دورية أكاديمية
原発性開放隅角緑内障(広義)への挑戦:臨床的諸問題とその科学的解決
| العنوان: | 原発性開放隅角緑内障(広義)への挑戦:臨床的諸問題とその科学的解決 |
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| المؤلفون: | 杉山 和久 |
| بيانات النشر: | Japanese Ophthalmological Society = 日本眼科学会 |
| سنة النشر: | 2012 |
| المجموعة: | Kanazawa University Repository for Academic Resources (KURA) / 金沢大学学術情報リポジトリ |
| مصطلحات موضوعية: | 原発性開放隅角緑内障(広義), 正常眼圧緑内障, 乳頭出血, 網膜神経線維層欠損, スペクトラルドメイン光干渉断層計, 眼底像視野計, 眼圧日内変動, 時計遺伝子, テーラーメイド薬物治療, 片眼トライアル, 走査レーザー検眼鏡, ラット専用光干渉断層計, 緑内障濾過手術, ハニカムフィルム, Primary open-angle glaucoma, normal-tension glaucoma, disc hemorrhage, Retinal nerve fiber layer defect, Spectral-domain optical coherence tomography (Spectral-domain OCT), Fundus-oriented perimeter, Diurnal intraocular pressure rhythm, Circadian clock gene, Tailor-made medicine, One-eye trial, Scanning laser ophthalmoscope, OCT system for rat eye, Glaucoma filtration surgery, Honeycomb film |
| الوصف: | Primary open-angle glaucoma (POAG), including normal-tension glaucoma (NTG), is reported by the Tajimi Study to afflict 3.9% of the total population, and this represents about 80% of all total glaucoma cases which, in total, afflict 5.0% of the population. We tried to analyze the clinical problems relating to POAG by looking at the pathogenesis, intraocular pressure (IOP), therapy, neuroprotection and surgery of the disease. To elucidate the pathogenesis of glaucoma progression, we measured retinal nerve fiber layer defect (RNFLD) angles', and divided the NTG cases into 2 groups, enlarged RNFLD and stable RNFLD. Disc hemorrhages were found to be significantly more frequent in the enlarged group than in the stable group. RNFLD was enlarged in the direction of disc hemorrhage in over 80% of the eyes. In the majority of the eyes of the enlarged group, the enlargement of RNFLD was toward the fovea. The enlargement of RNFLD in NTG was closely associated with disc hemorrhage and the deterioration of the visual field. We developed a simultaneous structure and function evaluation technique combining spectral-domain (SD) optical coherence tomography (OCT) and fundus-oriented perimeters for the detection of visual field abnormalities in the RNFLD area. We superimposed the ganglion cell complex map obtained by SD-OCT on the fundus-oriented perimeter image. We observed very early or preperimetric normal pressure glaucoma as well as disc hemorrhage adjacent to the borders of the RNFLD. The borderline of the RNFLD seemed to be the thinnest RNFL and had the lowest retinal sensitivity (Active site for RNFLD progression). To clarify the role of the circadian clock genes in the generation of a 24-hour IOP rhythm, we used the microneedle method to measure the IOP at eight time points daily, both in wild type mice and Cry-deficient (Cry 1-/-Cry 2-/-) mice. In the wild-type mice living in light-dark conditions, the pressure measured in the light phase was significantly lower than in the dark phase. This biphasic daily rhythm was ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | Japanese |
| تدمد: | 0029-0203 |
| العلاقة: | http://www.nichigan.or.jp/index.jspTest; https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=13841Test; http://hdl.handle.net/2297/32485Test; 日本眼科学会雜誌 = Nippon Ganka Gakkai zasshi, 116(3), 233-268(2012-03-01); AN00187157; https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=13841&item_no=1&attribute_id=26&file_no=1Test |
| الإتاحة: | http://hdl.handle.net/2297/32485Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=13841Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=13841&item_no=1&attribute_id=26&file_no=1Test |
| حقوق: | © 日本眼科学会 |
| رقم الانضمام: | edsbas.78A6EF4D |
| قاعدة البيانات: | BASE |
| تدمد: | 00290203 |
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