-gynecology/1172Test https://pubmed.ncbi.nlm.nih.gov/17187655Test/ |
| رقم الانضمام: | edsbas.C3157618 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |